Cognitive and behavioural problems usually accompany isolated clefts of the lip and/or the palate (ICLP) [1].

To investigate cognitive, emotional and personal features of children with ICLP in comparison with non-cleft children from complete families and non-cleft orphans.

The ICLP group consisted of 29 children (age 14.2 ± 0.7). The first comparison group (1CG) consisted of 34 non-cleft children (age 14.1 ± 0.5). The second comparison group (2CG) consisted of 30 non-cleft orphans (age 13.8 ± 0.8). Drawing tests “House-Tree-Person” have been selected to evaluate the level of children's development, emotional and personal features in all three groups. M. Luscher Color test was chosen to figure out the children's psychological state, regardless of education level.

The most characteristic features of the ICLP children and 2CG were similar. They included infantilism (69%; 43.3%), low self-control (65.5%; 56.7%), demonstrative demeanor (62%; 36.7%), escape from reality into fantasy (93%; 76.7%), anxiety (69%; 63.3%). ICLP children compared with the 1CG has shown significantly higher level of aggression (79.3% vs. 4.2%), increased self-esteem (59.6 vs. 4.2%), impulsiveness (51.7% vs. 16.7%), the importance of other people's opinions (59.6% vs. 29.2%). Contrary, the feelings of lack of emotional warmth, the need for protection were observed in 1CG more frequently–70.8% vs 55.2% in ICLP and 60% in 2CG.

Psychological correction in children with ICLP should be aimed at increasing the adaptive functions, facilitating communication with peers, search the area for self-realization.

The authors have not supplied their declaration of competing interest.

Autism spectrum disorders (ASD) are complex psychiatric disorders, with both genetic and environmental factors implicated in their etiology. Recent studies suggest the prenatal and early postnatal genesis of ASD, therefore, understanding the effect of environmental risk factors could be important for prevention and treatment of ASD.

The aim of this study was to determine the association of prenatal factors and perinatal complications with ASD.

Our study included 102 subjects with ASD (80% boys) aged 9.35 ± 5.85, and 107 age and sex matched healthy controls (77% boys). For the diagnosis of ASD, we used the ICD-10 criteria and Autism Diagnostic Interview-Revised (ADI-R). A questionnaire regarding prenatal and perinatal factors/complications was administered to all subjects.

Logistic regression model of having autism vs. being a control subject included gender, age, maternal and paternal age at birth, pregnancy order, smoking in pregnancy, number of medication during pregnancy (mostly tocolytics, antihypertensives, antiarrhythmics), and early postnatal complications (mostly prematurity, low birth weight, hyperbilirubinaemia). The model was significant, explaining about the third of variance, with number of medication during pregnancy and having an early postnatal complication as significant predictors.

Our study has shown a significant association of specific prenatal and perinatal factors and ASD, even after controlling for other potential confounding variables. Identifying specific risk factors is important for prevention of ASD. It is also the first step in defining basis of the gene–environment interaction mechanism, which might enable development of an individualised therapeutic approach for this group of disorders.

The authors have not supplied their declaration of competing interest.

Sensory processing is the individual's ability to receive, process and integrate sensory information from the environment and body movement in the central nervous system, in order to produce adaptive responses. Sensory processing disorders (SPD) are associated to difficulties in regulating emotions and behaviours as well as motor abilities in response to sensory stimulation that lead to impairment in development and functioning. It is estimated that SPD affect 5–16% of school-aged children. Although these diseases constitute a primary diagnostic category in the Diagnostic Classification of Mental Health and Development Disorders of Infancy and Early Childhood: DC0-3, they have not yet been validated by the Diagnostic and Statistical Manual of Mental Disorders-DSM. In the latest edition of DSM, SPD were only included as one of the diagnostic criteria of autism-spectrum disorders. However, several studies have suggested that SPD may present themselves solely or coexist with other clinical conditions.

The aim of this study was to review systematically the relationship between SPD and psychopathology.

