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Section 5 - Surgical Management of Insular Epilepsy

Published online by Cambridge University Press:  09 June 2022

Dang Nguyen
Affiliation:
Université de Montréal
Jean Isnard
Affiliation:
Claude Bernard University Lyon
Philippe Kahane
Affiliation:
Grenoble-Alpes University Hospital
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Insular Epilepsies , pp. 257 - 299
Publisher: Cambridge University Press
Print publication year: 2022

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References

References

Penfield, W, Faulk, ME, Jr. The insula: Further observations on its function. Brain. 1955;78(4):445470.CrossRefGoogle ScholarPubMed
Guillaume, J, Mazars, G. Technique de résection de l’insula dans les épilepsies insulaires. Revue Neurologie. 1949;81:900903.Google Scholar
Afif, A, Chabardes, S, Minotti, L, Kahane, P, Hoffmann, D. Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery. 2008;62(5 suppl 2):ONS471-9; discussion 980.Google Scholar
Ahmed, R, Otsubo, H, Snead, C III, Donner, E, Widjaja, E, Ochi, A, et al. Diagnostic evaluation and surgical management of pediatric insular epilepsy utilizing magnetoencephalography and invasive EEG monitoring. Epilepsy Res. 2018;140:7281.Google Scholar
Bouthillier, A, Surbeck, W, Weil, AG, Tayah, T, Nguyen, DK. The hybrid operculo-insular electrode: a new electrode for intracranial investigation of peri-Sylvian/insular refractory epilepsy. Neurosurgery. 2012;70(6):15741580; discussion 80.Google Scholar
Gras-Combe, G, Minotti, L, Hoffmann, D, Krainik, A, Kahane, P, Chabardes, S. Surgery for nontumoral insular epilepsy explored by stereoelectroencephalography. Neurosurgery. 2016;79(4):578588.Google Scholar
Isnard, J, Guenot, M, Sindou, M, Mauguiere, F. Clinical manifestations of insular lobe seizures: A stereo-electroencephalographic study. Epilepsia. 2004;45(9):10791090.Google Scholar
Levy, A, Tran Phuoc, Y, Boucher, O, Bouthillier, A, Nguyen, DK. Operculo-insular epilepsy: Scalp and intracranial electroencephalographic findings. Journal of Clinical Neurophysiology. 2017.Google Scholar
Mohamed, IS, Bouthillier, A, Berube, A, Cossette, P, Finet, P, Saint-Hilaire, JM, et al. The clinical impact of integration of magnetoencephalography in the presurgical workup for refractory nonlesional epilepsy. Epilepsy Behav. 2018;79:3441.Google Scholar
Nguyen, DK, Nguyen, DB, Malak, R, Leroux, JM, Carmant, L, Saint-Hilaire, JM, et al. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia. 2009;50(3):510520.CrossRefGoogle ScholarPubMed
Surbeck, W, Bouthillier, A, Weil, AG, Crevier, L, Carmant, L, Lortie, A, et al. The combination of subdural and depth electrodes for intracranial EEG investigation of suspected insular (perisylvian) epilepsy. Epilepsia. 2011;52(3):458466.Google Scholar
Malak, R, Bouthillier, A, Carmant, L, Cossette, P, Giard, N, Saint-Hilaire, JM, et al. Microsurgery of epileptic foci in the insular region. Journal of Neurosurgery. 2009;110(6):11531163.Google Scholar
Silfvenius, H, Gloor, P, Rasmussen, T. Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy. Epilepsia. 1964;5:307–20.CrossRefGoogle ScholarPubMed
Yasargil, M, Krisht, A, Türe, U, Al-Mefty, O, Yasargil, D. Microsurgery of insular gliomas. Part VI: Surgical treatment and outcome. Contemporary Neurosurg 2002;24:18.Google Scholar
Duffau, H. A personal consecutive series of surgically treated 51 cases of insular WHO Grade II glioma: advances and limitations. J Neurosurg. 2009;110(4):696708.Google Scholar
Duffau, H, Capelle, L, Lopes, M, Bitar, A, Sichez, JP, van Effenterre, R. Medically intractable epilepsy from insular low-grade gliomas: improvement after an extended lesionectomy. Acta Neurochir (Wien). 2002;144(6):563572; discussion 7273.Google Scholar
Sanai, N, Polley, MY, Berger, MS. Insular glioma resection: Assessment of patient morbidity, survival, and tumor progression. J Neurosurg. 2010;112(1):19.CrossRefGoogle ScholarPubMed
Bouthillier, A, Nguyen, DK. Epilepsy surgeries requiring an operculoinsular cortectomy: operative technique and results. Neurosurgery. 2017.Google Scholar
Park, YS, Lee, YH, Shim, KW, Lee, YJ, Kim, HD, Lee, JS, et al. Insular epilepsy surgery under neuronavigation guidance using depth electrode. Childs Nerv Syst. 2009;25(5):591597.Google Scholar
Jobst, BC, Gonzalez-Martinez, J, Isnard, J, Kahane, P, Lacuey, N, Lahtoo, SD, et al. The insula and its epilepsies. Epilepsy Curr. 2019;19(1):1121.Google Scholar
Finet, P, Nguyen, DK, Bouthillier, A. Vascular consequences of operculoinsular corticectomy for refractory epilepsy. J Neurosurg. 2015;122(6):12931298.CrossRefGoogle ScholarPubMed
Lazorthes, G. Vascularisation et circulation cérébrales. Masson & Cie; 1961.Google Scholar
Ture, U, Yasargil, DC, Al-Mefty, O, Yasargil, MG. Topographic anatomy of the insular region. J Neurosurg. 1999;90(4):720733.Google Scholar
