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Fefer, A, Cheever, MA, Thomas, ED, Boyd, C, Ramberg, R, Glucksburg, H, et al.Disappearance of Ph1-positive cells in four patients with chronic granulocytic leukemia after chemotherapy, irradiation and marrow transplantation from an identical twin. N Engl J Med. 1979;300:333–7.CrossRefGoogle ScholarPubMed
2
Goldman, JM, Apperley, JF, Jones, LM, Marcus, R, Goolden, A, Batchelor, R, et al.Bone marrow transplantation for patients with chronic myeloid leukaemia. N Eng J Med. 1986;314:202–7.CrossRefGoogle Scholar
3
Goldman, JM, Mackinnon, S. Bone marrow transplantation for chronic myeloid leukaemia using matched unrelated donors. Bone Marrow Transplant. 1989;Suppl 4:38–9.Google ScholarPubMed
4
Goldman, JM, Majhail, NS, Klein, JP, Wang, Z, Sobocinski, KA, Arora, M, et alRelapse and late mortality in 5-year survivors of myeloablative allogeneic hematopoietic cell transplantation for chronic myeloid leukemia in first chronic phase. J Clin Oncol. 2010;28:1888–95.CrossRefGoogle ScholarPubMed
5
Apperley, JF, Jones, L, Hale, G, Waldmann, H, Hows, J, Rombos, Y, et al.Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse. Bone Marrow Transplant. 1986;1:53–66.Google ScholarPubMed
6
Kolb, HJ, Mittermüller, J, Clemm, C, Holler, E, Ledderose, G, Brehm, Get al.Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood. 1990;76:2462–5.Google ScholarPubMed
7
Kolb, HJ, Schattenberg, A, Goldman, JM, Hertenstein, B, Jacobsen, N, Arcese, Wet al.Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood. 1995;86:2041–50.Google ScholarPubMed
8
Or, R, Shapira, MY, Resnick, I, Amar, A, Ackerstein, A, Samuel, Set al.Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase. Blood. 2003;101:441–5.CrossRefGoogle ScholarPubMed
9
Crawley, C, Szydlo, R, Lalancette, M, Bacigalupo, A, Lange, A, Brune, M, et al.Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT. Blood. 2005;106:2969–76.CrossRefGoogle ScholarPubMed
10
Kebriaei, P, Detry, MA, Giralt, S, Carrasco-Yalan, A, Anagnostopoulos, A, Couriel, D, et al.Long-term follow-up of allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning for patients with chronic myeloid leukemia. Blood. 2007;110:3456–62.CrossRefGoogle ScholarPubMed
11
Druker, BJ1, Talpaz, M, Resta, DJ, Peng, B, Buchdunger, E, Ford, JM, et al.Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031–7.Google ScholarPubMed
12
Goldman, JM. Chronic myeloid leukemia: a historical perspective. Semin Hematol. 2010;47: 302–11.CrossRefGoogle ScholarPubMed
13
Deininger, M, O’Brien, SG, Guilhot, F, Goldman, JM, Hochhaus, A, Hughes, TPet al.International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase treated with imatinib [abstract]. Blood (ASH Annual Meeting Abstracts). 2009;114:Abstract 1126.Google Scholar
14
Sasaki, K, Strom, S, O’Brien, S. Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trials. Lancet Haem. 2015;2:186–93.Google ScholarPubMed
15
Bower, H, Bjorkholm, M, Dickman, P, Hoglund, M, Lambert, P, Andersson, TML. Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population. JCO. 2016;34:2851–7.CrossRefGoogle ScholarPubMed
16
Baccarani, M, Saglio, G, Goldman, J, Hochhaus, A, Simonsson, B, Appelbaum, F, et al.European LeukemiaNet. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood2006;108:1809–1820.CrossRefGoogle Scholar
17
Baccarani, M, Deininger, MW, Rosti, G, Hochhaus, A, Soverini, S, Apperley, JF, et al.European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood. 2013;122:872–84.CrossRefGoogle ScholarPubMed
18
Hanfstein, B, Müller, MC, Hehlmann, R, Erben, P, Lauseker, M, Fabarius, A, et al.Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML). Leukemia. 2012;26:2096–102.Google Scholar
19
Marin, D, Ibrahim, AR, Lucas, C, Gerrard, G, Wang, L, Szydlo, RM, et al.Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. J Clin Oncol. 2012;30:232–8.CrossRefGoogle ScholarPubMed
20
Cortes, JE, Hochhaus, A, Kim, D, Shah, NP, Mayer, J, Rowlings, P, et al.Four-year (yr) follow-up of patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) receiving dasatinib or imatinib: efficacy based on early response. Blood (ASH Annual Meeting Abstracts). 2013; 122:Abstract 653.Google Scholar
21
Saglio, G, Hochhaus, A, Hughes, TP, Clark, RE, Nakamae, H, Kim, D, et al.ENESTnd update: nilotinib (NIL) vs imatinib (IM) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) and the impact of early molecular response (EMR) and Sokal risk at diagnosis on long-term outcomes. Blood (ASH Annual Meeting Abstracts). 2013; 122:Abstract 632.Google Scholar
