Book contents
- Non-Motor Parkinson’s Disease
- Non-Motor Parkinson’s Disease
- Copyright page
- Contents
- Contributors
- Introduction
- Chapter 1 Parkinson’s Disease: An Overview of the Non-Motor Symptomatology
- Chapter 2 Evaluation of the Patient with Parkinson’s Disease in the Early Stages: Non-Motor Phase
- Chapter 3 Non-Motor Symptoms in Late-Stage Parkinson’s Disease
- Chapter 4 Neuropathology of Non-Motor Parkinson’s Disease Symptoms
- Chapter 5 Neuroimaging Studies in Non-Motor Parkinson’s Disease Symptoms
- Chapter 6 Mild Cognitive Impairment
- Chapter 7 Cognitive Dysfunction in Parkinson’s Disease
- Chapter 8 Neuropsychiatric (Behavioral) Symptoms in Parkinson’s Disease
- Chapter 9 Mood Disorders in Parkinson’s Disease
- Chapter 10 Olfactory Dysfunction in Parkinson’s Disease and Related Disorders
- Chapter 11 Oculomotor and Visual-Vestibular Disturbances in Parkinson’s Disease
- Chapter 12 Autonomic Dysfunction and Failure in Parkinson’s Disease
- Chapter 13 Gastrointestinal Disturbances in Parkinson’s Disease Including the Management of Sialorrhea
- Chapter 14 Sexual Dysfunction in Parkinson’s Disease
- Chapter 15 Sleep Disturbances in Parkinson’s Disease
- Chapter 16 Musculoskeletal Disorders and Pain in Parkinson’s Disease
- Chapter 17 Cutaneous Manifestations of Parkinson’s Disease
- Chapter 18 Genetics of Non-Motor Symptoms of Parkinson’s Disease
- Chapter 19 Drug-Induced Non-Motor Symptoms in Parkinson’s Disease
- Chapter 20 Impulse Control Disorders and the Dopamine Dysregulation Syndrome
- Chapter 21 Serotonin Syndrome and Drug Interactions, Hypertensive Complications, and, Adverse Effects of Monoamine Oxidase Inhibitors in Patients with Parkinson’s Disease
- Chapter 22 Parkinson’s Disease and Pregnancy
- Index
- Plate Section (PDF Only)
- References
Chapter 4 - Neuropathology of Non-Motor Parkinson’s Disease Symptoms
Published online by Cambridge University Press: 05 March 2022
- Non-Motor Parkinson’s Disease
- Non-Motor Parkinson’s Disease
- Copyright page
- Contents
- Contributors
- Introduction
- Chapter 1 Parkinson’s Disease: An Overview of the Non-Motor Symptomatology
- Chapter 2 Evaluation of the Patient with Parkinson’s Disease in the Early Stages: Non-Motor Phase
- Chapter 3 Non-Motor Symptoms in Late-Stage Parkinson’s Disease
- Chapter 4 Neuropathology of Non-Motor Parkinson’s Disease Symptoms
- Chapter 5 Neuroimaging Studies in Non-Motor Parkinson’s Disease Symptoms
- Chapter 6 Mild Cognitive Impairment
- Chapter 7 Cognitive Dysfunction in Parkinson’s Disease
- Chapter 8 Neuropsychiatric (Behavioral) Symptoms in Parkinson’s Disease
- Chapter 9 Mood Disorders in Parkinson’s Disease
- Chapter 10 Olfactory Dysfunction in Parkinson’s Disease and Related Disorders
- Chapter 11 Oculomotor and Visual-Vestibular Disturbances in Parkinson’s Disease
- Chapter 12 Autonomic Dysfunction and Failure in Parkinson’s Disease
- Chapter 13 Gastrointestinal Disturbances in Parkinson’s Disease Including the Management of Sialorrhea
- Chapter 14 Sexual Dysfunction in Parkinson’s Disease
- Chapter 15 Sleep Disturbances in Parkinson’s Disease
- Chapter 16 Musculoskeletal Disorders and Pain in Parkinson’s Disease
- Chapter 17 Cutaneous Manifestations of Parkinson’s Disease
- Chapter 18 Genetics of Non-Motor Symptoms of Parkinson’s Disease
- Chapter 19 Drug-Induced Non-Motor Symptoms in Parkinson’s Disease
- Chapter 20 Impulse Control Disorders and the Dopamine Dysregulation Syndrome
- Chapter 21 Serotonin Syndrome and Drug Interactions, Hypertensive Complications, and, Adverse Effects of Monoamine Oxidase Inhibitors in Patients with Parkinson’s Disease
- Chapter 22 Parkinson’s Disease and Pregnancy
- Index
- Plate Section (PDF Only)
- References
Summary
Lewy body disease, an α-synucleinopathy, is the neuropathological counterpart of idiopathic Parkinson’s disease and one of the most frequent neurodegenerative diseases in humans [1]. Parkinson’s disease features compelling motor symptoms. Parkinson summarized these symptoms under the mixed Greek-Latin term paralysis agitans (shaking palsy) [2], and for decades, these motor symptoms described by Parkinson remained the most studied features of Lewy body disease.
However, autonomic dysfunctions and non-motor symptoms associated with Lewy body disease are frequent and often pre-date the onset of motor diseases [3]. Autonomic dysfunctions comprise constipation, bowel dysfunction, seborrheic face, dysphagia, dysarthria, impotence, urinary frequency, bladder dysfunction, orthostatic hypotension, and increased sweating. Other non-motor symptoms include sleep disorders (REM behavior disorder, vivid dreams, daytime drowsiness, sleep fragmentation cognitive impairment, bradyphrenia, tip-of-the-tongue (word-finding) phenomenon, depression, apathy, anhedonia, fatigue, behavioral and psychiatric problems, sensory symptoms including anosmia, ageusia, pain (shoulder, back), and paresthesias [4].
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- Non-motor Parkinson's Disease , pp. 35 - 45Publisher: Cambridge University PressPrint publication year: 2022