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Chapter 27 - Cytomegalovirus, Herpes Simplex Virus, Adenovirus, Coxsackievirus, and Human Papillomavirus in Pregnancy (Content last reviewed: 11th November 2020)

Published online by Cambridge University Press:  15 November 2017

David James
Affiliation:
University of Nottingham
Philip Steer
Affiliation:
Imperial College London
Carl Weiner
Affiliation:
University of Kansas
Bernard Gonik
Affiliation:
Wayne State University, Detroit
Stephen Robson
Affiliation:
University of Newcastle
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Summary

In an immunocompetent adult, viral infections may be asymptomatic or cause only mild nonspecific symptoms, but they can pose a serious threat to the fetus and the newborn.

Type
Chapter
Information
High-Risk Pregnancy
Management Options
, pp. 659 - 694
Publisher: Cambridge University Press
First published in: 2017

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References

Gouarin, S, Gault, E, Vabret, A, et al. Real-time PCR quantification of human cytomegalovirus DNA in amniotic fluid samples from mothers with primary infection. J Clin Microbiol 2002; 40: 1767–72.Google Scholar
Lazzarotto, T, Varani, S, Guerra, B, et al. Prenatal indicators of congenital cytomegalovirus infection. J Pediatr 2000; 137: 90–5.CrossRefGoogle ScholarPubMed
Revello, MG, Zavattoni, M, Furione, M, Baldanti, F, Gerna, G. Quantification of human cytomegalovirus DNA in amniotic fluid of mothers of congenitally infected fetuses. J Clin Microbiol 1999; 37: 3350–2.CrossRefGoogle ScholarPubMed
Barbi, M, Binda, S, Caroppo, S, et al. Multicity Italian study of congenital cytomegalovirus infection. Pediatr Infect Dis J 2006; 25: 156–9.Google Scholar
Reddy, UM, Baschat, AA, Zlatnik, MG, et al. Detection of viral deoxyribonucleic acid in amniotic fluid: association with fetal malformation and pregnancy abnormalities. Fetal Diagn Ther 2005; 20: 203–7.Google Scholar
Picone, O, Costa, JM, Leruez-Ville, M, et al. Cytomegalovirus (CMV) glycoprotein B genotype and CMV DNA load in the amniotic fluid of infected fetuses. Prenat Diagn 2004; 24: 1001–6.Google Scholar
Baschat, AA, Towbin, J, Bowles, NE, Harman, CR, Weiner, CP. Prevalence of viral DNA in amniotic fluid of low-risk pregnancies in the second trimester. J Matern Fetal Neonatal Med 2003; 13: 381–4.Google Scholar
Walter, S, Atkinson, C, Sharland, M, et al. Congenital cytomegalovirus: association between dried blood spot viral load and hearing loss. Arch Dis Child Fetal Neonatal Ed 2008; 93: F280–5.Google ScholarPubMed
Kumazaki, K, Ozono, K, Yahara, T, et al. Detection of cytomegalovirus DNA in human placenta. J Med Virol 2002; 68: 363–9.Google Scholar
Folkins, AK, Chisholm, KM, Guo, FP, et al. Diagnosis of congenital CMV using PCR performed on formalin-fixed, paraffin-embedded placental tissue. Am J Surg Pathol 2013; 37: 1413–20.CrossRefGoogle ScholarPubMed
Pereira, L, Maidji, E. Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge. Curr Top Microbiol Immunol 2008; 325: 383–95.Google Scholar
Maidji, E, McDonagh, S, Genbacev, O, Tabata, T, Pereira, L. Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis. Am J Pathol 2006; 168: 1210–26.Google Scholar
Chou, S. Newer methods for diagnosis of cytomegalovirus infection. Rev Infect Dis 1990; 12 (Suppl 7): S727–36.Google Scholar
Lazzarotto, T, Guerra, B, Lanari, M, Gabrielli, L, Landini, MP. New advances in the diagnosis of congenital cytomegalovirus infection. J Clin Virol 2008; 41: 192–7.Google Scholar
Guerra, B, Simonazzi, G, Banfi, A, et al. Impact of diagnostic and confirmatory tests and prenatal counseling on the rate of pregnancy termination among women with positive cytomegalovirus immunoglobulin M antibody titers. Am J Obstet Gynecol 2007; 196: 221.e1–6.Google Scholar
Revello, MG, Fabbri, E, Furione, M, et al. Role of prenatal diagnosis and counseling in the management of 735 pregnancies complicated by primary human cytomegalovirus infection: a 20-year experience. J Clin Virol 2011; 50: 303–7. doi: 10.1016/j.jcv.2010.12.012.CrossRefGoogle Scholar
Lazzarotto, T, Guerra, B, Gabrielli, L, Lanari, M, Landini, MP. Update on the prevention, diagnosis and management of cytomegalovirus infection during pregnancy. Clin Microbiol Infect 2011; 17: 1285–93. doi: 10.1111/j.1469-0691.2011.03564.x.Google Scholar
Griffiths, PD, Stagno, S, Pass, RF, Smith, RJ, Alford, CA. Infection with cytomegalovirus during pregnancy: specific IgM antibodies as a marker of recent primary infection. J Infect Dis 1982; 145: 647–53.Google Scholar
Ruellan-Eugene, G, Barjot, P, Campet, M, et al. Evaluation of virological procedures to detect fetal human cytomegalovirus infection: avidity of IgG antibodies, virus detection in amniotic fluid and maternal serum. J Med Virol 1996; 50: 915.Google Scholar
Lazzarotto, T, Varani, S, Spezzacatena, P, et al. Maternal IgG avidity and IgM detected by blot as diagnostic tools to identify pregnant women at risk of transmitting cytomegalovirus. Viral Immunol 2000; 13: 137–41.Google Scholar
Bodeus, M, Van Ranst, M, Bernard, P, Hubinont, C, Goubau, P. Anticytomegalovirus IgG avidity in pregnancy: a 2-year prospective study. Fetal Diagn Ther 2002; 17: 362–6.Google Scholar
Revello, MG, Lilleri, D, Zavattoni, M, et al. Human cytomegalovirus immediate-early messenger RNA in blood of pregnant women with primary infection and of congenitally infected newborns. J Infect Dis 2001; 184: 1078–81.Google Scholar
Tanimura, K, Yamada, H. Potential biomarkers for predicting congenital cytomegalovirus infection. Int J Mol Sci 2018; 19: 3760. doi: 10.3390/ijms19123760.Google Scholar
