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15 - Insulin resistance and implications for hippocampal volume/function and the default mode network

from Part II - Underlying biological substrates associated with cognitive dysfunction in major depressive disorder

Published online by Cambridge University Press:  05 March 2016

By
Heather A. Kenna ,
Tonita E. Wroolie ,
Danielle R. Balzafiore  and
Natalie L. Rasgon
Edited by
Roger S. McIntyre
Edited in association with
Danielle S. Cha
Roger S. McIntyre
Affiliation:
University of Toronto
Danielle S. Cha
Affiliation:
University of Toronto
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Type
Chapter
Information
Cognitive Impairment in Major Depressive Disorder
Clinical Relevance, Biological Substrates, and Treatment Opportunities
 , pp. 209 - 228
Publisher: Cambridge University Press
Print publication year: 2016

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References

Abbatecola, A. M., Paolisso, G., Lamponi, M., Bandinelli, S., Lauretani, F., Launer, L., & Ferrucci, L. (2004). Insulin resistance and executive dysfunction in older persons. Journal of the American Geriatrics Society, 52(10): 1713–1718.CrossRefGoogle ScholarPubMed
Adriaanse, M. C., Dekker, J. M., Nijpels, G., Heine, R. J., Snoek, F. J., & Pouwer, F. (2006). Associations between depressive symptoms and insulin resistance: The Hoorn Study. Diabetologia, 49(12): 2874–2877.Google Scholar
Akomolafe, A., Beiser, A., Meigs, J. B., Au, R., Green, R. C., Farrer, L. A., … Seshadri, S. (2006). Diabetes mellitus and risk of developing Alzheimer disease: Results from the Framingham Study. Archives of Neurology, 63(11): 1551–1555.CrossRefGoogle ScholarPubMed
Anttila, S. & Leinonen, E. (2001). A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Reviews, 7(3): 239–264.CrossRefGoogle ScholarPubMed
Arroyo, C., Hu, F., Ryan, L., Kawachi, I., Colditz, G., Speizer, F., & Manson, J. (2004). Depressive symptoms and risk of type 2 diabetes in women. Diabetes Care, 27(1): 129–133.Google Scholar
Awad, N., Gagnon, M., Desrochers, A., Tsiakas, M., & Messier, C. (2002). Impact of peripheral glucoregulation on memory. Behavioral Neuroscience, 116(4): 691–702.CrossRefGoogle ScholarPubMed
Awad, N., Gagnon, M., & Messier, C. (2004). The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. Journal of Clinical and Experimental Neuropsychology, 26(8): 1044–1080.Google Scholar
Banki, C. M., Karmacsi, L., Bissette, G., & Nemeroff, C. B. (1992). CSF corticotropin-releasing hormone and somatostatin in major depression: Response to antidepressant treatment and relapse. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 2(2): 107–113.CrossRefGoogle ScholarPubMed
Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H., Born, J., & Kern, W. (2004). Intranasal insulin improves memory in humans. Psychoneuroendocrinology, 29(10): 1326–1334.Google Scholar
Benkert, O., Szegedi, A., & Kohnen, R. (2000). Mirtazapine compared with paroxetine in major depression. Journal of Clinical Psychiatry, 61(9): 656–663.Google Scholar
Bot, M., Pouwer, F., De Jonge, P., Nolan, J. J., Mari, A., Hojlund, K., … Dekker, J. M. (2013). Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study. Diabetes & Metabolism, 39(1): 42–49.Google Scholar
Boyer, W. & Feighner, J. (1992). An overview of paroxetine. Journal of Clinical Psychiatry, 53(Suppl.): 3–6.Google Scholar
Brown, L., Majumdar, S., Newman, S., & Johnson, J. (2005). History of depression increases risk of type 2 diabetes in younger adults. Diabetes Care, 28(5): 1063–1067.CrossRefGoogle ScholarPubMed
Bruehl, H., Sweat, V., Hassenstab, J., Polyakov, V., & Convit, A. (2010). Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance. Journal of Clinical and Experimental Neuropsychology, 32(5): 487–493.Google Scholar
