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Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.
The outbreak has had a devastating impact, and efforts are underway to speed up vaccination. The study’s objective was to describe the clinical characteristics of the COVID-19 vaccination clinic in the Second People’s Hospital of Fujian Province, China. Meanwhile, We monitored all the vaccine recipients to evaluate adverse reactions.
A cross-sectional study was done at the COVID-19 Vaccination Clinic, the Second People’s Hospital of Fujian Province, China. We systematically collected Clinical data from the COVID-19 vaccination clinic between March 11 and November 11, 2021, including the type of vaccine, number of doses, gender, age, educational level, occupational category, adverse reactions, etc. Investigators will contact vaccine recipients via phone call or WeChat message to record the negative responses. Lastly, this report covers data through 8 months, so it will be better to Evaluate the Safety of two inactivated COVID-19 vaccines from China (BBIBP-CorV (Beijing Institute of Biological Products, Beijing, China) and CoronaVac (Sinovac Life Sciences, Beijing, China)).
The results indicated that the Second People’s Hospital of Fujian Province received a total of 64,602 COVID-19 vaccines from March 11 to November 11, 2021, including 34,331 (53.14%) first doses, 29,245 (45.27%) second doses, and 1,026 (1.59%) third doses. This study found the highest proportion in other personnel (38.69% at the first dose, 38.75% at the second dose, and 2.44% at the third dose), who were mainly retirees. People with higher levels of education are more likely to be vaccinated against COVID-19 during the early stages of vaccine rollout. In terms of age stratification, the highest proportion was found among people aged 18-49 (BBIBP-CorV: first dose 61%, second dose 62.6%, and third dose 76.8%; Corona Vac: first dose 66.1%, double dose 63.6%, and third dose 75.5%), followed by those over 60. The common adverse reactions were mainly local and systemic, and there were some differences between the two inactivated vaccines (P<0.05).
This is the first study to analyze the actual status of hospitals as COVID-19 vaccination clinics in China. The hospital has focused on vaccinating citizens and the initial rollout of vaccines to ensure any safety issues are identified. More citizens are willing to vaccinate in hospitals because of the uncertain safety of the available vaccines and adverse reactions. The good news is that vaccine-related severe adverse events have not been found in the hospital vaccination clinic. The Safety of BBIBP-CorV and Corona Vac is relatively high.
In this chapter, we address the issues related to sentence grammaticality and acceptability. We begin with a discussion of the relationship between the two notions, and point out that despite the differences in theoretical conceptualization, the two notions, grammaticality and acceptability, are often confluent and that grammaticality is usually measured as acceptability in linguistic research. We then discuss factors beyond syntax that may influence sentence acceptability, including processing factors and semantic/pragmatic considerations. Finally, we discuss the measurement of acceptability, via either experimental methods or corpus-based analyses. To conclude, we show in this chapter how grammaticality, a seemingly purely syntactic notion, is often materialized as acceptability, which encompasses multiple linguistic modules that go beyond syntax.
This paper investigates flow past a backward-facing step (BFS) in a duct at Reynolds number $Re = 5080$ based on step height, mean inflow velocity and fluid kinematic viscosity. The flow configuration matches a combustion experiment conducted by Pitz and Daily in 1983. High-resolution velocity fields are obtained in OpenFOAM by direct numerical simulation, and the flow field analysed by Lagrangian approaches. Trajectories of fluid particles in areas of interest are obtained by high-order numerical integration, and used to compute finite-time Lyapunov exponents (FTLEs) and polar rotation angles. Lagrangian coherent structures (LCSs) are extracted using geodesic theory, including hyperbolic LCSs and elliptic LCSs. We use complementary qualitative and quantitative LCS analyses to uncover the underlying flow structures. Notably, we find that a flow pathway in which fluid particles rarely diverge from adjacent particles is opened and closed by FTLE ridges determined by the periodic shedding of vortices from the BFS. Two dominant vortices with significant Lagrangian coherence, generated respectively by the separated boundary layer and shear layer, are self-sustaining and of comparable strength. Hyperbolic repelling LCSs act as transport barriers between the pathway and cores of the coherent vortices, thus playing a major part in the fluid entrainment process. Interactions between these different geometric regions partitioned by LCSs lead to intrinsic complexity in the BFS flow.
