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First published in 1973, this influential work discusses Einstein's General Theory of Relativity to show how two of its predictions arise: first, that the ultimate fate of many massive stars is to undergo gravitational collapse to form 'black holes'; and second, that there was a singularity in the past at the beginning of the universe. Starting with a precise formulation of the theory, including the necessary differential geometry, the authors discuss the significance of space-time curvature and examine the properties of a number of exact solutions of Einstein's field equations. They develop the theory of the causal structure of a general space-time, and use it to prove a number of theorems establishing the inevitability of singularities under certain conditions. A Foreword contributed by Abhay Ashtekar and a new Preface from George Ellis help put the volume into context of the developments in the field over the past fifty years.
This chapter examines four cases of collapsed states from the Middle East and North Africa – Lebanon, Libya, Somalia, and Yemen. State collapse was marked by the breakdown of national institutions and the effective loss of a functioning central government. Different governance arrangements appeared across the territory of the country. This chapter discusses the nature of state collapse and its bearing on constitution-making processes and constitutional design. International actors may be drawn in as partisans of different factions or as potential mediators and facilitators of conflict resolution and state reconstruction. Peace-making requires the main factions to accept that the costs of fighting outweigh any benefits and to agree on structured negotiations. Sustainable peace requires agreements on governance, including potentially interim power-sharing, a constitution-making process, transitional security arrangements, and some guiding principles for a reconstructed state. While a federal or devolved governance arrangement may seem logical, the factional elites may prefer power-sharing at the center. If they do opt for a federal or devolved structure, they face vexing issues in defining the constituent units, the allocation of powers, and the nature of central institutions, which may result in an extended period of muddled governance and power politics with no constitutional clarity.
Recent research has shown that risk and reward are positively correlated in many environments, and that people have internalized this association as a “risk-reward heuristic”: when making choices based on incomplete information, people infer probabilities from payoffs and vice-versa, and these inferences shape their decisions. We extend this work by examining people’s expectations about another fundamental trade-off — that between monetary reward and delay. In 2 experiments (total N = 670), we adapted a paradigm previously used to demonstrate the risk-reward heuristic. We presented participants with intertemporal choice tasks in which either the delayed reward or the length of the delay was obscured. Participants inferred larger rewards for longer stated delays, and longer delays for larger stated rewards; these inferences also predicted people’s willingness to take the delayed option. In exploratory analyses, we found that older participants inferred longer delays and smaller rewards than did younger ones. All of these results replicated in 2 large-scale pre-registered studies with participants from a different population (total N = 2138). Our results suggest that people expect intertemporal choice tasks to offer a trade-off between delay and reward, and differ in their expectations about this trade-off. This “delay-reward heuristic” offers a new perspective on existing models of intertemporal choice and provides new insights into unexplained and systematic individual differences in the willingness to delay gratification.
Timely euthanasia on swine farms can help to reduce the incidence of poor welfare outcomes for compromised pigs (Sus scrofa) when recovery is prolonged or impossible. Timely euthanasia relies upon caretakers’ abilities to identify compromised pigs and administer euthanasia in various environments. To determine appropriate timelines and most common reasons for on-farm euthanasia, an online survey was conducted with members of the United States National Pork Board. Additionally, two focus groups were conducted to investigate barriers and possible solutions associated with timely euthanasia. Clinical signs related to poor locomotion (57.6%), prolapses (47.2%), and hernias (43.5%) were identified by the greatest percentage of respondents who believed immediate euthanasia was warranted, while a greater percentage of respondents believed euthanasia was not warranted for clinical signs related to the integumentary (90.3%), reproductive (75.8%), and respiratory (67.5%) systems. The most common reason for euthanasia was poor body condition in pre-weaned piglets and non-ambulatory or severely weak for both breeding and non-breeding pigs. In the focus groups, two themes were identified when evaluating barriers to euthanasia on-farm, and participants agreed that making timely decisions relies upon several dimensions of risk analysis. An unsupportive farm culture was identified as a critical barrier to timely euthanasia decision-making, suggesting that caretaker characteristics may play a role in the success of any timely euthanasia programme. This present study has highlighted areas for future research and demonstrated the need to extend educational efforts both to swine industry leaders and producers to improve overall animal welfare by ensuring timely euthanasia in swine.