Carnethon, M., Kinder, L., Fair, J., Stafford, R., & Fortmann, S. (2003). Symptoms of depression as a risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971–1992. American Journal of Epidemiology, 158(5): 416–423.Google Scholar
Casper, R., Davis, J., Pandey, G., Garver, D., & Dekirmenjian, H. (1977). Neuroendocrine and amine studies in affective illness. Psychoneuroendocrinology, 2(2): 105–113.Google Scholar
Centers for Disease Control and Prevention (2011). National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.Google Scholar
Cheng, B. & Mattson, M. (1992). IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. Journal of Neuroscience, 12(4): 1558–1566.Google Scholar
Chiba, M., Suzuki, S., Hinokio, Y., Hirai, M., Satoh, Y., Tashiro, A., … Toyota, T. (2000). Tyrosine hydroxylase gene microsatellite polymorphism associated with insulin resistance in depressive disorder. Metabolism, 49(9): 1145–1149.Google Scholar
Clarke, D., Boyd, F., Kappy, M., & Raizada, M. (1984). Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. Journal of Biological Chemistry, 259: 11672–11675.Google Scholar
Convit, A., Wolf, O. T., Tarshish, C., & de Leon, M. J. (2003). Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2019–2022.Google Scholar
Craft, S. (2005). Insulin resistance syndrome and Alzheimer’s disease: Age- and obesity-related effects on memory, amyloid, and inflammation. Neurobiology of Aging, 26(Suppl. 1): 65–69.Google Scholar
Craft, S.S. (2006). Insulin resistance syndrome and Alzheimer disease: Pathophysiologic mechanisms and therapeutic implications. Alzheimer Disease and Associated Disorders, 20(4): 298–301.Google Scholar
Craft, S.S. (2009). The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged. Archives of Neurology, 66(3): 300–305.Google Scholar
Craft, S., Asthana, S., Cook, D., Baker, L., Cherrier, M., Purganan, K., … Krohn, A. J. (2003). Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: Interactions with apolipoprotein E genotype. Psychoneuroendocrinology, 28(6): 809–822.Google Scholar
Craft, S., Asthana, S., Schellenberg, G., Baker, L., Cherrier, M., Boyt, A., … Plymate, S. (2000). Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer’s disease differ according to apolipoprotein-E genotype. Annals of the New York Academy of Sciences, 903: 222–228.CrossRefGoogle ScholarPubMed
Craft, S., Asthana, S., Schellenberg, G., Cherrier, M., Baker, L., Newcomer, J., … Grimwood, K. (1999). Insulin metabolism in Alzheimer’s disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology, 70(2): 146–152.Google Scholar
Craft, S. & Watson, G. (2004). Insulin and neurodegenerative disease: Shared and specific mechanisms. Lancet Neurology, 3(3): 169–178.Google Scholar
Curb, J. D., Rodriguez, B. L., Abbott, R. D., Petrovitch, H., Ross, G. W., Masaki, K. H., … White, L. R. (1999). Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance. Neurology, 52(5): 971–975.Google Scholar
Davis, S., Colburn, C., Dobbins, R., Nadeau, S., Neal, D., & Williams, P. (1995). Evidence that the brain of the conscious dog is insulin sensitive. Journal of Clinical Investigation, 95(2): 593–602.Google Scholar
de Leon, M., Desanti, S., Zinkowski, R., Mehta, P., Pratico, D., Segal, S., … Rusinek, H. (2004). MRI and CSF studies in the early diagnosis of Alzheimer’s disease. Journal of Internal Medicine, 256(3): 205–223.CrossRefGoogle ScholarPubMed
Delaunay, F., Khan, A., Cintra, A., Davani, B., Ling, Z. C., Andersson, A., … Okret, S. (1997). Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. Journal of Clinical Investigation, 100(8): 2094–2098.Google Scholar
den Heijer, T., Vermeer, S., van Dijk, E., Prins, N., Koudstaal, P., Hofman, A., & Breteler, M. M. (2003). Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia, 46(12): 1604–1610.Google Scholar