Azam, AZ, Vial, Y, Fawer, CL, Zufferey, J, Hohlfeld, P. Prenatal diagnosis of congenital cytomegalovirus infection. Obstet Gynecol 2001; 97: 443–8.Google Scholar
Nigro, G, Mazzocco, M, Anceschi, MM, et al. Prenatal diagnosis of fetal cytomegalovirus infection after primary or recurrent maternal infection. Obstet Gynecol 1999; 94: 909–14.Google Scholar
Grose, C, Weiner, CP. Prenatal diagnosis of congenital cytomegalovirus infection: two decades later. Am J Obstet Gynecol 1990; 163: 447–50.Google Scholar
Van den Veyver, IB, Ni, J, Bowles, N, et al. Detection of intrauterine viral infection using the polymerase chain reaction. Mol Genet Metab 1998; 63: 8595.CrossRefGoogle ScholarPubMed
Lamy, ME, Mulango, KN, Gadisseux, JF, et al. Prenatal diagnosis of fetal cytomegalovirus infection. Am J Obstet Gynecol 1992; 166: 91–4.CrossRefGoogle ScholarPubMed
Liesnard, C, Donner, C, Brancart, F, et al. Prenatal diagnosis of congenital cytomegalovirus infection: prospective study of 237 pregnancies at risk. Obstet Gynecol 2000; 95: 881–8.Google Scholar
Hogge, WA, Buffone, GJ, Hogge, JS. Prenatal diagnosis of cytomegalovirus (CMV) infection: a preliminary report. Prenat Diagn 1993; 13: 131–6.Google Scholar
Xu, W, Sundqvist, V-A, Brytting, M, Linde, A. Diagnosis of cytomegalovirus infections using polymerase chain reaction, virus isolation and serology. Scand J Infect Dis 1993; 25: 311–16.Google Scholar
Catanzarite, V, Dankner, WM. Prenatal diagnosis of congenital cytomegalovirus infection: false-negative amniocentesis at 20 weeks’ gestation. Prenat Diagn 1993; 13: 1021–5.Google Scholar
Revello, MG, Gerna, G. Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin Microbiol Rev 2002; 15: 680715. doi: 10.1128/CMR.15.4.680-715.2002.Google Scholar
Revello, MG, Baldanti, F, Furione, M, et al. Polymerase chain reaction for prenatal diagnosis of congenital human cytomegalovirus infection. J Med Virol 1995; 47: 462–6.Google Scholar
Lynch, L, Daffos, F, Emanuel, D, et al. Prenatal diagnosis of fetal cytomegalovirus infection. Am J Obstet Gynecol 1991; 165: 714–18.Google Scholar
Watt-Morse, ML, Laifer, SA, Hill, LM. The natural history of fetal cytomegalovirus infection as assessed by serial ultrasound and fetal blood sampling: a case report. Prenat Diagn 1995; 15: 567–70.CrossRefGoogle ScholarPubMed
Peters, MT, Lowe, TW, Carpenter, A, Kole, S. Prenatal diagnosis of congenital cytomegalovirus infection with abnormal triple-screen results and hyperechoic fetal bowel. Am J Obstet Gynecol 1995; 173: 953–4.CrossRefGoogle ScholarPubMed
Lipitz, S, Achiron, R, Zalel, Y, et al. Outcome of pregnancies with vertical transmission of primary cytomegalovirus infection. Obstet Gynecol 2002; 100: 428–33.Google ScholarPubMed
Guerra, B, Simonazzi, G, Puccetti, C, et al. Ultrasound prediction of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 2008; 198: 380.e1–7.Google Scholar
Lipitz, S, Hoffmann, C, Feldman, B, et al. Value of prenatal ultrasound and magnetic resonance imaging in assessment of congenital primary cytomegalovirus infection. Ultrasound Obstet Gynecol 2010; 36: 709–17.Google ScholarPubMed
Benoist, G, Salomon, LJ, Mohlo, M, et al. Cytomegalovirus-related fetal brain lesions: comparison between targeted ultrasound examination and magnetic resonance imaging. Ultrasound Obstet Gynecol 2008; 32: 900–5.Google Scholar
Picone, O, Simon, I, Benachi, A, Brunelle, F, Sonigo, P. Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn 2008; 28: 753–8.CrossRefGoogle ScholarPubMed
Hadar, E, Dorfman, E, Bardin, R, et al. Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study. BMC Infect Dis 2017; 17: 31. doi: 10.1186/s12879-016-2161-3.Google Scholar
Stagno, S, Pass, RF, Dworsky, ME, Alford, CA. Congenital and perinatal cytomegalovirus infection. Semin Perinatol 1983; 7: 3142.Google Scholar
Raynor, BD. Cytomegalovirus infection in pregnancy. Semin Perinatol 1993; 17: 394402.Google ScholarPubMed
Slyker, JA, Lohman-Payne, BL, Rowland-Jones, SL, et al. The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1–infected woman and their infants. AIDS 2009; 23: 117–24.Google Scholar
Chretien, JH, McGinnis, CG, Muller, A. Venereal causes of cytomegalovirus mononucleosis. JAMA 1977; 238: 1644–5.Google Scholar
Chandler, SH, Handsfield, HH, McDougall, JK. Isolation of multiple strains of cytomegalovirus from women attending a clinic for sexually transmitted diseases. J Infect Dis 1987; 155: 655–60.Google Scholar
Yeager, AS, Grumet, FC, Hafleigh, EB, et al. Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr 1981; 98: 281–7.Google Scholar
Hersman, J, Meyers, JD, Thomas, ED, Buckner, CD, Clift, R. The effect of granulocyte transfusions on the incidence of cytomegalovirus infection after allogeneic marrow transplantation. Ann Intern Med 1982; 96: 149–52.Google Scholar
Stagno, S, Reynolds, DW, Pass, RF, Alford, CA. Breast milk and the risk of cytomegalovirus infection. N Engl J Med 1980; 302: 1073–6.Google Scholar
Miron, D, Brosilow, S, Felszer, K, et al. Incidence and clinical manifestations of breast milk–acquired cytomegalovirus infection in low birth weight infants. J Perinatol 2005; 25: 299303.Google Scholar
Doctor, S, Friedman, S, Dunn, MS, et al. Cytomegalovirus transmission to extremely low-birthweight infants through breast milk. Acta Paediatr 2005; 94: 53–8.Google Scholar
Gurevich, I, Cunha, BA. Nonparenteral transmission of cytomegalovirus in a neonatal intensive care unit. Lancet 1981; ii: 222–4.Google Scholar
Marshall, BC, Adler, SP. The frequency of pregnancy and exposure to cytomegalovirus infections among women with a young child in day care. Am J Obstet Gynecol 2009; 200: 163.e1–5.Google Scholar