22
Brümmendorf, TH, Cortes, JE, de Souza, CA, Guilhot, F, Duvillié, L, Pavlov, D, et al.Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukaemia: results from the 24-month follow-up of the BELA trial. Br J Haematol. 2014;Sep 8. doi: 10.1111/bjh.13108. [Epub ahead of print]Google ScholarPubMed
23
Mahon, FX, Réa, D, Guilhot, J, Guilhot, F, Huguet, F, Nicolini, F, et al.Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010;11:1029–35.CrossRefGoogle ScholarPubMed
24
Ross, DM, Branford, S, Seymour, JF, Schwarer, AP, Arthur, C, Yeung, DT, et al.Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study. Blood. 2013;122:515–22.CrossRefGoogle ScholarPubMed
25
Goldman, J, Gordon, M. Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter?Leuk Lymphoma. 2006;47:1–7.CrossRefGoogle ScholarPubMed
26
Gratwohl, A, Brand, R, Apperley, J, Crawley, C, Ruutu, T, Corradini, P, et al.Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica. 2006;91:513–21.Google Scholar
27
Gratwohl, A, Heim, D. Current role of stem cell transplantation in chronic myeloid leukaemia. Best Pract Res Clin Haematol. 2009;22:431–43.CrossRefGoogle ScholarPubMed
28
Pavlu, J, Szydlo, RM, Goldman, JM, Apperley, JF. Three decades of transplantation for chronic myeloid leukemia: what have we learned?Blood. 2011;117:755–63.CrossRefGoogle ScholarPubMed
29
Saussele, S, Lauseker, M, Gratwohl, A, Beelen, DW, Bunjes, D, Schwerdtfeger, R, et al.Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV. Blood. 2010;115:1880–5.CrossRefGoogle ScholarPubMed
30
Soverini, S, Hochhaus, A, Nicolini, FE, Gruber, F, Lange, T, Saglio, G, et al.BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood. 2011;118:1208–15.CrossRefGoogle Scholar
31
Ernst, T, La Rosée, P, Müller, MC, Hochhaus, A. BCR-ABL mutations in chronic myeloid leukemia. Hematol Oncol Clin North Am. 2011;25:997–1008.CrossRefGoogle ScholarPubMed
Cortes, JE, Kim, DW, Pinilla-Ibarz, J, le Coutre, P, Paquette, R, Chuah, C, et al.A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 2013;369:1783–96.CrossRefGoogle ScholarPubMed
34
Shah, NP, Guilhot, F, Cortes, JE, Schiffer, CA, le Coutre, P, Brümmendorf, TH, et al.Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study. Blood. 2014;123:2317–24.CrossRefGoogle ScholarPubMed
35
Giles, FJ, le Coutre, PD, Pinilla-Ibarz, J, Larson, RA, Gattermann, N, Ottmann, OGet al.Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study. Leukemia. 2013;27:107–12.Google ScholarPubMed
36
Kim, DD, Lee, H, Kamel-Reid, S, Lipton, JH. BCR-ABL1 transcript at 3 months predicts long-term outcomes following second generation tyrosine kinase inhibitor therapy in the patients with chronic myeloid leukaemia in chronic phase who failed Imatinib. Br J Haematol. 2013;160:630–9.CrossRefGoogle ScholarPubMed
37
Sokal, JE, Cox, EB, Baccarani, M, Tura, S, Gomez, GA, Robertson, JE, et al.Prognostic discrimination in “good-risk” chronic granulocytic leukemia. Blood. 1984;63:789–99.Google ScholarPubMed
38
Pemmaraju, N, Kantarjian, H, Shan, J, Jabbour, E, Quintas-Cardama, A, Verstovsek, S, et al.Analysis of outcomes in adolescents and young adults with chronic myelogenous leukemia treated with upfront tyrosine kinase inhibitor therapy. Haematologica. 2012;97:1029–35.CrossRefGoogle Scholar
39
Kalmanti, L, Saussele, S, Lauseker, M, Proetel, U, Müller, MC, Hanfstein, B, et al.Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV. Ann Hematol. 2014;93:71–80.CrossRefGoogle ScholarPubMed
Jiang, H, Xu, LP, Liu, DH, Liu, KY, Chen, SS, Jiang, B, et al.Allogeneic hematopoietic SCT in combination with tyrosine kinase inhibitor treatment compared with TKI treatment alone in CML blast crisis. Bone Marrow Transplant. 2014;49:1146–54.CrossRefGoogle ScholarPubMed
42
Khoury, HJ, Kukreja, M, Goldman, JM, Wang, T, Halter, J, Arora, M, et al.Prognostic factors for outcomes in allogeneic transplantation for CML in the imatinib era: a CIBMTR analysis. Bone Marrow Transplant. 2012;47:810–6.CrossRefGoogle ScholarPubMed
43
Kantarjian, HM, Cortes, J, OíBrien, S, Giles, FJ, Albitar, M, Rios, MBet al.Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood. 2002;99:3547–53.CrossRefGoogle ScholarPubMed
44
