Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- 41A AMH Is a Better Predictor of Ovarian Response Than AFC
- 41B AMH Is a Better Predictor of Ovarian Response Than AFC
- 42A Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 42B Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 43A The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 43B The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 44A There Is No Place for Natural and Mild Stimulation IVF
- 44B There Is No Place for Natural and Mild Stimulation IVF
- Section IX Hormones and the Environment
- Index
- References
42A - Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
For
from Section VIII - Ovarian Stimulation
Published online by Cambridge University Press: 25 November 2021
Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- 41A AMH Is a Better Predictor of Ovarian Response Than AFC
- 41B AMH Is a Better Predictor of Ovarian Response Than AFC
- 42A Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 42B Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 43A The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 43B The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 44A There Is No Place for Natural and Mild Stimulation IVF
- 44B There Is No Place for Natural and Mild Stimulation IVF
- Section IX Hormones and the Environment
- Index
- References
Summary
An equal probability of live birth to GnRH agonists, combined with a vastly superior safety and patient friendly profile, allows us beyond doubt to recognise that GnRH antagonist is the analogue of first choice in ovarian stimulation for IVF. Τhe use of GnRH antagonists in everyday practice shows an impressive and clear trend for replacing GnRH agonists as the analogue of choice for suppressing the premature LH rise, essentially leading to the end of the GnRH agonist era.
- Type
- Chapter
- Information
- 50 Big Debates in Reproductive Medicine , pp. 216 - 218Publisher: Cambridge University PressPrint publication year: 2021
References
Al-Inany, HG, Youssef, MA, Aboulghar, M, et al. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev. 2011;CD001750.CrossRefGoogle Scholar
Tarlatzis, B, Bosdou, J. Elimination of OHSS by GnRH agonist and freezing embryos. In: Rizk, B, Gerris, J (eds). Complications and Outcomes of Assisted Reproduction. Cambridge: Cambridge University Press, 2017, pp. 149–63.Google Scholar
Bosdou, JK, Venetis, CA, Tarlatzis, BC, et al. Higher probability of live-birth in high, but not normal, responders after first frozen-embryo transfer in a freeze-only cycle strategy compared to fresh-embryo transfer: a meta-analysis. Hum Reprod. 2019;34:491–505.CrossRefGoogle ScholarPubMed
Lambalk, CB, Banga, FR, Huirne, JA, et al. GnRH antagonist versus long agonist protocols in IVF: a systematic review and meta-analysis accounting for patient type. Hum Reprod Update. 2017;23:560–5.CrossRefGoogle ScholarPubMed
Kolibianakis, EM, Griesinger, G, Venetis, CA. GnRH antagonists vs. long GnRH agonists in IVF: significant flaws in a meta-analysis lead to invalid conclusions. Hum Reprod Update. 2018;24:242–3.CrossRefGoogle Scholar