Dringen, R. & Hamphrecht, B. (1992). Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of atroglia-rich primary cultures. Journal of Neurochemistry, 58(2): 511–517.CrossRefGoogle ScholarPubMed
Dunaif, A., Segal, K., Futterweit, W., & Dobrjansky, A. (1989). Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38(9): 1165–1174.CrossRefGoogle ScholarPubMed
Eaton, W., Armenian, H., Gallo, J., Pratt, L., & Ford, D. (1996). Depression and risk for onset of type II diabetes: A prospective population-based study. Diabetes Care 19(10): 1097–1102.Google Scholar
Enzinger, C., Fazekas, F., Matthews, P., Ropele, S., Schmidt, H., Smith, S., … Schmidt, R. (2005). Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology, 64(10): 1704–1711.Google Scholar
Everson-Rose, S., Meyer, P., Powell, L., Pandey, D., Torrens, J., Kravitz, H., … Matthews, K. A. (2004). Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care, 27(12): 2856–2862.CrossRefGoogle ScholarPubMed
Facchini, F., Hua, N., Abbasi, F., & Reaven, G. (2001). Insulin resistance as a predictor of age-related diseases. Journal of Clinical Endocrinology & Metabolism, 86(8): 3574–3578.Google Scholar
Farin, H., Abbasi, F., & Reaven, G. (2005). Body mass index and waist circumference correlate to the same degree with insulin-mediated glucose uptake. Metabolism, 54(10): 1323–1328.Google Scholar
Farin, H., Abbasi, F., & Reaven, G. (2006). Body mass index and waist circumference both contribute to differences in insulin-mediated glucose disposal in nondiabetic adults. American Journal of Clinical Nutrition, 83(1): 47–51.Google Scholar
Fava, M. (2000). Weight gain and antidepressants. Journal of Clinical Psychiatry, 61(Suppl. 11): 37–41.Google Scholar
Flood, J., Mooradian, A., & Morley, J. (1990). Characteristics of learning and memory in streptozocin-induced diabetic mice. Diabetes, 39(11): 1391–1398.Google Scholar
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America, 102(27): 9673–9678.Google Scholar
Freeman, H. (1946). Resistance to insulin in mentally disturbed soldiers. Archives of Neural Psychiatry, 56(1): 74–78.Google Scholar
Gerich, J. (2003). Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clinic Proceedings, 78(4): 447–456.Google Scholar
Geroldi, C., Frisoni, G. B., Paolisso, G., Bandinelli, S., Lamponi, M., & Abbatecola, A. M. (2005). Insulin resistance in cognitive impairment: The InCHIANTI study. Archives of Neurology, 62(7): 1067–1072.Google Scholar
Gerozissis, K. (2003). Brain insulin: Regulation, mechanisms of action and functions. Cellular and Molecular Neurobiology, 23(1): 1–25.Google Scholar
Gispen, W. & Biessels, G. (2000). Cognition and synaptic plasticity in diabetes mellitus. Trends in Neurosciences, 23(11): 542–549.Google Scholar
Golden, S., Williams, J., Ford, D., Yeh, H., Paton Sanford, C., Nieto, F., … Atherosclerosis Risk in Communities study (2004). Depressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study. Diabetes Care, 27(2): 429–435.Google Scholar
Goodnick, P. (2001). Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Annals of Clinical Psychiatry, 13(1): 31–41.Google Scholar
Green, R., Cupples, L., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., … Farrer, L. (2003). Depression as a risk factor for Alzheimer disease: The MIRAGE Study. Archives of Neurology, 60(5): 753–759.CrossRefGoogle ScholarPubMed
Greicius, M., Srivastava, G., Reiss, A., & Menon, V. (2004). Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: Evidence from functional MRI. Proceedings of the National Academy of Sciences of the United States of America, 101(13): 4637–4642.Google Scholar
Hampel, H., Burger, K., Teipel, S. J., Bokde, A. L., Zetterberg, H., & Blennow, K. (2008). Core candidate neurochemical and imaging biomarkers of Alzheimer’s disease. Alzheimer’s & Dementia: Journal of the Alzheimer’s Association, 4(1): 38–48.Google Scholar
