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  • Print publication year: 2018
  • Online publication date: January 2018

7 - Renal and Metabolic Aging

from Section 2 - General Health and Illness
1.Klotz, U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2009; 41(2):6776.
2.Deiner, S, Silverstein, JH. Anesthesia for geriatric patients. Minerva Anestesiol. 2011; 77(2):180189.
3.Sharma, A, Mucino, MJ, Ronco, C. Renal functional reserve and renal recovery after acute kidney injury. Nephron Clin Pract. 2014; 127(1-4):94100.
4.Sophie, S. Anaesthesia for the elderly patient. J Pak Med Assoc. 2007; 57(4):196201.
5.2014 National Population Projections: summary tables. 2014; Available at: (Accessed July 5, 2017).
6.Tonner, PH, Kampen, J, Scholz, J. Pathophysiological changes in the elderly. Best Pract Res Clin Anaesthesiol. 2003; 17(2):163177.
7.McLachlan, AJ, Bath, S, Naganathan, V, et al. Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol. 2011; 71(3):351364.
8.Grassi, M, Petraccia, L, Mennuni, G, et al. Changes, functional disorders, and diseases in the gastrointestinal tract of elderly. Nutr Hosp. 2011; 26(4):659668.
9.Steele, AC, Meechan, JG. Pharmacology and the elderly. Dent Update. 2010; 37(10):666–8, 670–2.
10.Hilmer, SN, McLachlan, AJ, Le Couteur, DG. Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007; 21(3):217230.
11.Butler, JM, Begg, EJ. Free drug metabolic clearance in elderly people. Clin Pharmacokinet. 2008; 47(5):297321.
12.Crome, P. Pharmacokinetics in older people. Exp Lung Res. 2005; 31(Suppl 1):8083.
13.Turnheim, K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol. 2003; 38(8):843853.
14.Vuyk, J. Pharmacodynamics in the elderly. Best Pract Res Clin Anaesthesiol. 2003; 17(2):207218.
15.Kazama, T, Ikeda, K, Morita, K, et al. Relation between initial blood distribution volume and propofol induction dose requirement. Anesthesiology. 2001; 94(2):205210.
16.Polasek, TM, Patel, F, Jensen, BP, et al. Predicted metabolic drug clearance with increasing adult age. Br J Clin Pharmacol. 2013; 75(4):10191028.
17.Colloca, G, Santoro, M, Gambassi, G. Age-related physiologic changes and perioperative management of elderly patients. Surg Oncol. 2010; 19(3):124130.
18.Lamb, EJ, O'Riordan, SE, Delaney, MP. Kidney function in older people: pathology, assessment and management. Clin Chim Acta. 2003; 334(1–2):2540.
19.Buemi, M, Nostro, L, Aloisi, C, et al. Kidney aging: from phenotype to genetics. Rejuvenation Res. 2005; 8(2):101109.
20.Giannelli, SV, Patel, KV, Windham, BG, et al. Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine. J Am Geriatr Soc. 2007; 55(6):816823.
21.El-Sharkawy, AM, Sahota, O, Maughan, RJ, Lobo, DN. The pathophysiology of fluid and electrolyte balance in the older adult surgical patient. Clin Nutr. 2014; 33(1):613.
22.Allison, SP, Lobo, DN. Fluid and electrolytes in the elderly. Curr Opin Clin Nutr Metab Care. 2004; 7(1):2733.
23.Ferenczi, E, Datta, SS, Chopada, A. Intravenous fluid administration in elderly patients at a London hospital: a two-part audit encompassing ward-based fluid monitoring and prescribing practice by doctors. Int J Surg. 2007; 5(6):408412.
24.Luckey, AE, Parsa, CJ. Fluid and electrolytes in the aged. Arch Surg. 2003; 138(10):10551060.
25.Keita, H, Tubach, F, Maalouli, J, Desmonts, JM, Mantz, J. Age-adapted morphine titration produces equivalent analgesia and adverse effects in younger and older patients. Eur J Anaesthesiol. 2008; 25(5):352356.
26.Paolisso, G. Pathophysiology of diabetes in elderly people. Acta Biomed. 2010; 81(Suppl 1):4753.
27.Meneilly, GS. Pathophysiology of type 2 diabetes in the elderly. Clin Geriatr Med. 1999; 15(2):239253.
28.Geloneze, B, de Oliveira Mda, S, Vasques, AC, Novaes, FS, Pareja, JC, Tambascia, MA. Impaired incretin secretion and pancreatic dysfunction with older age and diabetes. Metabolism. 2014; 63(7):922929.
29.Nin, V, Chini, CC, Escande, C, Capellini, V, Chini, EN. Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. J Biol Chem. 2014; 289(9):55185527.
30.Peeters, RP. Thyroid hormones and aging. Hormones (Athens). 2008; 7(1):2835.