Fruehauf, S, Topaly, J, Buss, EC, et al.Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis. Cancer.2007;109:1543–9.CrossRefGoogle ScholarPubMed
45
Oki, Y, Kantarjian, HM, Gharibyan, V, et al.Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia. Cancer.2007;109:899–906.CrossRefGoogle ScholarPubMed
46
Milojkovic, D, Ibrahim, A, Reid, A, Foroni, L, Apperley, J, Marin, D. Efficacy of combining dasatinib and FLAG-IDA for patients with chronic myeloid leukemia in blastic transformation. Haematologica. 2012;97:473–4.CrossRefGoogle ScholarPubMed
47
Hochhaus, A, Giles, F, Apperley, J, Ossenkoppele, G, Wang, J , Gallagher, NJ, et al.Nilotinib in chronic myeloid leukemia patients in accelerated phase (cml-ap) with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study. Haematologica2009;94(Suppl 2):256 (abstract 0631).Google Scholar
48
Jiang, Q, Xu, LP, Liu, DH, Liu, KY, Chen, SS, Jiang, B, et alImatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in the accelerated phase. Blood. 2011;117:3032–40.CrossRefGoogle ScholarPubMed
49
Ohanian, M, Kantarjian, HM, Quintas-Cardama, A, Jabbour, E, Abruzzo, L, Verstovsek, S, et al.Tyrosine kinase inhibitors as initial therapy for patients with chronic myeloid leukemia in accelerated phase. Clin Lymphoma Myeloma Leuk. 2014;14:155–62.CrossRefGoogle ScholarPubMed
50
Gratwohl, A, Hermans, J, Goldman, JM, Arcese, W, Carreras, E, Devergie, A, et al.Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet. 1998;352:1087–92.CrossRefGoogle ScholarPubMed
51
Gratwohl, A, Stern, M, Brand, R, Apperley, J, Baldomero, H, de Witte, T, et al.Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. Cancer. 2009;115:4715–26.CrossRefGoogle ScholarPubMed
52
Milojkovic, D,Szydlo, D, Hoek, J, Beelen, D, Hamladji, R, Kyrcz-Krzemien, S, et al.Prognostic significance of EBMT score for chronic myeloid leukaemia patients in the era of tyrosine kinase inhibitor therapy: a retrospective study from the chronic malignancy working party of the european group for blood and marrow transplantation (EBMT). Bone Marrow Transplant.2014;49:S34–5.Google Scholar
53
Sorror, ML, Maris, MB, Storb, R, Baron, F, Sandmaier, BM, Maloney, DG, et al.Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood2005;106:2912–9.CrossRefGoogle ScholarPubMed
54
Sorror, M, Storer, B, Sandmaier, BM, Maloney, DG, Chauncey, TR, Langston, A, et al.Hematopoietic cell transplantation-comorbidity index and Karnofsky performance status are independent predictors of morbidity and mortality after allogeneic nonmyeloablative hematopoietic cell transplantation. Cancer. 2008;112:1992–2001.CrossRefGoogle ScholarPubMed
55
Zipperer, E, Pelz, D, Nachtkamp, K, Kuendgen, A, Strupp, C, Gattermann, N, et al.The hematopoietic stem cell transplantation comorbidity index is of prognostic relevance for patients with myelodysplastic syndrome. Haematologica. 2009;94:729–32.CrossRefGoogle ScholarPubMed
Zaucha, JM, Prejzner, W, Giebel, S, Gooley, TA, Szatkowski, D, Kałwak, K, et al.Imatinib therapy prior to myeloablative allogeneic stem cell transplantation. Bone Marrow Transplant. 2005;36:417–24.CrossRefGoogle Scholar
58
Deininger, M, Schleuning, M, Greinix, H, Sayer, HG, Fischer, T, Martinez, J, et al.The effect of prior exposure to imatinib on transplant-related mortality. Haematologica. 2006;91:452–9.Google ScholarPubMed
59
Lee, SJ, Kukreja, M, Wang, T, Giralt, SA, Szer, J, Arora, M, et al.Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia. Blood. 2008;112:3500–7.CrossRefGoogle ScholarPubMed
60
Warlick, E, Ahn, KW, Pedersen, TL, Artz, A, de Lima, M, Pulsipher, M, et al.Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era. Blood. 2012;119:4083–90.CrossRefGoogle ScholarPubMed
61
Uzunel, M, Mattsson, J, Brune, M, Johansson, JE, Aschan, J, Ringdén, O.et al.Kinetics of minimal residual disease and chimerism in patients with chronic myeloid leukemia after nonmyeloablative conditioning and allogeneic stem cell transplantation. Blood. 2003;101:469–72.CrossRefGoogle ScholarPubMed
62
Anasetti, C, Logan, BR, Lee, SJ, Waller, EK, Weisdorf, DJ, Wingard, JR, et al.Peripheral-blood stem cells versus bone marrow from unrelated donors. N Engl J Med. 2012;367:1487–96.CrossRefGoogle ScholarPubMed
63
Krejci, M, Mayer, J, Doubek, M, Brychtova, Y, Pospisil, Z, Racil, Z, et al.Clinical outcomes and direct hospital costs of reduced-intensity allogeneic transplantation in chronic myeloid leukemia. Bone Marrow Transplant. 2006;38:483–91.CrossRefGoogle ScholarPubMed
