Chrono-nutrition is an emerging field that examines how the frequency and timing of meals impact health. Previous research shows inconsistency in the relationship between chrono-nutritional components and cardiometabolic health. We investigated cross-sectional associations between these components and cardiometabolic health in 825 Iranian adults aged 20–59 years. Dietary data, including the number of eating occasions, meal timing and meal irregularity of energy intake, were collected using three 24-h dietary recalls. Anthropometric measurements, blood pressure and laboratory tests (fasting plasma glucose, lipid profile, insulin, uric acid and C-reactive protein) were conducted. Insulin resistance and sensitivity (homeostatic model assessment for insulin resistance, homeostatic model assessment for insulin sensitivity), the TAG-glucose, the lipid accommodation product and BMI were calculated. The demographic and morning-evening questionnaire was completed. General linear regression was used to assess associations between chrono-nutritional components and outcomes. Interactions with age and BMI were examined in all associations. Chrono-nutrition components were not significantly related to cardiometabolic risk factors in the total population. However, a lower number of eating occasions was associated with an increased LDL-cholesterol:HDL-cholesterol ratio (β (95 % CI): 0·26 (0·06, 0·48)) among overweight and obese participants. Additionally, less irregularity in breakfast energy intake was associated with a lower total cholesterol:HDL-cholesterol ratio (–0·37 (–0·95, –0·18)) and a lower LDL-cholesterol:HDL-cholesterol ratio (–0·32 (–0·79, –0·13)) among participants with a normal BMI (all P< 0·05). The study concluded that more frequent meals and regular energy intake might enhance cardiometabolic health cross-sectionally, highlighting the need for prospective studies to further investigate these associations and the mediating role of BMI.

This paper uses a textual decision at Iliad 9.394 to argue for irregularity as a functional and meaningful principle in the constitution of the Homeric text. In contrast to almost all recent major editions, I argue that the ‘irregular’ MSS γαμέσσεται should be preferred to the Aristarchaean conjecture γε μάσσεται. Aristarchus’ widely adopted emendation, I suggest, is the product of a drive towards standardization that is still operative in Homeric text-critical practice. This paper opposes that standardization with the evidence of ancient, perhaps pre-Alexandrian, responses to Iliad 9.394, in which the ‘irregularity’ of γαμέσσεται is embraced as an interpretive opportunity. The formal disruptions of γαμέσσεται, I propose, can be understood by locating them both within the immediate context of Iliad 9 and within the wider thematics of irregularity that mark the character of Achilles. This paper thus attempts to reframe our approach to the role of irregularity in the Iliad as an integral feature of meaning rather than grounds for suspecting the integrity of the text.

The present cross-sectional study aimed to assess the association of daily irregularity in energy intake and diet quality among apparently healthy adults in Iran. The research was conducted on 850 adult men and women (age range: 20–59 years) who attended health care centres in Tehran. Dietary intake was assessed by three, 24-h dietary recalls. Diet quality was assessed using the Dietary Approaches to Stop Hypertension (DASH) diet score and Healthy Eating Index-2015 (HEI-2015). An irregularity score of daily energy intake was calculated based on the deviation from the 3-d mean energy intake, with a higher score indicating more fluctuations in daily energy intake. Multiple linear regression analysis was used to assess the association of irregularity score of daily energy intake with food group intakes and DASH diet score and HEI-2015, controlling for age, sex, BMI, physical activity, education level and occupation status. The range of irregularity score was 0·55–133·3 (22·4 (sd 19·0)). Higher irregularity score of daily energy intake was significantly associated with a lower consumption of fruit, vegetables, legumes, low-fat dairy products and poultry, higher consumption of soft drinks, processed meat and nuts, and lower overall DASH diet score and HEI-2015. Overall, our findings showed that more day-to-day variations in energy intake may be correlated with a lower diet quality. More research is needed to confirm the associations observed in the present study and to clarify potential mechanisms explaining these associations.

Studying irregular meal patterns fits in with the latest research focusing not only on what people eat but also when they eat, also called chrono-nutrition. Chrono-nutrition involves studying the impact of nutrition on metabolism via circadian patterns, including three aspects of time: (ir)regularity, frequency and clock time. The present paper aimed to narratively review research on irregular meal patterns and cardiometabolic consequences. Only few cross-sectional studies and prospective cohort studies were identified, and most of these suggested that eating meals irregularly is associated with a higher risk of the metabolic syndrome and cardiometabolic risk factors, including BMI and blood pressure. This was supported by two randomised controlled intervention studies showing that consuming meals regularly for 2 weeks v. an irregular meal pattern, led to beneficial impact on cardiometabolic risk factors as lower peak insulin, lower fasting total and LDL-cholesterol, both in lean and obese women. In conclusion, the limited evidence on meal regularity and cardiometabolic consequences supports the hypothesis that consuming meals irregularly is adversely associated with cardiometabolic risk. However, it also highlights the need for more large-scale studies, including detailed dietary assessment to further advance the understanding of the impact of chrono-nutrition on public health.

We show that, under conditions about the microcharacteristic variety of a coherent $\cal D$-module, the Cauchy problem is well-posed in the spaces of formal power series with Gevrey growth. We deduce that the filtration of the Irregularity Sheaf of a holonomic $\cal D$-module, which we defined in a previous work, is preserved under inverse image if some rather general geometric conditions are fullfilled.

We show that the cohomology of complexes of solutions of exponantial type associated to holonomic algebraic D-modules is constructible. We also compute the Euler–Poincaré index of such complexes.