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14 - Comparative betaherpes viral genome and virion structure

from Part II - Basic virology and viral gene effects on host cell functions: betaherpesviruses

Published online by Cambridge University Press:  24 December 2009

By
Andrew J. Davison  and
David Bhella
Edited by
Ann Arvin ,
Gabriella Campadelli-Fiume ,
Edward Mocarski ,
Patrick S. Moore ,
Bernard Roizman ,
Richard Whitley  and
Koichi Yamanishi
Andrew J. Davison
Affiliation:
MRC Virology Unit, Institute of Virology, Glasgow, UK
David Bhella
Affiliation:
MRC Virology Unit, Institute of Virology, Glasgow, UK
Ann Arvin
Affiliation:
Stanford University, California
Gabriella Campadelli-Fiume
Affiliation:
Università degli Studi, Bologna, Italy
Edward Mocarski
Affiliation:
Emory University, Atlanta
Patrick S. Moore
Affiliation:
University of Pittsburgh
Bernard Roizman
Affiliation:
University of Chicago
Richard Whitley
Affiliation:
University of Alabama, Birmingham
Koichi Yamanishi
Affiliation:
University of Osaka, Japan
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Summary

Introduction

The two major lineages in the Betaherpesvirinae are the cytomegaloviruses (the Cytomegalovirus and Muromegalovirus genera, plus a number of other viruses whose taxonomy is only partially defined) and the Roseolovirus genus (see Chapter 1). The best characterized members of these lineages are HCMV (the prototype of the subfamily) and HHV-6, respectively. Cytomegaloviruses are present in a wide range of mammalian species, and have been termed “salivary gland viruses” because of their ease of isolation from explanted tissue. An earlier divergence of the Betaherpesvirinae may be represented by a herpesvirus of elephants (Richman et al., 1999; Ehlers et al., 2001). This chapter starts by describing the genome structures of Betaherpesvirinae, then examines the genetic content of HCMV and HHV-6, and finally focuses on the virion structure of HCMV.

Genome structures

The genomes of viruses in the Roseolovirus genus are significantly smaller, at 145–162 kbp, than those of other Betaherpesvirinae, at 196–241 kbp. Indeed, HCMV has the largest genome among the human herpesviruses, and thus far its closest relative, CCMV, has the largest genome of all sequenced herpesviruses. It seems likely that the ancestor of the Betaherpesvirinae had a genome consisting of a unique region flanked by a direct repeat (the class A genome described in Chapter 2), since this structure is characteristic of most extant members of the subfamily. Earlier studies ruled out the presence of large repeats in the genomes of MCMV (Ebeling et al., 1983a; Mercer et al., 1983; Marks and Spector, 1984), THV (Koch et al., 1985) and RCMV (Meijer et al., 1986).

Type
Chapter
Information
Human Herpesviruses
Biology, Therapy, and Immunoprophylaxis
 , pp. 177 - 203
Publisher: Cambridge University Press
Print publication year: 2007

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