Cannabis is a widely used drug, which effects on human health remain controversial. Recent studies have found correlations between cannabis use and brain structural changes that may be related to ageing processes. Eotaxin-1 is a chemokine described as a marker of ageing, which also appear to increase with cognitive deficits and neurogenesis. Here, we aimed at characterising the effect of cannabis in accelerating normal ageing processes, by studying eotaxin-1 plasma levels in people who currently use cannabis, have used cannabis in the past, or have never used cannabis.

A total of 87 healthy volunteers participated in the study. Participants completed the Cannabis Experience Questionnaire, the General Practice Physical Activity Questionnaire, the Sociodemographic, Morphometric, Alcohol and Tobacco Questionnaire, and provided a blood sample. Eotaxin-1 was assessed by ELISA. The three groups were compared using one-way ANOVA to assess levels of eotaxin-1, and nonpaired Student t-tests to assess other factors effects.

Current users of cannabis (n=18) had significantly higher eotaxin-1 plasma levels compared to past users of cannabis (n=33) and individuals who never used cannabis (n=36). The latter two groups had similar eotaxin-1 levels. Higher eotaxin-1 plasma levels were not attributed to gender, age, body mass index, physical activity or use of other legal/illegal drugs.

These results suggest that cannabis use increases eotaxin-1 plasma levels and could result in accelerated brain ageing. However, the effects appear to be reversible when cannabis use ceases. These findings have important implications for treatment and care of mental health disorders, such as schizophrenia.

The use of an electronic-cigarette (e-cigarette) resulted in some previous studies in reduction and cessation of conventional cigarette smoking. This study aims to examine the reasons of using e-cigarettes instead of and in addition to conventional cigarettes in Germany. Furthermore it is determined to what extent e-cigarettes are used as a smoking cessation tool.

A cross-sectional study was conducted. The I-Change Model was used as theoretical framework and existing questionnaires were used to build up the present questionnaire. 320 Smokers participated in the study, divided in three groups: E-cigarette smokers (e-smokers) (33%), conventional cigarette smokers (c-smokers) (37%) and smokers of both cigarettes (b-smokers) (30%). Pearson Chi Square tests and analyses of variance were used to assess differences among the group of smokers on demographic variables, smoking behaviour and the constructs of the IChange Model.

About half of the e-cigarette users used the e-cigarette in addition to c. cigarettes and the other half instead of c. cigarettes. E-cigarette users were most often men, were less addicted to nicotine and had a higher motivation to stop smoking than c-smokers. E-smokers reported a more positive health and had a lower carbon monoxide concentration compared to c-smokers. E-smokers had a higher self-efficacy in terms of being abstinent from c. cigarettes in certain situations.

The results confirmed most of the hypotheses and also important results of previous studies. In addition, a well-conducted randomized-control trial is needed to confirm the efficacy of e-cigarettes as a smoking cessation aid.

Previous research suggests that various types of childhood maltreatment frequently co-occur and confer risk for multiple psychiatric diagnoses. This may mean that childhood maltreatment increases vulnerability to a great number of specific psychiatric disorders through diverse and specific mechanisms or that childhood maltreatment engenders a generalised liability to dimensions of psychopathology. Gender differences have been suggested to play a role in this associations.

To compare demographic and clinical characteristics of young adults with history of childhood maltreatment admitted to a psychiatric unit, according to gender.

To delineate the impact of gender on the psychopathology of young adults submitted to childhood maltreatment.

Retrospective data of patients aged 15 and 23 and admitted to a psychiatric outpatient unit, from December 2010 and December 2013, were reviewed. The demographic and clinical characteristics of the two genders were compared.

Childhood maltreatment was associated with elevated odds of mood, anxiety and drug disorders in both genders, but gender differences emerged with physical abuse associated only with externalising liability in men, and only with internalising liability in women. There were no gender differences in age of onset.

Childhood maltreatment have gender-specific consequences for the expression of psychopathology, suggesting gender-specific aetiological pathways between maltreatment and psychopathology.

Hyperprolactinaemia is a common side effect of some APS, associated to important clinical manifestations (sexual dysfunction, breast disturbances and even increase of certain types of cancer risk).

To evaluate the levels of prolactinemia associated to different APS, including the newest ones, and its association with sexual dysfunction (SD).

