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Chapter 8 - Some Aspects of the Lower Motor Neuron Syndrome

Published online by Cambridge University Press:  27 July 2023

Robert Laureno
Robert Laureno
Affiliation:
Georgetown University, Washington DC
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Summary

Disease of the lower motor neuron causes a decrease in strength and myotatic reflexes. Involved muscle shows weakness and twitching. The latter is of two types, fibrillation and fasciculation. Fibrillation is due to spontaneous depolarization of single muscle fiber. Fasciculation is due to spontaneous depolarization of the many muscle fibers of a motor unit. As a rule, fibrillation is pathological. Fasciculation may be pathological or benign.

Keywords

Lower motor neuronGroup atrophyfibrillationdenervation atrophycollateral reinnervation
Type
Chapter
Information
Insights into Clinical Neurology , pp. 48 - 51
Publisher: Cambridge University Press
Print publication year: 2023

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References

Denny-Brown, D., Pennybacker, J. B.. Fibrillation and fasciculation in voluntary muscle. Brain 1938; 61: 311–312.CrossRefGoogle Scholar
Lentz, T. L.. Trophic functions of the neuron. VI. Other trophic systems. Neurotrophic regulation at the neuromuscular junction. Ann N Y Acad Sci 1974; 228: 323–337.CrossRefGoogle ScholarPubMed
Korr, I. M., Wilkinson, P. N., Chornock, F. W.. Axonal delivery of neuroplasmic components to muscle cells. Science 1967; 155: 342–345.Google Scholar
Bray, J. J., Harris, A. J.. Dissociation between nerve-muscle transmission and nerve trophic effects on rat diaphragm using type D botulinum toxin. J Physiol 1975; 253: 53–77.CrossRefGoogle ScholarPubMed

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