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Glucose-responsive shape-memory cryogels

Published online by Cambridge University Press:  12 August 2020

Marc Behl
Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow14513, Germany Tianjin University − Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, Teltow14513, Germany
Qian Zhao
Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow14513, Germany Tianjin University − Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, Teltow14513, Germany
Andreas Lendlein*
Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow14513, Germany Tianjin University − Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, Teltow14513, Germany Institute of Chemistry, University of Potsdam, Potsdam14476, Germany
a)Address all correspondence to this author. e-mail:
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Boronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of Cglu varied between 0 and 300 mg/dL. In bending experiments, shape fixity Rf ≈ 80% and shape recovery Rr ≈ 100% from five programming/recovery cycles could be determined. Rr was a function of Cglu in the range from 0 to 300 mg/dL, which accords with the fluctuation range of Cglu in human blood. In this way, the shape-memory hydrogels could play a role in future diabetes treatment options.

Invited Feature Paper
Copyright © Materials Research Society 2020

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