64
Basak, GW, de Wreede, LC, van Biezen, A, Wiktor-Jedrzejczak, W, Halaburda, K, Schmid, Cet al.Donor lymphocyte infusions for the treatment of chronic myeloid leukemia relapse following peripheral blood or bone marrow stem cell transplantation. Bone Marrow Transplant. 2013;48:837–42.CrossRefGoogle ScholarPubMed
65
Eapen, M, Logan, BR, Appelbaum, F, Antin, A, Anasetti, C, Couriel, DR, et al.Long-term survival after transplantation of unrelated donor peripheral blood or bone marrow hematopoietic cells for hematologic malignancy. Biol Blood Marrow Transplant. 2015;21:55–9.CrossRefGoogle ScholarPubMed
66
Sehn, LH1, Alyea, EP, Weller, E, Canning, C, Lee, S, Ritz, J, et al.Comparative outcomes of T-cell-depleted and non-T-cell-depleted allogeneic bone marrow transplantation for chronic myelogenous leukemia: impact of donor lymphocyte infusion. J Clin Oncol. 1999;17:561–8.CrossRefGoogle ScholarPubMed
67
Socié, G, Schmoor, C, Bethge, WA, Ottinger, HD, Stelljes, M, Zander, AR, et al.Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius. Blood. 2011;117:6375–82.CrossRefGoogle ScholarPubMed
68
Lin, F, van Rhee, F, Goldman, JM, Cross, NC. Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation. Blood. 1996;87:4473–8.Google ScholarPubMed
69
Krejci, M, Mayer, J, Doubek, M, Brychtova, Y, Pospisil, Z, Racil, Z, et al.Clinical outcomes and direct hospital costs of reduced-intensity allogeneic transplantation in chronic myeloid leukemia. Bone Marrow Transplant. 2006;38:483–91.CrossRefGoogle ScholarPubMed
70
Dazzi, F, Szydlo, RM, Craddock, C, Cross, NC, Kaeda, J, Chase, A, et al.Comparison of single-dose and escalating-dose regimens of donor lymphocyte infusion for relapse after allografting for chronic myeloid leukemia. Blood. 2000;95:67–71.Google ScholarPubMed
71
Innes, AJ, Beattie, R, Sergeant, R, Damaj, G, Foroni, L, Marin, D, et al.Escalating-dose HLA-mismatched DLI is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allo-SCT. Bone Marrow Transplant. 2013;48:1324–8.CrossRefGoogle ScholarPubMed
Zeidner, JF1, Zahurak, M, Rosner, GL, Gocke, CD, Jones, RJ, Smith, BD. The evolution of treatment strategies for patients with chronic myeloid leukemia relapsing after allogeneic bone marrow transplant: can tyrosine kinase inhibitors replace donor lymphocyte infusions?Leuk Lymphoma. 2015;56:128–34.CrossRefGoogle ScholarPubMed
References
1
Tefferi, A.Pathogenesis of myelofibrosis with myeloid metaplasia. J Clin Oncol. 2005;23(33):8520–30.CrossRefGoogle ScholarPubMed
2
Mesa, RA, Verstovsek, S, Cervantes, F, Barosi, G, Reilly, JT, Dupriez, B, et al.Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT). Leuk Res. 2007;31(6):737–40.CrossRefGoogle Scholar
3
Cervantes, F, Dupriez, B, Pereira, A, Passamont, F, Reilly, JT, Morra, E, et al.New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113(13):2895–901.CrossRefGoogle Scholar
4
Passamonti, F, Cervantes, F, Vannucchi, AM, Morra, E, Rumi, E, Pereira, A, et al.A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703–08.CrossRefGoogle Scholar
5
Caramazza, D, Begna, KH, Gangat, N, Vaidya, R, Siragusa, S, Van Dyke, DL, et al.Refined cytogenetic-risk categorization for overall and leukemia-free survival in primary myelofibrosis: a single center study of 433 patients. Leukemia. 2011;25(1):82–8.Google ScholarPubMed
6
Tefferi, A, Siragusa, S, Hussein, K, Schwager, SM, Hanson, CA, Pardanani, A, et al.Transfusion-dependency at presentation and its acquisition in the first year of diagnosis are both equally detrimental for survival in primary myelofibrosis—prognostic relevance is independent of IPSS or karyotype. Am J Hematol. 2010;85(1):14–7.Google ScholarPubMed
7
Gangat, N, Caramazza, D, Vaidya, R, George, G, Begna, K, Schwager, S, et al.DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29(4):392–7.CrossRefGoogle ScholarPubMed
8
Guglielmelli, P, Lasho, TL, Rotunno, G, Score, J, Mannarelli, C, Pancrazzi, A, et al.The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients. Leukemia. 2014;28(9):1804–10.CrossRefGoogle ScholarPubMed
9
Kerbauy, DM, Gooley, TA, Sale, GE, Flowers, ME, Doney, KC, Georges, GE, et al.Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis, advanced polycythemia vera, and essential thrombocythemia. Biol Blood Marrow Transplant. 2007;13(3):355–65.CrossRefGoogle ScholarPubMed
10