Hempel, R., Onopa, R., & Convit, A. (2012). Type 2 diabetes affects hippocampus volume differentially in men and women. Diabetes/Metabolism Research and Reviews, 28(1): 76–83.Google Scholar
Hill, J., Lesniak, M., Pert, C., & Roth, J. (1986). Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas. Neuroscience, 17(4): 1127–1138.Google Scholar
Horacek, J., Kuzmiakova, M., Hoschl, C., Andel, M., & Bahbonh, R. (1999). The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers. Psychoneuroendocrinology, 24(8): 785–797.Google Scholar
Izumi, Y., Yamada, K., Matsukawa, M., & Zorumski, C. (2003). Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats. Diabetologia, 46(7): 1007–1012.Google Scholar
Kalmijn, S., Feskens, E., Launer, L., Stijnen, T., & Kromhout, D. (1995). Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. Diabetologia, 38(9): 1096–1102.Google Scholar
Kanaya, A. M., Barrett-Connor, E., Gildengorin, G., & Yaffe, K. (2004). Change in cognitive function by glucose tolerance status in older adults: A 4-year prospective study of the Rancho Bernardo study cohort. Archives of Internal Medicine, 164(12): 1327–1333.Google Scholar
Kawakami, N., Takatsuka, N., Shimizu, H., & Ishibashi, H. (1999). Depressive symptoms and occurrence of type 2 diabetes among Japanese men. Diabetes Care, 22(7): 1071–1076.Google Scholar
Kenna, H., Hoeft, F., Kelley, R., Wroolie, T., DeMuth, B., Reiss, A., & Rasgon, N. (2013). Fasting plasma insulin and the default mode network in women at risk for Alzheimer’s disease. Neurobiology of Aging, 34(3): 641–649.Google Scholar
Kern, W., Peters, A., Fruehwald-Schultes, B., Deininger, E., Born, J., & Fehm, H. (2001). Improving influence of insulin on cognitive functions in humans. Neuroendocrinology, 74(4): 270–280.Google Scholar
Kerr, D., Stanley, J., Barron, M., Thomas, R., Leatherdale, B., & Pickard, J. (1993). Symmetry of cerebral blood flow and cognitive responses to hypoglycemia in humans. Diabetologia, 36(1): 73–78.Google Scholar
Kessing, L., Nilsson, F., Siersma, V., & Andersen, P. (2004). Increased risk of developing diabetes in depressive and bipolar disorders? Journal of Psychiatric Research, 38(4): 395–402.Google Scholar
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kareholt, I., Winblad, B., … Nissinen, A. (2005). Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Archives of Neurology 62(10): 1556–1560.Google Scholar
Kopf, D., Westphal, S., Luley, C., Ritter, S., Gilles, M., Weber-Hamann, B., … Deuschle, M. (2004). Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment. Journal of Clinical Psychopharmacology, 24(5): 527–531.Google Scholar
Kopf, S. & Baratti, C. (1995). The impairment of retention induced by insulin in mice may be mediated by a reduction in central cholinergic activity. Neurobiology of Learning and Memory, 63(3): 220–228.Google Scholar
Kopf, S. & Baratti, C. (1996). Memory modulation by post-training glucose or insulin remains evident at long retention intervals. Neurobiology of Learning and Memory, 65(2): 189–191.Google Scholar
Kumar, R., Anstey, K. J., Cherbuin, N., Wen, W., & Sachdev, P. S. (2008). Association of type 2 diabetes with depression, brain atrophy, and reduced fine motor speed in a 60- to 64-year-old community sample. American Journal of Geriatric Psychiatry, 16(12): 989–998.CrossRefGoogle Scholar
Kumari, M., Head, J., & Marmot, M. (2004). Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study. Archives of Internal Medicine, 164(17): 1873–1880.Google Scholar
Kuusisto, J., Koivisto, K., Mykkanen, L., Helkala, E., Vanhanen, M., Hänninen, T., … Laakso, M. (1997). Association between features of the insulin resistance syndrome and Alzheimer’s disease independently of apolipoprotein E4 phenotype: cross sectional population based study. British Medical Journal, 315(7115): 1045–1049.Google Scholar