The poultry red mite (Dermanyssus gallinae) causes severe welfare concerns for laying hens arising from anaemia and disease transmission, and has been identified as an associated risk factor in cannibalistic feather pecking. Previous work suggests that essential oils may offer an alternative to synthetic acaricides to control D. gallinae. Such alternatives are needed due to the limitations of synthetic acaricides (eg availability, resistance, environmental concerns and product residues). The aim of the current study was to ensure that selected essential oils have no negative impact on either hen welfare or egg production. To achieve this aim, small groups of laying hens were confined in poultry huts for a period of eight weeks during which time the interior of the huts was sprayed at weekly intervals with one of four different treatments: i) Thyme essential oil at 5× the LC90 level (the concentration of oil previously found to kill 90% of D. gallinae under laboratory conditions) for D. gallinae in 500 ml of water, ii) Pennyroyal essential oil at 5× the LC90 level for D. gallinae in 500 ml of water, iii) Solvent-only (huts treated with 500 ml of water); and iv) Pseudo-spray where huts were not treated with any product, but subjected to sham-spraying. The results suggest that pennyroyal essential oil would not be suitable for further development as an acaricide for D. gallinae, since this treatment had to be terminated early in the study period as a result of concerns about the welfare of hens exposed to this oil. Conversely, there were few differences in feather condition, hen weight, feed intake, feeding efficiency, egg production or egg weight between thyme-treated huts and huts that were either pseudo-sprayed or sprayed with solvent-only (water). It is concluded that thyme essential oil is a promising candidate for further development as an acaricide for D. gallinae to help safeguard the welfare of laying hens in commercial poultry systems.
The paper describes the first report of Kandelia candel (Rhizophoraceae), a rare mangrove from Bhavanapadu, a coastal village in Srikakulam district in Andhra Pradesh, India. This species is relatively less abundant along the east coast of India. During our study covering all the 41 mangrove patches in the state of Andhra Pradesh, 16 mangrove species were observed throughout the state and the Kandelia candel was seen only in Bhavanapadu (patch 2). The plant sighted was identified using taxonomic keys and confirmed using DNA barcoding. The identified specimen is deposited in the museum repository at ICAR-Central Marine Fisheries Research Institute (CMFRI), Kochi (accession no. MB.1.1.1.1) and its gene sequence is deposited in National Center for Biotechnological Information (NCBI) (accession no. MH243746). Patch 2 where K. candel was observed is separated away from the other clusters in the principal component one, with the patch showing an average dissimilarity of about 71.79% from the other patches. K. candel is a mangrove highly sensitive to changes in salinity. The presence of a lone member of a rare species in the state at the sampling location raises questions on its endurance in the region. The study underlines the relevance of monitoring the mangroves and advocate adequate conservation measures for proper protection, proliferation and management of this globally dwindling resource.
The new mineral pohlite (IMA2022–043), Pb7(IO3)(OH)4Cl9, was found at La Compania mine, Sierra Gorda, Antofagasta Province, Antofagasta, Chile, where it occurs in cavities in an oxidised portion of a quartz vein in association with massive aragonite and anhydrite. Pohlite crystals are transparent, colourless to pale grey blades, up to 4 mm in length. The mineral has a white streak, adamantine lustre and is nonfluorescent. It is brittle with irregular, conchoidal fracture. The Mohs hardness is ~2½ and it has no cleavage. The calculated density is 5.838(2) g cm–3. Optically, the mineral is biaxial (+) with α < 2.01(est.), β = 2.02 (calc.), γ = 2.05 (calc.); 2V = 60(5)°; moderate r > v dispersion; orientation: Y∧a ≈ 20°, Z∧b ≈ 30°; and is nonpleochroic. The Raman spectrum exhibits bands consistent with IO3– and O–H. Electron microprobe analysis provided the empirical formula Pb6.74I1.00Cl9.29O6.71H4.23. The five strongest powder X-ray diffraction lines are [dobs Å(I)(hkl)]: 3.818(91)(023, 122, 1$\bar{2}$1), 3.674(85)($\bar{1}\bar{2}$1, $\bar{1}$22, 200, 104), 3.399(47)($\bar{2}$10, 210, $\bar{1}$04), 2.378(100)(302, 041, $\bar{2}$24) and 1.9943(45)(multiple). Pohlite is triclinic, P$\bar{1}$, a = 7.3366(5), b = 9.5130(9), c = 16.2434(15) Å, α = 81.592(7), β = 84.955(7), γ = 89.565(6)°, V = 1117.13(17) Å3 and Z = 2. The structure of pohlite (R1 = 0.0328 for 3394 I > 2σI) contains two types of clusters, a [Pb4(OH)3]5+ cluster formed by short Pb–O bonds and a [Pb3(OH)(IO3)]28+ ‘double cluster’ formed by short I–O bonds and short- to medium-length Pb–O bonds. Long Pb–Cl and I–Cl bonds link the clusters together in three dimensions.
With the ongoing advancement of capitalism, corporate capitalism – a specific variety of capitalism that is grounded in neoliberal ideology (Harvey, 2007) – has been engulfing economic and social relations worldwide (Giridharadas, 2018). Simultaneously, the search for alternatives to corporate capitalism has been ascending in both academic (Bollier, 2014; Cruz et al., 2017; Kothari and Joy, 2017; Parker et al., 2014; Wright, 2010) and non-academic circles (Cumbers, 2017; A. Ferguson, 2009). A major focus of this search has been in ‘developing’ countries like India that face the onslaught of corporate capitalism (Kothari and Joy, 2017; Shrivastava and Kothari, 2012) while being ranked 103 out of 119 countries in the Global Hunger Index. The neoliberal economic reforms introduced in India since the early 1990s have had a significant influence on developmental policies of even the states such as Kerala and West Bengal that have been governed by left-of-centre parties (for example, Communist Party of India–Marxist) (Das, 2019; Krishnamoorthy, 2010).