Ture, U, Yasargil, MG, Al-Mefty, O, Yasargil, DC. Arteries of the insula. J Neurosurg. 2000;92(4):676687.Google Scholar
Bouthillier, A, Weil, AG, Martineau, L, Létourneau-Guillon, L, Nguyen DK. Operculoinsular cortectomy for refractory epilepsy. Part II: Is-it safe ? J Neurosurg. 2019; DOI: 10.3171/2019.6.JNS191126.Google Scholar
Ackermann, H, Riecker, A. The contribution(s) of the insula to speech production: a review of the clinical and functional imaging literature. Brain Struct Funct. 2010;214(5–6):419433.Google Scholar
Ansari, SF, Maher, CO, Tubbs, RS, Terry, CL, Cohen-Gadol, AA. Surgery for extratemporal nonlesional epilepsy in children: A meta-analysis. Childs Nerv Syst. 2010;26(7):945951.Google Scholar
Ansari, SF, Tubbs, RS, Terry, CL, Cohen-Gadol, AA. Surgery for extratemporal nonlesional epilepsy in adults: an outcome meta-analysis. Acta Neurochir (Wien). 2010;152(8):12991305.Google Scholar
Tellez-Zenteno, JF, Dhar, R, Wiebe, S. Long-term seizure outcomes following epilepsy surgery: A systematic review and meta-analysis. Brain. 2005;128(pt 5):11881198.CrossRefGoogle ScholarPubMed
Wiebe, S, Blume, WT, Girvin, JP, Eliasziw, M, Effectiveness, efficiency of surgery for temporal lobe epilepsy study G. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345(5):311318.Google Scholar
Bouthillier, A, Weil, AG, Martineau, L, Létourneau-Guillon, L, Nguyen DK. Operculoinsular cortectomy for refractory epilepsy. Part I: Is-it effective? J Neurosurg. 2019. DOI: 10.3171/2019.4.JNS1912.Google Scholar
Fei, P, Soucy, J-P, Obaid, S, Boucher, O, Bouthillier, A, Nguyen, DK. The value of rCBF SPECT and FDG PET in operculo-insular epilepsy. Clinical Nuclear Imaging. 2017.Google Scholar
Mohamed, IS, Gibbs, SA, Robert, M, Bouthillier, A, Leroux, JM, Khoa Nguyen, D. The utility of magnetoencephalography in the presurgical evaluation of refractory insular epilepsy. Epilepsia. 2013;54(11):19501959.CrossRefGoogle ScholarPubMed
Obaid, S, Jodoin, P-M, Morency, F, Descoteaux, M, Tucholka, A, Nguyen, D. Cortical thickness analysis in operculo-insular epilepsy. Organization for Human Brain Mapping Annual Meeting (OHBM); Geneva, Switzerland, 2016.Google Scholar
Obaid, S, Zerouali, Y, Nguyen, DK. Insular epilepsy: Semiology and noninvasive investigations. J Clin Neurophysiol. 2017;34(4):315323.Google Scholar
Zerouali, Y, Pouliot, P, Robert, M, Mohamed, I, Bouthillier, A, Lesage, F, et al. Magnetoencephalographic signatures of insular epileptic spikes based on functional connectivity. Hum Brain Mapp. 2016;37(9):32503261.Google Scholar
Desai, A, Jobst, BC, Thadani, VM, Bujarski, KA, Gilbert, K, Darcey, TM, et al. Stereotactic depth electrode investigation of the insula in the evaluation of medically intractable epilepsy. J Neurosurg. 2011;114(4):11761186.Google Scholar
Weil, AG, Fallah, A, Lewis, EC, Bhatia, S. Medically resistant pediatric insular-opercular/perisylvian epilepsy. Part 1: Invasive monitoring using the parasagittal transinsular apex depth electrode. J Neurosurg Pediatr. 2016;18(5):511522.CrossRefGoogle ScholarPubMed
Matsumoto, R, Nair, DR, LaPresto, E, Najm, I, Bingaman, W, Shibasaki, H, et al. Functional connectivity in the human language system: A cortico-cortical evoked potential study. Brain. 2004;2004:23162330.CrossRefGoogle Scholar
Lehman, R, Andermann, F, Olivier, A, Tandon, PN, Quesney, LF, Rasmussen, TB. Seizures with onset in the sensorimotor face area: clinical patterns and results of surgical treatment in 20 patients. Epilepsia. 1994;35(6):11171124.Google Scholar
Freri, E, Matricardi, S, Gozzo, F, Cossu, M, Granata, T, Tassi, L. Perisylvian, including insular, childhood epilepsy: Presurgical workup and surgical outcome. Epilepsia. 2017;58(8):13601369.CrossRefGoogle ScholarPubMed
Ikegaya, N, Takahashi, A, Kaido, T, Kaneko, Y, Iwasaki, M, Kawahara, N, et al. Surgical strategy to avoid ischemic complications of the pyramidal tract in resective epilepsy surgery of the insula: Technical case report. J Neurosurg. 2018;128(4):11731177.Google Scholar
Engel, J Jr., Van Ness, P Rasmussen, C T B. Outcome with respect to epileptic seizures. In Engel, J, Jr., editor, Surgical treatment of the epilepsies, 2nd ed. New York: Raven; 1993. pp. 609621.Google Scholar
Barba, C, Minotti, L, Job, AS, Kahane, P. The insula in temporal plus epilepsy. J Clin Neurophysiol. 2017;34(4):324327.CrossRefGoogle ScholarPubMed
Blauwblomme, T, David, O, Minotti, L, Job, AS, Chassagnon, S, Hoffman, D, et al. Prognostic value of insular lobe involvement in temporal lobe epilepsy: A stereoelectroencephalographic study. Epilepsia. 2013;54(9):16581667.Google Scholar
Hale, AT, Sen, S, Haider, AS, Perkins, FF, Clarke, DF, Lee, MR, et al. Open resection versus laser interstitial thermal therapy for the treatment of pediatric insular epilepsy. Neurosurgery. 2019;85(4):E730E736.Google Scholar