Observational cross-sectional study. Adult patients treated with one APS for at least 4 weeks and with no other PRL-rising treatment were included. Hyperprolactinaemia was defined as 20 microgr/L in women, 18 microgr/L in men. SD was evaluated with the specific SD questionnaire PR-Sex-DQ-SALSEX (Montejo et al, 2001).

288 patients were evaluated, with the following APS treatment distribution: aripiprazol (22.2%), risperidone (17.01%), olanzapine (16.67%), quetiapine (7.99%), long-acting paliperidone (6.25%), long-acting risperidone (4.51%), oral paloperidone (4.17%), oral risperidone (4.17%) and others (21.18%; APS with N<10 were not evaluated). Paliperidone was associated with the higher mean PRL levels (98.28 and 71.48 microgr/L for LAP and OP respectively), followed by oral risperidone (71.36 microgr/L). Aripiprazol, oral olanzapine and quetiapine showed the lowest PRL levels (13.25, 27.10 and 28.55 microgr/L respectively). More than 70% of the sexually active patients treated with paliperidone or risperidone presented SD, less frequent in non PRL-raising APS.

In our sample paliperidone and risperidone were associated to higher mean PRL levels and sexual disfunction, while quetiapine, olanzapine and aripiprazol were the less PRL-raising APS. This might be taken in consideration when electing a long-term antipsychotic treatment for patients, given the important clinical consequences associated to sustained hyperprolactinaemia.

As weight-gain and metabolic abnormalities during treatment with psychotropic drugs are of great concern, we evaluated effects of psychoeducation and medical monitoring on metabolic changes among severely mentally ill patients.

During repeated, systematized psychoeducation about physical health among 66 consecutive patients diagnosed with DSM-IV schizophrenia (SZ; n=33) or type-I bipolar disorder (BD; n=33), we evaluated (at intake, 1, 2, 3, and 6 months) clinical psychiatric status, treatments and doses, rated drugs- attitude of patients, and recorded physiological parameters.

At intake, BD vs. SZ patients were receiving 3–7-times more psychotropic medication, with correspondingly higher initial body-mass index (BMI: 29.1 vs. 25.6 kg/m2), 12-times more obesity, and significantly higher serum lipid concentrations. During 6-month follow-up, ratings of drugs- attitude of patients improved, polytherapy decreased in BD, and BMI decreased slightly, as serum lipid concentrations declined continuously (e.g., total cholesterol+triglycerides: BD by 3.21 > SZ by 1.75%/month). Declining lipid levels were associated with: [a] older age, [b] BD diagnosis, [c] being unemployed, [d] higher antipsychotic dose, [e] lower initial BPRS scores (all p≤0.001).

To develop a physical health care policy within the Rotherham Doncaster and South Humber NHS Foundation Trust (RDASH NHS FT) and shared care policy with Primary care, for adult psychiatric patients. To carry out a physical health care pilot in community mental health team of adult psychiatric patients.

To achieve a baseline of physical health status of the patients.

To present the findings to the trust governance committee.

Plan further pilot in Primary care to ensure action plan.

Arrange systems in place within IT to store and share information.

Pilot was carried out in Ferham clinic in Rotherham.

Number of patients: 247

A physical health pro-forma was devised which was completed by patients.

Time period: May2013-September2013

Patients identified: 247, Respondents: 225

Type of pre-existing physical illness

Side effect profile

The results were presented at Trust Governance Committee and the pro-forma has been agreed as a trust wide minimum standard.

Pilot in primary care has been agreed with Kivetonpark Medical practice.

A system has been agreed with IT to store and share information in electronic case notes.

Pending the results of primary care pilot, a policy for physical health care will be agreed.

Psychotic symptoms such as hallucinations and delusions are common in patients with Parkinson's disease (PD). The estimated prevalence of hallucinations ranges from ~10% to 48%, and the prevalence of delusions ranges from 3% to 80%(ref 1–9). The various of the prevalence depends of the diagnostic criteria used. The etiologies of these symptoms are multiple and treatments are different. Through a clinical observation of a patient treated for a Parkinson disease (PD) and who develop two years ago a behavior disorder, irritability, visual hallucination and illusion, we suggest discussing the etiologies and the therapeutic difficulties of this disorder.

