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Chapter 22 - Neonatal and Perinatal Solid Tumors

from Section VIII - Neonatal Oncology

Published online by Cambridge University Press:  30 January 2021

By
Kevin F. Ginn ,
Jaszianne A. Tolbert ,
Glenson Samuel ,
J. Allyson Hays  and
Alan S. Gamis
Edited by
Pedro A. de Alarcón ,
Eric J. Werner ,
Robert D. Christensen  and
Martha C. Sola-Visner
Pedro A. de Alarcón
Affiliation:
University of Illinois College of Medicine
Eric J. Werner
Affiliation:
Children's Hospital of the King's Daughters
Robert D. Christensen
Affiliation:
University of Utah
Martha C. Sola-Visner
Affiliation:
Harvard University, Massachusetts
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Summary

Solid tumors in neonates can arise anywhere in the body and present unique challenges to clinicians. Benign tumors are most common [1], and are typically less amenable to chemotherapy or radiation and more in need of surgical approaches. Radiation’s role in childhood cancer is diminishing as better chemotherapeutic approaches are developed and its use in neonates is rare due to its devastating long-term toxicity. Finally, differences in neonatal physiology imparts a variable upon chemotherapy pharmacokinetics that is difficult to fully control and frequently results in greater toxicity. These factors, combined with the biology of the tumors uniquely seen in the neonate, worsen the survival for neonates with cancer. This chapter acquaints the clinician with the array of tumors most commonly found in the infant <28 days of age (Table 22.1).

Type
Chapter
Information
Neonatal Hematology
Pathogenesis, Diagnosis, and Management of Hematologic Problems
 , pp. 382 - 400
Publisher: Cambridge University Press
Print publication year: 2021

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References

Rao, S, Azmy, A, Carachi, R. Neonatal tumours: A single-centre experience. Pediatr Surg Int 2002;18(5–6):306–9.Google Scholar
Gurney, J, Smith, M, Ross, J. Cancer among infants. InRies, L, Smith, MA, Gurney, JG, et al. eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995, Vol. NIH Pub. No. 99–4649. (Bethesda, MD: National Cancer Institute, SEER Program, 1999).Google Scholar
Desandes, E, Guissou, S, Ducassou, S, Lacour, B. Neonatal solid tumors: Incidence and survival in France. Pediatr Blood Cancer 2016;63(8):1375–80.CrossRefGoogle ScholarPubMed
Alfaar, AS, Hassan, WM, Bakry, MS, Qaddoumi, I. Neonates with cancer and causes of death; lessons from 615 cases in the SEER databases. Cancer Med 2017;6(7):1817–26.Google Scholar
Parkes, SE, Muir, KR, Southern, L, et al. Neonatal tumours: A thirty-year population-based study. Med Pediatr Oncol 1994;22(5):309–17.Google Scholar
Ries, L, Percy, C, Bunin, G. Introduction. InRies, L, Smith, MA, Gurney, JG, et al. eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995, Vol. NIH Pub. No. 99–4649. (Bethesda, MD: National Cancer Institute, SEER Program,1999).Google Scholar
Smith, MA, Seibel, NL, Altekruse, SF, et al. Outcomes for children and adolescents with cancer: Challenges for the twenty-first century. J Clin Oncol 2010;28(15):2625–34.Google Scholar
Zhang, J, Walsh, MF, Wu, G, et al. Germline mutations in predisposition genes in pediatric cancer. N Engl J Med 2015;373(24):2336–46.CrossRefGoogle ScholarPubMed
Jongmans, MC, Loeffen, JL, Waanders, E, et al. Recognition of genetic predisposition in pediatric cancer patients: an easy-to-use selection tool. Eur J Med Genet 2016;59(3):116–25.Google Scholar
Chandrasekaran, A. Neonatal solid tumors. Pediatr Neonatol, 2018;59(1):65–70.Google Scholar
Bader, JL, Miller, RW. US cancer incidence and mortality in the first year of life. Am J Dis Child 1979;133(2):157–9.Google Scholar
