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Red blood cells membrane vehicle co-delivering DOX and IR780 for effective prostate cancer therapy

Published online by Cambridge University Press:  20 October 2020

Datian Zhang ,
Chengfu Zhou ,
Feng Liu ,
Tao Ding  and
Zhong Wang
Datian Zhang
Affiliation:
Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning121001, P.R. China
Chengfu Zhou
Affiliation:
The First People's Hospital of Tai'an (affiliated to Shandong First Medical University), Tai'an, Shandong271016, P.R. China
Feng Liu
Affiliation:
Department of Urology, Sixth People's Hospital South Campus Affiliated to Shanghai Jiaotong University, Shanghai201499, P.R. China
Tao Ding
Affiliation:
Department of Urology, Sixth People's Hospital South Campus Affiliated to Shanghai Jiaotong University, Shanghai201499, P.R. China
Zhong Wang*
Affiliation:
Department of Urology, Sixth People's Hospital South Campus Affiliated to Shanghai Jiaotong University, Shanghai201499, P.R. China
*
a)Address all correspondence to this author. e-mail: zhongwang0509@163.com
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Abstract

The cellular accumulation of drug delivery systems (DDSs) is a critical parameter to determine the final outcome of cancer chemotherapy. Herein, we designed a red blood cells membrane-based vehicle (RV) and employed it to load both doxorubicin (Dox) and IR 780 (RV/I-D). The photothermal-assisted chemotherapy efficacy of RV/I-D on the treatment of cancer was tested on a prostate cancer model. Excitingly, the results showed that RV/I-D was stable and safe nanoparticles with size at about 100 nm. Moreover, upon the increase of system temperature using photothermal effects of IR780, the drug release of the DDS was accelerated. Above all, the DDS also increased the accumulation of drugs into the Dox-resistant prostate cancer cells (PC-3/Dox) both in vitro and in vivo and showed enhanced anticancer performance.

Keywords

biomaterialbiomedicalbiomimetic
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 22 , 30 November 2020 , pp. 3116 - 3123
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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