Weil, AG, Le, NM, Jayakar, P, Resnick, T, Miller, I, Fallah, A, et al. Medically resistant pediatric insular-opercular/perisylvian epilepsy. Part 2: Outcome following resective surgery. J Neurosurg Pediatr. 2016;18(5):523535.Google Scholar
d’Orio, P, Rizzi, M, Mariani, V, Pelliccia, V, Lo Russo, G, Cardinale, F, et al. Surgery in patients with childhood-onset epilepsy: Analysis of complications and predictive risk factors for a severely complicated course. J Neurol Neurosurg Psychiatry. 2019;90(1):8489.Google Scholar
Boucher, O, Rouleau, I, Escudier, F, Malenfant, A, Denault, C, Charbonneau, S, et al. Neuropsychological performance before and after partial or complete insulectomy in patients with epilepsy. Epilepsy Behav. 2015;43:5360.CrossRefGoogle ScholarPubMed
Boucher, O, Rouleau, I, Lassonde, M, Lepore, F, Bouthillier, A, Nguyen, DK. Social information processing following resection of the insular cortex. Neuropsychologia. 2015;71:110.Google Scholar
Hébert-Seropian, B, Boucher, O, Sénéchal, C, Rouleau, I, Bouthillier, A, Lepore, F, et al. Does unilateral insular resection disturb personality? A study with epileptic patients. Journal of Clinical Neuroscience. 2017;43:121125.Google Scholar
Ding, H, Zhou, J, Guan, Y, Zhai, F, Wang, M, Wang, J, et al. Bipolar electro-coagulation with cortextomy in the treatment of insular and insulo-opercular epilepsy explored by stereoelectro-encephalography. Epilepsy Res. 2018;145:1826.Google Scholar

References

Kwan, P, Arzimanoglou, A, Berg, AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010;51(6):10691077.Google Scholar
Arya, R, Mangano, FT, Horn, PS, et al. Adverse events related to extraoperative invasive EEG monitoring with subdural grid electrodes: a systematic review and meta-analysis. Epilepsia. 2013;54(5):828839.Google Scholar
Mullin, JP, Shriver, M, Alomar, SA, et al. Stereotactic electroencephalography. Safe? A systematic review and meta-analysis of stereo-electroencephalography-related complications. Neurosurgery. 2016 Aug;63(suppl 1):211.CrossRefGoogle Scholar
Schmidt, RF, Wu, C, Lang, MJ, et al. Complications of subdural and depth electrodes in 269 patients undergoing 317 procedures for invasive monitoring in epilepsy. Epilepsia. 2016;57(10):16971708.Google Scholar
Narabayashi, H, Nagao, T, Saito, Y, et al. Stereotaxic amygdalotomy for behavior disorders. Arch Neurol. 1963 Jul;9:116.CrossRefGoogle ScholarPubMed
Schwab, RS, Sweet, WH, Mark, VH, et al. Treatment of intractable temporal lobe epilepsy by stereotactic amygdala lesions. Trans Am Neurol Assoc. 1965;90:1219.Google Scholar
Flanigin, HF, Nashold, BS. Stereotactic lesions of the amygdala and hippocampus in epilepsy. Acta Neurochir. 1976;23(suppl):235239.Google Scholar
Marossero, F, Ravagnati, L, Sironi, VA, et al. Late results of stereotactic radiofrequency lesions in epilepsy. Acta Neurochir Suppl. 1980;30:145149.Google Scholar
Parrent, AG, Blume, WT. Stereotactic amygdalohippocampotomy for the treatment of medial temporal lobe epilepsy. Epilepsia. 1999;40:14081416.Google Scholar
Parrent, AG, Lozano, AM. Stereotactic surgery for temporal lobe epilepsy. Can J Neurol Sc. 2000;27:S79S84.CrossRefGoogle ScholarPubMed
Talairach, J, Bancaud, J. Stereotactic approach to epilepsy: Methodology of anatomo-functional stereotactic investigations. Prog Neurol Surg. 1973;5:297354.Google Scholar
Guenot, M, Isnard, J, Ryvlin, P, et al. Neurophysiological monitoring for epilepsy surgery: The Talairach SEEG method. Stereotact Funct Neurosurg. 2001;77(14):29–32.Google Scholar
Guénot, M: SEEG electrodes implantation using flat-panel X-ray detectors and robot. In: Scarabin, J-M, editor. Stereotaxy and Epilepsy Surgery. Montrouge: John Libbey Eurotext; 2012. pp. 219244.Google Scholar
Gonzalez-Martinez, J, Mullin, J, Vadera, S, et al. Stereotactic placement of depth electrodes in medically intractable epilepsy. J Neurosurg 2014;120:639644.CrossRefGoogle ScholarPubMed
Cardinale, F, Cossu, M, Castana, L, et al. Stereoelectroencephalography: Surgical methodology, safety, and stereotactic application accuracy in 500 procedures. Neurosurgery. 2013 Mar;72(3):353366.Google Scholar
Afif, A, Chabardes, S, Minotti, L, Kahane, P, Hoffmann, D. Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery. 2008;62(5 Suppl 2):471479.Google Scholar
Gras-Combe, G, Minotti, L, Hoffmann, D, Krainik, A, Kahane, P, Chabardes, S. Surgery for nontumoral insular epilepsy explored by stereoelectroencephalography. Neurosurgery. 2016 Oct;79(4):578588.Google Scholar
Munari C, Hoffmann D, Francione S, et al. Stereo-electroencephalography methodology: Advantages and limits.Acta Neurol Scand Suppl. 1994;152:5667.Google Scholar
Isnard, J, Taussig, D, Bartolomei, F, et al. French guidelines on stereoelectroencephalography (SEEG). Neurophysiol Clin. 2018 Feb;48(1):513.Google Scholar