A central theme of inquiry on alternatives to corporate capitalism is of women-inclusive emancipation (Werlhof, 2007) and thereby the need to explore the emancipatory struggles of marginalized women who are involved in the creation of alternatives (A. Ferguson, 2009). In this chapter, we undertake such exploration through ethnographic field immersion in a programme called ‘Kudumbashree’ instituted by the Kerala state in 1998 with the objective of women empowerment and inclusion (NIPCCD, 2008).
The extant literature on Kudumbashree can be categorized into two broad streams. One stream evaluates the programme from the perspective of its ability to produce economic empowerment among women belonging to below poverty line (BPL) families, who are the primary targets for the Kudumbashree programme. This research uses traditional indicators of economic empowerment such as economic and financial asset accumulation and land productivity (for example, Agarwal, 2018; Chathukulam and Thottunkel, 2010) and finds that the Kudumbashree programme outperforms similar poverty eradication programmes elsewhere in terms of creating economic empowerment. The second stream of literature acknowledges the programme as being different from traditional anti-poverty programmes because of Kudumbashree's explicit focus on the participation of target groups in decisions that involve their livelihoods (for example, Williams et al., 2012).
The coronavirus disease 2019 (COVID-19) pandemic has placed significant burden on healthcare systems. We compared Clostridioides difficile infection (CDI) epidemiology before and during the pandemic across 71 hospitals participating in the Canadian Nosocomial Infection Surveillance Program. Using an interrupted time series analysis, we showed that CDI rates significantly increased during the COVID-19 pandemic.
The Global Alzheimer’s Platform Foundation® (GAP) is a patient-centric, non-profit organization founded in 2015. GAP is dedicated to speeding the delivery of innovative therapies to persons with Alzheimer’s disease (AD) or Parkinson’s disease (PD) by reducing the duration and cost while improving the effectiveness of AD and PD clinical trials. GAP’s growing network of high-performing AD and PD sites (GAP-Net) allows sponsors to complete clinical trials on a single, optimized trial site platform. GAP-Net sites activate 30% faster than non-GAP sites by leveraging trial services including a central institutional review board. GAP-Net sites experience up to a 24% faster screening rate, higher randomization rates, and fewer low/no randomizations per site compared with sites without the support of GAP Participant Services (GPS). GAP also sponsors the Bio-Hermes trial , designed to evaluate digital and blood-based biomarkers that are projected to accelerate enrollment and lower screen fail costs in clinical trials. Finally, GAP is extending its network globally as part of its mission to accelerate and improve the effectiveness of AD and PD clinical trials.
To analyze the spread of a novel sequence type (ST1478) of vancomycin-resistant Enterococcus faecium across Canadian hospitals.
Design:
Retrospective chart review of patients identified as having ST1478 VRE bloodstream infection.
Setting:
Canadian hospitals that participate in the Canadian Nosocomial Infection Surveillance Program (CNISP).
Methods:
From 2013 to 2018, VRE bloodstream isolates collected from participating CNISP hospitals were sent to the National Microbiology Laboratory (NML). ST1478 isolates were identified using multilocus sequence typing, and whole-genome sequencing was performed. Patient characteristics and location data were collected for patients with ST1478 bloodstream infection (BSI). The sequence and patient location information were used to generate clusters of infections and assess for intrahospital and interhospital spread.
Results:
ST1478 VRE BSI occurred predominantly in a small number of hospitals in central and western Canada. Within these hospitals, infections were clustered on certain wards, and isolates often had <20 single-nucleotide variants (SNV) differences from one another, suggesting a large component of intrahospital spread. Furthermore, some patients with bloodstream infections were identified as moving from one hospital to another, potentially having led to interhospital spread. Genomic analysis of all isolates revealed close relatedness between isolates at multiple different hospitals (<20 SNV) not predicted from our epidemiologic data.
Conclusions:
Both intrahospital and regional interhospital spread have contributed to the emergence of VRE ST1478 infections across Canada. Whole-genome sequencing provides evidence of spread that might be missed with epidemiologic investigation alone.
Although the Tax Cut and Jobs Act (TCJA) did not include any environmental tax provisions, numerous tax policy discussions in the United States have considered implementing a carbon tax, giving rise to concerns about such a tax‘s potential negative effects on economic growth and the distribution of income in the US economy. This chapter examines the macroeconomic and distributional effects of implementing a representative carbon tax under several assumptions about recycling resulting tax revenues. It simulates these effects using the Diamond-Zodrow (DZ) dynamic overlapping generations computable general equilibrium (CGE) model. Earlier literature and our results confirm that: (i) the negative effects of a carbon tax are moderate on the level of future GDP and negligible on the rate of economic growth; and (ii) the regressive effects of a carbon tax can easily be offset with judicious use of the resulting revenues. Policies that use carbon tax revenues to finance uniform per-household rebates and to enact policies favorable to capital formation, such as elimination of both personal taxes on dividends and capital gains, and national debt, can have a highly progressive net impact.