Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-18T19:25:22.116Z Has data issue: false hasContentIssue false

11 - Antiphospholipid Antibodies and Reproduction

Published online by Cambridge University Press:  16 February 2017

By
Lisa R. Sammaritano
Edited by
Roy G. Farquharson  and
Mary D. Stephenson
Roy G. Farquharson
Affiliation:
Liverpool Women's Hospital
Mary D. Stephenson
Affiliation:
University of Illinois College of Medicine
Get access
Type
Chapter
Information
Early Pregnancy , pp. 113 - 123
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Wasserman, A, Neisser, A, Bruck, C. Eine serodiagnostiche reaktion bei syphilis. Dtsch Med Wochenschr 1906;32:745–49.CrossRefGoogle Scholar
Moore, JE, Mohr, CF. Biologically false positive serologic tests for syphilis: type, incidence and cause. J Am Med Assoc 1952;150:467–73.CrossRefGoogle ScholarPubMed
Conley, CL, Hartmann, RC. A hemorrhagic disorder caused by circulating anticoagulants in patients with disseminated lupus erythematosus. J Clin Investigat 1952;31:621–22.Google Scholar
Beaumont, JL. Acquired hemorrhagic syndrome caused by a circulating anticoagulant: inhibition of the thromboplastic function of the blood platelets – description of a specific test. Sang 1954; 25:1–15.Google ScholarPubMed
Harris, EN, Gharavi, AE, Boey, ML, Patel, BM, Mackworth-Young, CG, Loizou, S. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. The Lancet 1983; 322(8361):1211–14.CrossRefGoogle Scholar
McNeil, HP, Simpson, RJ, Chesterman, CN, Krilis, SA. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid binding inhibitor of coagulation: beta 2 Glycoprotein I (apolipoprotein H). Proc Nat Acad Sci 1990; 87(11):4120–24.CrossRefGoogle ScholarPubMed
Miyakis, S, Lockshin, MD, Atsumi, T, Branch, DW, Brey, RL, Cervera, R, et al.(2006). International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemostas (2006);4(2): 295–306.CrossRefGoogle Scholar
Ruffatti, A, Olivieri, S, Tonello, M, Bortolati, M, Bison, E, Salvan, E, et al. Influence of different IgG anticardiolipin antibody cut-off values on antiphospholipid syndrome classification. J Thrombosis Haem 2008; 6(10):1693–96.Google ScholarPubMed
Bertolaccini, ML, Amengual, O, Atsumi, T, Binder, WL, de Laat, B, Forastiero, R, et al. ‘Non-criteria’ aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010. Lupus 2011; 20(2):191–205.CrossRefGoogle ScholarPubMed
Andreoli, L, Fredi, M, Nalli, C, Piantoni, S, Reggia, R, Dall'Ara, F, et al. Clinical significance of IgA anticardiolipin and IgA antiβ2Glycoprotein I antibodies. Curr Rheum Reports 2013;15(7):1–8.Google ScholarPubMed
Branch, DW, Silver, R, Pierangeli, S, Van Leeuwen, I, Harris, EN. Antiphospholipid antibodies other than lupus anticoagulant and anticardiolipin antibodies in women with recurrent pregnancy loss, fertile controls, and antiphospholipid syndrome. Obstet Gynecol 1997;89(4):549–55.Google ScholarPubMed
Staub, HL, Bertolaccini, ML, Khamashta, MA. Antiphosphatidylethanolamine antibody, thromboembolic events and the antiphospholipid syndrome. Autoimm Rev 2012;12(2):230–34.CrossRefGoogle ScholarPubMed
De Laat, B, Pengo, V, Pabinger, I, Musial, J, Voskuyl, AE, Bultink, IEM, et al. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemostas 2009;7(11):1767–73.CrossRefGoogle Scholar
Pregnolato, F, Chighizola, CB, Encabo, S, Shums, Z, Norman, GL, Tripodi, A, et al. Antiphosphatidylserine/ prothrombin antibodies: an additional diagnostic marker for APS? Immuno Res 2013;56(2–3):432–38.CrossRefGoogle Scholar
Giannakopoulo, B, Krilis, SA. The pathogenesis of the antiphospholipid syndrome. New Eng J Med 2013;368(11):1033.CrossRefGoogle Scholar
Salmon, JE, Girardi, G. Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation. J Repro Immuno 2008;77(1):51–56.CrossRefGoogle Scholar
Rand, JH, Wu, XX, Quinn, AS, Taatjes, DJ. The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis. Lupus 2010;19(4):460–69.CrossRefGoogle ScholarPubMed