Kralovics, R, Passamonti, F, Buser, AS, Teo, SS, Tiedt, R, Passweg, JR, et al.A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352(17):1779–90.CrossRefGoogle ScholarPubMed
11
James, C, Ugo, V, Le Couedic, JP, Staerk, J, Delhommeau, F, Lacout, C, et al.A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera. Nature. 2005;434(7037):1144–8.CrossRefGoogle ScholarPubMed
12
Verstovsek, S, Kantarjian, H, Mesa, R, Pardanani, AD, Cortes-Franco, J, Thomas, DA, et al.Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Eng J Med. 2010;363(12):1117–27.CrossRefGoogle ScholarPubMed
13
Harrison, C, Kiladjian, JJ, Al-Ali, HK, Gisslinger, H, Waltzman, R, Stabovskaya, V, et al.JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Eng J Med. 2012;366(9):787–98.CrossRefGoogle ScholarPubMed
14
Verstovsek, S, Mesa, RA, Gotlib, JR, Levy, RS, Gupta, V, DiPersio, JF, et al.A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Eng J Med. 2012;366(9):799–807.CrossRefGoogle ScholarPubMed
15
Cervantes, F, Vannucchi, AM, Kiladjian, JJ, Al-Ali, HK, Sirulnik, A, Stalbovskaya, V, et al.Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood2013;122(25):4057–3.CrossRefGoogle ScholarPubMed
16
Verstovsek, S, Mesa, RA, Gotlib, J, Levy, RS, Gupta, V, DiPersio, JF, et al.Efficacy, safety and survival with ruxolitinib treatment in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica. 2013;98(12):1865–71.CrossRefGoogle ScholarPubMed
17
Passamonti, F, Maffioli, M, Cervantes, F, Vannucchi, AM, Morra, E, Barbui, T, et al.Impact of ruxolitinib on the natural history of primary myelofibrosis: a comparison of the DIPSS and the COMFORT-2 cohorts. Blood. 2014;123(12):1833–5.CrossRefGoogle ScholarPubMed
18
Dokal, I, Jones, L, Deenmamode, M, Lewis, SM, Goldman, JM. Allogeneic bone marrow transplantation for primary myelofibrosis. Br J Haematol. 1989;71(1):158–60.CrossRefGoogle ScholarPubMed
19
Creemers, GJ, Lowenberg, B, Hagenbeek, A. Allogeneic bone marrow transplantation for primary myelofibrosis. Br J Haematol. 1992;82(4):772–3.CrossRefGoogle ScholarPubMed
20
Guardiola, P, Anderson, JE, Bandini, G, Cervantes, F, Runde, V, Arcese, W, et al.Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Société Franҁaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. Blood. 1999;93(9):2831–8.Google Scholar
21
Deeg, HJ, Gooley, TA, Flowers, ME, Sale, GE, Slattery, JT, Anasetti, C, et al.Allogeneic hematopoietic stem cell transplantation for myelofibrosis. Blood. 2003;102(12):3912–18.CrossRefGoogle ScholarPubMed
22
Daly, A, Song, K, Nevill, T, Nantel, S, Toze, C, Hogge, D, et al.Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplant. 2003;32(1):35–40.CrossRefGoogle ScholarPubMed
23
Byrne, JL, Beshti, H, Clark, D, Ellis, I, Haynes, AP, Das-Gupta, E, et al.Induction of remission after donor leucocyte infusion for the treatment of relapsed chronic idiopathic myelofibrosis following allogeneic transplantation: evidence for a ‘graft vs. myelofibrosis’ effect. Br J Haematol. 2000;108(2):430–3.CrossRefGoogle ScholarPubMed
24
Cervantes, F, Rovira, M, Urbano-Ispizua, A, Rozman, M, Carreras, E, Montserrat, E. Complete remission of idiopathic myelofibrosis following donor lymphocyte infusion after failure of allogeneic transplantation: demonstration of a graft-versus-myelofibrosis effect. Bone Marrow Transplant. 2000;26(6):697–9.CrossRefGoogle ScholarPubMed
25
Hessling, J, Kröger, N, Werner, M, Zabelina, T, Hansen, A, Kordes, U, et al.Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia. Br J Haematol. 2002;119(3):769–72.CrossRefGoogle ScholarPubMed
26
Devine, SM, Hoffman, R, Verma, A, Shah, R, Bradlow, BA, Stock, W, et al.Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. Blood. 2002;99(6):2255–8.CrossRefGoogle ScholarPubMed
27
Rondelli, D, Barosi, G, Bacigalupo, A, Prchal, U, Alessandrino, EP, Spivak, JL, et al.Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myelofibrosis with myeloid metaplasia. Blood. 2005;105(10):4115–9.CrossRefGoogle ScholarPubMed
28
Kröger, N, Zabelina, T, Schieder, H, Panse, J, Ayuk, F, Stute, N, et al.Pilot study of reduced-intensity conditioning followed by allogeneic stem cell transplantation from related and unrelated donors in patients with myelofibrosis. Br J Haematol. 2005;128(5):690–7.CrossRefGoogle ScholarPubMed
29
Kröger, N, Holler, E, Kobbe, G, Bornhäuser, M, Schwerdtfeger, R, Baurmann, H, et al.Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Blood. 2009;114(26):5264–70.CrossRefGoogle ScholarPubMed
