Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

39 results

Page 1 of 2

  • Urbanicity and rates of untreated psychotic disorders in three diverse settings in the Global South
  • Tessa Roberts, Ezra Susser, Joni Lee Pow, Casswina Donald, Sujit John, Vijaya Raghavan, Olatunde Ayinde, Bola Olley, Georgina Miguel Esponda, Joseph Lam, Robin M. Murray, Alex Cohen, Helen A. Weiss, Gerard Hutchinson, Rangaswamy Thara, Oye Gureje, Jonathan Burns, INTREPID Group , Craig Morgan
  • Journal: Psychological Medicine , First View
  • Published online by Cambridge University Press: 16 January 2023, pp. 1-9
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation
  • View abstract
    Background

    Extensive evidence indicates that rates of psychotic disorder are elevated in more urban compared with less urban areas, but this evidence largely originates from Northern Europe. It is unclear whether the same association holds globally. This study examined the association between urban residence and rates of psychotic disorder in catchment areas in India (Kancheepuram, Tamil Nadu), Nigeria (Ibadan, Oyo), and Northern Trinidad.

    Methods

    Comprehensive case detection systems were developed based on extensive pilot work to identify individuals aged 18–64 with previously untreated psychotic disorders residing in each catchment area (May 2018–April/May/July 2020). Area of residence and basic demographic details were collected for eligible cases. We compared rates of psychotic disorder in the more v. less urban administrative areas within each catchment area, based on all cases detected, and repeated these analyses while restricting to recent onset cases (<2 years/<5 years).

    Results

    We found evidence of higher overall rates of psychosis in more urban areas within the Trinidadian catchment area (IRR: 3.24, 95% CI 2.68–3.91), an inverse association in the Nigerian catchment area (IRR: 0.68, 95% CI 0.51–0.91) and no association in the Indian catchment area (IRR: 1.18, 95% CI 0.93–1.52). When restricting to recent onset cases, we found a modest positive association in the Indian catchment area.

    Conclusions

    This study suggests that urbanicity is associated with higher rates of psychotic disorder in some but not all contexts outside of Northern Europe. Future studies should test candidate mechanisms that may underlie the associations observed, such as exposure to violence.

  • Use of kinase inhibitors against schistosomes to improve and broaden praziquantel efficacy
  • Sujeevi S. K. Nawaratna, Donald P. McManus, Robin B. Gasser, Paul J. Brindley, Glen M. Boyle, Vanessa Rivera, Shiwanthi L. Ranasinghe, Malcolm K. Jones, Hong You, Geoffrey N. Gobert
  • Journal: Parasitology / Volume 147 / Issue 13 / November 2020
  • Published online by Cambridge University Press: 03 August 2020, pp. 1488-1498
  • View abstract

    Praziquantel (PZQ) is the drug of choice for schistosomiasis. The potential drug resistance necessitates the search for adjunct or alternative therapies to PZQ. Previous functional genomics has shown that RNAi inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII) gene in Schistosoma adult worms significantly improved the effectiveness of PZQ. Here we tested the in vitro efficacy of 15 selective and non-selective CaMK inhibitors against Schistosoma mansoni and showed that PZQ efficacy was improved against refractory juvenile parasites when combined with these CaMK inhibitors. By measuring CaMK activity and the mobility of adult S. mansoni, we identified two non-selective CaMK inhibitors, Staurosporine (STSP) and 1Naphthyl PP1 (1NAPP1), as promising candidates for further study. The impact of STSP and 1NAPP1 was investigated in mice infected with S. mansoni in the presence or absence of a sub-lethal dose of PZQ against 2- and 7-day-old schistosomula and adults. Treatment with STSP/PZQ induced a significant (47–68%) liver egg burden reduction compared with mice treated with PZQ alone. The findings indicate that the combination of STSP and PZQ dosages significantly improved anti-schistosomal activity compared to PZQ alone, demonstrating the potential of selective and non-selective CaMK/kinase inhibitors as a combination therapy with PZQ in treating schistosomiasis.

Textiles, Text, Intertext
  • Textiles, Text, Intertext
  • Essays in Honour of Gale R. Owen-Crocker
  • Edited by Maren Clegg Hyer
  • Published by: Boydell & Brewer
  • Published online: 05 July 2016
  • Print publication: 18 March 2016
  • View description
    The triple themes of textile, text, and intertext, three powerful and evocative subjects within both Anglo-Saxon studies and Old English literature itself, run through the essays collected here. Chapters evoke the semantic complexities of textile references and images drawn from the Bayeux Tapestry, examine parallels in word-woven poetics, riddling texts, and interwoven homiletic and historical prose, and identify iconographical textures in medieval art. The volume thus considers the images and creative strategies of textiles, texts, and intertexts, generating a complex and fascinating view ofthe material culture and metaphorical landscape of the Anglo-Saxon peoples. It is therefore a particularly fitting tribute to Professor Gale R. Owen-Crocker, whose career and lengthy list of scholarly works have centred on her interests in the meaning and cultural importance of textiles, manuscripts and text, and intertextual relationships between text and textile.

    Dr Maren Clegg Hyer is Associate Professor and Graduate Coordinator in the Department of English at Valdosta State University.; Jill Frederick is Professor of English at Minnesota State University Moorhead.

    Contributors: Marilina Cesario, Elizabeth Coatsworth, Martin Foys, Jill Frederick, Joyce Hill, Maren Clegg Hyer, Catherine E. Karkov, Christina Lee, Michael Lewis, Robin Netherton, Carol Neuman de Vegvar, Donald Scragg, Louise Sylvester, Paul Szarmach, Elaine Treharne.
  • Local Treatment of Spasmodic Torticollis with Botulinum Toxin
  • Joseph K.C. Tsui, Robin D. Fross, Susan Calne, Donald B. Calne
  • Journal: Canadian Journal of Neurological Sciences / Volume 14 / Issue S3 / August 1987
  • Published online by Cambridge University Press: 05 January 2016, pp. 533-535
    • Article
      • You have access
    • PDF
    • Export citation
  • View abstract

    Fifty-six patients with spasmodic torticollis were treated with local injections of botulinum toxin. The drop out rate was 21%. The remaining 44 patients were followed for a period of 3 to 21 months. Thirty-two patients (76%) had pain relief out of 42 presenting with pain; 37 (66%) improved in the amount of sustained movements of torticollis. The efficacy was reproducible after repeated injections.

Page 1 of 2