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Chapter 7 - Functional Connectome in Bipolar Disorder

from Section 3 - Functional and Neurochemical Brain Studies

Published online by Cambridge University Press:  12 January 2021

Sudhakar Selvaraj
Affiliation:
UTHealth School of Medicine, USA
Paolo Brambilla
Affiliation:
Università degli Studi di Milano
Jair C. Soares
Affiliation:
UT Harris County Psychiatric Center, USA
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Summary

Bipolar disorder (BD) is a major psychiatric illness which is thought to have strong biological underpinnings. A biological basis for BD is exemplified by a strong heritability of the disorder (1), occurrence of mood periods of mania (BPM), and depression (BPD), which may or may not be precipitated by environmental factors and dramatic improvement with specific medication treatment such as lithium(2). Therefore, with the augment of brain imaging techniques to study brain metabolism and task-induced activation there is an expectation that a brain state or trait abnormalities specific to BD will be identified.

Type
Chapter
Information
Mood Disorders
Brain Imaging and Therapeutic Implications
, pp. 59 - 82
Publisher: Cambridge University Press
Print publication year: 2021

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References

Nurnberger, JI. Genetics of bipolar disorder: Where we are and where we are going. Depression and Anxiety. 2012; 29(12): 991993.Google Scholar
Lenox, RH, Watson, DG, Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness. [Review] [61 refs]. Clinical Chemistry. 1994; 40(2): 309314.CrossRefGoogle Scholar
Anand, A, Li, Y, Wang, Y, Lowe, MJ, Dzemidzic, M, Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res. 2009; 171(3): 189198.CrossRefGoogle ScholarPubMed
Horwitz, B. The elusive concept of brain connectivity. Neuroimage. 2003; 19(2 Pt 1): 466470.CrossRefGoogle ScholarPubMed
Friston, KJ, Harrison, L, Penny, W, Dynamic causal modelling. Neuroimage. 2003; 19(4): 12731302.CrossRefGoogle ScholarPubMed
O’Reilly, JX, Woolrich, MW, Behrens, TEJ, Smith, SM, Johansen-Berg, H, Tools of the trade: Psychophysiological interactions and functional connectivity. Social Cognitive and Affective Neuroscience. 2012; 7(5): 604609.CrossRefGoogle ScholarPubMed
Caseras, X, Murphy, K, Lawrence, NS, et al. Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: A functional and diffusion-tensor imaging study. Bipolar Disord. 2015; 17(5): 461470.Google Scholar
Favre, P, Polosan, M, Pichat, C, Bougerol, T, Baciu, M, Cerebral correlates of abnormal emotion conflict processing in euthymic bipolar patients: A functional MRI study. PLoS One. 2015; 10(8): e0134961.Google Scholar
Tseng, WL, Thomas, LA, Harkins, E, et al. Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. Psychiatry Res Neuroimaging. 2016; 258: 19.Google Scholar
Townsend, JD, Torrisi, SJ, Lieberman, MD, et al. Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry. 2013; 73(2): 127135.Google Scholar
Cerullo, MA, Fleck, DE, Eliassen, JC, et al. A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states. Bipolar Disord. 2012; 14(2): 175184.Google Scholar
Versace, A, Thompson, WK, Zhou, D, et al. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry. 2010; 67(5): 422431.Google Scholar
Stegmayer, K, Usher, J, Trost, S, et al. Disturbed cortico-amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder. Eur Arch Psychiatry Clin Neurosci. 2015; 265(4): 303311.Google Scholar
Goikolea, JMD, Dima, D, Landin-Romero, R, et al. Multimodal brain changes in first-episode mania: A voxel-based morphometry, functional magnetic resonance imaging, and connectivity study. Schizophr Bull. 2019; 45(2): 464473.Google Scholar