Kyriaki, G. (2003). Brain insulin: Regulation, mechanisms of action and functions. Cellular and Molecular Neurobiology, 23(1): 1–25.Google Scholar
Lannert, H. & Hoyer, S. (1998). Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behavioral Neuroscience, 112(5): 1199–1208.Google Scholar
Luchsinger, J. A. (2010). Diabetes, related conditions, and dementia. Journal of the Neurological Sciences, 299(1–2): 35–38.Google Scholar
Luchsinger, J. A., Tang, M., Shea, S., & Mayeux, R. (2004). Hyperinsulinemia and risk of Alzheimer disease. Neurology, 63(7): 1187–1992.CrossRefGoogle ScholarPubMed
Ma, Y., Balasubramanian, R., Pagoto, S. L., Schneider, K. L., Hebert, J. R., Phillips, L. S., … Liu, S. (2013). Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease. American Journal of Public Health, 103(8): e34–e43.Google Scholar
Matthews, D., Hosker, J., Rudenski, A., Naylor, B., Treacher, D., & Turner, R. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7): 412–419.Google Scholar
McCowan, P. & Quastel, J. (1931). Blood sugar studies in abnormal mental states. British Journal of Psychiatry, 77(318): 525–548.Google Scholar
McIntyre, R. S., Rasgon, N. L., Kemp, D. E., Nguyen, H. T., Law, C. W., Taylor, V. H., … Goldstein, B. I. (2009). Metabolic syndrome and major depressive disorder: co-occurrence and pathophysiologic overlap. Current Diabetes Reports, 9(1): 51–59.Google Scholar
McLaughlin, T., Allison, G., Abbasi, F., Lamendola, C., & Reaven, G. (2004). Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism, 53(4): 495–499.Google Scholar
Mellitus ECotDaCoD (2003). Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care, 26(Suppl. 1): S5–S20.Google Scholar
Menna-Perper, M., Rochford, J., Mueller, P., Swartzburg, M., Jekelis, A., & Manowitz, P. (1984). Differential response of plasma glucose, amino acids and nonesterified fatty acids to insulin in depressed patients. Psychoneuroendocrinology, 9(2): 161–171.Google Scholar
Messier, C. (2003). Diabetes, Alzheimer’s disease and apolipoprotein genotype. Experimental Gerontology, 38(9): 941–946.Google Scholar
Mueller, P., Heninger, G., & McDonald, R. (1969a). Insulin tolerance test in depression. Archives of General Psychiatry, 21: 587–594.Google Scholar
Mueller, P., Heninger, G., & McDonald, R. (1969b). Intravenous glucose tolerance test in depression. Archives of General Psychiatry, 21: 470–477.Google Scholar
Muldoon, M., Mackey, R., Korytkowski, M., Flory, J., Pollock, B., & Manuck, S. (2006). The metabolic syndrome is associated with reduced central serotonergic responsivitity in healthy community volunteers. Journal of Clinical Endocrinology & Metabolism, 91(2): 718–721.Google Scholar
Muldoon, M., Mackey, R., Williams, K., Korytkowski, M., Flory, J., & Manuck, S. (2004). Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. Journal of Clinical Endocrinology & Metabolism, 89(1): 266–271.Google Scholar
Musen, G., Jacobson, A. M., Bolo, N. R., Simonson, D. C., Shenton, M. E., McCartney, R. L., … Hoogenboom, W. S. (2012). Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes, 61(9): 2375–2379.Google Scholar
Musselman, D. L., Betan, E., Larsen, H., & Phillips, L. S. (2003). Relationship of depression to diabetes types 1 and 2: Epidemiology, biology, and treatment. Biological Psychiatry, 54(3): 317–329.Google Scholar
Nathan, R., Sachar, E., Asnis, G., Halbreich, U., & Halpern, F. (1981). Relative insulin insensitivity and cortisol secretion in depressed patients. Psychiatry Research, 4(3): 291–300.Google Scholar
Neumann, K. F., Rojo, L., Navarrete, L. P., Farias, G., Reyes, P., & Maccioni, R. B. (2008). Insulin resistance and Alzheimer’s disease: Molecular links & clinical implications. Current Alzheimer Research, 5(5): 438–447.Google Scholar
Nichols, G. & Brown, J. (2003). Unadjusted and adjusted prevalence of diagnosed depression in type 2 diabetes. Diabetes Care, 26(3): 744–749.Google Scholar
