Hostname: page-component-848d4c4894-pjpqr Total loading time: 0 Render date: 2024-06-22T12:04:59.290Z Has data issue: false hasContentIssue false
  • English
  • Français

Are there “local hotspots?” When concepts of cognitive psychology do not fit with physiological results

Published online by Cambridge University Press:  05 January 2017

Quentin Gaucher  and
Jean-Marc Edeline
Quentin Gaucher
Affiliation:
Paris-Saclay Institute of Neurosciences (Neuro-PSI), University Paris-Sud, CNRS, and Paris-Saclay University, 91405 Orsay Cedex, Francejean-marc.edeline@u-psud.frgaucher.quentin@gmail.comhttp://neuro-psi.cnrs.fr/spip.php?article135
Jean-Marc Edeline
Affiliation:
Paris-Saclay Institute of Neurosciences (Neuro-PSI), University Paris-Sud, CNRS, and Paris-Saclay University, 91405 Orsay Cedex, Francejean-marc.edeline@u-psud.frgaucher.quentin@gmail.comhttp://neuro-psi.cnrs.fr/spip.php?article135
Get access Rights & Permissions [Opens in a new window]

Abstract

Mather and colleagues' arguments require rethinking at the mechanistic level. The arguments on the physiological effects of norepinephrine at the cortical level are inconsistent with large parts of the literature. There is no evidence that norepinephrine induces local “hotspots”: Norepinephrine mainly decreases evoked responses; facilitating effects are rare and not localized. More generally, the idea that perception benefits from “local hotspots” is hardly compatible with the fact that neural representations involve largely distributed activation of cortical and subcortical networks.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e208
Copyright
Copyright © Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bassant, M. H., Ennouri, K. & Lamour, Y. (1990) Effects of iontophoretically applied monoamines on somatosensory cortical neurons of unanesthetized rats. Neuroscience 39:431–39.Google Scholar
Berridge, C. & Foote, S. (1991) Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. The Journal of Neuroscience 11(10):3135–45.Google Scholar
Berridge, C., Page, M., Valentino, R. & Foote, S. (1993) Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus. Neuroscience 55(2):381–93.Google Scholar
Bouret, S. & Sara, S. J. (2002) Locus coeruleus activation modulates firing rate and temporal organization of odour-induced single-cell responses in rat piriform cortex. European Journal of Neuroscience 16:2371–82.Google Scholar
Chandler, D. J., Gao, W.-J. & Waterhouse, B. D. (2014) Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices. Proceedings of the National Academy of Sciences of the United States of America 111(18):6816–21.Google Scholar
Chandler, D. J., Lamperski, C. S. & Waterhouse, B. D. (2013) Identification and distribution of projections from monoaminergic and cholinergic nuclei to functionally differentiated subregions of prefrontal cortex. Brain Research 1522:38–58.Google Scholar
Devilbiss, D. M. & Waterhouse, B. D. (2004) The effects of tonic locus ceruleus output on sensory-evoked responses of ventral posterior medial thalamic and barrel field cortical neurons in the awake rat. Journal of Neuroscience 24:10773–85.Google Scholar
Edeline, J.-M. (1995) The α2-adrenergic antagonist idazoxan enhances the frequency selectivity and increases the threshold of auditory cortex neurons. Experimental Brain Research 107:221–40.Google Scholar
Edeline, J.-M (2012) Beyond traditional approaches to understanding the functional role of neuromodulators in sensory cortices. Frontiers in Behavioral Neuroscience 6:45.Google Scholar
Edeline, J.-M., Manunta, Y. & Hennevin, E. (2011) Induction of selective plasticity in the frequency tuning of auditory cortex and auditory thalamus neurons by locus coeruleus stimulation. Hearing Research 274:75–84.CrossRefGoogle ScholarPubMed