Marchand, WR, Lee, JN, Johnson, S, Gale, P, Thatcher, J. J, Abnormal functional connectivity of the medial cortex in euthymic bipolar II disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014; 51: 2833.Google Scholar
Dutra, SJ, Man, V, Kober, H, Cunningham, WA Gruber, J Disrupted cortico-limbic connectivity during reward processing in remitted bipolar I disorder. Bipolar Disord. 2017; 19(8): 661675.Google Scholar
Schreiter, S, Spengler, S, Willert, A, et al. Neural alterations of fronto-striatal circuitry during reward anticipation in euthymic bipolar disorder. Psychol Med. 2016; 46(15): 31873198.Google Scholar
Redlich, R, Dohm, K, Grotegerd, D, et al. Reward processing in unipolar and bipolar depression: A functional MRI study. Neuropsychopharmacology. 2015; 40(11): 26232631.CrossRefGoogle ScholarPubMed
Lois, G, Gerchen, MF, Kirsch, P, et al. Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients. Bipolar Disord. 2017; 19(6): 487495.Google Scholar
Biswal, B, Yetkin, FZ, Haughton, VM, Hyde, JS, Functional connectivity in the motor cortex of resting human brain. Magnetic Resonance in Medicine. 1995; 34(4): 537541.Google Scholar
Lowe, MJ, Dzemidzic, M, Lurito, JT, Mathews, VP, Phillips, MD, Correlations in low-frequency BOLD fluctuations reflect cortico-cortical connections. Neuroimage. 2000; 12(5): 582587.Google Scholar
Anand, A, Li, Y, Wang, Y, et al. Activity and connectivity of mood regulating circuit in depression: A functional magnetic resonance study. Biological Psychiatry. 2005; 15(10): 10791088.Google Scholar
Rey, G, Piguet, C, Benders, A, et al. Resting-state functional connectivity of emotion regulation networks in euthymic and non-euthymic bipolar disorder patients. Eur Psychiatry. 2016; 34: 5663.Google Scholar
Brady, RO Jr, Masters, GA, Mathew, IT, et al. State dependent cortico-amygdala circuit dysfunction in bipolar disorder. J Affect Disord. 2016; 201: 7987.Google Scholar
Anticevic, A, Brumbaugh, MS, Winkler, AM, et al.Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry. 2013; 73(6): 565573.Google Scholar
Favre, P, Baciu, M, Pichat, C, Bougerol, T, Polosan, M, fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients. J Affect Disord. 2014; 165: 182189.Google Scholar
Wei, S, Geng, H, Jiang, X, et al. Amygdala-prefrontal cortex resting-state functional connectivity varies with first depressive or manic episode in bipolar disorder. Neurosci Lett. 2017; 641: 5155.CrossRefGoogle ScholarPubMed
Chepenik, LG, Raffo, M, Hampson, M, et al. Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder. Psychiatry Res. 2010; 182(3): 207210.Google Scholar
Torrisi, S, Moody, TD, Vizueta, N, et al. Differences in resting corticolimbic functional connectivity in bipolar I euthymia. Bipolar Disord. 2013; 15(2): 156166.CrossRefGoogle ScholarPubMed
Li, M, Huang, C, Deng, W, et al. Contrasting and convergent patterns of amygdala connectivity in mania and depression: A resting-state study. J Affect Disord. 2015; 173: 5358.Google Scholar
Singh, MK, Kelley, RG, Chang, KD, Gotlib, IH, Intrinsic amygdala functional connectivity in youth with bipolar I disorder. J Am Acad Child Adolesc Psychiatry. 2015; 54(9): 763770.Google Scholar
Li, G, Liu, P, Andari, E, Zhang, A, Zhang, K, The role of amygdala in patients with euthymic bipolar disorder during resting state. Front Psychiatry. 2018; 9: 445.CrossRefGoogle ScholarPubMed
Chen, L, Wang, Y, Niu, C, et al. Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder. Neuroimage Clin. 2018; 20: 4250.Google Scholar
Magioncalda, P, Martino, M, Conio, B, et al. Functional connectivity and neuronal variability of resting state activity in bipolar disorder–reduction and decoupling in anterior cortical midline structures. Hum Brain Mapp. 2015; 36(2): 666682.Google Scholar
Gong, J, Chen, G. G, Jia, Y. Y, et al. Disrupted functional connectivity within the default mode network and salience network in unmedicated bipolar II disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 88: 1118.Google Scholar
