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49 - Cancer Nanotechnology Offers Great Promise for Cancer Research and Therapy

from THERAPIES

Published online by Cambridge University Press:  05 June 2012

Randy L. Scherer
Affiliation:
Vanderbilt University Medical Center, United States
Hanako Kobayashi
Affiliation:
Vanderbilt University Medical Center, United States
Kimberly Boelte
Affiliation:
Vanderbilt University Medical Center, United States
P. Charles Lin
Affiliation:
Vanderbilt University Medical Center, United States
David Lyden
Affiliation:
Weill Cornell Medical College, New York
Danny R. Welch
Affiliation:
Weill Cornell Medical College, New York
Bethan Psaila
Affiliation:
Imperial College of Medicine, London
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Summary

NANOTECHNOLOGY

Nanotechnology, sometimes shortened to “nanotech,” refers to a field of applied science whose goal is to control matter on an atomic and molecular scale. Nanotechnology is an extremely diverse and multidisciplinary field, ranging from novel extensions of conventional-device physics to completely new approaches based on molecular self-assembly and to developing new materials with sizes ranging from 0.1 to hundreds of nanometers. A nanometer is one-billionth of a meter (10−9 m), which is about ten times the size of the smallest atom, hydrogen, and approximately 1/80,000 the width of a human hair. As Richard Feynman's famous statement that “there is plenty of room at the bottom” [1] portends, nanotechnology has the potential to create new materials and devices in the nanoscale range with wide-ranging applications in medicine, electronics, and energy production.

The human cell is 10,000 to 20,000 nm in diameter. Cellular proliferation and replication operate at the nanometer scale, thus demonstrating the need to translate molecular-based science into machines or devices matching the size of molecules in biology. There are several advantages to designing devices of this size in every industry imaginable. The computer chip industry has vastly expanded computational speed by decreasing the size and increasing the number of transistors per chip. The reduction in the size of key elements, down to about 100 nm, is possible because of improvements in photolithography that characteristically reduce the cost of production.

Type
Chapter
Information
Cancer Metastasis
Biologic Basis and Therapeutics
, pp. 563 - 572
Publisher: Cambridge University Press
Print publication year: 2011

