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Chapter 21 - Electrical Stimulation of the Human Insular Cortex

from Section 4 - Invasive Investigation of Insular Epilepsy

Published online by Cambridge University Press:  09 June 2022

By
Laure Mazzola ,
Jean Isnard  and
François Mauguière
Edited by
Dang Nguyen ,
Jean Isnard  and
Philippe Kahane
Dang Nguyen
Affiliation:
Université de Montréal
Jean Isnard
Affiliation:
Claude Bernard University Lyon
Philippe Kahane
Affiliation:
Grenoble-Alpes University Hospital
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Summary

We provide here a functional mapping of the insular cortex obtained by electrical stimulation carried out during stereo-electro-encephalography (SEEG). Somatosensory sensations and visceral responses were the most frequent responses to insular stimulation, followed in decreasing order of frequency by auditory sensations, vestibular illusions, speech impairment, gustato-olfactory sensations, and motor reactions. The posterior part of the insula seems more implicated in somatosensory functions, notably in pain perception, whereas the anterior part seems more implicated in visceral functions. Although some degree of spatial segregation could be evidenced, there was a clear spatial overlap between the representations of the different types of responses. Electrical stimulations permit to evidence a singularly multi-modal representation in the insula that may support its integrative functions of polymodal inputs. They also provide a better understanding of physiological insular functions and the semiology of insular seizures.

Keywords

functional evaluationelectrical stimulationsemiology of insular seizureinsular cortex
Type
Chapter
Information
Insular Epilepsies , pp. 246 - 256
Publisher: Cambridge University Press
Print publication year: 2022