Martino, M, Magioncalda, P, Huang, Z, et al. Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania. Proc Natl Acad Sci U S A. 2016; 113(17): 48244829.Google Scholar
Martino, M, Magioncalda, P, Saiote, C, et al.Abnormal functional-structural cingulum connectivity in mania: Combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder. Acta Psychiatr Scand. 2016; 134(4): 339349.Google Scholar
He, Y, Wang, Y, Chang, TT, et al. Abnormal intrinsic cerebro-cerebellar functional connectivity in un-medicated patients with bipolar disorder and major depressive disorder. Psychopharmacology (Berl). 2018; 235(11): 31873200.Google Scholar
Minuzzi, L, Syan, SK, Smith, M, et al. Structural and functional changes in the somatosensory cortex in euthymic females with bipolar disorder. Aust N Z J Psychiatry. 2018; 52(11): 10751083.Google Scholar
Wang, Y, Zhong, S, Jia, Y, et al. Interhemispheric resting state functional connectivity abnormalities in unipolar depression and bipolar depression. Bipolar Disord. 2015; 17(5): 486495.Google Scholar
Yasuno, F, Kudo, T, Matsuoka, K, et al. Interhemispheric functional disconnection because of abnormal corpus callosum integrity in bipolar disorder type II. BJPsych Open. 2016; 2(6): 335340.Google Scholar
Reinke, B, Ven, V, Matura, S, Linden, DE, Oertel-Knochel, V, Altered intrinsic functional connectivity in language-related brain regions in association with verbal memory performance in euthymic bipolar patients. Brain Sci. 2013; 3(3): 13571373.Google Scholar
Pang, Y, Chen, H, Wang, Y, et al. Transdiagnostic and diagnosis-specific dynamic functional connectivity anchored in the right anterior insula in major depressive disorder and bipolar depression. Prog Neuropsychopharmacol Biol Psychiatry. 2018; 85: 715.Google Scholar
Ellard, KK, Gosai, AK, Felicione, JM, et al.Deficits in frontoparietal activation and anterior insula functional connectivity during regulation of cognitive-affective interference in bipolar disorder. Bipolar Disord. 2019; May; 21(3): 244258.Google Scholar
Marchand, WR, Lee, JN, Johnson, S, Gale, P, Thatcher, J, Differences in functional connectivity in major depression versus bipolar II depression. J Affect Disord. 2013; 150(2): 527532.Google Scholar
Yin, Z, Chang, M, Wei, S, et al. Decreased functional connectivity in insular subregions in depressive episodes of bipolar disorder and major depressive disorder. Front Neurosci. 2018; 12: 842.CrossRefGoogle ScholarPubMed
Liu, Y, Wu, X, Zhang, J, et al. Altered effective connectivity model in the default mode network between bipolar and unipolar depression based on resting-state fMRI. J Affect Disord. 2015; 182: 817.Google Scholar
Fateh, AA, Long, Z, Duan, X, et al. Hippocampal functional connectivity-based discrimination between bipolar and major depressive disorders. Psychiatry Res Neuroimaging. 2019; 284: 5360.Google Scholar
Oertel-Knochel, V, Reinke, B, Matura, S, Prvulovic, D, Linden, DE, van de Ven, V, Functional connectivity pattern during rest within the episodic memory network in association with episodic memory performance in bipolar disorder. Psychiatry Res. 2015; 231(2): 141150.Google Scholar
Dandash, O, Yucel, M, Daglas, R, et al. Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania. Transl Psychiatry. 2018; 8(1): 59.Google Scholar
He, Z, Sheng, W, Lu, F, et al. Altered resting-state cerebral blood flow and functional connectivity of striatum in bipolar disorder and major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 90: 177185.Google Scholar
Altinay, MI, Hulvershorn, LA, Karne, H, Beall, EB, Anand, A, Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania. Brain Connect. 2016; 6(3): 255265.Google Scholar