Pass, RF, Little, EA, Stagno, S, Britt, WJ, Alford, CA. Young children as a probable source of maternal and congenital cytomegalovirus infection. N Engl J Med 1987; 316: 1366–70.Google Scholar
Staras, SA, Dollard, SC, Radford, KW, et al. Seroprevalence of cytomegalovirus infection in the United States, 1988–1994. Clin Infect Dis 2006; 43: 1143–51.Google Scholar
Cannon, MJ. Congenital cytomegalovirus (CMV) epidemiology and awareness. J Clin Virol 2009; 46 (Suppl 4): S6–10.Google Scholar
Krech, U. Complement-fixing antibodies against cytomegalovirus in different parts of the world. Bull WHO 1973; 49: 103–6.Google Scholar
Stagno, S, Pass, RF, Cloud, G, et al. Primary cytomegalovirus infection in pregnancy. Incidence, transmission to the fetus, and clinical outcome. JAMA 1986; 256: 1904–8.Google Scholar
Tookey, PA, Ades, AE, Peckham, CS. Cytomegalovirus prevalence in pregnant women: the influence of parity. Arch Dis Child 1992; 67: 779–83.CrossRefGoogle ScholarPubMed
Peckham, CS, Coleman, JC, Hurley, R, et al. Cytomegalovirus infection in pregnancy: preliminary findings from a prospective study. Lancet 1983; i: 1352–5.Google Scholar
Colugnati, FA, Staras, SA, Dollard, SC, Cannon, MJ. Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis 2007; 7: 71.Google Scholar
Yow, MD, Williamson, DW, Leeds, LJ, et al. Epidemiologic characteristics of cytomegalovirus infection in mothers and their infants. Am J Obstet Gynecol 1988; 158: 1189–95.Google Scholar
Kenneson, A, Cannon, MF. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 2007; 17: 253–76.Google Scholar
Griffiths, PD, Campbell-Benzie, A, Heath, RB. A prospective study of primary cytomegalovirus infection in pregnant women. Br J Obstet Gynaecol 1980; 87: 308–14.Google Scholar
Stagno, S, Whitley, RJ. Herpesvirus infections of pregnancy. Part I: cytomegalovirus and Epstein–Barr virus infections. N Engl J Med 1985; 313: 1270–4.Google Scholar
Crumpacker, CS. Cytomegalovirus. In Mandell, GL, Douglas, RG, Bennett, JE (eds), Principles and Practice of Infectious Diseases, 5th edn. New York, NY: Churchill Livingstone, 2000, pp. 1586–99.Google Scholar
Arora, N, Novak, Z, Fowler, KB, Boppana, SB, Ross, SA. Cytomegalovirus viruria and DNAemia in healthy seropositive women. J Infect Dis 2010; 202: 1800–3.CrossRefGoogle ScholarPubMed
Ross, SA, Arora, N, Novak, Z, et al. Cytomegalovirus reinfections in healthy seroimmune women. J Infect Dis 2010; 201: 386–9.Google Scholar
Wang, C, Zhang, X, Bialek, S, Cannon, MJ. Attribution of congenital cytomegalovirus infection to primary versus non-primary maternal infection. Clin Infect Dis 2011; 52: e11–13.Google Scholar
Stagno, S. Cytomegalovirus. In Remington, JS, Klein, JO (eds), Infectious Diseases of the Fetus and Newborn Infant, 5th edn. Philadelphia, PA: Saunders, 2001, pp. 389424.Google Scholar
Picone, O, Vauloup-Fellous, C, Cordier, AG, et al. A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome. Prenat Diagn 2013; 33: 751–8.CrossRefGoogle ScholarPubMed
Giannattasio, A, Di Costanzo, P, Matteis, De, et al. Outcomes of congenital cytomegalovirus disease following maternal primary and non-primary infection. J Clin Virol 2017; 96: 32–6. doi: 10.1016/j.jcv.2017.09.006.Google Scholar
Puhakka, L, Renko, M, Helminen, M, et al. Primary versus non-primary maternal cytomegalovirus infection as a cause of symptomatic congenital infection: register-based study from Finland. Infect Dis 2017; 49: 445–53. doi: 10.1080/23744235.2017.1279344.CrossRefGoogle Scholar
Manicklal, S, Emery, VC, Lazzarotto, T, Boppana, SB, Gupta, RK. The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev 2013; 26: 86102. doi: 10.1128/CMR.00062-12.Google Scholar
Marsico, C, Kimberlin, DW. Congenital cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment. Ital J Pediatr 2017; 43: 38. doi: 10.1186/s13052-017-0358-8.CrossRefGoogle ScholarPubMed
Stagno, S. Cytomegalovirus. In Remington, JS, Klein, JO (eds), Infectious Diseases of the Fetus and Newborn Infant, 4th edn. Philadelphia, PA: Saunders, 1995, pp. 312–53.Google Scholar
Demmler, GJ. Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 1991; 13: 315–29.Google Scholar
Fowler, KB, McCollister, FP, Dahle, AJ, et al. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr 1997; 130: 624–30.Google Scholar
Boppana, SB, Rivera, LB, Fowler, KB, Mach, M, Britt, WJ. Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 2001; 344: 1366–71.Google Scholar
Fowler, KB, Stagno, S, Pass, RF, et al. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 1992; 326: 663–7.Google Scholar
Hicks, T, Fowler, K, Richardson, M, et al. Congenital cytomegalovirus infection and neonatal auditory screening. J Pediatr 1993; 123: 779–82.Google Scholar
Ahlfors, K, Ivarsson, SA, Bjerre, I. Microcephaly and congenital cytomegalovirus infection: a combined prospective and retrospective study of a Swedish infant population. Pediatrics 1986; 78: 1058–63.Google Scholar
Centers for Disease Control and Prevention (CDC). Knowledge and practices of obstetricians and gynecologists regarding cytomegalovirus infection during pregnancy: United States, 2007. MMWR Morb Mortal Wkly Rep 2008; 57: 65–8.Google Scholar
Ross, DS, Dollard, SC, Victor, M, Sumartojo, E, Cannon, MJ. The epidemiology and prevention of congenital cytomegalovirus infection and disease Activities of the Centers for Disease Control and Prevention Workgroup. J Womens Health (Larchmt) 2006; 15: 224–9.Google Scholar
Cannon, MF, Davis, KF. Washing our hands of the congenital cytomegalovirus disease epidemic. BMC Public Health 2005; 5: 70.Google Scholar