Parkes, S, Muir, KR, Southern, L, et al. Neonatal tumours: A thirty‐year population‐based study. Med Pediatr Oncol 1994;22(5):309–17.Google Scholar
Yamamoto, K, Ohta, S, Ito, E, et al. Marginal decrease in mortality and marked increase in incidence as a result of neuroblastoma screening at 6 months of age: Cohort study in seven prefectures in Japan. J Clin Oncol 2002;20(5):1209–14.CrossRefGoogle ScholarPubMed
Barrette, S, Bernstein, ML, Robison, LL, et al. Incidence of neuroblastoma after a screening program. J Clin Oncol 2007;25(31):4929–32.CrossRefGoogle ScholarPubMed
Puyo, A, Levin, G, Armando, I, Barontini, M. Total plasma dopamine/norepinephrine ratio in catecholamine-secreting tumors. Its relation to hypertension. Hypertension 1988;11(2 Pt 2):I202–6.Google Scholar
Maris, JM, Hogarty, MD, Bagatell, R, Cohn, SL. Neuroblastoma. Lancet 2007;369(9579):2106–20.Google Scholar
Monclair, T, Brodeur, GM, Ambros, PF, et al. The International Neuroblastoma Risk Group (INRG) Staging System: An INRG Task Force Report. J Clin Oncol 2009;27(2):298–303.Google Scholar
Cohn, SL, Pearson, AD, London, WB, et al. The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report. J Clin Oncol 2009;27(2):289–97.Google Scholar
Ora, I, Eggert, A. Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research. Semin Cancer Biol 2011;21(4):217–28.Google Scholar
Canete, A, Gerrard, M, Rubie, H, et al. Poor survival for infants with MYCN-amplified metastatic neuroblastoma despite intensified treatment: The International Society of Paediatric Oncology European Neuroblastoma Experience. J Clin Oncol 2009;27(7):1014–19.Google Scholar
Hero, B, Simon, T, Spitz, R, et al. Localized infant neuroblastomas often show spontaneous regression: Results of the prospective trials NB95-S and NB97. J Clin Oncol, 2008;26(9):1504–10.Google Scholar
Nuchtern, JG, London, WB, Barnewolt, CE, et al. A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: A Children’s Oncology Group Study. Ann Surg 2012;256(4):573–80.Google Scholar
Nickerson, HJ, Matthay, KK, Seeger, RC, et al. Favorable biology and outcome of stage IV-S neuroblastoma with supportive care or minimal therapy: A Children’s Cancer Group study. J Clin Oncol, 2000;18(3):477–86.Google Scholar
Rescorla, FJ, Sawin, RS, Coran, AG, Dillon, PW, Azizkhan, RG. Long-term outcome for infants and children with sacrococcygeal teratoma: A report from the Childrens Cancer Group. J Pediatr Surg 1998;33(2):171–6.Google Scholar
Fernandez, K, Solid tumors in the neonatal period. NeoReviews 2014;15(2):e56-e68.Google Scholar
Moppett, J, Haddadin, I, Foot, AB. Neonatal neuroblastoma. Arch Dis Child Fetal Neonatal Ed 1999;81(2):F134–7.Google Scholar
Isaacs, H, Jr. Fetal and neonatal neuroblastoma: Retrospective review of 271 cases. Fetal Pediatr Pathol 2007;26(4):177–84.Google Scholar
De Bernardi, B, Gerrard, M, Boni, L, et al. Excellent outcome with reduced treatment for infants with disseminated neuroblastoma without MYCN gene amplification. J Clin Oncol 2009;27(7):1034–40.Google Scholar
Nadler, EP, Barksdale, EM. Adrenal masses in the newborn. Semin Pediatr Surg 2000;9(3):156–64.CrossRefGoogle ScholarPubMed
Curtis, MR, Mooney, DP, Vaccaro, TJ, et al. Prenatal ultrasound characterization of the suprarenal mass: Distinction between neuroblastoma and subdiaphragmatic extralobar pulmonary sequestration. J Ultrasound Med 1997;16(2):75–83.Google Scholar
Isaacs, H, Jr. Congenital and neonatal malignant tumors. A 28-year experience at Children’s Hospital of Los Angeles. Am J Pediatr Hematol Oncol 1987;9(2):121–9.Google Scholar
Isaacs, H, Jr. Perinatal (fetal and neonatal) germ cell tumors. J Pediatr Surg 2004;39(7):1003–13.Google Scholar