Articles indexed in the Pubmed database were analyzed.

Although sensory processing problems are well known to occur in association with autism, their relationship with other mental disorders is not a well studied area. Some studies have related them with ADHD, behavioural disorders and learning disorders. Some studies also comproved that SPD are a valid diagnosis and that there are individuals with SPD who do not meet the criteria for other known disorder. One study found an abnormal white matter microstructure in children with SPD. Despite these findings SPD need to be further studied.

The authors have not supplied their declaration of competing interest.

In industrialised countries, the age of puberty onset has substantially diminished over the last 150 years. Several factors, like improved nutrition and health care have contributed to this, but there are concerns about other factors, like obesity, levels of divorce and chemicals. There is an association between early puberty and externalizing disorders in both girls and boys.

To describe trends in advanced puberty timing and adolescence-onset conduct disorder (CD), analyse if an association exists between both and evaluate which measures can be taken to prevent youth from antisocial activities during adolescence.

A systematic literature review using Medline, Embase and Psycinfo Databases.

Family break-up and increased stress are risk factors for adolescence-onset conduct disorder. Obesity is associated with low SES families, so prevention campaigns giving advice on healthy nutrition may be beneficial. On the general level, there is no clear positive correlation between adolescence-onset CD and early puberty over the last decades as numbers of CD are decreasing.

Potential mental health gains can be obtained to focus on children with multiple risk factors for early puberty. More research is needed to assess, which interventions (diet, advice on body changes, social expectations, etc.) are most useful.

The authors have not supplied their declaration of competing interest.

There is a lack of epidemiological evidence on the prevalence and incidence of mental health disorders in adolescence in Croatia. Depressive disorder and paranoid symptoms have been demonstrated to be closely related in adult community samples or patients with adult depression. The present study used a cross-sectional design to evaluate a sample of Croatian adolescents.

Examine the prevalence of paranoid symptoms in adolescents attending grammar school as a preliminary study of clinical characteristic of depression in adolescence.

A sample of 450 individuals, average age 15.7 (SD = 0.45); female 232 (51.6%), male 218 (48.4%). The screening was followed by the use of a structured psychiatric interview (HAMD-21), which was administered to confirm the presence or absence of depression disorder. Item paranoid symptoms were administered to evaluate the level OD symptoms (0–none; 1–suspicious; 2–ideas of reference; 3–delusions of reference and persecutions).

A total of 450 participants were screened, using HAMD-21, paranoid symptoms occurred (44.9%). Depressed adolescents: moderate, severe and very severe, defined as more than 14 points in HAMD-21 presented paranoid symptoms 68.1%, and non-depressed 32.2%.

The depressive group displayed more frequent and intense paranoid symptoms than the control group (P < 0.001). Among non-depressed the incidence of paranoid symptoms is a surprisingly high. This could be the consequences of the war in Croatia, transition, as well as the influence of social networks on adolescent communication. This requires future studies.

The authors have not supplied their declaration of competing interest.

The authors have not supplied their declaration of competing interest.

The author has not supplied his/her declaration of competing interest.

The authors have not supplied their declaration of competing interest.

In order to provide evidence-based intervention for autism from this approach in practice.

In reference to a longitudinal approach, an intervention program was designed and implemented to serve 40 children with ASD, who were treated for one (1) year at the Victory BRT Institute in Florida, US. The behaviors targeted for reduction (excess behavioral), are the following: physical aggression, self-aggression and non-compliance. The program began with a baseline (12 consecutive days) with observations at home and others different natural contexts. The last three (3) months of the year consisted of monthly follow-up sessions to monitor the treatment implemented. The results were analyzed by repeated measures, ANOVA Sig (P = 0.003) (F = 8). Analyses show that the critical level associated with the effect of time-content interaction is strong, so the treatment generated a positive effect by reducing the behaviors targeted in time.

These results provide evidence that interventions from applied behavior analysis are effective.