Ambrosi, E, Arciniegas, DB, Madan, A, et al. Insula and amygdala resting-state functional connectivity differentiate bipolar from unipolar depression. Acta Psychiatr Scand. 2017; 136(1): 129139.Google Scholar
Teng, S, Lu, CF, Wang, PS, et al. Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder. PLoS One. 2014; 9(5): e96422.Google Scholar
Lv, D, Lin, W. W, Xue, Z. Z, et al. Decreased functional connectivity in the language regions in bipolar patients during depressive episodes but not remission. J Affect Disord. 2016; 197: 116124.Google Scholar
Luo, X, Chen, G, Jia, Y, et al. Disrupted cerebellar connectivity with the central executive network and the default-mode network in unmedicated bipolar II disorder. Front Psychiatry. 2018; 9: 705.Google Scholar
Chen, G, Zhao, L, Jia, Y, et al. Abnormal cerebellum-DMN regions connectivity in unmedicated bipolar II disorder. J Affect Disord. 2019; 243: 441447.Google Scholar
Wang, J, Wang, Y. Y, Wu, X. X, et al. Shared and specific functional connectivity alterations in unmedicated bipolar and major depressive disorders based on the triple-network model. Brain Imaging Behav. 2020; February; 14(1):186199.CrossRefGoogle ScholarPubMed
Wang, Y, Zhong, S, Chen, G, et al. Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study. Aust N Z J Psychiatry. 2018; 52(10): 962971.Google Scholar
Shi, J, Geng, J, Yan, R, et al. Differentiation of transformed bipolar disorder from unipolar depression by resting-state functional connectivity within reward circuit. Front Psychol. 2018; 9: 2586.Google Scholar
Han, S, He, Z, Duan, X, et al. Dysfunctional connectivity between raphe nucleus and subcortical regions presented opposite differences in bipolar disorder and major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2018; 92: 7682.CrossRefGoogle ScholarPubMed
Calhoun, VD, Adali, T, Pearlson, GD, Pekar, JJ, Spatial and temporal independent component analysis of functional MRI data containing a pair of task-related waveforms. Hum Brain Mapp. 2001; 13(1): 4353.Google Scholar
Beckmann, CF, DeLuca, M, Devlin, JT, Smith, SM, Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci. 2005; 360(1457): 10011013.Google Scholar
Raichle, ME. Modern phrenology: Maps of human cortical function. Annals of the New York Academy of Sciences. 1999; 882: 107118; discussion 128–134.CrossRefGoogle ScholarPubMed
Raichle, ME, MacLeod, AM, Snyder, AZ, et al. A default mode of brain function. Proc Natl Acad Sci U S A. 2001; 98(2): 676682.Google Scholar
Ishida, T, Donishi, T, Iwatani, J, et al. Interhemispheric disconnectivity in the sensorimotor network in bipolar disorder revealed by functional connectivity and diffusion tensor imaging analysis. Heliyon. 2017; 3(6): e00335.Google Scholar
Syan, SK, Minuzzi, L, Smith, M, et al. Resting state functional connectivity in women with bipolar disorder during clinical remission. Bipolar Disord. 2017; 19(2): 97106.Google Scholar
Lois, G, Linke, J, Wessa, M, Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients. PLoS One. 2014; 9(10): e107829.Google Scholar
Ford, KA, Theberge, J, Neufeld, RJ, Williamson, PC, Osuch, EA, Correlation of brain default mode network activation with bipolarity index in youth with mood disorders. J Affect Disord. 2013; 150(3): 11741178.CrossRefGoogle ScholarPubMed
He, H, Sui, J, Du, Y, et al. Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders. Brain Struct Funct. 2017; 222(9): 40514064.CrossRefGoogle ScholarPubMed
Goya-Maldonado, R, Brodmann, K, Keil, M, et al. Differentiating unipolar and bipolar depression by alterations in large-scale brain networks. Hum Brain Mapp. 2016; 37(2): 808818.Google Scholar
Bullmore, E, Sporns, O, Complex brain networks: Graph theoretical analysis of structural and functional systems. Nat Rev Neurosci. 2009; 10(3): 186198.Google Scholar
Doucet, GE, Bassett, DS, Yao, N, Glahn, DC, Frangou, S, The role of intrinsic brain functional connectivity in vulnerability and resilience to bipolar disorder. Am J Psychiatry. 2017; 174(12): 12141222.Google Scholar