Okamura, F., Tashiro, A., Utumi, A., Imai, T., Suchi, T., Tamura, D., … Hongo, M. (2000). Insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis. Metabolism, 49(10): 1255–1260.Google Scholar
Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. (1996). Association of diabetes mellitus and dementia: The Rotterdam Study. Diabetologia, 39(11): 1392–1397.CrossRefGoogle ScholarPubMed
Palinkas, L., Lee, P., & Barrett-Connor, E. (2004). A prospective study of Type 2 diabetes and depressive symptoms in the elderly: The Rancho Bernardo Study. Diabetic Medicine, 21(11): 1185–1191.Google Scholar
Pan, A., Ye, X., Franco, O. H., Li, H., Yu, Z., Zou, S., … Lin, X. (2008). Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study. Journal of Affective Disorders, 109(1–2): 75–82.Google Scholar
Pariante, C. M. & Lightman, S. L. (2008). The HPA axis in major depression: Classical theories and new developments. Trends in Neurosciences, 31(9): 464–468.Google Scholar
Park, C. (2001). Cognitive effects of insulin in the central nervous system. Neuroscience and Biobehavioral Reviews, 25(4): 311–323.Google Scholar
Park, C., Seeley, R., Craft, S., & Woods, S. (2000). Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiology & Behavior 68(4): 509–514.CrossRefGoogle Scholar
Pearson, S., Schmidt, M., Patton, G., Dwyer, T., Blizzard, L., Otahal, P., & Venn, A. (2010). Depression and insulin resistance: Cross-sectional associations in young adults. Diabetes Care, 33(5): 1128–1133.Google Scholar
Pestell, R., Crock, P., & Ward, G. (1989). Fenfluramine increases insulin action in patients with NIDDM. Diabetes Care, 12(4): 252–258.Google Scholar
Porte, D. Jr. & Woods, S. C. (1981). Regulation of food intake and body weight in insulin. Diabetologia, 20(Suppl.): 274–280.Google Scholar
Potter Van Loon, B., Radder, J., Krans, H., Zwinderman, A., & Meinders, A. (1991). Fluoxetine increases insulin action in obese nondiabetic and obese non-insulin-dependent diabetic individuals. International Journal of Obesity and Related Metabolic Disorders, 16(2): 78–85.Google Scholar
Pryce, I. (1958). Melancholia, glucose tolerance, and bodyweight. Journal of Mental Science, 104(435): 421–427.Google Scholar
Ramasubbu, R. (2002). Insulin resistance: A metabolic link between depressive disorder and atherosclerotic vascular diseases. Medical Hypotheses, 59(5): 537–551.Google Scholar
Rasgon, N., Altshuler, L., Fairbanks, L., Elman, S., Bitran, J., Labarca, R., … Mintz, J. (2005). Reproductive function and risk for PCOS in women treated for bipolar disorder. Bipolar Disorders, 7(3): 246–259.Google Scholar
Rasgon, N. & Jarvik, L. (2004). Insulin resistance, affective disorders, and Alzheimer’s disease: Review and hypothesis. Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 59(2): 178–183.Google Scholar
Rasgon, N. L., Carter, M. S., Elman, S., Bauer, M., Love, M., & Korenman, S. G. (2002). Common treatment of polycystic ovarian syndrome and major depressive disorder: Case report and review. Current Drug Targets: Immune Endocrine & Metabolic Disorders, 2(1): 97–102.Google Scholar
Rasgon, N. L., Kenna, H. A., Wroolie, T. E., Kelley, R., Silverman, D., Brooks, J., … Reiss, A. (2011). Insulin resistance and hippocampal volume in women at risk for Alzheimer’s disease. Neurobiology of Aging, 32(11): 1942–1948.Google Scholar
Rasgon, N. L., Kenna, H. A., Wroolie, T. E., Williams, K. E., DeMuth, B. N., & Silverman, D. H. (2014). Insulin resistance and medial prefrontal gyrus metabolism in women receiving hormone therapy. Psychiatry Research, 223(1): 28–36.Google Scholar
Rasgon, N. L., Rao, R. C., Hwang, S., Altshuler, L. L., Elman, S., Zuckerbrow-Miller, J., & Korenman, S. G. (2003). Depression in women with polycystic ovary syndrome: clinical and biochemical correlates. Journal of Affective Disorders, 74(3): 299–304.Google Scholar