The authors have not supplied their declaration of competing interest.

The authors have not supplied their declaration of competing interest.

Publications and studies have shown that the existence of serious mental disorders in parents is a risk in the development of children and is more common the existence of mental illness in them than in the general pediatric population. This work aims to reflect in depth on the study of the influence of psychotic parents on child development through a review of a clinical study. We present the case of 14 years old adolescent who is being treated in a mental health center, whose parents suffers from a severe mental illness. We also defend the importance of a preventive approach or treatment that impinges on the child and family environment.

A way of community work, in coordination with the different teams (social services, educational services, etc.) allows more efficient and appropriate treatment, using various resources. When risk factors for developing mental health problems in childhood, family history and especially the existence of one or both parents of mentally pathology type schizophrenia or other psychoses are studied become important. It seems essential to address as a priority to the social group have called “high-risk group of psychosis’, and in particular to the” sons of patients diagnosed with psychosis”, both for its size and the severity and chronicity of psychopathology if developing means for early psychosocial care does not occur.

The authors have not supplied their declaration of competing interest.

The determination of IQ is essential in the assessment and diagnosis of children. There are multitude of tests, one of the most used are the Wechsler Scales.

Hypothesis: Assessment of IQ is equivalent using the Wechsler Intelligence Scale for Children-Revised (WISCr) and Kaufman inteligence brief test (KBIT).

Subjects Children undergoing treatment at Unit Child and Adolescent Mental Health of Talavera with determination IQ at some point in the intervention: 39 pairings determination of IQ subjects atended: 20 males and 19 females, aged between 4 and 14 years.

Subjects are evaluated with KBIT and WISCr tests.

Design: Quasi-experimental with two conditions.

Independent variables: IQ Total WISCr and age management KBIT (for eight years application of the full test, under this age not full test).

Dependent variable: IQ KBIT.

Calculation of correlation between IQ by non-parametric test. Comparison between groups using non-parametric test for dependent data (sign test). Rejecting null hypothesis for alpha significance P < 0.05.

Partial KBIT; 21 comments, 11 males, 10 females; Spearman r = .714 (P < .001); average estimate of 12.71 points higher in KBIT, Dt 18.07, sign test Z = –2.012 (P < .041).

18 observations, 9 males, 9 females; Spearman r = .739 (P < .001); lower average estimate of 3.44 points in KBIT, Dt 12.43, sign test Z = –.236 (P < .815).

The results support high validity regardless of age management KBIT, although IQ scores obtained before 8 years should be considered with caution. The KBIT has the advantage of its shorter evaluation, however the information obtained from WISCr is wider.

The authors have not supplied their declaration of competing interest.

Although prenatal maternal smoking is an established risk factor for offspring's attention deficit hyperactivity disorder (ADHD), the studies of association between paternal smoking and childhood ADHD have produced inconsistent results.

The objective of the present study was to determine whether paternal smoking during early developmental period is associated with an increased risk of offspring's ADHD.

We conducted hospital-based case-control study with 107 medically diagnosed ADHD cases and 205 controls (aged 6–12 years). The diagnoses of ADHD were assessed with DSM-IV based semi-structured diagnostic interviews. Paternal smoking behavior was assessed with spouse-report questionnaire. The association between exposure to paternal smoking and ADHD were analyzed using multivariate logistic regression analysis. The primary outcome of interest was an odds ratio (ORs) reflecting the risk of offspring's ADHD incidence associated with father's smoking during the index pregnancy, up to one year after birth, and current smoking status. Control variables in our regression model were age, sex, financial status, parents’ education levels, low birth weight, and premature birth.

Our final regression model revealed that paternal smoking during pregnancy (OR = 1.68, 95% CI = 1.03–2.76) and up to one year after birth (OR = 1.69, 95% CI = 1.04–2.77) were significantly related to their offspring's ADHD.