Problematic internet use, especially in people with substance use disorder, may negatively affect their quality of life (QoL). However, it is unclear whether sleep quality is a key mediator in the association between problematic internet use and QoL among people with substance use disorder.
This study aimed to investigate the relationship between problematic internet use and QoL and how sleep quality may mediate the association between these two variables.
Overall, 319 people (85% male) with substance use disorder (mean age 42.2 years, s.d. 8.9) participated in a cross-sectional study in Taiwan. The Smartphone Application-Based Addiction Scale, Bergan Social Media Addiction Scale, Internet Gaming Disorder-Short Form, Pittsburgh Sleep Quality Index and World Health Organization Quality of Life Questionnaire Brief Version were used.
The prevalence of sleep problems was 56%. There were significant and direct associations between sleep quality and two types of problematic internet use, and between sleep quality and different dimensions of QoL. All types of problematic internet use were significantly and negatively correlated with QoL. Mediated effects of sleep quality in relationships between the different types of problematic internet use and all dimensions of QoL were significant, except for problematic use of social media.
Different types of problematic internet use in people with substance use disorder may be directly associated with reduced QoL. Sleep quality as a significant mediator in this association may be an underlying mechanism to explain pathways between problematic internet use and QoL in this population.
The linguistic study of Chinese, with its rich morphological, syntactic and prosodic/tonal structures, its complex writing system, and its diverse socio-historical background, is already a long-established and vast research area. With contributions from internationally renowned experts in the field, this Handbook provides a state-of-the-art survey of the central issues in Chinese linguistics. Chapters are divided into four thematic areas: writing systems and the neuro-cognitive processing of Chinese, morpho-lexical structures, phonetic and phonological characteristics, and issues in syntax, semantics, pragmatics, and discourse. By following a context-driven approach, it shows how theoretical issues in Chinese linguistics can be resolved with empirical evidence and argumentation, and provides a range of different perspectives. Its dialectical design sets a state-of-the-art benchmark for research in a wide range of interdisciplinary and cross-lingual studies involving the Chinese language. It is an essential resource for students and researchers wishing to explore the fascinating field of Chinese linguistics.
Maternal gestational weight gain (GWG) is an important determinant of infant birth weight, and having adequate total GWG has been widely recommended. However, the association of timing of GWG with birth weight remains controversial. We aimed to evaluate this association, especially among women with adequate total GWG. In a prospective cohort study, pregnant women’s weight was routinely measured during pregnancy, and their GWG was calculated for the ten intervals: the first 13, 14–18, 19–23, 24–28, 29–30, 31–32, 33–34, 35–36, 37–38 and 39–40 weeks. Birth weight was measured, and small-for-gestational-age (SGA) and large-for-gestational-age were assessed. Generalized linear and Poisson models were used to evaluate the associations of GWG with birth weight and its outcomes after multivariate adjustment, respectively. Of the 5049 women, increased GWG in the first 30 weeks was associated with increased birth weight for male infants, and increased GWG in the first 28 weeks was associated with increased birth weight for females. Among 1713 women with adequate total GWG, increased GWG percent between 14 and 23 weeks was associated with increased birth weight. Moreover, inadequate GWG between 14 and 23 weeks, compared with the adequate GWG, was associated with an increased risk of SGA (43 (13·7 %) v. 42 (7·2 %); relative risk 1·83, 95 % CI 1·21, 2·76). Timing of GWG may influence infant birth weight differentially, and women with inadequate GWG between 14 and 23 weeks may be at higher risk of delivering SGA infants, despite having adequate total GWG.