Guenot, M, Isnard, J. Multiple SEEG-guided RF-thermolesions of epileptogenic foci. Neurochirurgie. 2008;54:441447.CrossRefGoogle ScholarPubMed
Cossu, M, Fuschillo, D, Casaceli, G, et al. Stereoelectroencephalography-guided radiofrequency thermocoagulation in the epileptogenic zone: A retrospective study on 89 cases. J Neurosurg. 2015. 123(6):13581367.Google Scholar
Bourdillon, P, Isnard, J, Catenoix, H, et al. Stereo-electro-encephalography-guided radiofrequency thermocoagulation: From in vitro and in vivo data to technical guidelines. World Neurosurg. 2016 Oct;94:7379.Google Scholar
Catenoix, H, Bourdillon, P, Guénot, M, et al. The combination of stereo-EEG and radiofrequency ablation. Epilepsy Res. 2018 May;142:117120.Google Scholar
Guenot, M, Isnard, J, Ryvlin, P, et al. SEEG-guided RF thermocoagulation of epileptic foci: Feasibility, safety, and preliminary results. Epilepsia 2004;45(11):13681374.Google Scholar
Catenoix, H, Mauguière, F, Guenot, M, et al. SEEG-guided thermocoagulations: A palliative treatment of non operable partial epilepsies. Neurology. 2008;71:17171726.Google Scholar
Cossu, M, Fuschillo, D, Casaceli, G, et al. Stereoelectroencephalography-guided radiofrequency thermocoagulation in the epileptogenic zone: A retrospective study on 89 cases. J Neurosurg. 2015;123(6):13581367.Google Scholar
Moles, A, Guénot, M, Rheims, S, et al. SEEG-guided radiofrequency coagulation (SEEG-guided RFTC) versus anterior temporal lobectomy (ATL) in temporal lobe epilepsy. J Neurol. 2018 Sep;265(9):982004.Google Scholar
Guenot, M, Isnard, J, Catenoix, H, et al. SEEG-guided RF thermocoagulations of epileptic foci: A therapeutic alternative for drug resistant non-operable partial epilepsies. Adv Tech Stand Neurosurg. 2011;36:6178.Google Scholar
Bourdillon, P, Rheims, S, Catenoix, H, et al. Surgical techniques: Stereoelectroencephalography-guided radiofrequency-thermocoagulation. Seizure. 20; PII:S1059-1311(18)30568-5.Google Scholar
Mullatti, N, Landre, E, Mellerio, C, et al. Stereotactic thermocoagulation for insular epilepsy: Lessons from successes and failures. Epilepsia. 2019 Aug;60(8):15651579.Google Scholar
Bourdillon, P, Cucherat, M, Isnard, J, et al. Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta-analysis. Epilepsia. 2018 Dec;59(12):22962304.Google Scholar
Cossu, M, Fuschillo, D, Cardinale, F, et al. Stereo-EEG-guided radio-frequency thermocoagulations of epileptogenic gray-matter nodular heterotopy. J Neurol Neurosurg Psychiatry. 2014;85(6):611617.Google Scholar
Schmitt, FC, Voges, J, Buentjen, L, et al. Radiofrequency lesioning for epileptogenic periventricular nodular heterotopia: A rational approach. Epilepsia 2011;52:101105.Google Scholar
Thompson, SA, Kalamangalam, GP, Tandon, N. Intracranial evaluation and laser ablation for epilepsy with periventricular nodular heterotopia. Seizure. 2016 Jul 16. PII: S1059-1311(16)30082-6.Google Scholar
Bourdillon, P, Isnard, J, Catenoix, H, et al. Stereo electroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RFTC) in drug-resistant focal epilepsy: Results from a 10-year experience. Epilepsia. 2017a Jan;58(1):8593.Google Scholar
Isnard, J, Hagiwara, K, Montavont, A, et al. Semiology of insular lobe seizures. Rev Neurol (Paris). 2019 Jan;30. PII: S0035-3787(18)30811-7.Google Scholar
Bourdillon, P, Ryvlin, P, Isnard, J, et al. Stereotactic electroencephalography is a safe procedure, including for insular implantations. World Neurosurg. 2017 Mar;99:353361.Google Scholar
Zhi-Qiang, C, Guo-Ming, L, Jian, Z, et al. Treatment of epilepsy with bipolar electro-coagulation: An analysis of cortical blood flow and histological change in temporal lobe. Chin Med J (Engl). 2015 Jan 20;128(2):210215.Google Scholar
Dimova, P, de Palma, L, Job-Chapron, AS, et al. Radiofrequency thermocoagulation of the seizure-onset zone during stereoelectroencephalography. Epilepsia. 2017 Mar;58(3):381392.CrossRefGoogle ScholarPubMed
Willie, JT, Laxpati, NG, Drane, DL, et al. Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy. Neurosurgery. 2014;74:569585.Google Scholar
Finet, P, DK, Nguyen, Bouthillier, A. Vascular consequences of operculoinsular corticectomy for refractory epilepsy. J Neurosurg. 2015 Jun;122(6):12931298.Google Scholar
Bouthillier, A, Nguyen, DK. Epilepsy surgeries requiring an operculoinsular cortectomy: Operative technique and results. Neurosurgery. 2017 Oct 1;81(4):602612.Google Scholar
Quigg, M, Harden, C. Minimally invasive techniques for epilepsy surgery: Stereotactic radiosurgery and other technologies. J Neurosurg. 2014;121(suppl):232240.Google Scholar
Cohen-Gadol, AA, Stoffman, MR, Spencer, DD. Emerging surgical and radiotherapeutic techniques for treating epilepsy. Curr Opin Neuro. 2003;16:213219.CrossRefGoogle ScholarPubMed