The current results suggest that exposure to paternal smoking during the fetal and newborn period is associated with increased risk of ADHD. This study warrants public health policies to reduce children's exposure to secondhand smoke and their risk of ADHD.

The authors have not supplied their declaration of competing interest.

The association between parental severe mental illness (SMI) and depression in offspring may be due to genetic liability or adverse environments. We investigated the effect of parental SMI, SES, and adversity on depression in a sample of youth enriched for familial risk of mental illness.

We assessed 217 youth (mean age 11.95, SD 4.14, range 6–24), including 167 (77%) offspring of parents with SMI. We measured exposure to childhood maltreatment and bullying with the Juvenile Victimization Questionnaire (JVQ) and Childhood Experiences of Care and Abuse (CECA) interview.

In total, 13.36% participants reported significant bullying and 40.76% had a history of childhood maltreatment. Rates of bullying and maltreatment were similar in offspring of parents with and without SMI. Maltreatment likelihood increased with decreasing socioeconomic status. Exposure to bullying (OR = 3.11, 95%CI 1.08–8.88, P = 0.03) predicted depression in offspring more strongly than family history of SMI in parents.

Adversity, such as maltreatment and bullying, has a stronger impact on the risk of developing depression than family history of mental illness in parents. These adverse experiences are associated with socioeconomic status rather than parental mental illness.

The authors have not supplied their declaration of competing interest.

In the last years, there has been a paradigm shift in the educational system of young people with disabilities. Regular schools associated with specific support plans have become the destination of choice for these adolescents, instead of schools with special education. This integrated teaching seeks to reduce stigma and to promote tolerance but frequently these students become easy targets of psychological and physical violence or discrimination.

To evaluate the integration of adolescents with disabilities in mainstream education compared to special teaching.

Analysis of 32 patients with disabilities from the adolescence consultation of the psychiatry service of hospital de Santa Maria, between January 2015 and September 2016.

About 30% of the adolescents with disabilities who attend regular schools with special support complains of poor adjustment associated with some kind of mistreatment by peers.

Violence among students in school is a current problem very difficult to fight. Young people with disabilities often find themselves in a significant minority presenting less efficient defense mechanisms. If unprotected, they may easily develop school phobia or refusal. These situations must be identified and avoided to prevent the associated suffering.

The authors have not supplied their declaration of competing interest.

Irritability is the most frequently reported symptom in child and adolescent depression. The association of both has been linked with high rates of chronicity, comorbility and impairment.

To study the association between irritability and depressive symptoms in children and adolescents.

We have studied 857 participants recruited from the only child and adolescent mental health clinic in a catchment area of 122,968 people under 18 (2004–2010). A sample of 857 participants (112 controls and 745 patients) was included to carry out a cross-sectional study. Irritability was measured by a Visual Analog Scale (VAS irritability)–scored from 0 to 10–, and depressive symptoms by the Children's Depression Inventory (CDI). The participants were categorized into controls and patients, and according to their irritability (≤ 4 [I], 5 [II] and ≥ 6 [III]). The mean of CDI score was calculated for each of the groups, adjusted by sex and age, and analyzed by ANCOVA.

The following means were obtained from the controls: 13,71 (group I), 9,82 (group II) and 17,45 (group III). Regarding to the patients: 13,92 (group I), 11,54 (group II) and 15,64 (group III). A quadratic association (P < 0.0015) was found between VAS irritability score and CDI score.

There is not a linear association between irritability and depressive symptoms in children and adolescent. High rates of depressive symptoms were associated both with high and low rates of irritability. Several questions remain unexplained about the status of irritability in psychiatry, as Stringaris group has been pointed out.

The authors have not supplied their declaration of competing interest.

The authors have not supplied their declaration of competing interest.

several ethipathogenic hypotheses in ASD deal with the traits of parents. The objectives of our study were to measure the ADHD and autism spectrum disorder quotients in parents of children diagnosed with ASD comorbid with ADHD and to correlate the measurements for the tests in parents with those in their children. The specific aim was to identify whether any significant correlations exist.