Y.N., a 64 year-old man, with family history of dementia, and personal history of diabetes and tuberculosis. He is followed for Parkinson's disease since the age of 57 years. He received Trihexyphenidyle (5 mg per day), Piribedil (200mg per day) and levodopa (500mg per day) with a progressive increase and excessive consumption of levodopa (more than 1000mg per day). Since the age of 62 years old, he presented with elaborated and invalidating auditory hallucinations with ideas of persecution and prejudice. The neuropsychological evaluation showed no other signs of dementia (MMSE=30/30). The diagnosis of dopaminergic psychosis was established. Levodopa was decreased; Trihexyphenidyle and Piribedil were discontinued with a notable improvement of hallucinations.

The psychotic symptoms in PD should be searched, such as systemic illness and other psycho-active medications. If none are identified or can be eliminated, the PD medications should be reduced to the lowest levels that allow tolerable motor function. Once this level has been reached we can use either acetylcholinesterase inhibitors or typical anti-psychotics

Previous studies concerning early experiences in childhood show that these play a crucial role in the individuals’ development and may lead to a decrease in the vulnerability to show psychological problems. Mindfulness skills and feelings of hope seem to function as mechanisms that promote adjustment and psychological well-being.

The aim of this study was to explore the relationship between early positive emotional memories, hope, and mindfulness skills, as well as their role in the psychological well-being.

A sample of 402 adolescents with ages ranging from 12 to 18 years old completed four self-report instruments: the Early Memories of Warmth and Safeness Scale, the Children and Adolescent Mindfulness Measure, the Children Hope Scale and the Positive and Negative Affect Schedule.

Girls exhibited more negative affect when compared to boys. Age and years of education were not correlated with any of the study variables. Students with no school disapprovals showed more positive emotional memories and more hope. Mindfulness skills, hope, warmth and safety memories, and positive and negative affect were significantly correlated in an expected way. The set of variables that better predicted positive affect was: hope, early warmth and safety memories, and mindfulness skills. For negative affect, mindfulness was the best predictor followed by hope and lastly by positive emotional memories.

The current study heightened the role of positive emotional memories, mindfulness, and hope in affective states, suggesting that they may be addressed in intervention programs for the adjustment or the psychological well-being of the adolescents.

Social relationships (e.g. family, friendships and romantic relationships) are fundamental to human development and well-being.

The current study aimed to explore the psychometric properties of the Social Values Questionnaire (SVS; Blackledge & Ciarrochi, 2006) in a sample of Portuguese adolescents. Furthermore we sought to understand motives for and commitment to social values and how these elements are associated with well-being across age and gender.

The sample included 268 adolescents (150 girls and 118 boys) with ages ranging from 14 to 18 years old, attending high school. Participants completed a set of self-report measures: the SVS, the Positive and Negative Affect Schedule (PANAS-C; Sadin, 1997), the Students’ Life Satisfaction Scale (SLSS;Huebner 1991) and the Children's Hope Scale (CHS; Snyder, Hoza, Pelham, Rapoff, Ware, Danovsky, Highberger, Rubinstein & Stahl, 1997).

The Portuguese version of the SVS showed high internal consistency: Intrinsic motivation (α=0,91), extrinsic motivation (α=0,90), commitment (α=0,79). It also showed adequate test retest reliability. Gender revealed a relevant role with girls presenting more intrinsic motivation, less extrinsic motivation and a higher degree of commitment when compared with boys. Age was positively correlated with intrinsic motivation and commitment. Significant and expected relationships were also found between SVS subscales and positive and negative affect, life satisfaction, and hope.

The SVS seems to be a valid and reliable instrument for the assessment of social values in adolescents. This construct is an important one in the context of mindfulness and acceptance based therapies and thus its assessment is pertinent.

We analyzed the first visits carried out by a local mountain psychiatric service in 9 months from January to September 2013.

Analyze the mode of access to the service, and the continuation of the course of treatment.

Different variables were considered: sex, how to access, the level of urgency, the prescription drug, the previous psychiatric history, duration of taking charge and sending to other facilities of the Mental Health Department.

The total number of patients was 176, of which 64% were female; scheduled visits were the most (146), the remaining (30) were urgent. The majority (110) were sent from their GPs, among these, more than half (63) are still in load. Half had a positive psychiatric history, and most (92) had a positive psychiatric drug history. It was set to a drug therapy to the majority of patients visited (147), especially anxiolytics (112) and secondarily antidepressants (109). A small part was hospitalized (3) or sent to Psychogeriatrics (11) or Pathological Addictions or Clinical Psychology; about one-third (57) were discharged.

