The Yin-Yang represents two opposing and complementary traits of nature such as introvert-extrovert and passive-active, and has been primary framework of medicine for thousands of years in the East. The purpose of this study was to examine the problem behaviors of the middle school students, which is a major social and psychopathological issue in Korea, from the Yin-Yang temperaments.

Subjects of 670 middle school students (365 boys and 305 girls) finished Korean version of youth self-report (YSR) for describing the problem behaviors and Sasang personality questionnaire (SPQ) for measuring Yin-Yang temperament. The high (30%) and low (30%) SPQ score groups were shown to represent Yin and Yang temperament groups with acceptable reliability and validity. We examined the correlation between YSR and SPQ, and YSR subscale differences between high and low SPQ score groups.

The SPQ significantly (P < 0.01) correlated positively with YSR externalizing problem (r = 0.148, r = 0.182) and negatively with YSR Internalizing Problem (r = −0.212, r = −0.177) in boys and girls, respectively. The Yang temperament group (8.42 ± 6.24, 8.36 ± 6.59) is significantly (P < 0.01) higher than Yin group (6.17 ± 4.82, 5.83 ± 5.32) in Externalizing Problem, and the Yin temperament group (9.55 ± 7.72, 11.38 ± 8.18) is significantly (P < 0.01) higher than Yang group (6.01 ± 5.95, 8.28 ± 7.49) in Internalizing Problem with boys and girls, respectively.

These results showed that the Yin-Yang temperament of traditional eastern medicine might be clinically useful for screening psychopathological problems in adolescents. Implications and suggestions for cross-cultural psychological study of the East and West are also suggested.

The authors have not supplied their declaration of competing interest.

At least half of first depressive episode appear before adulthood. A negative cognitive bias is present among individuals who suffer from major depression. This bias is also reported among individuals at high risk of major depression (e.g. child of depressed mother). When present, cognitive vulnerability may predispose to major depression. No study to date aimed to evaluate the cognitive vulnerability of siblings of depressed individuals.

To review the principles behind cognitive vulnerability. To assess cognitive vulnerability in depressed adolescents, in healthy siblings and in a control group.

Eighty adolescents (27 adolescents treated for depression, 24 healthy siblings and 29 controls), aged between 12 and 20 years old, were recruited and assessed using validated measures of bio-psycho-social vulnerabilities. All diagnoses were confirmed using a K-SADS interview. Cortisol level samples were obtained through morning saliva. Cognitive vulnerability was assessed using self-report questionnaires (CES-D, LEIDS-R, EPQ) as well as computer-based tasks (Ekman's tasks of facial recognition and the movie for assessment of social cognition [MASC]). We translated the MASC from German to French. The parents of the adolescents also filled the LEIDSR and the CESD.

The LEIDS-R presented a significant increase in certain subscales (hopelessness, aggression and rumination) compared to the healthy siblings and the controls. Interestingly, there was also a correlation between the LEIDS R results of the parents and of the depressed adolescent (r = 0.43, P = 0.04).

The LEIDSR appears to be the most sensitive task to detect cognitive vulnerability. A relation between the parent response and the depressed adolescent response could be found.

The authors have not supplied their declaration of competing interest.

Few studies examine comorbidity in a pediatric population. This poster presents results that extend our understanding of the relationship between mental disorder and physical disorders using a population-based study approach.

To review the evidence behind comorbidity of psychiatric disorders and other medical disorders. To propose an informatic approach that evaluates those comorbidity on a population-scale.

Using an informatics approach, a dataset containing physician billing data for 235,968 (51% male) individuals up to 18 years old spanning sixteen fiscal years (1994–2009) in Calgary, Alberta, was compiled permitting examination of the relationship between physical disorders and mental disorders, based on the International classification of diseases (ICD).

All major classes of ICD physical disorders had odds ratios with confidence intervals above the value of 1.0, ranging from 1.08 (Perinatal Conditions in 4–6 year olds) to 4.95 (Respiratory Conditions in 0-3 year olds). Distinct major class ICD disorder patterns arise in comparing all children with adults and specific age strata for those under 19 years of age.

This study represents the first evidence reported in a population-based data set of the effect of mental disorders on each major class of ICD diagnoses related to a physical disorder. The focus on the early intertwinements between physical and mental disorders in a pediatric population may help to target strategic areas for future research and investment.

