Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- 41A AMH Is a Better Predictor of Ovarian Response Than AFC
- 41B AMH Is a Better Predictor of Ovarian Response Than AFC
- 42A Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 42B Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 43A The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 43B The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 44A There Is No Place for Natural and Mild Stimulation IVF
- 44B There Is No Place for Natural and Mild Stimulation IVF
- Section IX Hormones and the Environment
- Index
- References
41B - AMH Is a Better Predictor of Ovarian Response Than AFC
Against
from Section VIII - Ovarian Stimulation
Published online by Cambridge University Press: 25 November 2021
Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- 41A AMH Is a Better Predictor of Ovarian Response Than AFC
- 41B AMH Is a Better Predictor of Ovarian Response Than AFC
- 42A Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 42B Pituitary Suppression Using GnRH Agonist for IVF Is Outdated
- 43A The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 43B The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU
- 44A There Is No Place for Natural and Mild Stimulation IVF
- 44B There Is No Place for Natural and Mild Stimulation IVF
- Section IX Hormones and the Environment
- Index
- References
Summary
Ovarian response prediction may be advantageous if the predicted response may be prevented or the inherent risks may be managed. In ART today, high/excessive response is the only condition to predict as OHSS prevention may be improved by prior knowledge of this risk condition. The scientific literature on the AFC and serum AMH, markers of the number of FSH responsive antral follicles, demonstrates equal accuracy. AMH- and AFC-based individualised FSH dosing studies have revealed equal effects on safety outcome measures compared to standard dosing. However, with the preference for antagonist cycles, OHSS preventive management is well possible without any prior ovarian response testing, making both tests equally futile.
- Type
- Chapter
- Information
- 50 Big Debates in Reproductive Medicine , pp. 212 - 215Publisher: Cambridge University PressPrint publication year: 2021
References
Broer, SL, van Disseldorp, J, Broeze, KA, et al. Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach. Hum Reprod Update. 2013;19(1): 26–36.CrossRefGoogle ScholarPubMed
liodromiti, S, Anderson, RA, Nelson, SM. Technical and performance characteristics of anti-mullerian hormone and antral follicle count as biomarkers of ovarian response. Hum Reprod Update. 2015;21(6): 698–710.CrossRefGoogle Scholar
Oudshoorn, SC, van Tilborg, TC, Hamdine, O, et al. Ovarian response to controlled ovarian hyperstimulation: what does serum FSH say? Hum Reprod. 2017;32(8): 1701–9.CrossRefGoogle ScholarPubMed
Lan, VT, Linh, NK, Tuong, HM, Wong, PC, Howles, CM. Anti-mullerian hormone versus antral follicle count for defining the starting dose of FSH. Reprod Biomed Online. 2013;27(4): 390–9.CrossRefGoogle ScholarPubMed
Magnusson, A, Nilsson, L, Olerod, G, Thurin-Kjellberg, A, Bergh, C. The addition of anti-mullerian hormone in an algorithm for individualized hormone dosage did not improve the prediction of ovarian response – a randomized, controlled trial. Hum Reprod. 2017;32(4): 811–19.CrossRefGoogle Scholar
Lensen, SF, Wilkinson, J, Leijdekkers, JA, et al. Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI). Cochrane Database Syst Rev. 2018;2018(2).Google Scholar
Leijdekkers, JA, Eijkemans, MJC, van Tilborg, TC, et al. Cumulative live birth rates in low-prognosis women. Hum Reprod. 2019;34(6): 1030–41.CrossRefGoogle ScholarPubMed