Gopal, M, Turnpenny, PD, Spicer, R. Hereditary sacrococcygeal teratoma–not the same as its sporadic counterpart! Eur J Pediatr Surg 2007;17(3):214–6.Google Scholar
Dharmarajan, H, Rouillard-Bazinet, N, Chandy, BM. Mature and immature pediatric head and neck teratomas: A 15-year review at a large tertiary center. Int J Pediatr Otorhinolaryngol 2018;105:43–7.Google Scholar
Frazier, AL, Weldon, C, Amatruda, J. Fetal and neonatal germ cell tumors. Semin Fetal Neonatal Med 2012;17(4):222–30.Google Scholar
Wu, JT, Book, L, Sudar, K. Serum alpha fetoprotein (AFP) levels in normal infants. Pediatr Res, 1981;15:50–2.Google Scholar
Blohm, ME, Gobel, U. Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: A review. Eur J Pediatr 2004;163(1):1–6.Google Scholar
Ferrari, A, Sultan, I, Huang, TT, et al. Soft tissue sarcoma across the age spectrum: A population-based study from the Surveillance Epidemiology and End Results database. Pediatr Blood Cancer 2011;57(6):943–9.Google Scholar
Sultan, I, Casanova, M, Al-Jumaily, U, et al. Soft tissue sarcomas in the first year of life. Eur J Cancer 2010;46(13):2449–56.Google Scholar
Ferrari, A, Orbach, D, Sultan, I, Casanova, M, Bisogno, G. Neonatal soft tissue sarcomas. Semin Fetal Neonatal Med 2012;17(4):231–8.Google Scholar
Güra, A, Tezcan, G, Karagüzel, G, Cevikol, C, Oygür, N. An unusual localization of embryonal rhabdomyosarcoma in a neonate. Turk J Pediatr 2007;49(1):82–4.Google Scholar
Rodriguez-Galindo, C, Hill, DA, Onyekwere, O, et al. Neonatal alveolar rhabdomyosarcoma with skin and brain metastases. Cancer 2001;92(6):1613–20.Google Scholar
De Giovanni, C, Landuzzi, L, Nicoletti, G, Lollini, PL, Nanni, P. Molecular and cellular biology of rhabdomyosarcoma. Future Oncol 2009;5(9):1449–75.CrossRefGoogle ScholarPubMed
Lobe, TE, Wiener, ES, Hays, DM, et al. Neonatal rhabdomyosarcoma: The IRS experience. J Pediatr Surg 1994;29(8):1167–70.Google Scholar
Lackner, H, Urban, C, Kerbl, R, Schwinger, W, Beham, A. Noncytotoxic drug therapy in children with unresectable desmoid tumors. Cancer 1997;80(2):334–40.Google Scholar
Domont, J, Salas, S, Lacroix, L, et al. High frequency of beta-catenin heterozygous mutations in extra-abdominal fibromatosis: A potential molecular tool for disease management. Br J Cancer 2010;102(6):1032–6.Google Scholar
Ferrari, A, Casanova, M, Bisogno, G, et al. Hemangiopericytoma in pediatric ages: A report from the Italian and German Soft Tissue Sarcoma Cooperative Group. Cancer 2001;92(10):2692–8.Google Scholar
Staples, JJ, Robinson, RA, Wen, BC, Hussey, DH. Hemangiopericytoma: The role of radiotherapy. Int J Radiat Oncol Biol Phys 1990;19(2):445–51.Google Scholar
Rodriguez-Galindo, C, Ramsey, K, Jenkins, JJ, et al. Hemangiopericytoma in children and infants. Cancer 2000;88(1):198–204.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Cecchetto, G, Carli, M, Alaggio, R, et al. Fibrosarcoma in pediatric patients: Results of the Italian Cooperative Group studies (1979–1995). J Surg Oncol 2001;78(4):225–31.Google Scholar
Orbach, D, Rey, A, Oberlin, O, et al. Soft tissue sarcoma or malignant mesenchymal tumors in the first year of life: experience of the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Committee. J Clin Oncol 2005;23(19):4363–71.Google Scholar
Coffin, CM, Jaszcz, W, O‘Shea, PA, Dehner, LP. So-called congenital-infantile fibrosarcoma: does it exist and what is it? Pediatr Pathol 1994;14(1):133–50.Google Scholar
Bourgeois, JM, Knezevich, SR, Mathers, JA, Sorensen, PH. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol 2000;24(7):937–46.Google Scholar
Orbach, D, Rey, A, Cecchetto, G, et al. Infantile fibrosarcoma: management based on the European experience. J Clin Oncol 2010;28(2):318–23.Google Scholar
Hwang, ES, Gerald, W, Wollner, N, Meyers, P, La Quaglia, MP. Leiomyosarcoma in childhood and adolescence. Ann Surg Oncol 1997;4(3):223–7.Google Scholar