Wang, Y, Zhong, S, Jia, Y, et al. Disrupted resting-state functional connectivity in nonmedicated bipolar disorder. Radiology. 2016; 280(2): 529536.Google Scholar
Spielberg, JM, Beall, EB, Hulvershorn, LA, et al. Resting state brain network disturbances related to hypomania and depression in medication-free bipolar disorder. Neuropsychopharmacology. 2016; 41(13): 30163024.Google Scholar
He, H, Yu, Q, Du, Y, et al. Resting-state functional network connectivity in prefrontal regions differs between unmedicated patients with bipolar and major depressive disorders. J Affect Disord. 2016; 190: 483493.Google Scholar
Wang, Y, Wang, J, Jia, Y, et al. Shared and specific intrinsic functional connectivity patterns in unmedicated bipolar disorder and major depressive disorder. Sci Rep. 2017; 7(1): 3570.Google Scholar
Wang, Y, Wang, J, Jia, Y, et al.Topologically convergent and divergent functional connectivity patterns in unmedicated unipolar depression and bipolar disorder. Transl Psychiatry. 2017; 7(7): e1165.Google Scholar
Wiest, G. Neural and mental hierarchies. Front. Psychol. 2012 November 26; 3(516).CrossRefGoogle ScholarPubMed
Solms, L, Gamwell, M. (2006). From Neurology to Psychoanalysis: Sigmund Freud’s Neurological Drawings and Diagrams of the Mind, Binghamton University Art Museum.Google Scholar
Wang, F, Kalmar, JH, He, Y, et al. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry. 2009; 66(5): 516521.Google Scholar
Almeida, JR, Versace, A, Mechelli, A, et al. Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression. Biol Psychiatry. 2009; 66(5): 451459.CrossRefGoogle ScholarPubMed
Benson, BE, Willis, MW, Ketter, TA, et al. Differential abnormalities of functional connectivity of the amygdala and hippocampus in unipolar and bipolar affective disorders. J Affect Disord. 2014; 168: 243253.Google Scholar
Satterthwaite, TD, Kable, JW, Vandekar, L, et al. Common and dissociable dysfunction of the reward system in bipolar and unipolar depression. Neuropsychopharmacology. 2015; 40(9): 22582268.Google Scholar
Pompei, F, Dima, D, Rubia, K, Kumari, V, Frangou, S, Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder. Neuroimage. 2011; 57(2): 576582.Google Scholar
Nguyen, TT, Kovacevic, S, Dev, SI, et al. Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study.” Neuropsychology. 2017; 31(1): 7383.Google Scholar
Brady, RO Tandon, Jr Masters, N GA, et al. Differential brain network activity across mood states in bipolar disorder. J Affect Disord. 2017; 207: 367376.Google Scholar
Ellard, KK, Zimmerman, J. P. JP, Kaur, N. N, et al. Functional connectivity between anterior insula and key nodes of frontoparietal executive control and salience networks distinguish bipolar depression from unipolar depression and healthy control subjects. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018; 3(5): 473484.Google Scholar
Yip, SW, Mackay, CE, Goodwin, GM, Increased temporo-insular engagement in unmedicated bipolar II disorder: An exploratory resting state study using independent component analysis. Bipolar Disord. 2014; 16(7): 748755.Google Scholar
Ladouceur, CD, Diwadkar, VA, White, R, et al. Fronto-limbic function in unaffected offspring at familial risk for bipolar disorder during an emotional working memory paradigm. Dev Cogn Neurosci. 2013; 5: 185196.CrossRefGoogle ScholarPubMed
Soehner, AM, Bertocci, MA, Manelis, A, et al. Preliminary investigation of the relationships between sleep duration, reward circuitry function, and mood dysregulation in youth offspring of parents with bipolar disorder. J Affect Disord. 2016; 205: 144153.Google Scholar