Ross, DS, Victor, M, Sumartojo, E, Cannon, MJ. Women’s knowledge of congenital cytomegalovirus: results from the 2005 Health Styles survey. J Womens Health (Larchmt) 2008; 17: 849–58.Google Scholar
Piper, J, Wen, TS. Perinatal cytomegalovirus and toxoplasmosis: challenges of antepartum therapy. Clin Obstet Gynecol 1999; 42: 8196.Google Scholar
American College of Obstetricians and Gynecologists. Practice bulletin no. 151: cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Obstet Gynecol 2015; 125: 1510–25.Google Scholar
Griffiths, PD, McLean, A, Emery, VC. Encouraging prospects for immunisation against primary cytomegalovirus infection. Vaccine 2001; 19: 1356–62.Google Scholar
Cheeran, MC, Lokensgard, JR, Schleiss, MR. Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev 2009; 22: 99126.Google Scholar
Pass, RF, Zhang, C, Evans, A, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med 2009; 360: 1191–9.Google Scholar
Dasari, V, Smith, C, Zhong, J, et al. Recombinant glycoprotein B vaccine formulation with Toll-like receptor 9 agonist and immune-stimulating complex induces specific immunity against multiple strains of cytomegalovirus. J Gen Virol 2011; 92: 1021–31.Google Scholar
Sabbaj, S, Pass, RF, Goepfert, PA, Pichon, S. Glycoprotein B vaccine is capable of boosting both antibody and CD4 T-cell responses to cytomegalovirus in chronically infected women. J Infect Dis 2011; 203: 1534–41.Google Scholar
Adler, SP. Cytomegalovirus and child day care. Evidence for an increased infection rate among day-care workers. N Engl J Med 1989; 321: 1290–6.Google Scholar
McGregor, JA, Rubright, G, Ogle, JW. Congenital cytomegalovirus infection as a preventable complication of maternal transfusion. A case report. J Reprod Med 1990; 35: 61–4.Google ScholarPubMed
Revello, MG, Rercivalle, E, Baldanti, F, et al. Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir. Clin Diagn Virol 1993; 1: 61–7.Google Scholar
Puliyanda, DP, Silverman, NS, Lehman, D, et al. Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient. Transpl Infect Dis 2005; 7: 71–4.Google Scholar
Jacquemard, F, Yamamoto, M, Costa, JM, et al. Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection. BJOG 2007; 114: 1113–21.Google Scholar
Leruez-Ville, M, Ghout, I, Bussières, L, et al. In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study. Am J Obstet Gynecol 2016; 215: 462.e1–10.Google Scholar
Kimberlin, DW, Jester, PM, Sánchez, PJ, et al. Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 2015; 372: 933–43.Google Scholar
Nigro, G, Adler, SP, La Torre, R, et al. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 2005; 353: 1350–62.Google Scholar
Nigro, G, Torre, RL, Pentimalli, H, et al. Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy. Prenat Diagn 2008; 28: 512–17.Google Scholar
Moxley, K, Knudtson, EJ. Resolution of hydrops secondary to cytomegalovirus after maternal and fetal treatment with human cytomegalovirus hyperimmune globulin. Obstet Gynecol 2008; 111: 524–6.CrossRefGoogle ScholarPubMed
Nigro, G, Adler, SP, Parruti, G, et al. Immunoglobulin therapy of fetal cytomegalovirus infection occurring in the first half of pregnancy: a case-control study of the outcome in children. J Infect Dis 2012; 205: 215–27.Google Scholar
Visentin, S, Manara, R, Milanese, L, et al. Early primary cytomegalovirus infection in pregnancy: maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age. Clin Infect Dis 2012; 55: 497503.Google Scholar
Revello, MG, Lazzarotto, T, Guerra, B, et al. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N Engl J Med 2014; 370: 1316–26.Google Scholar
Minsart, AF, Smiljkovic, M, Renaud, C, et al. Use of cytomegalovirus-specific hyperimmunoglobulins in pregnancy: a retrospective cohort. J Obstet Gynaecol Can 2018; 40: 1409–16. doi: 10.1016/j.jogc.2018.03.013.Google Scholar
Kimberlin, DW, Lin, CY, Sanchez, PJ, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized controlled trial. J Pediatr 2003; 143: 1625.Google Scholar
Oliver, SE, Cloud, GA, Sánchez, PJ, et al. Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. J Clin Virol 2009; 46 (Suppl 4): S22–6.Google Scholar
Ryder, N, Jin, F, McNulty, AM, Grulich, AE, Donovan, B. Increasing role of herpes simplex virus type 1 in first-episode anogenital herpes in heterosexual women and younger men who have sex with men, 1992–2006. Sex Transm Infect 2009; 85: 416–19.Google Scholar
Bernstein, DI, Bellamy, AR, Hook, EW, et al. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Clin Infect Dis 2013; 56: 344–51.Google Scholar
Landy, HJ, Grossman, JH. Herpes simplex virus. Obstet Gynecol Clin North Am 1989; 16: 495515.Google Scholar
Wald, A, Huang, ML, Carrell, D, Selke, S, Corey, L. Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. J Infect Dis 2003; 188: 1345–51.Google Scholar
Van Der Pol, B, Warren, T, Taylor, SN, et al. Type-specific identification of anogenital herpes simplex virus infections by use of a commercially available nucleic acid amplification test. J Clin Microbiol 2012; 50: 3466–71.Google Scholar
Cone, RW, Hobson, AC, Brown, ZA, et al. Frequent detection of genital herpes simplex virus DNA by polymerase chain reaction among pregnant women. JAMA 1994; 272: 792–6.Google Scholar
Workowski, KA, Bolan, GA; Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 2015; 64 (RR-03): 1137.Google Scholar
Ashley, RL. Sorting out the new HSV type specific antibody tests. Sex Transm Infect 2001; 77: 232–7.Google Scholar
