Field research conducted for 3 yr evaluated weed control in glyphosate-resistant soybean with glyphosate applied alone and in mixtures with reduced rates of the broadleaf herbicides acifluorfen, CGA-277476 (proposed name: oxasulfuron), chlorimuron, fomesafen, or lactofen. Barnyardgrass was controlled at least 95% with glyphosate at 840 and 1,120 g ai/ha, and control was not antagonized with any of the mixtures. At 14 d after treatment (DAT), wild poinsettia and prickly sida were controlled at least 90% with all glyphosate treatments. Control remained greater than 90% 28 DAT in one of the 2 yr, but in the other year, wild poinsettia was controlled 80%, and prickly sida was controlled 43% with the high rate of glyphosate. Acifluorfen or fomesafen (210 and 315 g ai/ha), or lactofen (112 and 168 g ai/ha) applied with glyphosate increased wild poinsettia control to 91 to 95% and prickly sida to 60 to 83%. At 14 DAT, pitted morningglory control improved in most cases when acifluorfen, fomesafen, or lactofen was applied with glyphosate. Hemp sesbania control was increased when glyphosate was applied with these same herbicides as well as CGA-277476 (39 and 59 g ai/ha) and chlorimuron (4.5 and 6.7 g ai/ha). But by 28 DAT, improvement in weed control with glyphosate and broadleaf herbicide mixtures was noted only in 1998, when pitted morningglory and hemp sesbania were larger at time of application (15 to 18 cm). Glyphosate alone in 1998 controlled these weeds no more than 30%, and only for hemp sesbania was control consistently more than 80% with the addition of acifluorfen or lactofen. At 28 DAT in 1999 and 2000, when weeds were no more than 10 cm, pitted morningglory was controlled 91 and 98%, respectively, and hemp sesbania 88 and 100%, respectively, with glyphosate alone at 1,120 g/ha. Soybean injury 28 DAT, consisting of foliar chlorosis and height reduction, was as much as 14, 13, and 23% for the acifluorfen, chlorimuron, and lactofen treatments, respectively, but no more than 6% for the CGA-277476 and fomesafen treatments. When weed control with glyphosate alone was at least 85%, addition of broadleaf herbicides did not improve soybean yield.