Tolpyralate is a herbicide that is usually mixed with atrazine for broad-spectrum weed control in corn. Previous research has provided information on the effective dose (ED) of tolpyralate applied alone and in a 1:33.3 mixture with atrazine; however, tolpyralate is commercially applied at a dose of 30-40 g ai ha-1 with a minimum of 560 g ai ha-1 of atrazine. Therefore, five field trials were conducted over three years (2019-2021) to determine the ED of atrazine to complement 30 g ai ha-1 of tolpyralate for 80, 90, and 95% control of seven weed species 2, 4, and 8 weeks after application (WAA). Tolpyralate was applied alone and in a mixture with atrazine doses ranging from 50-2,000 g ai ha-1. At 8 WAA, the ED of atrazine for 95% control of velvetleaf, common ragweed, common lambsquarters, and wild mustard was below the minimum label dose of atrazine on the commercial tolpyralate label, ranging from 430-520 g ai ha-1, which supports the use of the minimum label dose of atrazine. In contrast, redroot pigweed required 1,231 g ai ha-1 of atrazine to complement tolpyralate for 95% control 8 WAA. At 8 WAA, barnyardgrass and a mixture of green foxtail and giant foxtail (Setaria spp.) were not controlled 80, 90, or 95% with tolpyralate applied alone or co-applied with any dose of atrazine evaluated in this study. The results of this study conclude that tolpyralate + atrazine is highly efficacious on several weed species at atrazine doses of 40-130 g ai ha-1 below the label dose of 560 g ai ha-1, but the use of the higher dose of tolpyralate or another herbicide may be required to improve control of redroot pigweed and grass weed species.