30
Alchalby, H, Zabelina, T, Wollf, D, Kobbe, G, Bornhäuser, M, Baurmann, H, et al.Long Term Follow-up of the Prospective Multicenter Study of reduced-Intensity Allogeneic Stem Cell Transplantation for Primary or Post ET/PV Myelofibrosis. Blood (ASH Annual Meeting Abstracts). 2011;118: Abstract 1019.Google Scholar
31
Rondelli, D, Goldberg, J, Isola, L, Price, LS, Shore, TB, Boyer, M, et al.MPD-RC 101 prospective study of reduced intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. Blood. 2014;124(7):1183–91.CrossRefGoogle ScholarPubMed
32
Bacigalupo, A, Soraru, M, Dominietto, A, Pozzi, S, Geroldi, S, Van Lint, MT, et al.Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen, and donor type. Bone Marrow Transplant. 2010;45(3): 458–63.CrossRefGoogle ScholarPubMed
33
Gupta, V, Malone, AK, Hari, PN, Ahn, KW, Hu, ZH, Gale, RP, et al.Reduced-intensity hematopoietic cell transplantation for patients with primary myelofibrosis: a cohort analysis from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant. 2014;20(1): 89–97.CrossRefGoogle ScholarPubMed
34
Stewart, WA, Pearce, R, Kirkland, KE, Bloor, A, Thomson, K, Apperley, J, et al.The role of allogeneic SCT in primary myelofibrosis: a British Society for Blood and Marrow Transplantation study. Bone Marrow Transplant. 2010;45(11):1587–93.CrossRefGoogle ScholarPubMed
35
Ballen, KK, Shrestha, A, Sobocinski, KA, Zhang, MJ, Bashey, A, Bolwell, BJ, et al.Outcome of transplantation for myelofibrosis. Biol Blood Marrow Transplant. 2010;16(3):358–67.CrossRefGoogle ScholarPubMed
36
Robin, M, Tabrizi, R, Mohty, M, Furst, S, Michallet, M, Bay, JO, et al.Allogeneic haematopoietic stem cell transplantation for myelofibrosis: a report of the Société Franҁaise de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC). Br J Haematol. 2011;152(3):331–9.CrossRefGoogle Scholar
37
Gupta, V, Kröger, N, Aschan, J, Xu, W, Leber, B, Dalley, C, et al.A retrospective comparison of conventional intensity conditioning and reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in myelofibrosis. Bone Marrow Transplant. 2009;44(5):317–20.CrossRefGoogle ScholarPubMed
38
Abelsson, J, Merup, M, Birgegard, G, Weis Bjerrum, O, Brinch, L, Brune, M, et al.The outcome of allo-HSCT for 92 patients with myelofibrosis in the Nordic countries. Bone Marrow Transplant. 2012;47(3):380–6.CrossRefGoogle ScholarPubMed
39
Ditschkowski, M, Elmaagacli, AH, Trenschel, R, Gromke, T, Steckel, NK, Koldehoff, M, et al.Dynamic International Prognostic Scoring scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis. Haematologica. 2012;97(10):1574–81.CrossRefGoogle ScholarPubMed
40
Scott, BL, Gooley, TA, Sorror, ML, Rezvani, AR, Linenberger, ML, Grim, J, et al.The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation. Blood. 2012;119(11): 2657–64.CrossRefGoogle ScholarPubMed
41
Nivison-Smith, I, Dodds, AJ, Butler, J, Bradstock, KF, Ma, DD, Simpson, JM, et al.Allogeneic hematopoietic cell transplantation for chronic myelofibrosis in Australia and New Zealand: older recipients receiving myeloablative conditioning at increased mortality risk. Biol Blood Marrow Transplant. 2012;18(2):302–8.CrossRefGoogle ScholarPubMed
42
Patriarca, F, Bacigalupo, A, Sperotto, A, Isola, M, Soldano, F, Bruno, B, et al.Allogeneic hematopoietic stem cell transplantation in myelofibrosis: the 20-year experience of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Haematologica. 2008;93(10):1514–22.CrossRefGoogle Scholar
43
Kröger, N, Alchalby, H, Klyuchnnikov, E, Badbaran, A, Hildebrandt, Y, Ayuk, F, et al.JAK2-V617F-triggered preemptive and salvage adoptive immunotherapy with donor-lymphocyte infusion in patients with myelofibrosis after allogeneic stem cell transplantation. Blood. 2009;113(8):1866–8.CrossRefGoogle ScholarPubMed
44
Vainchenker, W, Delhommeau, F, Constantinescu, SN, Bernard, OA. New mutations of myeloproliferative neoplasms. Blood. 2011;118(7):1723–35.CrossRefGoogle ScholarPubMed
45
Klampfl, T, Gisslinger, H, Harutyunyan, AS, Nivarthi, H, Rumi, E, Milosevic, JD, et al.Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369(25):2379–90.CrossRefGoogle ScholarPubMed
46
Nangalia, J, Massie, CE, Baxter, EJ, Nice, FL, Gundem, G, Wedge, DC, et al.Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369(25):2391–405.CrossRefGoogle ScholarPubMed
47