The authors have not supplied their declaration of competing interest.

Our work comprises an integrated intervention strategy for the treatment of psychotic manifestations and functioning in adolescents which, following the theories of Laufer and Chan, questions the usefulness of the diagnosis ‘psychotic’ during adolescence. We apply an “open light treatment” (IPOLT), which includes psychodynamically oriented peer-support.

To build a new form of therapeutic alliance with peer-support based on shared real life experiences enabling adolescents to reintegrate within their environment and re-establish cognitive functioning which has become disorganised, aiding a gradual return of the cohesion of ego and self and in some cases, cessation of psychotic symptoms.

An observational study of one year on a group of ten adolescents aged 17 to 20 in institutional and private settings with psychotic manifestations and functioning. The group were tested at the start and end of the study using WAIS-IV and MMPI-A.

The adolescents recruited showed a faster recovery of the cohesive processes of their fragmented ego as well as a quicker resumption of social relations. Our model provided an organising function and a flexible yet secure ‘container’ (Bion, 1988) for the young people's psychic structure. The tests showed a demonstrable improvement in their verbal comprehension, visual-spazial reasoning, fluid reasoning, working memory and processing speed.

Psychotic manifestations occurring in adolescence may decrease with an immediate integrated and rehabilitative intervention, without need of an institutional psychiatric setting. In conclusion, we find that “psychosis” in adolescence is a prognosis and not a diagnosis.

The authors have not supplied their declaration of competing interest.

Vitamin D deficiency is widespread globally in pregnant women and is suggested to contribute to offspring risk of symptoms of autism spectrum disorders (ASD), but findings are inconsistent.

To investigate whether low prenatal 25OHD exposure and 25OHD status in early life increase risk of early symptoms of ASD.

To investigate early signs of ASD.

From the prospective birth cohort, Odense child cohort (n = 2.549), Denmark, we included singletons with their mothers with available serum concentrations of 25OHD at early pregnancy (n = 1.231), late pregnancy (n = 1.361), and birth (n = 2.082). ASD symptoms were rated by parents on the pervasive developmental problem (PDP) scale of the Child behavior checklist for ages 1½-5 (CBCL 1½-5). Associations between 25OHD and PDP score were analyzed by multiple linear and logistic regression models. A priori included covariates were gestational age, child gender, birth weight, season of birth, parity, parental psychiatric diagnoses, maternal age, smoking habits, alcohol consumption, education level, vitamin D supplementation, and pre-gestational BMI.

Means (SD) of 25OHD for early pregnancy, late pregnancy, and cord were 65.5 (21.5), 78.7 (27.0), and 47.0 (21.7) nmol/L, respectively. PDP data were obtained at a mean (SD) of 2.7 (0.6) years of age. Data from the regression analyses are pending.

In this well-off cohort with relatively high levels of cord 25OHD, power calculations allows us to detect a true change of 0.02 PDP scores per 10 nmol/L change in 25OHD. Further studies will clarify whether early PDP scores track later ASD diagnosis.

The authors have not supplied their declaration of competing interest.

Suicide in children and adolescents is commonly underreported and studied. It is an interplay area of multiple static (sociodemographic), and modifiable (impulsivity, psychiatric morbidities, adverse life events (ALE), abuse, bullying) variables.

To assess and identify relative significance of dependent and independent risk factors in youngsters attempting self-inflicted poisoning.

Consecutive recruitment of patients aged 7–18, with normal IQ, admitted to poison control centre over 13 continuous months, with self-induced poisoning. All were assessed after guardians’ written informed consent for different risk factors identified for suicidal behavior using appropriate scales (PPS, SRRS-Y, FSSCS, BIS-11, J-TCI, Mini-Kid). Controls with no history of suicidal attempt were matched for age, sex and sociodemographics among their families.

One hundred and twenty cases (16.7 years ± 1.6 SD, 91% females) and 100 controls (age 16.4 years ± 1.7 SD, 90.8% females) were assessed. In cases, 90.8% were of low/middle socioeconomic status, 73.5% had previous attempt, average within 10 months, 17.5% planned their attempt, 10.8% had a witnessed attempt. Stressor within 2 days was reported in 75.9%, severe in 40%. Impulsivity was more in its cognitive, planning and motor components (P = 0.001 in each) among attempters. Cases scored more on Novelty seeking, harm avoidance and reward dependence than controls who had more persistence, self-directedness and cooperativeness. Attempters had significantly more past medical and psychiatric history (P = 0.001, 0.05 respectively), 77.5% had a working psychiatric illness, 2% in controls.