Morrow, R, Friedrich, D. Performance of a novel test for IgM and IgG antibodies in subjects with culture-documented genital herpes simplex virus-1 or -2 infection. Clin Microbiol Infect 2006; 12: 463–9.Google Scholar
Brown, ZA. Case study: type-specific HSV serology and the correct diagnosis of first-episode genital herpes during pregnancy. Herpes 2002; 9: 24–6.Google Scholar
Koutsky, LA, Stevens, CE, Holmes, KK, et al. Underdiagnosis of genital herpes by current clinical and viral-isolation procedures. N Engl J Med 1992; 326: 1533–9.Google Scholar
Arvin, AM, Hensleigh, PA, Prober, CG, et al. Failure of antepartum maternal culture to predict the infant’s risk of exposure to herpes simplex virus at delivery. N Engl J Med 1986; 315: 796800.Google Scholar
Riley, LE. Herpes simplex virus. Semin Perinatol 1998; 22: 284–92.Google Scholar
Rouse, DJ, Stringer, JSA. An appraisal of screening for maternal type-specific herpes simplex virus antibodies to prevent neonatal herpes. Am J Obstet Gynecol 2000; 183: 400–6.Google Scholar
Kulhanjian, JA, Soroush, V, Au, DS, et al. Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy. N Engl J Med 1992; 326: 916–20.Google Scholar
Corey, L, Wald, A, Patel, R, et al. Once daily valacyclovir reduces transmission of genital herpes. N Engl J Med 2004; 350: 1120.Google Scholar
Baker, DA, Amstey, MS. Herpes simplex virus: biology, epidemiology, and clinical infection. Semin Perinatol 1983; 7: 18.Google Scholar
Rooney, JF, Felser, JM, Ostrove, JM, Straus, SE. Acquisition of genital herpes from an asymptomatic sexual partner. N Engl J Med 1986; 314: 1561–4.Google Scholar
Koelle, DM, Benedetti, J, Langenberg, A, Corey, L. Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes. Ann Intern Med 1992; 116: 433–7.Google Scholar
Whitley, RJ, Soong, SJ, Linneman, C, et al. Herpes simplex encephalitis. Clinical assessment. JAMA 1982; 247: 317–20.Google Scholar
Rubin, MH, Ward, DM, Painter, CJ. Fulminant hepatic failure caused by genital herpes in a healthy person. JAMA 1985; 253: 1299–301.Google Scholar
Laffery, WE, Coombs, RW, Benedetti, J, Critchlow, C, Corey, L. Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type. N Engl J Med 1987; 316: 1444–9.Google Scholar
Fleming, DT, McQuillan, GM, Johnson, RE, et al. Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med 1997; 16: 1105–10.Google Scholar
Mertz, GL, Benedetti, J, Ashley, R, Selke, SA, Corey, L. Risk factors for the sexual transmission of genital herpes. Ann Intern Med 1992; 116: 197202.Google Scholar
Amstrong, GL, Schillinger, J, Markowitz, L, et al. Incidence of herpes simplex virus type 2 infection in the United States. Am J Epidemiol 2001; 153: 912–20.Google Scholar
Brown, ZA, Selke, S, Zeh, J, et al. The acquisition of herpes simplex virus during pregnancy. N Engl J Med 1997; 337: 509–15.Google Scholar
Gonik, B, Loo, LS, West, S, Kohl, S. Natural killer cell cytotoxicity and antibody-dependent cellular cytotoxicity to herpes simplex virus-infected cells in human pregnancy. Am J Reprod Immunol Microbiol 1987; 13: 23–6.Google Scholar
Lagrew, DC, Furlow, TG, Hager, WD, Yarrish, RL. Disseminated herpes simplex virus infection in pregnancy. Successful treatment with acyclovir. JAMA 1984; 252: 2058–9.Google Scholar
Whitley, RJ, Corey, L, Arvin, A, et al. Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 1988; 158: 109–16.CrossRefGoogle ScholarPubMed
Brown, ZA, Benedetti, J, Ashley, R, et al. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 1991; 324: 1247–52.Google Scholar
Brown, ZA, Vontver, LA, Benedetti, J, et al. Effects on infants of a first episode of genital herpes during pregnancy. N Engl J Med 1987; 317: 1246–51.Google Scholar
Brown, ZA, Wald, A, Morrow, RA, et al. Effect of serologic status and caesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA 2003; 289: 203–9.Google Scholar
Catalono, PM, Meritt, AO, Mead, PB. Incidence of genital herpes simplex virus at the time of delivery in women with known risk factors. Am J Obstet Gynecol 1991; 164: 1303–6.Google Scholar
Stone, KM, Brooks, CA, Guinan, ME, Alexander, ER. National surveillance for neonatal herpes simplex virus infections. Sex Transm Dis 1989; 16: 152–6.Google Scholar
Kerkering, K, Gardella, C, Selke, S, et al. Isolation of herpes simplex virus from the genital tract during symptomatic recurrence on the buttocks. Obstet Gynecol 2006; 108: 947–52.Google Scholar
Whitley, R, Arvin, A, Prober, C, et al. Predictors of morbidity and mortality in neonates with herpes simplex infections. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. N Engl J Med 1991; 324: 450–4.Google Scholar
Looker, KJ, Magaret, AS, May, MT, et al. First estimates of the global and regional incidence of neonatal herpes infection. Lancet Glob Health 2017; 5: e300–9. doi: 10.1016/S2214-109X(16)30362-X.Google Scholar
Casper, C, Wald, A. Condom use and the prevention of genital herpes acquisition. Herpes 2002; 9: 1014.Google Scholar
Scott, LL, Sanchez, PJ, Jackson, GL, Zeray, F, Wendel, GD. Acyclovir suppression to prevent cesarean delivery after first-episode genital herpes. Obstet Gynecol 1996; 87: 6973.Google Scholar
Centers for Disease Control and Prevention (CDC). Pregnancy outcomes following systemic acyclovir exposure. June 1, 1984–June 30, 1993. MMWR Morb Mortal Wkly Rep 1993; 42: 806–9.Google Scholar
Stone, KM, Reiff-Eldridge, R, White, AD, et al. Pregnancy outcomes following systemic prenatal acyclovir exposure: conclusions from the International Acyclovir Pregnancy Registry, 1984–1999. Birth Defects Res A Clin Mol Teratol 2004; 70: 201–7.Google Scholar