Salmon, JE, Heuser, C, Triebwasser, M, Liszewski, MK, Kavanagh, D, Roumenina, L, et al. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med 2011;8(3):e1001013.CrossRefGoogle ScholarPubMed
De Jesus, GR, Agmon-Levin, N, Andrade, CA, Andreoli, L, Chighizola, CB, Porter, TF, et al. 14th international congress on antiphospholipid antibodies task force report on obstetric antiphospholipid syndrome. Autoimm Rev 2014;13:795–813.CrossRefGoogle ScholarPubMed
Robertson, L, Wu, O, Langhorne, P, Twaddle, S, Clark, P, Lowe, GDO, et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006;132:171–96.CrossRefGoogle ScholarPubMed
Oshiro, BT, Silver, RM, Scott, JR, Yu, H, Branch, DW. Antiphospholipid antibodies and fetal death. Obstet Gynecol 1996;87:489–93.CrossRefGoogle ScholarPubMed
Abou-Nassar, K, Carrier, M, Ramsay, T, Rodger, MA. The association between antiphospholipid antibodies and placenta-mediated complications: a systematic review and meta-analysis. Thromb Res 2011;128(1):77–85.CrossRefGoogle ScholarPubMed
Opatrny, L, David, M, Kahn, SR, Shrier, I, Rey, E. Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a meta-analysis. J Rheumatol 2006; 33:2214–21.Google Scholar
Silver, RM, Parker, CB, Reddy, UM, Goldenberg, R, Ciustan, D, Dudley, DJ, et al. Antiphospholipid antibodies in stillbirth. Obstet Gynecol 2013;122 (3):641–57.CrossRefGoogle ScholarPubMed
Geis, W, Branch, DW. Obstetric implications of antiphospholipid antibodies: pregnancy loss and other complications. Clin Obstet Gynecol 2001;44:2–10.CrossRefGoogle ScholarPubMed
Heilmann, L, Schorsch, M, Hahn, T, Fareed, J. Antiphospholipid syndrome and preeclampsia. Semin Thromb Hemost 2011;37:141–45.CrossRefGoogle ScholarPubMed
Dekker, GA, De Vries, JIP, Doelitzsch, PM, Huijgens, PC, Von Blomberg, BME, Jakobs, C, et al. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173(4): 1042–48.CrossRefGoogle ScholarPubMed
Do Prado, AD, Piovesan, DM, Staub, HL, Horta, BL. Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta-analysis. Obstet Gynecol 2010;116:1433–43.CrossRefGoogle ScholarPubMed
Appenzeller, S, Souza, FH, Wagner Silva de Souza, A, Shoenfeld, Y, de Carvalho, JF. HELLP syndrome and its relationship with antiphospholipid syndrome and antiphospholipid antibodies. Sem Arthritis Rheum 2011;41(3):517–23.CrossRefGoogle ScholarPubMed
Chauler, C, Galanaud, JP, Alonso, S, Cochery-Nouvellon, E, Balducchi, JP, Mares, P, et al. Observational study of pregnant women with a previous spontaneous abortion before the 10th gestational week with and without antiphospholipid antibodies. J Thromb Haemost 2010;8(4):699–706.CrossRefGoogle Scholar
Branch, DW, Silver, RM, Blackwell, JL, Reading, JC, Scott, JR. Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet Gynecol 1992;80:614–20.Google ScholarPubMed
Silver, RM, Draper, ML, Scott, JR, Lyon, JL, Reading, J, Branch, DW. Clinical consequences of antiphospholipid antibodies: an historic cohort study. Obstet Gynecol 1994;83:372–77.Google ScholarPubMed
Gómez-Puerta, JA, Cervera, R, Espinosa, G, Asherson, RA, García-Carrasco, M, da Costa, IP, et al. Catastrophic antiphospholipid syndrome during pregnancy and puerperium: maternal and fetal characteristics of 15 cases. Ann Rheum Dis 2007; 66(6):740–46.CrossRefGoogle ScholarPubMed
Ruffatti, A, Calligaro, A, Hoxha, A, Trevisanuto, D, Ruffatti, AT, Gervasi, MT, et al. Laboratory and clinical features of pregnant women with antiphospholipid syndrome and neonatal outcome. Arthritis Care Res 2010; 62(3): 302–07.CrossRefGoogle ScholarPubMed
Boffa, MC, Lachassinne, E. Infant perinatal thrombosis and antiphospholipid antibodies: a review. Lupus 2007;16(8): 634–41.CrossRefGoogle ScholarPubMed
Ruffatti, A, Tonello, M, Visentin, MS, Bontadi, A, Hoxha, A, De Carolis, S, et al. Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre, case–control study. Rheumatology 2011; 50(9):1684–89.CrossRefGoogle ScholarPubMed
De Carolis, S, Botta, A, Santucci, S, Salvi, S, Moresi, S, Di Pasquo, E, et al. Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome. Lupus 2012; 21(7):776–78.Google ScholarPubMed