Repeated suicidal attempts were the majority, with impulsivity as a predictive risk, especially if psychiatric morbidity or ALE in youths were encountered.

The authors have not supplied their declaration of competing interest.

The authors have not supplied their declaration of competing interest.

The last two decades increase in early detection and diagnosing children with autism spectrum disorders (ASD) has challenged child and youth habilitation centers to offer the best and most appropriate treatment and support.

To evaluate an ongoing Comprehensive Intensive Early Intervention (CIEI) program for children with ASD based on principles of behaviour learning and developmental science, implemented in the child's natural setting.

The change in autism symptoms among children participating in CIEI (intervention group, n = 67) was compared with children who received traditional habilitation services only (comparison group, n = 27). Symptom changes were measured as evaluation-ADOS-R-scores, total-, severity-, and module-adjusted-scores (ADOS-MAS), minus the corresponding baseline-scores, divided by the time between baseline and evaluation, and estimated using ANOVA adjusting for confounders. The ADOS-MAS were developed to allow improved communicative functions to be counted in the overall symptom improvement.

Children in both study groups improved their autism symptoms as measured with the ADOS-MAS, and the improvement was statistically significantly larger among children without any developmental delay (P < .001). When adjustments were made for developmental delay, there was a statistically significant larger improvement of ADOS-MAS among children in the intervention group than in the comparison group (P = 0.047). Similar results were found for ADOS-R-total and ADOS-severity scores (P = 0.023 and P = 0.060. respectively).

The results of the current study indicate that the CIEI program significantly improve social and communicative skills among children with autism, and that children with developmental delay could benefit to a similar degree as other children.

The authors have not supplied their declaration of competing interest.

The aim is to analyse the frequency emotional and behavioural problems early adolescents and association with socio-demographic risk factors.

We analysed a group of 240 early adolescents (11–15 years) from the area of Tuzla Canton, Bosnia and Herzegovina, in the general population. For the assessment of children's emotional and behavioural problems, the Strength and Difficulties Questionnaire – SDQ is used. Data were processed by descriptive statistics. For the assessment association between socio-demographic risk factors and emotional and behavioural problems in early adolescents we used Pearson correlation test.

The result show that the frequency of emotional and behavioural problems are present in 3% of cases, The results of correlation sociodemographic risk factors and emotional and behavioral problems, showed that unemployed mothers have a significant increased risk of developing behavioral disorders in early adolescents (P < 0.05). Low family economic status leads to a significantly higher frequency of emotional symptoms in early adolescents, poor attitude towards society and significantly higher overall difficulties (P < 0.05). Higher levels of parental education was significantly associated with a higher frequency of behavioral problems and illness in the family leads to a much more emotional problems (P < 0.05).

The obtained results of this study indicate that early adolescents showed low levels of emotional and behavioral problems. There is a significant correlation between socio-demographic risk factors and emotional and behavioral problems early adolescents.

The author has not supplied his/her declaration of competing interest.

The authors have not supplied their declaration of competing interest.

Individuals with attention-deficit/hyperactivity disorder (ADHD) may require long-term medication.

To measure growth and sexual maturation of children and adolescents with ADHD receiving lisdexamfetamine dimesylate (LDX) in a 2-year trial (SPD489-404).

To investigate the impact of long-term LDX treatment on growth and maturation.

Participants (6–17 years) received dose-optimized, open-label LDX (30–70 mg/day) for 104 weeks. Weight, height and BMI z-scores were derived using the Centers for Disease Control and Prevention norms [1]. Sexual maturation was assessed using the Tanner scale (participant-rated as closest to their stage of development based on standardized drawings).

Of 314 enrolled participants, 191 (60.8%) completed the study. Mean z-scores at baseline and last on-treatment assessment (LOTA) were 0.53 (standard deviation, 0.963) and 0.02 (1.032) for weight, 0.61 (1.124) and 0.37 (1.131) for height, and 0.32 (0.935) and–0.27 (1.052) for BMI. In general, z-scores shifted lower over the first 36 weeks and then stabilized. At LOTA, most participants remained at their baseline Tanner stage or shifted higher, based on development of hair (males, 95.5%; females, 92.1%) or genitalia/breasts (males, 94.7%; females, 98.4%).