Klyuchnikov, E, Holler, E, Bornhäuser, M, Kobbe, G, Nagler, A, Shimoni, A, et al.Donor lymphocyte infusions and second transplantation as salvage treatment for relapsed myelofibrosis after reduced-intensity allografting. Br J Haematol. 2012;159(2):172–81.CrossRefGoogle ScholarPubMed
48
Barbui, T, Barosi, G, Birgegard, G, Cervantes, F, Finazzi, G, Griesshammer, M, et al.Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol. 2011;29(6):761–70.CrossRefGoogle ScholarPubMed
49
Alchalby, H, Yunus, DR, Zabelina, T, Kobbe, G, Holler, E, Bornhäuser, M, et al.Risk models predicting survival after reduced-intensity transplantation for myelofibrosis. Br J Haematol. 2012;157(1):75–85.CrossRefGoogle ScholarPubMed
50
Alchalby, H, Zabelina, T, Stübig, T, van Biezen, A, Bornhäuser, M, Di Bartolomeo, M, et al.Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation: a study from the Myeloproliferative Neoplasm Subcommittee of the CMWP of the European Group for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2014;20(2):279–81.CrossRefGoogle ScholarPubMed
51
Cahu, X, Chevallier, P, Clavert, A, Suarez, F, Michallet, M, Vincent, L, et al.Allo-SCT for Philadelphia-negative myeloproliferativer neoplasms in blast phase: a study from the Societe Franҁaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC). Bone Marrow Transplant. 2014;49(6):756–60.CrossRefGoogle Scholar
52
Lussana, F, Rimbaldi, A, Finazzi, MC, van Biezen, A, Scholten, M, Oldani, E, et al.Allogeneic hematopoietic stem cell transplantation in patients with polycythemia vera or essential thrombocythemia transformed to myelofibrosis or acute myeloid leukemia: a report from the MPN Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation. Haematologica. 2014;99(5):916–21.CrossRefGoogle ScholarPubMed
53
Alchalby, H, Badbaran, A, Zabelina, T, Kobbe, G, Hahn, J, Wolff, D, et al.Impact of JAK2V617F mutation status, alelle burden, and clearance after allogeneic stem cell transplantation for myelofibrosis. Blood. 2010;116(18):3572–81.CrossRefGoogle Scholar
54
Panagiota, V, Thol, F, Markus, B, Fehse, B, Alchalby, H, Badbaran, A, et al.Prognostic effect of calreticulin mutations in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation. Leukemia. 2014;28(7):1552–5.CrossRefGoogle ScholarPubMed
55
Alchalby, H, Lioznov, M, Fritzsche-Friedland, U, Badbaran, A, Zabelina, T, Bacher, U, et al.Circulating CD34(+) cells as prognostic and follow-up marker in patients with myelofibrosis undergoing allo-SCT. Bone Marrow Transplant. 2012;47(1):143–5.CrossRefGoogle ScholarPubMed
56
Kerbauy, DM, Gooley, TA, Sale, GE, Flowers, ME, Doney, KC, Georges, GE, et al.Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis, advanced polycythemia very, and essential thrombocythemia. Biol Blood Marrow Transplant. 2007;13(3):355–65.CrossRefGoogle ScholarPubMed
57
Samuelson, S, Sandmaier, BM, Heslop, HE, Popat, U, Carrum, G, Champlin, RE, et al.Allogeneic haematopoietic cell transplantation for myelofibrosis in 30 patients 60–78 years of age. Br J Haematol. 2011;153(1):76–82.CrossRefGoogle ScholarPubMed
58
Robin, M, Giannotti, F, Deconinck, E, Mohty, M, Michallet, M, Sanz, G, et al.Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis. Biol Blood Marrow Transplant. 2014;20(11):1841–6.CrossRefGoogle ScholarPubMed
59
Ciurea, SO, Sadegi, B, Wilbur, A, Alagiozian-Angelova, V, Gaitonde, S, Dobogai, LC, et al.Effects of extensive splenomegaly in patients with myelofibrosis undergoing a reduced intensity allogeneic stem cell transplantation. Br J Haematol. 2008;141(1):80–3.CrossRefGoogle ScholarPubMed
60
Mesa, RA, Nagorney, DS, Schwager, S, Allred, J, Tefferi, A. Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic. Cancer. 2006;107(2):361–70.CrossRefGoogle ScholarPubMed
61
Stübig, T, Alchalby, H, Ditschkowski, M, Wolf, D, Wulf, G, Zabelina, T, et al.JAK inhibition with ruxolitinib as pretreatment for allogeneic stem cell transplantation in primary or post-ET/PV myelofibrosis. Leukemia. 2014;28(8):1736–8.CrossRefGoogle ScholarPubMed
62
Tefferi, A, Constantinescu, SN. Introduction to ‘A special spotlight review series on BCR-ABL-negative myeloproliferative neoplasms’. Leukemia. 2008;22(1):3–13.CrossRefGoogle ScholarPubMed
63
Tefferi, A. Myelofibrosis with myeloid metaplasia. N Engl J Med. 2000;342(17):1255–66.CrossRefGoogle ScholarPubMed
64
Chagraoui, H, Komura, E, Tulliez, M, Giraudier, S, Vainchenker, W, Wendling, F. Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice. Blood. 2002;100(10):3495–503.CrossRefGoogle ScholarPubMed