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References

Feynman, R (1961) There's plenty of room at the bottom. In Gilbert, HD, ed. Miniaturization. Reinhold, New York. pp. 282–96.Google Scholar
Wolf, EL (2004) Nanophysics and Nanotechnology. Weinheim, Germany: Wiley VCH.Google Scholar
Sanvicens, N, Marco, MP (2008) Multifunctional nanoparticles–properties and prospects for their use in human medicine. Trends Biotech. 26(8): 425–33.CrossRefGoogle ScholarPubMed
Torchilin, VP (2005) Recent advances with liposomes as pharmaceutical carriers. Nat Rev. 4(2): 145–60.Google ScholarPubMed
Lee, CC, MacKay, JA, Frechet, JM, Szoka, FC (2005) Designing dendrimers for biological applications. Nat Biotechnol. 23(12): 1517–26.CrossRefGoogle ScholarPubMed
Polizu, S, Savadogo, O, Poulin, P, Yahia, L (2006) Applications of carbon nanotubes-based biomaterials in biomedical nanotechnology. J Nanosci Nanotechnol. 6(7): 1883–904.CrossRefGoogle ScholarPubMed
Cuenca, AG, Jiang, H, Hochwald, SN, Delano, M, Cance, WG, Grobmyer, SR (2006) Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 107(3): 459–66.CrossRefGoogle ScholarPubMed
McCarthy, JR, Weissleder, R (2008) Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev. 60(11): 1241–51.CrossRefGoogle ScholarPubMed
Huang, X, Jain, PK, El-Sayed, IH, El-Sayed, MA (2007) Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (London). 2(5): 681–93.CrossRefGoogle ScholarPubMed
Rasooly, A, Jacobson, J (2006) Development of biosensors for cancer clinical testing. Biosensors Bioelectron. 21(10): 1851–8.CrossRefGoogle ScholarPubMed
Panchapakesan, B, Wickstrom, E (2007) Nanotechnology for sensing, imaging, and treating cancer. Surg Oncol Clin N Am. 16(2): 293–305.CrossRefGoogle ScholarPubMed
Soper, SA, Brown, K, Ellington, A et al. (2006) Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosensors Bioelectron. 21(10): 1932–42.CrossRefGoogle ScholarPubMed
Scherer, RL, McIntyre, JO, Matrisian, LM (2008) Imaging matrix metalloproteinases in cancer. Cancer Metastasis Rev. 27(4): 679–90.CrossRefGoogle Scholar
Scherer, R, VanSaun, M, McIntyre, JO, Matrisian, LM (2008) Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon. Mol Imaging. 7(3): 118–31.CrossRefGoogle ScholarPubMed
Cai, W, Chen, X (2007) Nanoplatforms for targeted molecular imaging in living subjects. Small. 3(11): 1840–54.CrossRefGoogle ScholarPubMed
Voura, EB, Jaiswal, JK, Mattoussi, H, Simon, SM (2004) Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission scanning microscopy. Nat Med. 10(9): 993–8.CrossRefGoogle ScholarPubMed
Seydel, C (2003) Quantum dots get wet. Science. 300(5616): 80–1.CrossRefGoogle ScholarPubMed
Kobayashi, H, Hama, Y, Koyama, Y et al. (2007) Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. Nano Lett. 7(6): 1711–6.CrossRefGoogle ScholarPubMed
Cho, K, Wang, X, Nie, S, Chen, ZG, Shin, DM (2008) Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res. 14(5): 1310–6.CrossRefGoogle Scholar
Nie, S, Xing, Y, Kim, GJ, Simons, JW (2007) Nanotechnology applications in cancer. Annu Rev Biomed Eng. 9: 257–88.CrossRefGoogle Scholar
Murphy, EA, Majeti, BK, Barnes, et al. (2008) Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc Natl Acad Sci USA. 105(27): 9343–8.CrossRefGoogle ScholarPubMed
Dowlatshahi, K, Fan, M, Snider, HC, Habib, FA (1997) Lymph node micrometastases from breast carcinoma: reviewing the dilemma. Cancer. 80(7): 1188–97.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Kobayashi, H, Kawamoto, S, Sakai, Y et al. (2004) Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent. J Natl Cancer Inst. 96(9): 703–8.CrossRefGoogle ScholarPubMed
Harisinghani, MG, Barentsz, J, Hahn, PF et al. (2003) Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 348(25): 2491–9.CrossRefGoogle ScholarPubMed
Weissleder, R, Elizondo, G, Wittenberg, J, Lee, AS, Josephson, L, Brady, TJ (1990) Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 175(2): 494–8.CrossRefGoogle ScholarPubMed
Kim, S, Lim, YT, Soltesz, EG et al. (2004) Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. 22(1): 93–7.CrossRefGoogle ScholarPubMed
Knapp, DW, Adams, LG, Degrand, AM et al. (2007) Sentinel lymph node mapping of invasive urinary bladder cancer in animal models using invisible light. Eur Urol. 52(6): 1700–8.CrossRefGoogle ScholarPubMed
Yang, J, Lee, CH, Ko, HJ et al. (2007) Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer. Angew Chem Int Ed Engl. 46(46): 8836–9.CrossRefGoogle ScholarPubMed
Reddy, GR, Bhojani, MS, McConville, P et al. (2006) Vascular targeted nanoparticles for imaging of brain tumors. Clin Cancer Res. 12(22): 6677–86.CrossRefGoogle ScholarPubMed
Farokhzad, OC, Cheng, J, Teply, BA et al. (2006) Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci. 103(16): 6315–20.CrossRefGoogle ScholarPubMed
Ibrahim, NK, Samuels, B, Page, R et al. (2005) Multicenter Phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer. J Clin Oncol. 23(25): 6019–26.CrossRefGoogle ScholarPubMed
Desai, N, Trieu, V, Yao, Z et al. (2006) Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel. Clin Cancer Res. 12(4):1317–24.CrossRefGoogle ScholarPubMed
John, TA, Vogel, SM, Tiruppathi, C, Malik, AB, Minshall, RD (2003) Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer. Am J Physiol Lung Cell Mol Physiol. 284(1): L187–96.CrossRefGoogle ScholarPubMed
Wiedenmann, N, Valdecanas, D, Hunter, N et al. (2007) 130-nm albumin-bound paclitaxel enhances tumor radiocurability and therapeutic gain. Clin Cancer Res. 13(6): 1868–74.CrossRefGoogle ScholarPubMed

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