Consistent with previous studies of stimulants used to treat ADHD [2], z-scores for weight, height and BMI decreased, mostly in the first year, then stabilized. No clinically concerning trends of LDX treatment on sexual maturation or the onset of puberty were observed.

Study funded by Shire Development LLC.

Dr Isabel Hernández Otero (Alicia Koplowitz Foundation, Eli Lilly, Forest, Janssen-Cilag, Junta de Andalucia, Roche, Shire, Shire Pharmaceuticals Iberica S.L., and Sunovion).

The purpose of this study was to verify the effect of Cognition Enhancement Program (CEP) using toy-robot for children aged 5–10 years. We thought that CEP using toy-robot might be a more kids-friendly method for improving cognitive ability than traditional programs. The enhancement of cognitive functions such as attention, response inhibition, memory, and working memory after the cognition training were the focus of the study.

One hundred and twenty children aged 5 to 10 were ramdomly assigned to 3 groups: (1) experimental group receiving CEP training using toy-robot, (2) control group receiving previously developed internet-based cognitive training, (3) waiting list. The children of experiment and control groups received individual 8 training sessions. The effect of the program was measured with Smart Toyweb's cognitive assessment tools we had developed (smart device based assessment) as well as traditional neuropsychological tests throughout 3 times (pre-training, post-training, and 1-month follow-up).

The training is in progress since it started in October 2016. We observed some of children on the CEP training tend to show improvement of cognitive function. The final assessment is planned for February 2017.

The CEP using toy-robot could be very promising and useful in that it is a non-invasive and non-pharmacological treatment for children with attention or memory problem in home and clinical settings.

The authors have not supplied their declaration of competing interest.

Multidisciplinary guidelines in adolescent mental health care are based on RCTs, while treatment efficacy can be different from effectiveness seen in ‘the real world’. Studies in the real world conducted so far suggest that treatment has a negligible effect on follow-up symptomatology. However, these studies did not incorporate the pre-treatment trajectory of symptoms nor investigated a dose-response relationship.

To test whether future treatment users and non-users differed in emotional and behavioural problem scores, whether specialist mental health treatment (SMHT) was effective in reducing problem levels while controlling for pre-treatment trajectory, and to seek evidence of a dose-response relationship.

Six-year follow up data were used from the Tracking Adolescents’ Individual Lives Survey (TRAILS). We identified adolescents with a clinical level of problem behaviour on the Child Behaviour Checklist or Youth Self Report and first SMHT between the ages 13 and 16. Adolescents with a clinical level of problem behaviour but without SMHT use served as control group. A psychiatric case register provided data on number of treatment contacts. Using regression analysis, we predicted the effect of treatment on post-treatment problem scores.

Treated adolescents more often had a (severe) diagnosis than untreated adolescents. Pre-treatment trajectories barely differed between treated and untreated adolescents. Treatment predicted an increase in follow-up problem scores, regardless of the number of sessions.

The quasi-experimental design calls for modest conclusions. We might however need to take a closer look at real-world service delivery, and invest in developing treatments that can achieve sustainable benefits.

The authors have not supplied their declaration of competing interest.

Perceived competence (PC) is a self-perception of an individual in its capabilities and ability to control his environment. It is posited to orient individuals to the possibility of success and to facilitate the adoption of approach goals.

We aimed to assess the PC of adolescents engaged in prosocial activities and to determine factors that influence it.

We led a transversal study, over four months, from June until September 2016. It included 90 adolescents aged 14–20 years and members of voluntary association in Sfax (Tunisia). PC was assessed using the “perceived competence in life domains” (PCLD) for the life spheres of leisure, interpersonal relationships, school, and general domains.

The average age of participants was 16 (14 to 20 years). The sample was female-dominated (53%). All participants were secondary school pupils. Almost 70% were from a high socio-economic level and over 60% had parents’ high level of education.

The mean scores of PC ranged from 19 (SD = 5.4) in leisure domain to 16 (SD = 4) in interpersonal relationships domain. PC was significantly correlated with socio-economic level (P = 0.00), participating in sports and extra- curricular activities (P = 0.00), academic proficiency (P = 0.01) and smoking (P = 0.00).