Irislimane, M, Mathieu, D, Bouthillier, A, et al. Gamma knife surgery for refractory insular cortex epilepsy. Stereotact Funct Neurosurg. 2013;91(3):170176.Google Scholar

References

Rolston, JD, Englot, DJ, Wang, DD, et al. Comparison of seizure control outcomes and the safety of vagus nerve, thalamic deep brain, and responsive neurostimulation: Evidence from randomized controlled trials. Neurosurg Focus. 2012;32(3):E14.Google Scholar
Boon, P, De Cock, E, Mertens, A, et al. Neurostimulation for drug-resistant epilepsy: A systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response. Curr Opin Neurol. 2018;31(2):198210.Google Scholar
Benbadis, SR, Geller, E, Ryvlin, P, et al. Putting it all together: Options for intractable epilepsy. An updated algorithm on the use of epilepsy surgery and neurostimulation. Epilepsy Behav. 2018;88S:3338.Google Scholar
Ikegaya, N, Takahashi, A, Kaido, T, et al. Surgical strategy to avoid ischemic complications of the pyramidal tract in resective epilepsy surgery of the insula: Technical case report. J Neurosurg. 2018;128(4):11731177.Google Scholar
Barba, C, Rheims, S, Minotti, L, et al. Temporal plus epilepsy is a major determinant of temporal lobe surgery failures. Brain. 2016;139(pt 2):444451.Google Scholar
Bourdillon, P, Ryvlin, P, Isnard, J, et al. Stereotactic electroencephalography is a safe procedure, including for insular implantations. World Neurosurg. 2017;99:353361.Google Scholar
Bouthillier, A, Nguyen, DK. Epilepsy surgeries requiring an operculoinsular cortectomy: Operative techniques and results. Neurosurgery. 2017;81(4):602612.Google Scholar
Von Lehe, M, Wellmer, J, Urbach, H, et al. Insular lesionectomy for refractory epilepsy: Management and outcome. Brain. 2009;132(pt 4):10481056.Google Scholar
Von Lehe, M, Parpaley, Y. Insular cortex surgery for the treatment of refractory epilepsy. J Clin Neurophysiol. 2017 Jul;34(4):333339.Google Scholar
Bouthillier, A, Weil, AG, Martineau, L, et al. Operculoinsular cortectomy for refractory epilepsy. Part 1: Is it safe? J Neurosurg. 2019 Sep;20:111.Google Scholar
Klein, TA, Ullsperger, M, Danielmeier, C. Error awareness and the insula: Links to neurological and psychiatric diseases. Front Hum Neurosci. 2013;7:14.Google Scholar
Hébert-Seropian, B, Boucher, O, Sénéchal, C, et al. Does unilateral insular resection disturb personality? A study with epileptic patients. J Clin Neurosci. 2017;43:121125.Google Scholar
Jobst, BC, Gonzalez-Martinez, J, Isnard, J, et al. The insula and its epilepsies. Epilepsy Curr. 2019 Jan;19(1):1121.Google Scholar
Market, MS, Fisher, RS. Neuromodulation – Science and practice in epilepsy: Vagus nerve stimulation, thalamic deep brain stimulation, and responsive neurostimulation. Expert Rev Neurother. 2019;19(1):1729.Google Scholar
Skarpaas, TL, Jarosiewicz, B, Morrell, MJ. Brain-responsive neurostimulation for epilepsy (RNS® System). Epilepsy Res. 2019;153:6870.Google Scholar
Geller, EB. Responsive neurostimulation: Review of clinical trials and insights into focal epilepsy. Epilepsy Behav. 2018;88S:1120.Google Scholar
Ma, BB, Rao, VR. Responsive neurostimulation: Candidates and considerations. Epilepsy Behav. 2018 Nov;88:388395.Google Scholar
Morrell, MJ. RNS system in epilepsy study group: Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011 Sep 27;77(13):12951304.Google Scholar
Nair, D, System Investigators, RNS, Morrell, MJ. Nine-year prospective safety and effectiveness outcomes from the long-term treatment trial of the RNS® System. AES Annual Meeting Abstract Database; 2018; AESnet.org.CrossRefGoogle Scholar
Bergey, GK, Morrell, MJ, Mizrahi, EM, et al. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology. 2015;84(8):810817.Google Scholar
Heck, CN, King-Stephens, D, Massey, AD, et al. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal Trial. Epilepsia. 2014;55(3):432441.Google Scholar
Devinsky, O, Friedman, D, Duckrow, RB, et al. Sudden unexpected death in epilepsy in patients treated with brain-responsive stimulation. Epilepsia. 2018;59:555561.Google Scholar
Meador, KJ, Kapur, R, Loring, DW, et al. Quality of life and mood in patients with medically intractable epilepsy treated with targeted responsive neurostimulation. Epilepsy Behav. 2015 Apr;45:242247.CrossRefGoogle ScholarPubMed
Loring, DW, Kapur, R, Meador, KJ, et al. Differential neuropsychological outcomes following targeted responsive neurostimulation for partial-onset epilepsy. Epilepsia. 2015 Nov;56(11):18361844.Google Scholar
Jobst, BC, Kapur, R, Barkley, G, et al. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia. 2017;58(6):10051014.Google Scholar
Smith, JR, Fountas, KN, Murro, AM, et al. Closed-loop stimulation in the control of focal epilepsy of insular origin. Stereotact Funct Neurosurg. 2010;88(5):281287.Google Scholar
