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13 - Is there a role for social factors in a comprehensive development model for schizophrenia?

Published online by Cambridge University Press:  04 August 2010

By
Jane Boydell ,
Jim van Os  and
Robin M. Murray
Edited by
Matcheri S. Keshavan ,
James L. Kennedy  and
Robin M. Murray
Jane Boydell
Affiliation:
Institute of Psychiatry King's College London, UK
Jim van Os
Affiliation:
Maastricht University, Maastricht, the Netherlands
Robin M. Murray
Affiliation:
Institute of Psychiatry King's College London, UK
Matcheri S. Keshavan
Affiliation:
University of Pittsburgh
James L. Kennedy
Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray
Affiliation:
Institute of Psychiatry, London
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Summary

In the 1950s and 1960s, there was much extravagant discussion of the role of social factors in the etiology of schizophrenia. A decade later, the neurodevelopmental model of schizophrenia was proposed, and it became the dominant etiological and pathogenetic model. This chapter reviews the social factors that are postulated to operate early in life and those which may act more proximal to the onset of the disorder. It considers how animal research has informed on psychiatric conditions. Studies using intensive field methods to examine subjective experience of stress in the flow of daily life have found that individuals with schizophrenia, and individuals with genetic susceptibility to schizophrenia, display greater levels of emotional reactivity to small daily life stressors than do control subjects. The chapter also presents the evidence that early social adversity can affect brain development.

Keywords

animal modelsetiological factorsneuro development modelsocial factorsschizophrenia
Type
Chapter
Information
Neurodevelopment and Schizophrenia , pp. 224 - 247
Publisher: Cambridge University Press
Print publication year: 2004

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