Fife, KH, Crumpacker, CS, Mertz, GJ, Hill, EL, Boone, GS. Recurrence and resistance patterns of herpes simplex virus following cessation of ≥ 6 years of chronic suppression with acyclovir. Acyclovir Study Group. J Infect Dis 1994; 169: 1338–41.Google Scholar
Reyes, M, Shaik, NS, Graber, JM, et al. Acyclovir-resistant genital herpes among persons attending sexually transmitted disease and human immunodeficiency virus clinics. Arch Intern Med 2003; 163: 7680.Google Scholar
Levin, MJ, Bacon, TH, Leary, JJ. Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients. Clin Infect Dis 2004; 39 (Suppl 5): S248–257.Google Scholar
Frenkel, LM, Brown, ZA, Bryson, YJ, et al. Pharmacokinetics of acyclovir in the term human pregnancy and neonate. Am J Obstet Gynecol 1991; 164: 569–76.Google Scholar
Sheffield, JS, Hollier, LM, Hill, JB, Stuart, GS, Wendel, GD. Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review. Obstet Gynecol 2003; 102: 1396–403.Google Scholar
Sheffield, JS, Wendel, GD, Laibl, V, et al. Valacyclovir prophylaxis to prevent recurrent herpes at delivery: a randomized controlled trial. Obstet Gynecol 2006; 108: 1550–2.Google Scholar
American College of Obstetricians and Gynecologists. Management of Herpes in Pregnancy ACOG Practice Bulletin No. 8. Washington, DC: ACOG, 1999.Google Scholar
American College of Obstetricians and Gynecologists. Management of Herpes in Pregnancy ACOG Practice Bulletin No. 82. Washington, DC: ACOG, 2007.Google Scholar
Baker, D, Brown, Z, Hollier, LM, et al. Cost-effectiveness of herpes simplex virus type 2 serologic testing and antiviral therapy in pregnancy. Am J Obstet Gynecol 2004; 191: 2074–84.Google Scholar
Major, CA, Towers, CV, Lewis, DF, Garite, TJ. Expectant management of preterm premature rupture of membranes complicated by active recurrent genital herpes. Am J Obstet Gynecol 2003; 188: 1551–4.Google Scholar
Goldkrand, JW. Intrapartum inoculation of herpes simplex virus by fetal scalp electrode. Obstet Gynecol 1982; 59: 263–5.Google Scholar
Hollier, LM, Scott, LL, Murphree, SS, Wendel, GD. Postpartum endometritis caused by herpes simplex virus. Obstet Gynecol 1997; 89: 836–8.Google Scholar
Larson, JE, Morrow, SL, Happel, L, Sharp, JF, Cohen, JC. Reversal of cystic fibrosis phenotype in mice by gene therapy in utero. Lancet 1997; 349: 619–20.Google Scholar
Kita, Y, Li, XK, Ohba, M, et al. Prolonged cardiac allograft survival in rats systemically injected adenoviral vectors containing CTLA4IG-gene. Transplantation 1999; 68: 758–66.Google Scholar
Schneider, H, Muehle, C, Douar, AM, et al. Sustained delivery of therapeutic concentrations of human clotting factor IX: a comparison of adenoviral and AAV vectors administered in utero. J Gene Med 2002; 4: 4653.Google Scholar
Yano, K, Liaw, PC, Mullington, JM, et al. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med 2006; 203: 1447–58.Google Scholar
Lu, F, Bytautiene, E, Tamayo, E, et al. Gender-specific effect of overexpression of sFit-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life. Am J Obstet Gynecol 2007; 197: 418.e1–5.Google Scholar
Sylvester, KG, Yang, EY, Cass, DL, Crombleholme, TM, Adzick, NS. Fetoscopic gene therapy for congenital lung disease. J Pediatr Surg 1997; 32: 964–9.Google Scholar
Baumgartner, TL, Baumgartner, BJ, Hudon, L, Moise, KJ. Ultrasonographically guided direct gene transfer in utero: successful induction of beta-galactosidase in a rabbit model. Am J Obstet Gynecol 1999; 181: 848–52.Google Scholar
Iwamoto, HS, Trapnell, BC, McConnell, CJ, Daugherty, C, Whitsett, JA. Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep. Gene Ther 1999; 6: 98106.Google Scholar
Xing, A, Boileau, P, Caüzac, M, et al. Comparative in vivo approaches for selective adenovirus-mediated gene delivery to the placenta. Hum Gene Ther 2000; 11: 167–77.Google Scholar
David, AL, Torondel, B, Zachary, I, et al. Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep. Gene Ther 2008; 15: 1344–50.Google Scholar
Grisafi, D, Piccoli, M, Pozzobon, M, et al. High transduction efficiency of human amniotic fluid stem cells mediated by adenovirus vectors. Stem Cells Dev 2008; 17: 953–62.Google Scholar
Horwitz, MS. Adenoviruses. In Fields, BN, Knipe, DM, Howley, PM (eds), Fields Virology, 3rd edn. Philadelphia, PA: Lippincott-Raven, 1995, pp. 2149–71.Google Scholar
Foy, HM. Adenoviruses. In Evans, A, Kaslow, R (eds), Viral Infection in Humans: Epidemiology and Control, 4th edn. New York, NY: Plenum, 1997, pp. 119–38.Google Scholar
Matsuoka, T, Naito, T, Kubato, Y, et al. Disseminated adenovirus (type 19) infection in a neonate: rapid detection of the infection by immunofluorescence. Acta Paediatr Scand 1990; 79: 568–71.Google Scholar
Montone, KT, Furth, EE, Pietra, GG, Gupta, PK. Neonatal adenovirus infection: a case report with in situ hybridization confirmation of ascending intrauterine infection. Diagn Cytopathol 1995; 12: 341–4.Google Scholar
Ranucci-Weiss, D, Uerpairojkit, B, Bowles, N, Towbin, JA, Chan, L. Intrauterine adenoviral infection associated with fetal nonimmune hydrops. Prenat Diagn 1998; 18: 182–5.Google Scholar
Towbin, JA, Griffin, LD, Martin, AB, et al. Intrauterine adenoviral myocarditis presenting as nonimmune hydrops fetalis: diagnosis by polymerase chain reaction. Pediatr Infect Dis J 1994; 13: 144–50.Google Scholar
Abzug, MJ, Levine, MJ. Neonatal adenovirus infection: four patients and review of the literature. Pediatrics 1991; 87: 890–6.Google Scholar
Angella, JJ, Connor, JD. Neonatal infection caused by adenovirus type 7. J Pediatr 1968; 72: 474–8.Google Scholar
Kinney, JS, Hierholzer, JC, Thibault, DW. Neonatal pulmonary insufficiency caused by adenovirus infection successfully treated with extracorporeal membrane oxygenation. J Pediatr 1994; 125: 110–12.Google Scholar