Chen, H, Dugan, P, Chong, DJ, et al. Application of RNS in refractory epilepsy: Targeting insula. Epilepsia Open. 2017;2(3):345349.Google Scholar
Gooneratne, IK, Green, AL, Dugan, P, et al. Comparing neurostimulation technologies in refractory focal-onset epilepsy. J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):11741182.Google Scholar
Wheless, JJ, Gienapp, AJ. Vagus nerve stimulation (VNS) therapy update. Epilepsy Behav. 2018 Nov;88S:210.Google Scholar
Englot, DJ, Chang, EF, Auguste, KI. Vagus nerve stimulation for epilepsy: A meta-analysis of efficacy and predictors of response. J Neurosurg. 2011;115:248255.Google Scholar
Ben-Menachem, E. Vagus nerve stimulation, side effects, and long-term safety. J Clin Neurophysiol. 2001 Sep;18(5):415418.Google Scholar
Ryvlin, P, Gilliam, FG, Nguyen, DK, et al. The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: The PuLsE (open prospective randomized long-term effectiveness) trial. Epilepsia. 2014;55:893900.Google Scholar
Vonck, K, Raedt, R, Naulaerts, J, et al. Vagus nerve stimulation … 24 years later! What do we know about the effects on cognition? Neurosci Biobehav Rev. 2014 Sep;45:6371.Google Scholar
Ryvlin, P, So, El, Gordon, CM, et al. Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy. Epilepsia. 2018;59(3):562572.Google Scholar
Kuba, R, Novak, Z, Chrastina, J, et al. Comparing the effects of cortical resection and vagus nerve stimulation in patients with nonlesional extratemporal epilepsy. Epilepsy Behav. 2013;28(3):474480.Google Scholar
Lehtimaki, K, Coenan, VA, Goncalves Ferreira, A, et al. The surgical approach to the anterior nucleus of the thalamus in patients with refractory epilepsy: Experience from the international multicenter registry (MORE). Neurosurgery. 2019;84(1):141150.Google Scholar
Salanova, V. Deep brain stimulation for epilepsy. Epilepsy Behav. 2018 Nov;88S:2124.Google Scholar
Li, MC, Cook, MJ. Deep brain stimulation for drug-resistant epilepsy. Epilepsia. 2018 Feb;59(2):273290.Google Scholar
Fisher, R, Salanova, V, Witt, T, et al. Electrical stimulation of the anterior nucleus of the thalamus for treatment of refractory epilepsy. Epilepsia. 2010; 51(5):899908.Google Scholar
Sprengers, M, Vonck, K, Carrette, E, et al. Deep brain and cortical stimulation for epilepsy. Cochrane Database Syst Rev. 2017;7:CD008497.Google Scholar
Tröster, AI, Meador, KJ, Irwin, CP, et al. Memory and mood outcomes after anterior thalamic stimulation for refractory partial epilepsy. Seizure. 2017;45:133141.Google Scholar
Lee, KJ, Shon, YM, Cho, CB. Long-term outcome of anterior thalamic nucleus stimulation for intractable epilepsy. Stereotact Funct Neurosurg. 2012;90:379385.Google Scholar
Oh, YS, Kim, HJ, Lee, KJ, et al. Cognitive improvement after long-term electrical stimulation of bilateral anterior thalamic nucleus in refractory epilepsy patients. Seizure. 2012;22:183187.Google Scholar
Voges, BR, Schmitt, FC, Hamel, W, et al. Deep brain stimulation of anterior nucleus thalami disrupts sleep in epilepsy patients. Epilepsia. 2015;56:e99e103.Google Scholar

References

Alexander, H, Cobourn, K, Fayed, I, et al. Magnetic resonance-guided laser interstitial thermal therapy for the treatment of non-lesional insular epilepsy in pediatric patients: Thermal dynamic and volumetric factors influencing seizure outcomes. Childs Nerv Syst. 2019;35(3):453461.Google Scholar
Anzai, Y, Lufkin, RB, Castro, DJ, et al. MR imaging-guided interstitial Nd:YAG laser phototherapy: Dosimetry study of acute tissue damage in an in vivo model. J Magn Reson Imaging. 1991;1(5):553559.Google Scholar
Anzai, Y, Lufkin, RB, Saxton, RE, et al. Nd: YAG interstitial laser phototherapy guided by magnetic resonance imaging in an ex vivo model: dosimetry of laser-MR-tissue interaction. Laryngoscope. 1991;101(7 p. 1):755760.Google Scholar
Atsina, KB, Sharan, AD, Wu, C, et al. Journal Club: Longitudinal qualitative characterization of MRI features after laser interstitial thermal therapy in drug-resistant epilepsy. AJR Am J Roentgenol. 2017;208(1):4856.Google Scholar
Baxendale, S, Thompson, PJ, Duncan, JS. Improvements in memory function following anterior temporal lobe resection for epilepsy. Neurology. 2008;71(17):13191325.Google Scholar
Bell, ML, Rao, S, So, EL, et al. Epilepsy surgery outcomes in temporal lobe epilepsy with a normal MRI. Epilepsia. 2009;50(9):20532060.Google Scholar
Bown, SG. Phototherapy in tumors. World J Surg. 1983;7(6):700709.Google Scholar
Bosman, S, Phoa, SS, Bosma, A, van Gemert, MJ. Effect of percutaneous interstitial thermal laser on normal liver of pigs: Sonographic and histopathological correlations. Br J Surg. 1991;78(5):572575.Google Scholar
Castro, DJ, Saxton, RE, Layfield, LJ, et al. Interstitial laser phototherapy assisted by magnetic resonance imaging: a new technique for monitoring laser-tissue interaction. Laryngoscope. 1990;100(5):541547.Google Scholar