Ostrom, QT, Gittleman, H, Farah, P, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2008–2012. Neuro Oncol 2015;17(Suppl 4):iv1–iv62.Google Scholar
Buetow, PC, Smirniotopoulos, JG, Done, S. Congenital brain tumors: A review of 45 cases. AJNR Am J Neuroradiol 1990. 11(4):793–9.Google Scholar
Isaacs, H, Jr. I. Perinatal brain tumors: A review of 250 cases. Pediatr Neurol, 2002;27(4):249–61.Google Scholar
Severino, M, Schwartz, ES, Thurnher, MM, et al. Congenital tumors of the central nervous system. Neuroradiol J 2010;52(6):531–48.Google Scholar
Isaacs, H, Jr. II. Perinatal brain tumors: A review of 250 cases. Pediatr Neurol 2002;27(5):333–42.Google Scholar
Huang, X, Zhang, R, Zhou, LF. Diagnosis and treatment of intracranial immature teratoma. Pediatr Neurosurg 2009;45(5):354–60.Google Scholar
Arslan, E, Usul, H, Baykal, S, et al. Massive congenital intracranial immature teratoma of the lateral ventricle with retro-orbital extension: A case report and review of the literature. Pediatr Neurosurg 2007;43(4):338–42.Google Scholar
Im, SH, Wang, KC, Kim, SK, et al. Congenital intracranial teratoma: Prenatal diagnosis and postnatal successful resection. Med Pediatr Oncol 2003;40(1):57–61.Google Scholar
Louis, DN, Ohgaki, H, Wiestler, OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114(2):97–109.CrossRefGoogle ScholarPubMed
Louis, DN, Perry, A, Reifenberger, G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A summary. Acta Neuropathol 2016;131(6):803–20.Google Scholar
Isaacs, H, Jr. Perinatal (fetal and neonatal) astrocytoma: A review. Childs Nerv Syst 2016;32(11):2085–2096.Google Scholar
Nageswara Rao, AA, Packer, RJ. Advances in the management of low-grade gliomas. Curr Oncol Rep 2014;16(8):398.CrossRefGoogle ScholarPubMed
Kotulska, K, Borkowska, J, Mandera, M, et al. Congenital subependymal giant cell astrocytomas in patients with tuberous sclerosis complex. Childs Nerv Syst 2014;30(12):2037–42.Google Scholar
Franz, DN, Agricola, K, Mays, M, et al. Everolimus for subependymal giant cell astrocytoma: 5-year final analysis. Ann Neurol 2015;78(6):929–38.Google Scholar
Nemes, K, Bens, S, Bourdeaut, F, et al. Rhabdoid tumor predisposition syndrome. In Adam, MP, Ardinger, HH, Pagon, RA, et al., eds. GeneReviews® (Seattle, WA: University of Washington, 1993).Google Scholar
Nemes, K, Clément, N, Kachanov, D, et al. The extraordinary challenge of treating patients with congenital rhabdoid tumors: A collaborative European effort. Pediatr Blood Cancer 2018;65(6):e26999.Google Scholar
Schrey, D, Carceller Lechón, F, Malietzis, G, et al. Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: Individual pooled data analysis and review of the literature. J Neurooncol 2016;126(1):81–90.Google Scholar
Cavalli, FMG, Remke, M, Rampasek, L, et al. Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell, 2017;31(6):737–54 e6.Google Scholar
Thalakoti, S, Geller, T. Basal cell nevus syndrome or Gorlin syndrome. Handb Clin Neurol 2015;132:119–28.Google Scholar
Lafay-Cousin, L, Smith, A, Chi, SN, et al. Clinical, pathological, and molecular characterization of infant medulloblastomas treated with sequential high-dose chemotherapy. Pediatr Blood Cancer 2016;63(9):1527–34.Google Scholar
Lafay-Cousin, L, Fay-McClymont, T, Johnston, D, et al. Neurocognitive evaluation of long term survivors of atypical teratoid rhabdoid tumors (ATRT): The Canadian registry experience. Pediatr Blood Cancer 2015;62(7):1265–9.Google Scholar
Lafay-Cousin, L, Bouffet, E, Hawkins, C, et al. Impact of radiation avoidance on survival and neurocognitive outcome in infant medulloblastoma. Curr Oncol 2009;16(6):21–8.Google Scholar