Reaven, G. (1988). Banting Lecture 1988: Role of insulin resistance in human disease. Diabetes, 37(12): 1595–1607.CrossRefGoogle ScholarPubMed
Reaven, G.G. (1992). Syndrome X. Blood Pressure Supplement, 4: 13–16.Google Scholar
Reaven, G.G. (1993). Role of insulin resistance in human disease. Annual Review of Medicine, 44: 121–131.Google Scholar
Reaven, G.G. (2005). All obese individuals are not created equal: Insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diabetes & Vascular Disease Research, 2(3): 105–112.Google Scholar
Roos, C., Lidfeldt, J., Agardh, C. D., Nyberg, P., Nerbrand, C., Samsioe, G., & Westrin, A. (2007). Insulin resistance and self-rated symptoms of depression in Swedish women with risk factors for diabetes: the Women’s Health in the Lund Area study. Metabolism, 56(6): 825–829.Google Scholar
Rosmond, R., Bouchard, C., & Bjorntorp, P. (2002). Increased abdominal obesity in subjects with a mutation in the 5-HT(2A) receptor gene promoter. Annals of the New York Academy of Sciences, 967: 571–575.Google Scholar
Sachar, E., Finkelstein, J., & Hellman, L. (1971). Growth hormone responses in depressive illness. Archives of General Psychiatry, 25(3): 263–269.Google Scholar
Santucci, A., Schroeder, H., & Riccio, D. (1990). Homeostatic disruption and memory: Effect of insulin administration in rats. Behavioral and Neural Biology, 53(3): 321–333.Google Scholar
Scheen, A., Paolisso, G., Salvatore, T., & Lefèbvre, P. J. (1991). Improvement of insulin-induced glucose disposal in obese patients with NIDDM after 1-week treatment with D-fenfluramine. Diabetes Care, 14(4): 325–332.Google Scholar
Schulingkamp, R., Pagano, T., Hung, D., & Raffa, R. (2000). Insulin receptors and insulin action in the brain: Review and clinical implications. Neuroscience and Biobehavioral Reviews, 24(8): 855–872.Google Scholar
Schuur, M., Henneman, P., van Swieten, J. C., Zillikens, M. C., de Koning, I., Janssens, A. C., … Van Duijn, C. M. (2010). Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study. European Journal of Epidemiology, 25(8): 561–568.Google Scholar
Schwarzberg, H., Bernstein, H., Reiser, M., & Gunther, O. (1989). Intracerebroventricular administration of insulin attenuates retrieval of a passive avoidance response in rats. Neuropeptides, 13(2): 79–81.Google Scholar
Sorg, C., Riedl, V., Muhlau, M., Calhoun, V. D., Eichele, T., Laer, L., … Wohlschläger, A. M. (2007). Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America, 104(47): 18760–18765.Google Scholar
Spaner, D., Bland, R., & Newman, S. (1994). Epidemiology of psychiatric disorders in Edmonton: major depressive disorder. Acta Psychiatrica Scandinavica Supplement,376: 7–15.Google Scholar
Stolk, R., Breteler, M., Ott, A., Pols, H., Lamberts, S., Grobbee, D., & Hofman, A. (1997). Insulin and cognitive function in an elderly population: The Rotterdam Study. Diabetes Care, 20(5): 792–795.CrossRefGoogle Scholar
Timonen, M., Laakso, M., Jokelainen, J., Rajala, U., Meyer-Rochow, V., & Keinanen-Kiukaanniemi, S. (2005). Insulin resistance and depression: Cross sectional study. British Medical Journal, 330(7481): 17–18.Google Scholar
Timonen, M., Salmenkaita, I., Jokelainen, J., Laakso, M., Harkonen, P., Koskela, P., … Keinänen-Kiukaanniemi, S. (2007). Insulin resistance and depressive symptoms in young adult males: Findings from Finnish military conscripts. Psychosomatic Medicine, 69(8): 723–728.Google Scholar
Unger, E., Kjellen, L., & Eriksson, U. J. (1991). Effect of insulin on the altered production of proteoglycans in rib cartilage of experimentally diabetic rats. Archives of Biochemistry and Biophysics, 285(2): 205–210.Google Scholar
