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  • Print publication year: 2021
  • Online publication date: January 2021

Chapter 6 - Resting-State Functional Connectivity in Unipolar Depression

from Section 3 - Functional and Neurochemical Brain Studies


Unipolar depression, also known as unipolar or major depressive disorder (MDD), is a globally prevalent psychiatric disorder characterized by persistent sadness and a loss of interest in normally enjoyable activities, accompanied by an inability to carry out daily activities, for at least two weeks. Furthermore, patients with unipolar depression usually exhibit some of the following symptoms: loss of energy, sleeping more or less, anxiety, change in appetite, reduced concentration, indecisiveness, feeling of worthlessness, guilt, hopelessness, and thoughts or acts of self-harm or suicide. The lifetime risk of depression is approximately 10–20%, with rates being almost doubled in women.

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