Lockshin, MD, Kim, M, Laskin, CA, Guerra, M, Branch, D, Merrill, J, et al. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum 2012; 64(7):2311–18.CrossRefGoogle Scholar
Mak, A, Cheung, MW, Cheak, AA, Ho, RC. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology (Oxford) 2010;49:281–88.CrossRefGoogle ScholarPubMed
Ziakas, PD, Pavlou, M, Voulgarelis, M. Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysis. Obstet Gynecol 2010; 115(6):1256.CrossRefGoogle Scholar
Rai, R, Cohen, H, Dave, M, Regan, L. Randomized controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997;314:253–57.CrossRefGoogle ScholarPubMed
Kutteh, WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996;174:1584–89.CrossRefGoogle ScholarPubMed
Farquharson, RG, Quenby, S, Greaves, M. Antiphospholipid syndrome in pregnancy: a randomized controlled trial of treatment. Obstet Gynecol 2002;100:408–13.CrossRefGoogle ScholarPubMed
Laskin, CA, Spitzer, KA, Clark, CA, Crowther, MR, Ginsberg, JS, Hawker, GA, et al. Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA trial. J Rheumatol 2009;36:279–87.CrossRefGoogle ScholarPubMed
Noble, LS, Kutteh, WH, Lashley, N, Franklin, RD, Herrada, J. Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective multicenter controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin. Fertil Steril 2005;83:684–90.CrossRefGoogle ScholarPubMed
Stephenson, MD, Ballem, PJ, Tsang, P, Purkiss, S, Ensworth, S, Houlihan, E, et al. Treatment of antiphospholipid antibody syndrome (APS) in pregnancy: a randomized pilot trial comparing low molecular weight heparin to unfractionated heparin. J Obstet Gynecol Can 2004;26:729–34.Google ScholarPubMed
ACOG Practice Bulletin No. 118: Antiphospholipid syndrome. Obstet Gynecol 2010;117:192–99.Google Scholar
Pattison, NS, Chamley, LW, Birdsall, M, Zanderigo, AM, Liddell, HS, McDougell, J. Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? Am J Obstet Gynecol 2000;183:1008–12.CrossRefGoogle ScholarPubMed
Triolo, G, Ferrante, A, Accardo-Palumbo, A, Ciccia, F, Cadelo, M, Castelli, A, et al. IVIG in APS pregnancy. Lupus 2004;13:731–35.CrossRefGoogle ScholarPubMed
Branch, DW, Peaceman, AM, Druzin, M, Silver, RK, El-Sayed, Y, Silver, RM, et al. A multicenter placebo-controlled pilot study of intravenous immunoglobulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol 1995;172:690–94.Google Scholar
Bortolati, M, Marson, P, Chiarelli, S, Tison, T, Facchinetti, M, Gervasi, MT, et al. Case reports of the use of immunoadsorption or plasma exchange in high-risk pregnancies of women with antiphospholipid syndrome. Ther Apheresis Dialysis 2009;13(2):157–60.Google ScholarPubMed
Cowchock, FS, Reece, EA, Balaban, D, Branch, DW, Plouffe, L. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 1992;166(5):1318–23.CrossRefGoogle ScholarPubMed
Albert, CR, Schlesinger, WJ, Viall, CA, Mulla, MJ, Brosens, JJ, Chamley, LW, et al. Effects of hydroxychloroquine on antiphospholid antibody-induced changes in first trimester trophoblast function. Am J Reprod Immunol 2014; 71(2):154–64.CrossRefGoogle Scholar
Mekinian, A, Lazzaroni, MG, Kuzenko, A, Alijotas-Reig, J, Ruffatti, A, Levy, P, et al. The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: data from a European multicenter retrospective study. Autoimm Rev 2015; 14 (6):498–502.CrossRefGoogle ScholarPubMed
Practice Committee of the American Society for Reproductive Medicine. Anti-phospholipid antibodies do not affect IVF success. Fertility Sterility 2008; 90(5):S172–73.Google Scholar
Fishman, P, Falach-Vaknin, E, Sredni, B, Meroni, PL, Rudniki, C, Shoenfeld, Y. Aspirin modulates interleukin-3 production: additional explanation for the preventive effects of aspirin in antiphospholipid antibody syndrome. J Rheumatol 1995;22:1086–90.Google ScholarPubMed
De la Torre, YM, Pregnolato, F, D'Amelio, F, Grossi, C, Di Simone, N, Pasqualini, F, et al. Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site. Implications for human fetal loss. J Autoimmun 2012;38(2):J209–15.Google ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×