Brown, M, Rossier, E, Carpenter, B, Anand, CM. Fatal adenovirus type 35 infection in newborns. Pediatr Infect Dis J 1991; 10: 955–6.Google Scholar
Meyer, K, Girgis, N, McGravey, V. Adenovirus associated with congenital pleural effusions. J Pediatr 1985; 107: 433–5.Google Scholar
Finn, A, Anday, E, Talbot, GH. An epidemic of adenovirus 7a infection in a neonatal nursery: course, morbidity, and management. Infect Control Hosp Epidemiol 1988; 9: 398404.Google Scholar
Carter, BA, Karpen, SJ, Quiros-Tejeira, RE, et al. Intravenous cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation 2002; 74: 1050–2.Google Scholar
Arav-Boger, R, Echavarria, M, Forman, M, Charache, P, Persaud, D. Clearance of adenoviral hepatitis with ribavirin therapy in a pediatric liver transplant recipient. Pediatr Infect Dis J 2000; 19: 1097–100.Google Scholar
Ronchi, A, Doern, C, Brock, E, Pugni, L, Sánchez, PJ. Neonatal adenoviral infection: a seventeen year experience and review of the literature. J Pediatr 2014; 164: 529–35.Google Scholar
Prodhan, P, Bhutta, AT, Gossett, JM, et al. Extracorporeal membrane oxygenation support among children with adenovirus infection: a review of the Extracorporeal Life Support Organization registry. ASAIO J 2014; 60: 4956.Google Scholar
Lyons, A, Longfield, J, Kuschner, R, et al. A double-blind, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults. Vaccine 2008; 26: 2890–8.Google Scholar
Radin, JM, Hawksworth, AW, Blair, PJ, et al. Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines. Clin Infect Dis 2014; 59: 962–8.Google Scholar
Tindall, JP, Callaway, JL. Hand-foot-and-mouth disease: it’s more common than you think. Am J Dis Child 1972; 124: 372–5.Google Scholar
Zoll, GJ, Melchers, WJG, Kopecka, H, et al. General primer-mediated polymerase chain reaction for detection of enteroviruses: application for diagnostic routine and persistent infections. J Clin Microbiol 1992; 30: 160–5.Google Scholar
Pozzetto, B, Gaudin, OG, Aouni, M, Ros, A. Comparative evaluation of immunoglobulin M neutralizing antibody response in acute-phase sera and virus isolation for the routine diagnosis of enterovirus infection. J Clin Microbiol 1989; 27: 705–8.Google Scholar
Shin, SY, Kim, KS, Lee, YS, et al. Identification of enteroviruses by using monoclonal antibodies against a putative common epitope. J Clin Microbiol 2003; 41: 3028–34.Google Scholar
Cherry, JD, Krogstad, P. Enteroviruses. In Wilson, CB, Nizet, V, Maldonado, YA. Remington, JS, Klein, JO (eds), Infectious Diseases of the Fetus and Newborn Infant, 8th edn. Philadelphia, PA: Saunders, 2016, pp. 782827.Google Scholar
Ettischer-Schmid, N, Normann, A, Sauter, M, et al. A new monoclonal antibody (Cox mAB 31A2) detects VP1 protein of coxsackievirus B3 with high sensitivity and specificity. Virchows Arch 2016; 469: 553–62.Google Scholar
Miao, LY, Pierce, C, Gray-Johnson, J, et al. Monoclonal antibodies to VP1 recognize a broad range of enteroviruses. J Clin Microbiol 2009; 47: 3108–13.Google Scholar
Redline, R, Genest, D, Tycko, B. Detection of enteroviral infection in paraffin-embedded tissue by the RNA polymerase chain reaction technique. Am J Clin Pathol 1991; 96: 568–71.Google Scholar
Modlin, JF. Perinatal echovirus and group B coxsackievirus infections. Clin Perinatol 1988; 15: 233–46.Google Scholar
Baker, DA, Phillips, CA. Maternal and neonatal infection with coxsackievirus. Obstet Gynecol 1980; 55 (Suppl 3): 12S15S.Google Scholar
Archer, JS. Acute liver failure in pregnancy. J Reprod Med 2001; 46: 137–40.Google Scholar
Frisk, G, Diderholm, H. Increased frequency of coxsackie B virus IgM in women with spontaneous abortion. J Infect 1992; 24: 141–5.Google Scholar
Johansson, ME, Holmström, S, Abebe, A, et al. Intrauterine fetal death due to echovirus 11. Scand J Infect Dis 1992; 24: 381–5.Google Scholar
Modlin, JF. Fatal echovirus 11 disease in premature neonates. Pediatrics 1980; 66: 775–80.Google Scholar
Sever, JL, Huebner, RJ, Castellano, GA, Bell, JA. Serologic diagnosis “en masse” with multiple antigens. Am Rev Respir Dis 1963; 88: 342–9.Google Scholar
Cherry, JD, Soriano, F, Jahn, CL. Search for perinatal virus infection: a prospective, clinical, virologic and serologic study. Am J Dis Child 1968; 116: 245–50.Google Scholar
Kaplan, MH, Klein, SW, McPhee, J, Harper, RG. Group B coxsackievirus infection in infants younger than three months of age: a serious childhood disease. Rev Infect Dis 1983; 5: 1019–32.Google Scholar
Amstey, MS, Miller, KR, Menegus, AM, di Sant’Agnese, PA. Enterovirus in the pregnant women in the perfused placenta. Am J Obstet Gynecol 1988; 158: 775–82.Google Scholar
Bates, HR. Coxsackievirus B3 calcific pancarditis and hydrops fetalis. Am J Obstet Gynecol 1970; 106: 629–30.Google Scholar
Strong, BS, Young, SA. Intrauterine coxsackievirus group B type 1 infection: viral cultivation from amniotic fluid in the third trimester. Am J Perinatol 1995; 12: 78–9.Google Scholar
Reyes, MP, Zalenski, D, Smith, F, Wilson, FM, Lerner, AM. Coxsackievirus-positive cervices in women with febrile illness during the third trimester in pregnancy. Am J Obstet Gynecol 1986; 155: 159–61.Google Scholar
Brown, GC, Karunas, RS. Relationship of congenital anomalies and maternal infection with selected enteroviruses. Am J Epidemiol 1972; 95: 207–17.Google Scholar
Gauntt, CJ, Gudvangen, RJ, Brans, YW, Marlin, AE. Coxsackievirus group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system. Pediatrics 1985; 76: 64–8.Google Scholar
