At the outbreak of War in 1939 the drug control system stood as a mixture of contradictions and uncertainty. On the one side were the strict control advocates, led by the United States. On the other side were producing states, agrarian countries whose economic, cultural and political systems were entwined with the very drugs the system sought to limit. In the middle were the old colonial powers, recognised the role opium played within many their colonies. The outbreak of war would fundamentally reshape international drug control. Moreover, it was driven by US-led bilateral efforts, utilising its wartime leverage, while other states were confined to rear-guard defensive actions. The reshaping of control during wartime was in many ways the result of aggressive wartime diplomatic manoeuvring by Harry Anslinger and key members of the Washington drug control lobby. The most radical wartime departure occurred in 1943 when Britain and Holland promised to adopt a policy of total prohibition of opium smoking and monopolies in many of their colonial territories. This shift, enabled Anslinger to bring new pressure to bear on the traditionally recalcitrant states such as Iran and Afghanistan to impose stricter controls and prohibitions.