Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-pjpqr Total loading time: 0 Render date: 2024-07-06T22:52:37.740Z Has data issue: false hasContentIssue false

Chapter 11 - Transneuronal Effects

Published online by Cambridge University Press:  27 July 2023

Robert Laureno
Affiliation:
Georgetown University, Washington DC
Get access

Summary

Transneuronal effects distant from acute brain lesions are called diaschisis. Examples are spinal shock and hyporeflexia after acute stroke. Pathological effects distant from chronic brain lesions are anterograde and retrograde transneuronal atrophy. This atrophy is best seen in the visual and cerebro-cerebellar systems, but it almost certainly occurs in other regions of the cerebral cortex. The mechanism of transneuronal trophism is not fully understood.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Nguyen, D. K., Botez, M. I.. Diaschisis and neurobehavior. Can J Neurol Sci 1998; 25: 512.CrossRefGoogle ScholarPubMed
Lin, D. D. M., Kleinman, J. T., Wityk, R. J. et al. Crossed cerebellar diaschisis in acute stroke detected by dynamic susceptibility contrast MR perfusion imaging. AJNR Am J Neuroradiol 2009; 30: 710715.CrossRefGoogle ScholarPubMed
Cowan, W. M.. Anterograde and retrograde transneuronal degeneration in the central and peripheral nervous system. In: Nauta, W. J. H., Ebbesson, S. O. E., eds. Contemporary Research Methods in Neuroanatomy. New York, Springer, 1970; 217251.CrossRefGoogle Scholar
Strefling, A. M., Urich, H.. Crossed cerebellar atrophy: an old problem revisited. Acta Neuropathol 1982; 57: 197202.CrossRefGoogle ScholarPubMed
Baudrimont, M., Gray, F., Meininger, V. et al. [Crossed cerebellar atrophy following hemispheric lesions occurring in adulthood]. [French]. Rev Neurol (Paris) 1983; 139: 485495.Google Scholar
Beatty, R. M., Sadun, A. A., Smith, L. et al. Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes. J Neurol Neurosurg Psychiatry 1982; 45: 143146.CrossRefGoogle ScholarPubMed
Tur, C., Goodkin, O., Altmann, D. R. et al. Longitudinal evidence for anterograde trans-synaptic degeneration after optic neuritis. Brain 2016; 139: 816828.CrossRefGoogle ScholarPubMed
Smith, M. C.. Histological findings after hemicerebellectomy in man: anterograde, retrograde and transneuronal degeneration. Brain Res 1975; 95: 423442.CrossRefGoogle ScholarPubMed
Cowey, A., Alexander, I., Stoerig, P.. Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans. Brain 2011; 134: 21492157.CrossRefGoogle ScholarPubMed
Jindahra, P., Petrie, A., Plant, G. T.. The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans. Brain 2012; 135: 534541.CrossRefGoogle ScholarPubMed
Wang, H., Wang, Y., Wang, R. et al. Hypertrophic olivary degeneration: a comprehensive review focusing on etiology. Brain Res 2019; 1718: 5363.CrossRefGoogle ScholarPubMed
Horton, J. C., Hedley-Whyte, E. T.. Mapping of cytochrome oxidase patches and ocular dominance columns in human visual cortex. Philos Trans R Soc Lond B Biol Sci 1984; 304: 255272.Google ScholarPubMed
Grafstein, B., Laureno, R.. Transport of radioactivity from eye to visual cortex in the mouse. Exp Neurol 1973; 39: 4457.CrossRefGoogle ScholarPubMed
Kourouyan, H. D., Horton, J. C.. Transneuronal retinal input to the primate Edinger-Westphal nucleus. J Comp Neurol 1997; 381: 6880.3.0.CO;2-I>CrossRefGoogle Scholar
Kelly, R. M., Strick, P. L.. Rabies as a transneuronal tracer of circuits in the central nervous system. J Neurosci Methods 2000; 103: 6371.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Transneuronal Effects
  • Robert Laureno, Georgetown University, Washington DC
  • Book: Insights into Clinical Neurology
  • Online publication: 27 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009234986.012
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Transneuronal Effects
  • Robert Laureno, Georgetown University, Washington DC
  • Book: Insights into Clinical Neurology
  • Online publication: 27 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009234986.012
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Transneuronal Effects
  • Robert Laureno, Georgetown University, Washington DC
  • Book: Insights into Clinical Neurology
  • Online publication: 27 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009234986.012
Available formats
×