Overall, our results evidenced the positive self-perception of competence among adolescents having prosocial activities. It indicated that high socio-economic level, participating in sports and extra-curricular activities and smoking were enhancing factors of adolescents PC.

The authors have not supplied their declaration of competing interest.

The occurrence of acute leukemia (AL) in childhood causes a profound upheaval in the child itself and also within his family. Exposure to this test could contribute to the emergence of anxiety.

Our work aims to describe the characteristics of anxiety in this population during the management of the AL.

Our study, still in progress, is prospective and conducted among 20 children hospitalised in hematology department of UMC Hedi Chaker Sfax (Tunisia) during the year 2015–2016. It is performed in two times. The anxiety was assessed using the STAI scale.

The average age of our population is 7 years (minimum age = 4 years, maximum age = 11 years). The majority of our patients come from urban areas (76.9% of cases). About their sibling rank, they are mostly the youngest in 53.8% of cases, the oldest in 30.8% of cases and juniors in 7.7% of cases. The most common diagnosis is the lymphoblastic B AL (46.2% of cases).

Referring to the STAI scale, 30% of our patients were anxious and had high scores during the first evaluation. Then, the anxiety level attenuates gradually during management period and only 15% were anxious at the 2nd evaluation time.

Several factors such as hospitalisation, diagnosis announcement and cancer treatment contribute to the triggering and maintaining of anxiety. Early detection of anxiety and the good listening between the care team and the parents could appease the high level of anxiety and ensure better management.

The authors have not supplied their declaration of competing interest.

Most parents to children with Autism Spectrum Disorder (ASD) can report concerns about their child's development within the first year of life. In spite of this, children with ASD are rarely diagnosed before the age of 3–4 years. Early identification allows early intervention, which seems to be substantial for improvement of core behavioural symptoms in children with ASD. The Child Behaviour Checklist for ages 1½ to 5 (CBCL/1½–5) have shown promising utility for early detection of children with ASD.

This study will estimate the positive predictive value of CBCL/1½–5 Pervasive Developmental Problems (PDP) scale in a 2 phase screening study. Furthermore, it will analyse the stability of the CBCL/1½–5 PDP-score in pre-school children from 2½ to 5 years.

The present study aims to validate CBCL/1½–5 for early screening of ASD in a general population sample.

Parents, enrolled in the Odense Child Cohort (OCC), answered the CBCL/1½–5 when the child reached 27 months of age. Parents with children above the age of four and a raw score ≥5 (90th percentile) on the PDP scale, received the Social Responsiveness Scale (SRS) questionnaire. Children with a high score on the SRS were invited to a clinical examination consisting of ADOS and ADI-R. Children in OCC were re-assessed with CBCL/1½–5 again at age five years.

Results will be presented at the EPA conference 2017 in Florence.

The results may contribute to enhance the outcome of treatment by detecting children with ASD at an earlier age.

The authors have not supplied their declaration of competing interest.

Substance use disorders (SUD) are common in adults with ADHD. A co-occurring ADHD diagnosis is associated with poorer treatment outcomes for both the ADHD and the SUD and higher rates of relapse to substance use.

To explore the relationship between ADHD and SUD longitudinally to identify factors to help improve treatment outcomes.

Prevalence of ADHD symptoms was investigated in a national cohort of SUD patients one year after SUD treatment initiation. Factors at baseline related to ADHD symptoms were explored at follow up.

Five hundred and forty-eight individuals were interviewed in a multi-center study involving 21 treatment facilities at treatment initiation and one year later (n = 261). ADHD symptoms were measured by the Adult ADHD Self Report Scale (ASRS-v.1-1) at follow-up. Individuals who screened positively for ADHD (ADHD + ) were compared to those who screened negatively on baseline variables. Emotional distress was measured by Hopkin's Symptom Check List-25.

At follow-up 35% screened positively for ADHD. In bivariate analysis the ADHD+ group was older, was less likely to have children, reported lower educational level, had more frequent use of stimulants, cannabis and benzodiazepines, and experienced higher degree of emotional stress. When controlling for other significant variables in a logistic regression analysis, the ADHD+ group was associated with more frequent use of cannabis (OR 2.14; CI 1.08–4.23) and of higher psychiatric symptom burden (OR 1.79; CI 1.22–2.61).