Nimjee, SM, Powers, CJ, McLendon, RE, Grant, GA, Fuchs, HE. Single-stage bilateral choroid plexectomy for choroid plexus papilloma in a patient presenting with high cerebrospinal fluid output. J Neurosurg Pediatr 2010;5(4):342–5.Google Scholar
Fujimura, M, Onuma, T, Kameyama, M, et al. Hydrocephalus due to cerebrospinal fluid overproduction by bilateral choroid plexus papillomas. Childs Nerv Syst 2004;20(7):485–8.Google Scholar
Gopal, P, Parker, JR, Debski, R, Parker, JC Jr. Choroid plexus carcinoma. Arch Pathol Lab Med 2008;132(8):1350–4.Google Scholar
Gozali, AE, Britt, B, Shane, L, et al. Choroid plexus tumors; management, outcome, and association with the Li–Fraumeni syndrome: The Children’s Hospital Los Angeles (CHLA) experience, 1991–2010. Pediatr Blood Cancer 2012;58(6):905–9.Google Scholar
Powis, M. Neonatal renal tumours. Early Hum Dev 2010;86(10):607–12.Google Scholar
Isaacs, H Jr. Fetal and neonatal renal tumors. J Pediatr Surg 2008;43(9):1587–95.Google Scholar
England, RJ, Haider, N, Vujanic, GM, et al. Mesoblastic nephroma: A report of the United Kingdom Children’s Cancer and Leukaemia Group (CCLG). Pediatr Blood Cancer 2011;56(5):744–748.Google Scholar
Lee, EY. CT imaging of mass-like renal lesions in children. Pediatr Radiol 2007;37(9):896–907.Google Scholar
van den Heuvel‐Eibrink, MM, Grundy, P, Graf, N, et al. Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: A collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups. Pediatr Blood Cancer 2008;50(6):1130–34.Google Scholar
Vokuhl, C, Nourkami-Tutdibi, N, Furtwängler, R, et al. ETV6–NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study. Pediatr Blood Cancer 2018;65(4):e26925.Google Scholar
Patel, Y, Mitchell, CD, Hitchcock, RJ. Use of sarcoma-based chemotherapy in a case of congenital mesoblastic nephroma with liver metastases. Urology 2003;61(6):1260.Google Scholar
Glick, RD, Hicks, MJ, Nuchtern, JG, et al. Renal tumors in infants less than 6 months of age. J Pediatr Surg 2004;39(4):522–5.CrossRefGoogle Scholar
Gooskens, S, Houwing, ME, Vujanic, GM, et al. Congenital mesoblastic nephroma 50 years after its recognition: A narrative review. Pediatr Blood Cancer 2017;64(7):e26437.CrossRefGoogle ScholarPubMed
Royer-Pokora, B. Genetics of pediatric renal tumors. Pediatr Nephrol 2013;28(1):13–23.Google Scholar
Beckwith, JB, Nephrogenic rests and the pathogenesis of Wilms tumor: Developmental and clinical considerations. Am J Med Genet 1998;79(4):268–73.Google Scholar
Fernandez, CV, Perlman, EJ, Mullen, EA, et al. Clinical outcome and biological predictors of relapse after nephrectomy only for very low-risk Wilms tumor: A report from Children’s Oncology Group AREN0532. Ann Surg 2017;265(4):835–40.Google Scholar
Tomlinson, GE, Breslow, NE, Dome, J, et al. Rhabdoid tumor of the kidney in the National Wilms’ Tumor Study: Age at diagnosis as a prognostic factor. J Clin Oncol 2005;23(30):7641–5.Google Scholar
Eaton, KW, Tooke, LS, Wainwright, LM, et al. Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors. Pediatr Blood Cancer, 2011;56(1):7–15.Google Scholar
Ueno-Yokohata, H, Okita, H, Nakasato, K, et al. Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney. Nat Genet 2015;47(8):861.Google Scholar
Cronin, KA, Ries, LA, Edwards, BK. The Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. Cancer 2014;120(Suppl 23):3755–7.Google Scholar
Wan, MJ, VanderVeen, DK. Eye disorders in newborn infants (excluding retinopathy of prematurity). Arch Dis Child Fetal Neonatal Ed 2015;100(3):F264-9.Google Scholar
Skalet, AH, Gombos, DS, Gallie, BL, et al. Screening children at risk for retinoblastoma: Consensus Report from the American Association of Ophthalmic Oncologists and Pathologists. Ophthalmology 2018;125(3):45358.CrossRefGoogle Scholar