Fifty-two pairs of parents of children with autism spectrum disorders and ADHD were included in this study, based on informed consent and the ethical committee's approval. The child's diagnosis was established by a specialist in child and adolescent psychiatry, based on the child's clinical symptoms and on specific diagnostic scales, such as the ADOS and ADHD-rating scale. The parents completed an Autism Spectrum Quotient Scale (ASQS) and an adult ADHD scale. The data were analyzed using SPSS 22.0 and Excel. The correlations were verified using Spearman's non-parametric correlation test.

There was a strong correlation between the parents’ ADHD scores (r = 0.5, P < 0.001), and a reverse medium correlation between the mother's ADHD score and the child's ADOS score (r = –0.32, P = 0.02). The father's ASQS and ADHD scores correlated between each other (r = 0.31, P = 0.02). There were no correlations between the parents’ and the child's ADHD score, nor between the child's ADOS score and the parents’ ASQS scores.

Our results suggest that ADHD symptoms in parents of children with autism spectrum disorders comorbid with ADHD might be predictors for the child's prognosis.

The authors have not supplied their declaration of competing interest.

The phenomenon of non-suicidal self-injury (NSSI) as an act of deliberate destruction of body tissue without suicidal intent is common in adolescence. NSSI and suicide attempts (SA), although distinct behaviors differing in intent, form and function, often co-occur in the same individual.

Recent studies investigate the association between SA and NSSI among adolescent, as well as risk factors associated with these phenomenon. We investigated the co-ccurrence of NSSI and SA among adolescents treated in hospital during the previous year.

We conducted a cross-sectional study among hospitalized adolescents in the Clinic for mental disorde “Dr Laza Lazarevic”, aged 14 to 18 years, in the period from 01.01.2015 to 01.01.2016. The data were obtained from clinical interviews of patients.

Study included 146 adolescents, 51.4% male and 48.6% female, average age 15.5. We found a statistically significant difference of NSSI (c2 = 9.951, P = 0.002, phi = 0.276) and SA (c2 = 4.517, P = 0.034, fi = 0.192) among female adolescent. The co-occurrence of NSSI and SA was found in 4.8% of adolescents, which does not indicate a statistically significant difference (c2 = 1.009, P = 0.315, phi = –0.101) compared to the total population of hospitalized adolescents.

Although our study did not confirmed a higher incidence of SA in adolescent with NSSI, understanding of what percentage of those engaging in NSSI also make SA, and how they are related have great significance in their prevention taking into account the dangerousness and lethality of those behavior.

The authors have not supplied their declaration of competing interest.

Mental health problems are highly prevalent and are associated with a high burden, but such problems are often left untreated. This is referred to as the “treatment gap”. The question of who is most likely to remit from their mental health problems without treatment has received surprisingly little attention. A few studies do suggest that untreated remission is common in the general population, but these are in particular limited by short follow-up times.

The aims of this study are to describe untreated remission of mental health problems in adolescence, and to assess the extent to which mental health problems recur after untreated remission.

Data from the Dutch community-based cohort study TRacking Adolescents’ Individual Lives Survey (TRAILS) were used. Depressive and anxiety problems were assessed using the Youth Self-Report at ages 11, 13, and 16, and the Adult Self-Report at ages 19 and 22.

Preliminary analyses show high rates of untreated remission (approximately 80% over all waves). However, a substantial proportion of remitted cases still report sub clinical levels of mental health problems at follow-up. More elaborate analyses are ongoing, and will be presented at the conference.

First results suggest that untreated remission is common in adolescents. The presence of residual symptoms may point towards an elevated risk of recurrence in adolescents who remit without treatment. Further knowledge about untreated remission is of vital importance for an accurate assessment of the treatment gap, and for prevention and early intervention programmes.

The authors have not supplied their declaration of competing interest.