Ego-Stengel, V., Bringuier, V. & Shulz, D. E. (2002) Noradrenergic modulation of functional selectivity in the cat visual cortex: An in vivo extracellular and intracellular study. Neuroscience 111(2):275–89.CrossRefGoogle Scholar
Foote, S. L., Freedman, R. & Oliver, A. P. (1975) Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex. Brain Research 86(2):229–42.Google Scholar
Gaucher, Q. & Edeline, J. M. (2015) Stimulus-specific effects of noradrenaline in auditory cortex: Implications for the discrimination of communication sounds. The Journal of Physiology 593(4):1003–20.CrossRefGoogle ScholarPubMed
Kim, M. A., Lee, H. S., Lee, B. Y. & Waterhouse, B. D. (2004) Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the rat. Brain Research 1026(1):56–67.Google Scholar
Kolta, A., Diop, L. & Reader, TA (1987) Noradrenergic effects on rat visual cortex: Single-cell microiontophoretic studies of alpha-2 adrenergic receptors. Life Sciences 20:281–89.Google Scholar
Lecas, J. C. (2001) Noradrenergic modulation of tactile responses in rat cortex: Current source-density and unit analyses. Comptes Rendus de l'Académie des Sciences – III 324:33–44.Google Scholar
Lecas, J. C. (2004) Locus coeruleus activation shortens synaptic drive while decreasing spike latency and jitter in sensorimotor cortex: Implications for neuronal integration. European Journal of Neuroscience 19:2519–30.Google Scholar
Manunta, Y. & Edeline, J.-M. (1997) Effects of noradrenaline on frequency tuning of auditory cortex neurons. European Journal of Neuroscience 9:833–47.CrossRefGoogle ScholarPubMed
Manunta, Y. & Edeline, J.-M. (1998) Effects of noradrenaline on rate-level function of auditory cortex neurons: Is there a gating effect of noradrenaline? Experimental Brain Research 118:361–72.CrossRefGoogle Scholar
Manunta, Y. & Edeline, J.-M. (1999) Effects of norepinephrine on frequency tuning of auditory cortex neurons during wakefulness and slow wave sleep. European Journal of Neuroscience 11:2134–50.Google Scholar
Manunta, Y. & Edeline, J. M. (2004) Noradrenergic induction of selective plasticity in the frequency tuning of auditory cortex neurons. Journal of Neurophysiology 92:1445–63.Google Scholar
Martins, A. R. & Froemke, R. C. (2015) Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex. Nature Neuroscience 18(10):1483–92.Google Scholar
McLean, J. & Waterhouse, B. D. (1994) Noradrenergic modulation of cat area 17 neuronal responses to moving stimuli. Brain Research 667:83–97.Google Scholar
Olpe, H. R., Glatt, A., Laszlo, J. & Schellenberg, A. (1980) Some electrophysiological and pharmacological properties of the cortical, noradrenergic projection of the locus coeruleus in the rat. Brain Research 186:9–19.Google Scholar
Sato, H., Fox, K. & Daw, N. W. (1989) Effect of electrical stimulation of locus coeruleus on the activity of neurons in the cat visual cortex. Journal of Neurophysiology 62:946–58.Google Scholar
Snow, P. J., Andre, P. & Pompeiano, O. (1999) Effects of locus coeruleus stimulation on the responses of SI neurons of the rat to controlled natural and electrical stimulation of the skin. Archives Italiennes de Biologie 137:1–28.Google Scholar
Videen, T. O., Daw, N. W. & Rader, R. K. (1984) The effect of norepinephrine on visual cortical neurons in kitten and adult cats. Journal of Neuroscience 4:1607–17.Google Scholar
Waterhouse, B. D., Devilbiss, D., Fleischer, D., Sessler, F. M. & Simpson, K. L. (1998a) New perspectives on the functional organization and postsynaptic influences of the locus ceruleus efferent projection system. Advances in Pharmacology and Chemotherapy 42:749–54.Google Scholar
Waterhouse, B. D., Moises, H. C. & Woodward, D. J. (1998b) Phasic activation of the locus coeruleus enhances responses of primary sensory cortical neurons to peripheral receptive field stimulation. Brain Research 790:33–44.Google Scholar