Soliman, SE, Dimaras, H, Khetan, V, et al. Prenatal versus postnatal screening for familial retinoblastoma. Ophthalmology 2016;123(12):2610–17.Google Scholar
Hurwitz, R, et al. Retinoblastoma. In Pizzo, P, Poplack, D, eds. Principles and Practice of Pediatric Oncology, (Philadelphia, PA: Lippincott Williams & Wilkins, 2011), pp. 809–37.Google Scholar
Draper, GJ Sanders, BM, Brownbill, PA, Hawkins, MM. Patterns of risk of hereditary retinoblastoma and applications to genetic counselling. Br J Cancer 1992;66(1):211–9.Google Scholar
Abramson, DH, Frank, CM, Susman, M, et al. Presenting signs of retinoblastoma. J Pediatr 1998;132(3 Pt 1):505–8.Google Scholar
Gobin, YP, Dunkel, IJ, Marr, BP, et al. Combined, sequential intravenous and intra-arterial chemotherapy (bridge chemotherapy) for young infants with retinoblastoma. PLoS One, 2012;7(9):e44322.Google Scholar
Desandes, E, Guissou, S, Ducassou, S, Lacour, B. Neonatal solid tumors: Incidence and survival in France. Pediatr Blood Cancer 2016;63(8):1375–80.Google Scholar
Kamihara, J, Bourdeaut, F, Foulkes, WD, et al. Retinoblastoma and neuroblastoma predisposition and surveillance. Clin Cancer Res 2017;23(13):e98–e106.Google Scholar
Isaacs, H. Tumors of the Fetus and Infant: An Atlas, 2nd ed. (New York: Springer,2013).Google Scholar
Weinberg, AG, Finegold, MJ. Primary hepatic tumors in childhood. In Finegold, MJ, ed. Pathology of Neoplasia in Children and Adolescents (Philadelphia, PA: WB Saunders, 1986), pp. 333–65.Google Scholar
von Schweinitz, D. Neonatal liver tumours. Semin Neonatol 2003;8(5):403–10.Google Scholar
Boon, LM, Burrows, PE, Paltiel, HJ, et al. Hepatic vascular anomalies in infancy: A twenty-seven-year experience. J Pediatr 1996;129(3):346–54.Google Scholar
Cohen, RC, Myers, NA. Diagnosis and management of massive hepatic hemangiomas in childhood. J Pediatr Surg 1986;21(1):6–9.Google Scholar
Isaacs, H, Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg 2007;42(11):1797–803.Google Scholar
DeMaioribus, CA, Lally, KP, Sim, K, Isaacs, H, Mahour, GH. Mesenchymal hamartoma of the liver. A 35-year review. Arch Surg 1990;125(5):598–600.Google Scholar
Stringer, MD, Alizai, NK. Mesenchymal hamartoma of the liver: A systematic review. J Pediatr Surg 2005;40(11):1681–90.Google Scholar
Anil, G, Fortier, M, Low, Y. Cystic hepatic mesenchymal hamartoma: The role of radiology in diagnosis and perioperative management. Br J Radiol 2011;84(1001):e91–4.Google Scholar
Hiyama, E. Pediatric hepatoblastoma: Diagnosis and treatment. Transl Pediatr 2014;3(4):293–9.Google Scholar
Fernandez-Pineda, I, Cabello-Laureano, R. Differential diagnosis and management of liver tumors in infants. World J Hepatol 2014;6(7):486–95.Google Scholar
Oue, T, Kubota, A, Okuyama, H, et al. Hepatoblastoma in children of extremely low birth weight: a report from a single perinatal center. J Pediatr Surg 2003;38(1):134–7; discussion 134–7.Google Scholar
Kapfer, SA, Petruzzi, MJ, Caty, MG. Hepatoblastoma in low birth weight infants: An institutional review. Pediatr Surg Int 2004;20(10):753–6.Google Scholar
Pizzo, P, Poplack, D. Principles and Practice of Pediatric Oncology, 6th ed. (Philadelphia, PA: Lippincott Williams & Wilkins,2011).Google Scholar
De Ioris, M, Brugieres, L, Zimmermann, A, et al. Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: The SIOPEL group experience. Eur J Cancer 2008;44(4):545–50.Google Scholar
Davidoff, AM, Fernandez-Pineda, I, Santana, VM, Shochat, SJ. The role of neoadjuvant chemotherapy in children with malignant solid tumors. Semin Pediatr Surg 2012;21(1):88–99.Google Scholar
Perilongo, G, Shafford, E, Maibach, R, et al. Risk-adapted treatment for childhood hepatoblastoma. final report of the second study of the International Society of Paediatric Oncology–SIOPEL 2. Eur J Cancer 2004;40(3):411–21.Google Scholar
