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Cancer Metastasis
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Book description

Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

Reviews

"This text gives renewed attention to the problem of metastasis and its mechanistic basis; it is a timely and important endeavor."
Joan Massague, Howard Hughes Medical Institute Investigator, Memorial Sloan-Kettering Cancer Center

"Metastasis is a critical aspect of tumor progression that is receiving substantial interest in the research and clinical arena. Many recent advances have provided fascinating and insightful models of metastasis, which has improved our understanding of the underlying biology as well as revealing further avenues for investigation. As researchers and clinicians coordinate their efforts to find out more about this lethal stage of cancer new therapeutic strategies to target metastatic disease are being developed."
Gemma K. Alderton, Senior Editor, Nature Reviews Cancer

"Metastasis is the next frontier for cancer researchers and clinicians, and this book can help chart the way to conquer it."
Victoria Aranda, Associate Editor, Nature Medicine

"As tumor metastasis remains the main cause of cancer-related death, this isa timely book that brings together scientists and clinicians to address thisissue. An important feature is the way it gives equal emphasis to basic andclinical research, succeeding in showing how basic research contributes tobetter treatment for cancer patients, and how the clinical aspects ofmetastasis help direct basic research."
Hidayatullah G. Munshi, MD, Doody's Review Service

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