Valastro, B., Cossette, J., Lavoie, N., Gagnon, S., Trudeau, F., & Massicotte, G. (2002). Up-regulation of glutamate receptors is associated with LTP defects in the early stages of diabetes mellitus. Diabetologia, 45(5): 642–650.Google Scholar
Van den Akker, M., Schuurman, A., Metsemakers, J., & Buntinx, F. (2004). Is depression related to subsequent diabetes mellitus? Acta Psychiatrica Scandinavica, 110(3): 178–183.Google Scholar
Vanhanen, M., Koivisto, K., Karjalainen, L., Helkala, E. L., Laakso, M., & Soininen, H. (1997). Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function. Neuroreport, 8(6): 1527–1530.Google Scholar
Vanhanen, M., Koivisto, K., Kuusisto, J., Mykkanen, L., Helkala, E., Hänninen, T., … Laakso, M. (1998). Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care, 21(3): 398–402.Google Scholar
Vrbikova, J., Bendlova, B., Hill, M., Vankova, M., Vondra, K., & Starka, L. (2002). Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome. Diabetes Care, 25(7): 1217–1222.Google Scholar
Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990). Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Annals of Internal Medicine, 113(12): 909–915.Google Scholar
Watson, G. & Craft, S. (2004). Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease. European Journal of Pharmacology, 490(1–3): 97–113.Google Scholar
Weissman, M., Bland, R., Canino, G., Faravelli, C., Greenwald, S., Hwu, H., … Yeh, E.-K. (1996). Cross-national epidemiology of major depression and bipolar disorder. JAMA, 276(4): 293–299.Google Scholar
Werner, H., Raizada, M., Mudd, L., Foyt, H. L., Simpson, I., & Roberts, C. T. (1989). Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. Endocrinology, 125(1): 314–320.Google Scholar
Winocur, G., Greenwood, C., Piroli, G., Grillo, C., Reznikov, L., & Reagan, L. (2005). Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behavioral Neuroscience, 119(5): 1389–1395.Google Scholar
Winokur, A., Maislin, G., Phillips, J., & Amsterdam, J. (1988). Insulin resistance after oral glucose tolerance testing in patients with major depression. American Journal of Psychiatry, 145(3): 325–330.Google Scholar
Wright, J., Jacisin, J., Radin, N., & Bell, R. (1978). Glucose metabolism in unipolar depression. British Journal of Psychiatry, 132(386–393).Google Scholar
Wroolie, T. E., Kenna, H. A., Singh, M. K., & Rasgon, N. L. (2015). Association between insulin resistance and cognition in patients with depressive disorders: Exploratory analyses into age-specific effects. Journal of Psychiatric Research, 60: 65–72.Google Scholar
Yaffe, K. (2007). Metabolic syndrome and cognitive decline. Current Alzheimer Research, 4(2): 123–126.Google Scholar
Yaffe, K., Blackwell, T., Kanaya, A., Davidowitz, N., Barrett-Connor, E., & Krueger, K. (2004). Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology, 63(4): 658–663.Google Scholar
Yip, J., Facchini, F., & Reaven, G. (1998). Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. Journal of Clinical Endocrinology & Metabolism 83: 2773–2776.Google Scholar
Young, S. E., Mainous, A. G. III, & Carnemolla, M. (2006). Hyperinsulinemia and cognitive decline in a middle-aged cohort. Diabetes Care, 29(12): 2688–2693.Google Scholar
Yuan, X., Yamada, K., Ishiyama-Shigemoto, S., Koyama, W., & Nonaka, K. (2000). Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia, 43(3): 373–376.Google Scholar
Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M., & Alkon, D. L. (1999). Brain insulin receptors and spatial memory: Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. Journal of Biological Chemistry, 274(49): 34893–34902.Google Scholar
Zhou, J., Greicius, M. D., Gennatas, E. D., Growdon, M. E., Jang, J. Y., Rabinovici, G. D., … Seeley, W. W. (2010). Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer’s disease. Brain, 133(Pt 5): 1352–1367.Google Scholar

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