Chen, H, Dugan, P, Chong, DJ, Liu, A, Doyle, W, Friedman, D. Application of RNS in refractory epilepsy: Targeting insula. Epilepsia Open. 2017;2(3):345349.Google Scholar
Chitanondh, H. Stereotaxic amygdalotomy in the treatment of olfactory seizures and psychiatric disorders with olfactory hallucination. Confin Neurol. 1966;27(1):181196.Google Scholar
Chou, CC, Shih, YH, Yen, DJ, Kwan, SY, Yu, HY. Long-term health-related quality of life in drug-resistant temporal lobe epilepsy after anterior temporal lobectomy. Epileptic Disord. 2015;17(2):177183.Google Scholar
Cloppenborg, T, May, TW, Blumcke, I, et al. Trends in epilepsy surgery: Stable surgical numbers despite increasing presurgical volumes. J Neurol Neurosurg Psychiatry. 2016;87(12):13221329.Google Scholar
Duffau, H. A personal consecutive series of surgically treated 51 cases of insular WHO grade II glioma: Advances and limitations. J Neurosurg. 2009;110(4):696708.Google Scholar
Englot, DJ, Ouyang, D, Garcia, PA, Barbaro, NM, Chang, EF. Epilepsy surgery trends in the United States, 1990–2008. Neurology. 2012;78(16):12001206.Google Scholar
Fauser, S, Essang, C, Altenmuller, DM, et al. Long-term seizure outcome in 211 patients with focal cortical dysplasia. Epilepsia. 2015;56(1):6676.Google Scholar
Fiest, KM, Sauro, KM, Wiebe, S, et al. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology. 2017;88(3):296303.CrossRefGoogle ScholarPubMed
Gaitatzis, A, Johnson, AL, Chadwick, DW, Shorvon, SD, Sander, JW. Life expectancy in people with newly diagnosed epilepsy. Brain. 2004;127(pt 11): 24272432.Google Scholar
Gras-Combe, G, Minotti, L, Hoffmann, D, Krainik, A, Kahane, P, Chabardes, S. Surgery for nontumoral insular epilepsy explored by stereoelectroencephalography. Neurosurgery. 2016;79(4):578588.Google Scholar
Guillaume, MMJ, Mazars, G. Technique de resection de l’insula dans les epilepsies insulaires. Rev Neurol. 1949;81:900903.Google Scholar
Guillaume, J, Mazars, G, Mazars, Y. Surgical indications in so-called temporal epilepsy.Ann Med Psychol (Paris). 1953;111(24):552553.Google Scholar
Hale, AT, Sen, S, Haider, AS, et al. Open resection versus laser interstitial thermal therapy for the treatment of pediatric insular epilepsy. Neurosurgery. 2019;85(4):E730E736.Google Scholar
Hawasli, AH, Bagade, S, Shimony, JS, Miller-Thomas, M, Leuthardt, EC. Magnetic resonance imaging-guided focused laser interstitial thermal therapy for intracranial lesions: Single-institution series. Neurosurgery. 2013;73(6):10071017.Google Scholar
Hawasli, AH, Bandt, SK, Hogan, RE, Werner, N, Leuthardt, EC. Laser ablation as treatment strategy for medically refractory dominant insular epilepsy – therapeutic and functional considerations. Stereotact Funct Neurosurg. 2014;92(6):397404.Google Scholar
Heimburger, RF, Whitlock, CC, Kalsbeck, JE. Stereotaxic amygdalotomy for epilepsy with aggressive behavior. JAMA. 1966;198(7):741745.Google Scholar
Ho, AL, Muftuoglu, Y, Pendharkar, AV, et al. Robot-guided pediatric stereoelectroencephalography: Single-institution experience. J Neurosurg Pediatr. 2018;22(5):18.Google Scholar
Irislimane, M, Mathieu, D, Bouthillier, A, Deacon, C, Nguyen, DK. Gamma knife surgery for refractory insular cortex epilepsy. Stereotact Funct Neurosurg. 2013;91(3):170176.Google Scholar
Isnard, J, Guenot, M, Sindou, M, Mauguiere, F. Clinical manifestations of insular lobe seizures: A stereo-electroencephalographic study. Epilepsia. 2004;45(9):10791090.Google Scholar
Jermakowicz, WJ, Cajigas, I, Dan, L, et al. Ablation dynamics during interstitial thermal therapy for mesiotemporal epilepsy. PLoS One. 2018;13(7):e0199190.Google Scholar
Kang, JY, Wu, C, Tracy, J, et al. Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia. 2016;57(2):325334.Google Scholar
Levitt, MR, Ojemann, JG, Kuratani, J. Insular epilepsy masquerading as multifocal cortical epilepsy as proven by depth electrode. J Neurosurg Pediatr. 2010;5(4):365367. PMID:20367341.Google Scholar
Lindholm, CE, Kjellen, E, Nilsson, P, Hertzman, S. Microwave-induced hyperthermia and radiotherapy in human superficial tumours: Clinical results with a comparative study of combined treatment versus radiotherapy alone. Int J Hyperthermia. 1987;3(5):393411. PMID:3681040.Google Scholar
Malak, R, Bouthillier, A, Carmant, L, Cossette, P, Giard, N, Saint-Hilaire, JM, Nguyen, DB, Nguyen, DK. Microsurgery of epileptic foci in the insular region. J Neurosurg. 2009;110(6):11531163. PMID:19249926.Google Scholar
Matthewson, K, Coleridge-Smith, P, O’Sullivan, JP, Northfield, TC, Bown, SG. Biological effects of intrahepatic neodymium:yttrium-aluminum-garnet laser photocoagulation in rats. Gastroenterology. 1987;93(3):550557. PMID:3609664.Google Scholar
Milligan, AJ. Whole-body hyperthermia induction techniques. Cancer Res. 1984;44(10 suppl):4869s–4872s. PMID:6467239.Google Scholar