A high prevalence of ADHD symptoms and associated challenges underline the importance of systematic screening of individuals entering SUD treatment.

The authors have not supplied their declaration of competing interest.

Study the impact of substance use disorders (SUD) co-morbidity on the duration of undiagnosed bipolar disorder (DUBP).

Case-control study during a period of six months from July 2015 to December 2015. One hundred euthymic patients with BD (type I, II or unspecified) were recruited in the department of psychiatry C Razi Hospital, during their follow-up. Two groups were individualized by the presence or not of a SUD co-morbidity. In our study DUBP was defined as the period between the first symptoms and the beginning of treatment by a mood stabilizer.

The beginning of addictive behaviour preceded the installation of bipolar disease in 32% of cases. Installation of bipolar disorder preceded the installation of addictive behaviour in 12% of cases. The beginning of addictive behaviour was concomitant with the installation of bipolar disease in 6% of cases. The average DUBP in the full sample was 4.80 years with a standard deviation of 8.04 and extremes ranging from 0.08 to 37.5.

The average DUBP in patients with SUD co-morbidity was 5.91 years with a standard deviation of 8.16 and extremes ranging from 0.08 to 35, and 3.68 years with a standard deviation of 7.84 and extremes ranging from 0.08 to 37.5 in patients without SUD co-morbidity.

According to studies over two thirds of patients with bipolar disorder received misdiagnoses before diagnosis of BD, and among the factors involved can report the presence of SUD co-morbidity. Hence, we should detect BD among patients with SUD.

The authors have not supplied their declaration of competing interest.

Smoking is a serious health problem for people with mental illness like the bipolar disorder patients. The developmental of motivational tools such as brief intervention it is necessary in the context of community care.

Evaluating the change in motivational stage after brief intervention and evaluating the clinical and smoking factors in relation with this.

Two hundred and twenty patients diagnosed with bipolar disorder (according DSM-5 criteria) that were in the euthymic phase (defined as less than 7 points in YMRS and 10 points in HDRS) and attended the community care centers of three provinces of Andalusia (Spain). Patients who consumed in the last month qualified for the level of motivation for change (measured by URICA scale).

After brief intervention the 29.3% of the smoking patients change in their motivational stage. The results of the multivariate analysis showed three factors in relation with dificultar the progression of the evolution of motivation to change. The high punctuation in Hamilton anxiety scale (OR = 0.53; IC95%, P = 0.002), the high puntuation in the Fageström scale (OR = 0.56, IC95%, P = 0.01), and have high autoperception of the capacity of change (OR = 0.52; IC95%, P = 0.002).

The anxiety (measure with Hamilton anxiety scale) plus factors in relation with smoking, like the puntuation in Fagestrom scale and the autoperception of the capacity of change decrease the possibilities to change.

The authors have not supplied their declaration of competing interest.

Adults with Intellectual disability (ID) and Autism Spectrum Disorder (ASD) are more vulnerable to mental health problems than the general population.

This study investigates presence and rate of psychiatric disorders in comparison with ID or ASD alone, and appropriateness of assessment and diagnostic procedures or tools.

A systematic mapping of the literature was carried out on the basis of the above mentioned issues. The search was conducted using PubMed and ScienceDirect, according to the following keywords: psychiatric comorbidity, psychiatric disorders, autism, ASD, intellectual disability, mental health problems, adults, assessment tools, diagnosis. Twenty-eight papers were selected for pertinence to mapping issues among more than 500.

Many studies show that ASD is an important vulnerability factor for psychiatric co-morbidity and for challenging behaviors (CBs) in adults with ID. Highest rates were reported for psychotic, mood, anxiety, and obsessive-compulsive disorders. Few studies show that the difference between adults with ID plus ASD and adults with only ID are not statistically significant, but for the presence of CBs in those with ID plus ASD. The disagreement of results is based on a variety of factors such as diagnostic over-shadowing, scarcity of specific assessment tools, consideration of the introspective and communication difficulties, incompleteness of medical records, and low reliability of information sources.

Although low studies concordance, the literature mapping suggests the presence of ASD in ID to be associated with higher rates of psychopathology. Since the relevant implications for prevention and clinical management, further research with high-level evidence is hoped.

The authors have not supplied their declaration of competing interest.