According to the literature the women access more frequently than men. From the data it can be inferred that submissions by GPs have become more appropriate in the course of time and that send to the specialist after trying a first drug therapy. The use of anxiolytic drugs remains an issue of clinical practice.

The concepts of well-being and hope are associated with life satisfaction. Public policies should include the promotion of quality of life in the elderly.

The current study sought out to address the concepts of hope and well-being in the elderly, analysing the role of socio-demographic variables. It also aimed to characterize this population in terms of other quality of life indicators such as perception of general health status, loneliness and degree of activity.

The sample included 130 elderly people, both from the community and institutionalized, with ages between 65 and 94 years old. Participants answered questions about socio-demographic data, quality of life indicators, cognitive functioning and measures of hope (HP; Snyder et al.; 1991), life satisfaction (SWLS; Diener et al, 1985), and positive and negative affect (PANAS; Watson, Clark, & Tellegen, 1998).

The majority of participants perceived their health status as reasonable and mentioned feelings of loneliness. Only 20% considered themselves active. Men presented higher levels of hope when compared with women. Participants who were not institutionalized showed higher levels of hope and positive affect, considering themselves more active when compared to the ones living in nursing homes or attending day centres. Hope showed to be positively correlated with life satisfaction, positive affect, health status perception and degree of activity, and negatively correlated with negative affect. Negative affect showed to be correlated with the perception of loneliness.

This study enhances the importance of socio-demographic and psychological variables in the promotion of well-being in the elderly.

Immigration involves significant changes in the psychosocial context, due to losses, relationship breakdowns, lack of social support, not feeling at home, novelty, discrimination, resettlement demands (occupation, language). These life stressors might lead to psychological distress, including depression.

To explore if there are differences in the prevalence of depression and depressive symptoms in immigrant and Portuguese women during the perinatal period.

The sample comprises 397 women. 348 (87.7%) of them were Portuguese and the remaining 49 (12.4%) were born in other Countries (5.8% Other/European, 3.8% African, 2.8% South America). They were both interviewed at the last trimester of pregnancy (T0) and at 3 months postpartum (T1), using the Diagnostic Interview for Genetic Studies, which allows CID-10 and DSM-IV diagnoses of depression. Both at T0 and T1, they also completed the Postpartum Depression Screening Scale (PDSS) to evaluate depressive symptoms.

Immigrants compared with Portuguese women did not differ in respect to a CID-10/DSM-IV depression diagnosis and in respect to PDSS total scores at T0 and T1. Being immigrant is associated with higher levels of passive suicidal ideation (death seem the only way out of this nightmare) (rs=.116, p<.05), feelings of loneliness (rs=.118, p<.05) and being overwhelmed by anguished (rs=.134, p<.01) at pregnancy and with feelings of being inadequate as a mother (rs=.128, p<.05) at the postpartum.

Being immigrant might contribute to higher levels of depressive symptoms during the perinatal period, including suicidal ideation. These findings have clinical implications, while working with immigrants.

Leber hereditary optic neuropathy (LHON), an inherited mitochondriopathy, can result in progressive degeneration of retinal ganglial cells and thus in worsening and even loss of vision. Smoking is probably the most important risk factor for the onset and progression of the disease.

To assess the smoking history and status of LHON patients to determine the need for tobacco cessation programmes in this collective.

From November 2011 to January 2012, 27 LHON patients completed a standardised questionnaire including Fagerström Test for Nicotine Dependence (FTND), age when smoking started and quit attempts. Smoking history was confirmed by measuring expired carbon monoxide and saliva levels of nicotine and cotinine.

Twenty men (74%) and 7 women (26%) were evaluated. The average age at disease onset was 29 years. Fifteen (56%) of the participants were smokers at the time of the evaluation, 3 (11%) had quit smoking after diagnosis of LHON and 9 (33%) had never smoked. Saliva nicotine and cotinine concentration correlated significantly with the degree of physical dependence (p<0.05), but carbon monoxide did not.

Even after being informed of the probability of blindness if they continued to smoke, only 3 of 18 patients quit smoking. Further studies need to assess the effects of integrating smoking cessation programmes into the treatment offered to patients with manifest LHON. Also, the role of smoking in the onset and progression of the disease needs to be validated to optimise prevention and treatment measures for carriers and LHON patients.