Trobaugh‐Lotrario, AD, Chaiyachati, BH, Meyers, RL, et al. Outcomes for patients with congenital hepatoblastoma. Pediatr Blood Cancer 2013;60(11):1817–25.Google Scholar
Dall’Igna, P, Brugieres, L, Christin, AS, et al. Hepatoblastoma in children aged less than six months at diagnosis: A report from the SIOPEL group. Pediatr Blood Cancer 2018;65(1):e26791.Google Scholar
Wassef, M, Blei, F, Adams, D, et al. Vascular anomalies classification: Recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics 2015;136(1):e203-e214.Google Scholar
Darrow, DH, Greene, AK, Mancini, AJ, Nopper, AJ. Diagnosis and management of infantile hemangioma: Executive summary. Pediatrics 2015;136(4):786–91.Google Scholar
Munden, A, Butschek, R, Tom, WL, et al. Prospective study of infantile haemangiomas: Incidence, clinical characteristics and association with placental anomalies. Br J Dermatol 2014;170(4):907–13.Google Scholar
Bruckner, AL, Frieden, IJ. Hemangiomas of infancy. J Am Acad Dermatol 2003;48(4):477–93; quiz 494–6.Google Scholar
Darrow, DH, Greene, AK, Mancini, AJ, et al. Diagnosis and management of infantile hemangioma. Pediatrics 2015; 136(4):e1060–e1104.Google Scholar
Metry, D, Heyer, G, Hess, C, et al. Consensus statement on diagnostic criteria for PHACE syndrome. Pediatrics 2009;124(5):1447–56.Google Scholar
Buckmiller, L, Dyamenahalli, U, Richter, GT. Propranolol for airway hemangiomas: case report of novel treatment. Laryngoscope 2009;119(10):2051–4.Google Scholar
Keller, RG, Patel, KG. Evidence-based medicine in the treatment of infantile hemangiomas. Facial Plast Surg Clin North Am 2015;23(3):373–92.Google Scholar
Mazereeuw-Hautier, J, Hoeger, PH, Benlahrech, S, et al. Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis. J Pediatr 2010;157(2):340–2.Google Scholar
Wasserman, JD, Mahant, S, Carcao, M, Perlman, K, Pope, E. Vincristine for successful treatment of steroid-dependent infantile hemangiomas.Pediatrics 2015;135(6):e1501–5.Google Scholar
Vlahovic, A, Simic, R, Djokic, D, Ceran, C. Diffuse neonatal hemangiomatosis treatment with cyclophosphamide: A case report. J Pediatr Hematol Oncol 2009;31(11):858–60.Google Scholar
Sundar Alagusundaramoorthy, S, Vilchez, V, Zanni, A, et al. Role of transplantation in the treatment of benign solid tumors of the liver: a review of the United Network of Organ Sharing data set. JAMA Surg 2015;150(4):337–42.Google Scholar
North, PE, Waner, M, James, CA, et al. Congenital nonprogressive hemangioma: A distinct clinicopathologic entity unlike infantile hemangioma. Arch Dermatol 2001;137(12):1607–20.Google Scholar
Subash, A, Senthil, GK, Ramamoorthy, R, Appasamy, A, Selvarajan, N. Kaposiform hemangioendothelioma with Kasabach–Merritt phenomenon in a neonate of life- and limb-threatening nature: A case report. J Indian Assoc Pediatr Surg 2015;20(4):194–6.Google Scholar
Arunachalam, P, Kumar, VR, Swathi, D. Kasabach–Merritt syndrome with large cutaneous vascular tumors. J Indian Assoc Pediatr Surg 2012;17(1):33–6.Google Scholar
Fahrtash, F, McCahon, E, Arbuckle, S. Successful treatment of kaposiform hemangioendothelioma and tufted angioma with vincristine. J Pediatr Hematol Oncol 2010;32(6):506–10.Google Scholar
Fernandez-Pineda, I, Lopez-Gutierrez, JC, Chocarro, G, Bernabeu-Wittel, J, Ramirez-Villar, GL. Long-term outcome of vincristine-aspirin-ticlopidine (VAT) therapy for vascular tumors associated with Kasabach–Merritt phenomenon. Pediatr Blood Cancer 2013;60(9):1478–81.Google Scholar
Acharya, S, Pillai, K, Francis, A, Criton, S, Parvathi, VK. Kasabach–Merritt syndrome: Management with interferon. Indian J Dermatol, 2010;55(3):281–3.Google Scholar