65
Le Bousse-Kerdilès, MC, Martyré, MC, Samson, M. Cellular and molecular mechanisms underlying bone marrow and liver fibrosis: a review. Eur Cytokine Netw. 2008;19(2):69–80.Google ScholarPubMed
66
Thiele, J, Kvasnicka, HM. Grade of bone marrow fibrosis is associated with relevant hematological findings– a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis. Ann Hematol. 2006;85(4):226–32.CrossRefGoogle ScholarPubMed
67
Barosi, G, Rosti, V, Bonetti, E, Campanelli, R, Carolei, A, Catarsi, P, et al.Evidence that prefibrotic myelofibrosis is aligned along a clinical and biological continuum featuring primary myelofibrosis. PLOS One. 2012;7:e35631CrossRefGoogle ScholarPubMed
68
Gianelli, U, Vener, C, Bossi, A, et al.The European Consensus on grading of bone marrow fibrosis allows a better prognostication of patients with primary myelofibrosis. Mod Pathol. 2012;25(9):1193–202.CrossRefGoogle ScholarPubMed
69
Nazha, A, Estrov, Z, Cortes, J, Bueso-Ramos, CE, Kantarjian, H, Verstovsek, S. Prognostic implications and clinical characteristics associated with bone marrow fibrosis. Leuk Lymphoma. 2013;54(11):2537–9.CrossRefGoogle ScholarPubMed
70
Strasser-Weippl, K, Steurer, M, Kees, M, Agustin, F, Tzankov, A, Dirnhofer, S, et al.Age and hemoglobin level emerge as most important clinical prognostic parameters in patients with osteomyelofibrosis: introduction of a simplified prognostic score. Leuk Lymphoma. 2006;47(3):441–50.CrossRefGoogle ScholarPubMed
71
Anger, B, Seidler, R, Haug, U, Popp, C, Heimpel, H. Idiopathic myelofibrosis: a retrospective study of 103 patients. Haematologica. 1990;75(3): 226–34.Google ScholarPubMed
72
Thiele, J, Kvasnicka, HM, Dietrich, H, Stein, G, Hann, M, Kaminski, A, et al.Dynamics of bone marrow changes in patients with chronic idiopathic myelofibrosis following allogeneic stem cell transplantation. Histol Histopathol. 2005;20(3):879–89.Google ScholarPubMed
73
Silver, RT, Vadris, K, Goldman, JJ. Recombinant interferon-α may retard progression of early primary myelofibrosis: a preliminary report. Blood. 2011;117(24):6669–72.CrossRefGoogle ScholarPubMed
74
Tefferi, A, Verstovsek, S, Barosi, G, Passamonti, F, Roboz, GJ, Gisslinger, H, et al.Pomalidomide is active in the treatment of anemia associated with myelofibrosis. J Clin Oncol. 2009;27(27):4563–9.CrossRefGoogle ScholarPubMed
75
Kvasnicka, HM, Thiele, J, Bueso-Ramos, CE, Hou, K, Cortes, JE, Kantarjian, HM, et al.Exploratory analysis of the effect of ruxolitinib on bone marrow morphology in patients with myelofibrosis. (ASCO Annual Meeting Abstract). J Clin Oncol. 2013;31(15):7030.Google Scholar
76
Kröger, N, Zabelina, T, Alchalby, H, Stübig, T, Wolschke, C, Ayuk, F, et al.Dynamic of bone marrow fibrosis regression predicts survival after allogeneic stem cell transplantation for myelofibrosis. Biol Blood Marrow Transplant. 2014;20(6):812–5.CrossRefGoogle ScholarPubMed
77
Verstovsek, S, Mesa, RA, Gotlib, JR, Levy, RS, Gupta, V, DiPersio, JF, et al.Results of COMFORT-I, a randomized double-blind phase III trial of JAK1/2 inhibitor INCB18424 (424) versus placebo (PB) for patients with myelofibrosis (MF) (ASCO Annual Meeting Abstract). J Clin Oncol. 2011;29(15):6500.CrossRefGoogle Scholar
78
Harrison, CN, Kiladijan, H, Al-Ali, HK, Gisslinger, H, Waltzman, RJ, Stalbovskaya, V, et al.Results of a randomized study of the JAK inhibitor INC424 compared with best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera-myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF). (ASCO Annual Meeting Abstract). J Clin Oncol. 2011;29(15): LBA6501.Google Scholar
79
Spoerl, S, Mathew, NR, Bscheider, M, Schmitt-Graeff, A, Chen, S, Mueller, T, et al.Activity of therapeutic JAK ½ blockade in graft-versus-host disease. Blood. 2014;123(24):3832–42.CrossRefGoogle ScholarPubMed
80
Jaekel, N, Behre, G, Behning, A, Wickenhauser, C, Lange, T, Niederwieser, D, et al.Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib. Bone Marrow Transplant. 2014;49(2):179–84.CrossRefGoogle ScholarPubMed
81
Robin, M, Francois, S, Huynh, A, Cassimat, B, Bay, JO, Cornillon, J, et al.Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis: a preliminary descriptive report of the JAK ALLO study, a phase II trial sponsored by Goelams-FIM in collaboration with the Sfgmtc. Blood. 2013;122(21):abstract 306.Google Scholar