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Chapter 7 - Which Drug is Best?

Published online by Cambridge University Press:  22 May 2018

Dieter Schmidt
Affiliation:
Epilepsy Research Group, Free University of Berlin
William O. Tatum
Affiliation:
Department of Neurology, Beth Israel Deaconess Medical Center, Boston
Steven Schachter
Affiliation:
Department of Neurology, Beth Israel Deaconess Medical Center, Boston
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Common Pitfalls in Epilepsy
Case-Based Learning
, pp. 108 - 139
Publisher: Cambridge University Press
Print publication year: 2018

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References

Arana, A., Wentworth, C. E., Ayuso-Mateos, J. L., Arellano, F. M. (2010) Suicide-related events in patients treated with antiepileptic drugs. New Engl J Med 2010;363: 542–51.Google Scholar
Baulac, M., Leon, T., O'Brien, T. J., Whalen, E., Barrett, J. A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. Epilepsy Res 2010;91: 10–9.CrossRefGoogle ScholarPubMed
Beyenburg, S., Stavem, K., Schmidt, D. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis. Epilepsia 2010 Jan; 51(1): 726.Google Scholar
Bill, P. A., Vigonius, U., Pohlmann, H., et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in adults with previously untreated epilepsy. Epilepsy Res 1997 Jun; 27(3): 195204.Google Scholar
Brodie, M. J., Overstall, P. W., Giorgi, L. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res 1999 Oct; 37(1): 81–7.Google Scholar
Brodie, M. J., Perucca, E., Ryvlin, P., et al. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 2007;68: 402–8.CrossRefGoogle ScholarPubMed
Brodie, M. J., Richens, A., Yuen, A. W. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. UK Lamotrigine/Carbamazepine Monotherapy Trial Group. Lancet 1995 Feb 25; 345(8948): 476–9.CrossRefGoogle ScholarPubMed
Callaghan, B. C., Anand, K., Hesdorffer, D., Hauser, W. A., French, J. A. Likelihood of seizure remission in an adult population with refractory epilepsy. Ann Neurol 2007;62: 382–9.CrossRefGoogle Scholar
Chiron, C., Dumas, C., Jambaqué, I., Mumford, J., Dulac, O. Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. Epilepsy Res 1997 Jan; 26(2): 389–95.CrossRefGoogle ScholarPubMed
Chiron, C., Marchand, M. C., Tran, A., et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet 2000;356: 1638–42.CrossRefGoogle ScholarPubMed
Darke, K., Edwards, S. W., Hancock, E., et al. Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial. Arch Dis Child 2010;95: 382–6.Google Scholar
Elger, C. E., Schmidt, D. Modern management of epilepsy: a practical approach. Epilepsy Behav 2008;12: 501–39.CrossRefGoogle ScholarPubMed
Engel, J. Jr., Pedley, T. (Editors). Epilepsy: a comprehensive textbook. Second edition. Vols. 1–3. Wolters Kluwer, Lippincott Williams & Wilkins, Philadelphia, PA, 2007.Google Scholar
FDA Alert [12/12/2007]. Information on Carbamazepine. 2007. www.fda.gov/cder/drug/infopage/carbamazepine/default.htmGoogle Scholar
FDA Safety Alert [2011]. Topamax (topiramate): Label change-risk for development of cleft lip and /or cleft palate in newborns. www.fda.gove/SafetyInformation/SafteyAlertsforHumanMedicalProducts/ucm24577.htm posted 3.4.2011Google Scholar
French, J. A., Kanner, A. M., Bautista, J., et al. Efficacy and tolerability of the new antiepileptic drugs. I. Treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004a; 62: 1252–60.Google Scholar
French, J. A., Kanner, A. M., Bautista, J., et al. Efficacy and tolerability of the new antiepileptic drugs. II. Treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment. Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004b; 62(8): 1261–73.Google Scholar
Glauser, T., Ben-Menachem, E., Bourgeois, B., et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006 Jul; 47(7): 1094–120.Google Scholar
Glauser, T. A., Cnaan, A., Shinnar, S., et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med 2010;362: 790–9.Google Scholar
Glauser, T., Kluger, G., Sachdeo, R., et al. Rufinamide for generalized seizures associated with Lennox–Gastaut syndrome. Neurology 2008;70: 1950–8.CrossRefGoogle ScholarPubMed
Guerreiro, M. M., Vigonius, U., Pohlmann, H., et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy. Epilepsy Res 1997 Jun; 27(3): 205–13.Google Scholar
Löscher, W., Schmidt, D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011;52(4): 657–78.CrossRefGoogle ScholarPubMed
Luciano, A. L., Shorvon, S. D. Results of treatment changes in patients with apparently drug-resistant chronic epilepsy. Ann Neurol 2007;62(4): 375–81.CrossRefGoogle ScholarPubMed
Marson, A. G., Appleton, R., Baker, G. A., et al. A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. Health Technol Assess 2007 Oct; 11(37): iiiiv, ixx, 1134.Google ScholarPubMed
Mattson, R. H., Cramer, J. A., Collins, J. F., et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985 Jul 18; 313(3): 145–51.Google Scholar
Mattson, R. H., Cramer, J. A., Collins, J. F., et al. Comparison of valproate with carbamazepine for focal epilepsy in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic–clonic seizures in adults. N Engl J Med 1992.CrossRefGoogle Scholar
Mintzer, S., Mattson, R. T. Should non enzyme-inducing AEDs be preferred over enzyme-inducing AEDs as first-line agents? Epilepsia 2009 Sep; 50(Suppl 8): 4250.Google Scholar
Mula, M., Sander, J. W. Negative effects of antiepileptic drugs on mood in patients with epilepsy. Drug Saf 2007;30: 555–67.CrossRefGoogle ScholarPubMed
Privitera, M. D., Brodie, M. J., Mattson, R. H., et al., Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. Acta Neurol Scand 2003 Mar; 107(3): 165–75.CrossRefGoogle ScholarPubMed
Saetre, E., Perucca, E., Isojärvi, Y., et al. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia 2007;48: 1292–302.Google Scholar
Scheffer, I. E., Zhang, Y. H., Jansen, F. E., et al. Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? Brain Dev 2009 May; 31(5): 394400.CrossRefGoogle ScholarPubMed
Schmidt, D. Single drug therapy for intractable epilepsy. J Neurol 1983;229: 221–6.Google Scholar
Schmidt, D. Drug treatment of epilepsy: options and limitations. Epilepsy Behav 2009;15: 5665.CrossRefGoogle ScholarPubMed
Schmidt, D. Efficacy of new antiepileptic drugs. Epilepsy Curr 2011;11(1): 911.Google Scholar
Schmidt, D., Beyenburg, S. Antiepileptic drugs. In Side effects of drugs. Annual 31, Aronson, J. K. (ed.), pp. 105–48. Elsevier: Amsterdam, 2009.Google Scholar
Tomson, T., Battino, D. Teratogenic effects of antiepileptic medications. Neurol Clin 2009;27: 993–1002.CrossRefGoogle ScholarPubMed
US Food and Drug Administration. FDA alerts health care providers to risk of suicidal thoughts and behavior with antiepileptic medications, 2008. www.fda.gov/Google Scholar
Wilby, J., Kainth, A., Hawkins, N., et al. Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. Health Technol Assess 2005;9(15): 1157, iiiiv.Google Scholar

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