Filippi, L, Tamburini, A, Berti, E, et al. Successful propranolol treatment of a kaposiform hemangioendothelioma apparently resistant to propranolol. Pediatr Blood Cancer 2016;63(7):1290–2.Google Scholar
Chiu, YE, Drolet, BA, Blei, F, et al. Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach–Merritt phenomenon. Pediatr Blood Cancer 2012;59(5):934–8.Google Scholar
Hammill, AM, Wentzel, M, Gupta, A, et al. Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer 2011;57(6):1018–24.Google Scholar
Schaefer, BA, Wang, D, Merrow, AC, Dickie, BH, Adams, DM. Long-term outcome for kaposiform hemangioendothelioma: A report of two cases. Pediatr Blood Cancer 2017;64(2):284–6.Google Scholar
Krafchik, B, Pope, E, Walsch, SRA. Histiocytosis of the skin in children and adults. In Weitzman, S, Egeler, MR, eds. Histiocytic Disorders of Children and Adults (Cambridge, UK: Cambridge University Press, 2005), pp. 130–53.Google Scholar
Minkov, M, Prosch, H, Steiner, M, et al. Langerhans cell histiocytosis in neonates. Pediatr Blood Cancer 2005;45(6):802–7.Google Scholar
Stein, SL, Paller, AS, Haut, PR, Mancini, AJ. Langerhans cell histiocytosis presenting in the neonatal period: A retrospective case series. Arch Pediatr Adolesc Med 2001;155(7):778–83.Google Scholar
Isaacs, H, Jr. Fetal and neonatal histiocytoses. Pediatr Blood Cancer 2006;47(2):123–9.Google Scholar
Ladisch, S, Jaffe, E. The histiocytoses. In Pizzo, P, Poplack, D, eds. Principles and Practice of Pediatric Oncology (Philadelphia, PA: Lippincott, 2006).Google Scholar
Suzuki, N, Morimoto, A, Ohga, S, et al. Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan. J Pediatr 2009;155(2):235–8, e1.Google Scholar
Janka, GE. Familial and acquired hemophagocytic lymphohistiocytosis. Annu Rev Med 2012;63:233–46.Google Scholar
Henter, JI, Horne, A, Aricó, M, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007;48(2):124–31.Google Scholar
Bergsten, E, Horne, A, Aricó, M, et al. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: Long-term results of the cooperative HLH-2004 study. Blood 2017;130(25):2728–38.Google Scholar
Weitzman, S, Whitlock, J. Uncommon histiocytic disorder: The non-Langerhans cell histiocytosis. In Weitzman, S, Egeler, MR, eds. Histiocytic Disorders of Children and Adults (Cambridge, UK:Cambridge University Press, 2005), pp. 293–320.Google Scholar
Oza, VS, Stringer, T, Campbell, C, et al. Congenital-type juvenile xanthogranuloma: A case series and literature review. Pediatr Dermatol 2018;35(5):582–7.Google Scholar
Yule, SM, Boddy, AV, Cole, M, et al. Cyclophosphamide pharmacokinetics in children. Br J Clin Pharmacol 1996;41(1):13–19.Google Scholar
Periclou, AP, Avramis, VI. NONMEM population pharmacokinetic studies of cytosine arabinoside after high-dose and after loading bolus followed by continuous infusion of the drug in pediatric patients with leukemias. Cancer Chemother Pharmacol 1996;39(1–2):42–50.Google Scholar
McLeod, HL, Relling, MV, Crom, WR, et al. Disposition of antineoplastic agents in the very young child. Br J Cancer Suppl 1992;18:S23–9.Google Scholar
Kearns, GL, Abdel-Rahman, SM, Alander, SW, et al. Developmental pharmacology: Drug disposition, action, and therapy in infants and children. N Engl J Med 2003;349(12):1157–67.Google Scholar
Hutson, JR, Weitzman, S, Schechter, T, et al. Pharmacokinetic and pharmacogenetic determinants and considerations in chemotherapy selection and dosing in infants. Expert Opin Drug Metab Toxicol 2012;8(6):709–722.Google Scholar
Weitzman, S, Grant, R. Neonatal oncology: diagnostic and therapeutic dilemmas. Semin Perinatol 1997;21(1):102–11.Google Scholar
Littman, P, D’Angio, GJ. Radiation therapy in the neonate. Am J Pediatr Hematol Oncol 1981;3(3):279–85.Google ScholarPubMed

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