Narabayashi, H, Nagao, T, Saito, Y, Yoshida, M, Nagahata, M. Stereotaxic amygdalotomy for behavior disorders. Arch Neurol. 1963;9:116. PMID:13937583.Google Scholar
Nguyen, DK, Nguyen, DB, Malak, R, Leroux, JM, Carmant, L, Saint-Hilaire, JM, Giard, N, Cossette, P, Bouthillier, A. Revising the role of the insula in refractory partial epilepsy. Epilepsia. 2009;50(3):510520. PMID:18717706Google Scholar
Penfield, W, Faulk, ME Jr. The insula: Further observations on its function. Brain. 1955;78(4):445470. PMID:13293263.Google Scholar
Perry, MS, Donahue, DJ, Malik, SI, Keator, CG, Hernandez, A, Reddy, RK, Perkins, FF, Lee, MR, Clarke, DF. Magnetic resonance imaging-guided laser interstitial thermal therapy as treatment for intractable insular epilepsy in children. J Neurosurg Pediatr. 2017;20(6):575582. PMID:29027866.Google Scholar
Picot, MC, Baldy-Moulinier, M, Daures, JP, Dujols, P, Crespel, A. The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population-based study in a Western European country. Epilepsia. 2008;49(7):12301238. PMID:18363709.Google Scholar
Sabaz, M, Cairns, DR, Lawson, JA, Bleasel, AF, Bye, AM. The health-related quality of life of children with refractory epilepsy: A comparison of those with and without intellectual disability. Epilepsia. 2001;42(5):621628. PMID:11380569.Google Scholar
Sala-Padro, J, Fong, M, Rahman, Z, Bartley, M, Gill, D, Dexter, M, Bleasel, A, Wong, C. A study of perfusion changes with insula epilepsy using SPECT. Seizure. 2019;69:4450. PMID:30974406.Google Scholar
Schwab, RS, Sweet, WH, Mark, VH, Kjellberg, RN, Ervin, FR. Treatment of intractable temporal lobe epilepsy by stereotactic amygdala lesions. Trans Am Neurol Assoc. 1965;90:1219. PMID:5323371.Google Scholar
Silfvenius, H, Gloor, P, Rasmussen, T. Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy. Epilepsia. 1964;5:307320. PMID:14273592CrossRefGoogle ScholarPubMed
Skrap, M, Mondani, M, Tomasino, B, Weis, L, Budai, R, Pauletto, G, Eleopra, R, Fadiga, L, Ius, T. Surgery of insular nonenhancing gliomas: Volumetric analysis of tumoral resection, clinical outcome, and survival in a consecutive series of 66 cases. Neurosurgery. 2012;70(5):10811093. PMID:22067417.Google Scholar
Smith, JR, Fountas, KN, Murro, AM, Park, YD, Jenkins, PD, Morrell, M, Esteller, R, Greene, D. Closed-loop stimulation in the control of focal epilepsy of insular origin. Stereotact Funct Neurosurg. 2010;88(5):281287. PMID:20588079.Google Scholar
Steger, AC, Lees, WR, Walmsley, K, Bown, SG. Interstitial laser hyperthermia: A new approach to local destruction of tumours. BMJ. 1989;299(6695):362365. PMID:2506968.Google Scholar
Storm, FK, Kaiser, LR, Goodnight, JE, Harrison, WH, Elliott, RS, Gomes, AS, Morton, DL. Thermochemotherapy for melanoma metastases in liver. Cancer. 1982;49(6):12431248. PMID:7059946.Google Scholar
Sun, XR, Patel, NV, Danish, SF. Tissue ablation dynamics during magnetic resonance-guided, laser-induced thermal therapy. Neurosurgery. 2015;77(1):5158. PMID:26086908.Google Scholar
Thompson, PJ, Duncan, JS. Cognitive decline in severe intractable epilepsy. Epilepsia. 2005;46(11):17801787. PMID:16302858.Google Scholar
Vadera, S, Mullin, J, Bulacio, J, Njam, I, Bingaman, W, Gonzalez-Martinez, J. Sterioencephalography following Subdural Grid placement for difficult to localize epilepsy. Neurosurgery. 2013;72(5):723729 PMID:23313979.Google Scholar
Vakharia, VN, Sparks, R, O’Keeffe, AG, Rodionov, R, Miserocchi, A, McEvoy, A, Ourselin, S, Duncan, J. Accuracy of intracranial electrode placement for stereoencephalography: A systematic review and meta-analysis. Epilepsia. 2017;58(6):921932. PMID:28261785.Google Scholar
Waseem, H, Osborn, KE, Schoenberg, MR, Kelley, V, Bozorg, A, Cabello, D, Benbadis, SR, Vale, FL. Laser ablation therapy: An alternative treatment for medically resistant mesial temporal lobe epilepsy after age 50. Epilepsy Behav. 2015;51:152157. PMID:26280814.Google Scholar
Widjaja, E, Papastavros, T, Sander, B, Snead, C, Pechlivanoglou, P. Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy. PLoSOne. 2019;14(11):e0224571. PMID:31747402.Google Scholar
Wiebe, S, Blume, WT, Girvin, JP, Eliasziw, M. Effectiveness and efficiency of surgery for temporal lobe epilepsy study group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345(5):311318. PMID:11484687.Google Scholar
Yasargil, MG, Reeves, JD. Tumours of the limbic and paralimbic system. Ata Neurochir (Wien). 1992;116(24):147149. PMID:1502948.Google Scholar
Youngerman, BE, Oh, JY, Anbarasan, D, et al. Laser ablation is effective for temporal lobe epilepsy with and without mesial temporal sclerosis if hippocampal seizure onsets are localized by stereoelectroencephalography. Epilepsia. 2018;59(3):595606. PMID:29392715.Google Scholar

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