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References

Penfield, W, Faulk, Jr ME. The insula; further observations on its function. Brain. 1955;78:445–470.Google Scholar
Penfield, W, Jasper, H. Epilepsy and the functional anatomy of the human brain. Boston: Little Brown; 1954.CrossRefGoogle Scholar
Mazzola, L, Isnard, J, Peyron, R, Mauguiere, F. Stimulation of the human cortex and the experience of pain: Wilder Penfield’s observations revisited. Brain. 2012;135:631–640.CrossRefGoogle ScholarPubMed
Silfvenius, H, Gloor, P, Rasmussen, T. Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy. Epilepsia. 1964;5:307–320Google Scholar
Bourdillon, P, Ryvlin, P, Isnard, J, Montavont, A, Catenoix, H, Mauguière, F, et al. Stereo-electroencephalography (SEEG) is a safe procedure including for insular implantations. World Neurosurgery. 2017;99:353–361.CrossRefGoogle Scholar
Afif, A, Minotti, L, Kahane, P, Hoffmann, D. Anatomofunctional organization of the insular cortex: a study using intracerebral electrical stimulation in epileptic patients. Epilepsia. 2010;51:2305–2315.CrossRefGoogle ScholarPubMed
Stephani, C, Fernandez-Baca Vaca, G, Maciunas, R, Koubeissi, M, Luders, HO. Functional neuroanatomy of the insular lobe. Brain Struct Funct. 2011;216:137–149.Google Scholar
Pugnaghi, M, Meletti, S, Castana, L, Francione, S, Nobili, L, Mai, R, et al. Features of somatosensory manifestations induced by intracranial electrical stimulations of the human insula. Clin Neurophysiol. 2011;122:2049–2058.CrossRefGoogle ScholarPubMed
Mazzola, L, Mauguière, F, Isnard, J. Electrical stimulations of the human insula: their contribution to the ictal semiology of insular seizures. J Clin Neurophysiol. 2017;34(4):307–314.CrossRefGoogle Scholar
Yih, J, Beam, DE, Fox, KCR, Parvizi, J. Intensity of affective experience is modulated by magnitude of intracranial electrical stimulation in human orbitofrontal, cingulate and insular cortices. Soc Cogn Affect Neurosci. 2019;14(4):339–351.Google Scholar
Nathan, SS, Sinha, SR, Gordon, B, Lesser, RP, Thakor, NV. Determination of current density distributions generated by electrical stimulation of the human cerebral cortex. Electroencephalogr Clin Neurophysiol. 1993;86:183–192.CrossRefGoogle ScholarPubMed
Oppenheimer, SM, Gelb, A, Girvin, JP, Hachinski, VC. Cardiovascular effects of human insular cortex stimulation. Neurology. 1992;42:1727–1732.Google Scholar
Chouchou, F, Mauguière, F, Vallayer, O, Catenoix, H, Isnard, J, Montavont, A, Jung, J, Pichot, V, Rheims, S, Mazzola, L. How the insula speaks to the heart: Cardiac responses to insular stimulation in humans.Hum Brain Mapp. 2019;40(9):2611–2622.Google Scholar
Nguyen, DK, Nguyen, DB, Malak, R, Leroux, JM, Carmant, L, Saint-Hilaire, JM, et al. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia. 2009;50:510–520.Google Scholar
Ostrowsky, K, Magnin, M, Ryvlin, P, Isnard, J, Guenot, M, Mauguière, F. Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb Cortex. 2002;12(4):376–385.Google Scholar
Mazzola, L, Isnard, J, Peyron, R, Guenot, M, Mauguière, F. Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortex. Pain. 2009;146:99–104.Google Scholar
Mazzola, L, Isnard, J, Mauguière, F. Somatosensory and pain responses to stimulation of the second somatosensory area (SII) in humans: A comparison with SI and insular responses.Cereb Cortex. 2006;16:960–968.CrossRefGoogle ScholarPubMed
Frot, M, Magnin, M, Mauguière, F, Human, Garcia-Larrea L SII and posterior insula differently encode thermal laser stimuli. Cereb Cortex. 2007;17(3):610–620.Google Scholar
Catenoix, H, Isnard, J, Guénot, M, Petit, J, Rémy, C, Mauguière, F. The role of the anterior insular cortex in ictal vomiting: A stereotactic electroencephalography study. Epilepsy Behav. 2008;13:560–563.Google Scholar
Isnard, J, Guenot, M, Sindou, M, Mauguière, F. Clinical manifestations of insular lobe seizures: A stereo-electroencephalographic study. Epilepsia. 2004;45:1079–1090.CrossRefGoogle ScholarPubMed
Ghaziri, J, Tucholka, A, Girard, G, Boucher, O, Houde, JC, Descoteaux, M, Obaid, S, Gilbert, G, Rouleau, I, Nguyen, DK. Subcortical structural connectivity of insular subregions. Sci Rep. 2018;8(1):8596.Google Scholar
Augustine, JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev. 1996;22(3):229–244.Google Scholar
Mazzola, L, Royet, JP, Catenoix, H, Montavont, A, Isnard, J, Mauguière, F. Gustatory and olfactory responses to stimulation of the human insula. Ann Neurol. 2017;82(3):360–370.Google Scholar
Mazzola, L, Lopez, C, Faillenot, I, Chouchou, F, Mauguière, F, Isnard, J. Vestibular responses to direct stimulation of the human insular cortex. Ann Neurol. 2014;76:609–619.Google Scholar
Lopez, C, Blanke, O, Mast, FW. The vestibular cortex in the human brain revealed by coordinate-based activation likelihood estimation meta-analysis. Neuroscience. 2012;212:159–179.Google Scholar
Kahane, P, Hoffmann, D, Minotti, L, Berthoz, A. Reappraisal of the human vestibular cortex by cortical electrical stimulation study. Ann Neurol. 2003;54:615–624.Google Scholar
Zhang, Y, Zhou, W, Wang, S, Zhou, Q, Wang, H, Zhang, B, Huang, J, Hong, B, Wang, X. The roles of subdivisions of human insula in emotion perception and auditory processing. Cereb Cortex. 2019;29(2):517–528.Google Scholar
Burton, H, Jones, EG. The posterior thalamic region and its cortical projection in New World and Old World monkeys. J Comp Neurol. 1976;168(2):249–301.Google Scholar
Picard, F, Scavarda, D, Bartolomei, F. Induction of a sense of bliss by electrical stimulation of the anterior insula. Cortex. 2013;49(10):2935–2937.Google Scholar
Bartolomei, F, Lagarde, S, Scavarda, D, Carron, R, Bénar, CG, Picard, F. The role of the dorsal anterior insula in ecstatic sensation revealed by direct electrical brain stimulation. Brain Stimul. 2019 Jun 5. PII: S1935-861X(19)30230-X. DOI: 10.1016/j.brs.2019.06.005. Epub ahead of print.Google Scholar
Yan, H, Liu, C, Yu, T, Yu, K, Xu, C, Wang, X, Ni, D, Li, Y. Mirth and laughter induced by electrical stimulation of the posterior insula. J Clin Neurosci. 2019;61:269–271.Google Scholar
Kurth, F, Zilles, K, Fox, PT, Laird, AR, Eickhoff, SB. A link between the systems: Functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct. 2010;214:519–534.CrossRefGoogle ScholarPubMed
Craig, AD. How do you feel now? The anterior insula and human awareness. Nat Rev Neurosci. 2009;10(1):59–70.CrossRefGoogle Scholar
Legrain, V, Iannetti, GD, Plaghki, L, Mouraux, A. The pain matrix reloaded: A salience detection system for the body.Prog Neurobiol. 2011;93:111–124.CrossRefGoogle ScholarPubMed
Liberati, G, Klöcker, A, Safranova, M, Ferrao Santos, S, Ribeiro Vaz, G, Raftopoulos, C, Mouraux, A. Nociceptive local fields potentials recorded from the human insula are not specific for nociception. PLoS Biol. 2016;6:14(1):e1002345. DOI: 10.1371/journal.pbio.1002345.Google Scholar
Liang, M, Su, Q, Mouraux, A, Iannetti, GD. Spatial patterns of brain activity preferentially reflecting transient pain and stimulus intensity. Cereb Cortex. 2019;29(5):2211–2227.Google Scholar
Montavont, A, Mauguière, F, Mazzola, L, Garcia-Larrea, L, Catenoix, H, Ryvlin, P, Isnard, J. On the origin of painful somatosensory seizures. Neurology. 2015;84:594–601.Google Scholar
Garcia-Larrea, L, Peyron, R. Pain matrices and neuropathic pain matrices: A review. Pain. 2013;154 (suppl 1):S29–S43.Google Scholar
Blawblomme, T, Kahane, P, Minotti, L, Grouiller, F, Krainik, A, Vercueil, L, Chabardès, S, Hoffmann, D, David, O. Multimodal imaging reveals the role of gamma activity in eating reflex seizures. J Neurol Neurosurg Psychiatry. 2011;82:1171–1173.Google Scholar
Small, DM. Taste representation in the human insula. Brain Struct Funct. 2010;214:551–61.Google Scholar

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