Acuff, HE, Versace, A, Bertocci, MA, et al. Association of neuroimaging measures of emotion processing and regulation neural circuitries with symptoms of bipolar disorder in offspring at risk for bipolar disorder. JAMA Psychiatry. 2018; 75(12): 12411251.Google Scholar
Acuff, HE, Versace, A, Bertocci, MA, et al. Baseline and follow-up activity and functional connectivity in reward neural circuitries in offspring at risk for bipolar disorder. Neuropsychopharmacology. 2019 August; 44(9): 15701578.CrossRefGoogle ScholarPubMed
Manelis, A, Ladouceur, CD, Graur, S, et al. Altered amygdala-prefrontal response to facial emotion in offspring of parents with bipolar disorder. Brain. 2015; 138(Pt 9): 27772790.Google Scholar
Meluken, I, Ottesen, NM, Phan, KL, et al. Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders. Neuroimage Clin. 2019; 21: 101598.Google Scholar
Hafeman, DM, Chase, HW, Monk, K, et al. Intrinsic functional connectivity correlates of person-level risk for bipolar disorder in offspring of affected parents. Neuropsychopharmacology. 2019; 44(3): 629634.Google Scholar
Singh, MK, Chang, KD, Kelley, RG, et al. Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder. Bipolar Disord. 2014; 16(7): 678689.Google Scholar
Singh, MK, Leslie, SM, Bhattacharjee, K, et al. Vulnerabilities in sequencing and task switching in healthy youth offspring of parents with mood disorders. J Clin Exp Neuropsychol. 2018; 40(6): 606618.Google Scholar
Sole-Padulles, C, Castro-Fornieles, J, de la Serna, E, et al. Altered cortico-striatal connectivity in offspring of schizophrenia patients relative to offspring of bipolar patients and controls. PLoS One. 2016; 11(2): e0148045.CrossRefGoogle ScholarPubMed
Whittaker, JR, Foley, SF, Ackling, E, Murphy, K, Caseras, X, The functional connectivity between the nucleus accumbens and the ventromedial prefrontal cortex as an endophenotype for bipolar disorder. Biol Psychiatry. 2018; 84(11): 803809.Google Scholar
Li, CT, Tu, PC, Hsieh, JC, et al. Functional dysconnection in the prefrontal-amygdala circuitry in unaffected siblings of patients with bipolar I disorder. Bipolar Disord. 2015; 17(6): 626635.Google Scholar
Roberts, G, Lord, A, Frankland, A, et al. Functional dysconnection of the inferior frontal gyrus in young people with bipolar disorder or at genetic high risk. Biol Psychiatry. 2017; 81(8): 718727.Google Scholar
Collin, G, Scholtens, LH, Kahn, RS, Hillegers, MHJ, van den Heuvel, MP, Affected anatomical rich club and structural-functional coupling in young offspring of schizophrenia and bipolar disorder patients. Biol Psychiatry. 2017; 82(10): 746755.Google Scholar
Altinay, M, Karne, H, Anand, A, Lithium monotherapy associated clinical improvement effects on amygdala-ventromedial prefrontal cortex resting state connectivity in bipolar disorder. J Affect Disord. 2018; 225: 412.Google Scholar
Spielberg, JM, Matyi, MA, Karne, H, Anand, A, Lithium monotherapy associated longitudinal effects on resting state brain networks in clinical treatment of bipolar disorder. Bipolar Disord. 2019; 21(4): 361371.Google Scholar
Kazemi, R, Rostami, R, Khomami, S, et al. Bilateral transcranial magnetic stimulation on dlPFC changes resting state networks and cognitive function in patients with bipolar depression. Front Hum Neurosci. 2018; 12: 356.Google Scholar
Shinn, AK, Roh, YS, Ravichandran, CT, et al. Aberrant cerebellar connectivity in bipolar disorder with psychosis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017; 2(5): 438448.Google Scholar
Samudra, N, Ivleva, EI, Hubbard, NA, et al. Alterations in hippocampal connectivity across the psychosis dimension. Psychiatry Res. 2015; 233(2): 148157.Google Scholar
Anticevic, A, Savic, A, Repovs, G, et al. Ventral anterior cingulate connectivity distinguished nonpsychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophr Bull. 2015; 41(1): 133143.Google Scholar

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