Nathenson, G, Spigland, I, Eisenberg, R. Benign neonatal arrhythmias and coxsackie B virus infection. J Pediatr 1975; 86: 152–3.Google Scholar
Murray, D, Altschul, M, Dyke, J. Aseptic meningitis in a neonate with an oral vesicular lesion. Diagn Microbiol Infect Dis 1985; 3: 7780.Google Scholar
Theodoridou, M, Kakourou, T, Laina, I, Mostrou, G, Tsakris, A. Vesiculopapular rash as a single presentation in intrauterine coxsackie virus infection. Eur J Pediatr 2002; 161: 412–13.Google Scholar
Euscher, E, Davis, J, Holzman, I, Nuovo, GJ. Coxsackie virus infection of the placenta associated with neurodevelopmental delays in the newborn. Obstet Gynecol 2001; 98: 1019–26.Google Scholar
Hurley, R, Norman, AP, Pryse-Davies, J. Massive pulmonary haemorrhage in the newborn associated with coxsackie B virus infection. Br Med J 1969; 3: 636–7.Google Scholar
Gear, JHS. Coxsackievirus infections in Southern Africa. Yale J Biol Med 1961/1962; 34: 289–96.Google Scholar
Burch, GE, Sun, SC, Chu, KC, Sohal, RS, Colcolough, HL. Interstitial and coxsackievirus B myocarditis in infants and children: a comparative histologic and immunofluorescent study of 50 autopsied hearts. JAMA 1968; 203: 18.Google Scholar
Overall, JC. Intrauterine virus infections and congenital heart disease. Am Heart J 1972; 84: 823–33.Google Scholar
Abzug, MJ. Prognosis for neonates with enterovirus hepatitis and coagulopathy. Pediatr Infect Dis J 2001; 20: 758–63.Google Scholar
Rantakallio, P, Jones, P, Moring, J, von Wendt, L. Association between central nervous system infections during childhood and adult onset schizophrenia and other psychoses: a 28-year follow-up. Int J Epidemiol 1997; 26: 837–43.Google Scholar
Farmer, K, MacArthur, BA, Clay, MM. A follow-up study of 15 cases of neonatal meningoencephalitis due to coxsackie virus B5. J Pediatr 1975; 87: 568–71.Google Scholar
Drash, A. The etiology of diabetes mellitus. N Engl J Med 1979; 300: 1211–13.CrossRefGoogle ScholarPubMed
Dahlquist, GG, Ivarsson, S, Lindberg, B, Forsgren, M. Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. Diabetes 1995; 44: 408–13.Google Scholar
Hyöty, H, Hiltunen, M, Knip, M, et al. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 1995; 44: 652–7.Google Scholar
Füchtenbusch, M, Irnstetter, A, Jäger, G, Ziegler, AG. No evidence for an association of coxsackievirus infections during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetes. J Autoimmun 2001; 17: 333–40.Google Scholar
Viskari, HR, Roivainen, M, Reunanen, A, et al. Maternal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus. Diabetes 2002; 51: 2568–71.Google Scholar
Balduzzi, PC, Greendyke, RM. Sudden unexpected death in infancy and viral infection. Pediatrics 1966; 38: 201–6.Google Scholar
Gold, E, Carver, DH, Heineberg, H, Adelson, L, Robbins, FC. Viral infection: a possible cause of sudden, unexpected death in infants. N Engl J Med 1961; 264: 53–5.Google Scholar
Valdes-Dapena, MA, Hummeler, K. Sudden and unexpected death in infants. II. Viral infections as causative factors. J Pediatr 1963; 63: 398401.Google Scholar
Lapinleimu, K, Kaski, U. An outbreak caused by coxsackie B5 among newborn infants. Scand J Infect Dis 1987; 4: 2730.Google Scholar
Borulf, S, Walder, M, Ulmsten, U. Outbreak of coxsackie virus A14 meningitis among newborns in a maternity hospital ward. Acta Paediatr Scand 1987; 76: 234–8.Google Scholar
Brightman, VJ, McNair, STF, Westphal, M, Boggs, TR. An outbreak of coxsackie B5 virus infection in a newborn nursery. J Pediatr 1966; 69: 179–92.Google Scholar
Hammond, GW, Lukes, H, Wells, B, et al. Maternal and neonatal neutralizing antibody titers to selected enteroviruses. Pediatr Infect Dis 1985; 4: 32–5.Google Scholar
Abzug, MJ, Keyserling, HL, Lee, ML, Rotbart, HA. Neonatal enterovirus infection: virology, serology, and effect of intravenous immune globulin. Clin Infect Dis 1995; 20: 1201–6.Google Scholar
Abzug, MJ, Cloud, G, Bradley, J, et al. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Pediatr Infect Dis J 2003; 22: 335–41.Google Scholar
Abzug, MJ, Michaels, MG, Wald, E, et al.; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis. J Pediatric Infect Dis Soc 2016; 5: 5362.Google Scholar
Nagington, J, Gandy, G, Walker, J, Gray, JJ. Use of normal immunoglobulin in an echovirus 11 outbreak in a special-care baby unit. Lancet 1983; 2: 443–6.Google Scholar
Chapman, NM, Ragland, A, Leser, JS, et al. A group B coxsackievirus/poliovirus 5′ nontranslated region chimera can act as an attenuated vaccine strain in mice. J Virol 2000; 74: 4047–56.Google Scholar
Liang, ZL, Mao, QY, Wang, YP, et al. Progress on the research and development of inactivated EV71 whole-virus vaccines. Hum Vaccin Immunother 2013; 9: 1701–5.Google Scholar
Zhu, FC, Meng, FY, Li, JX, et al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2013; 381: 2024–32.Google Scholar
de Villiers, EM, Fauquet, C, Broker, TR, Bernard, HU, zur Hausen, H. Classification of papillomaviruses. Virology 2004; 324: 1727.Google Scholar
zur Hausen, H. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. Curr Top Microbiol Immunol 1994; 186: 131–56.Google Scholar
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 99: management of abnormal cervical cytology and histology. Obstet Gynecol 2008; 112: 1419–44.Google Scholar
American College of Obstetricians and Gynecologists. Practice Bulletin No. 140: management of abnormal cervical cancer screening test results and cervical cancer precursors. Obstet Gynecol 2013; 122: 1338–67.Google Scholar
Trottier, H, Franco, EL. The epidemiology of genital human papillomavirus infection. Vaccine 2006; 24 (Suppl 1): S1–15.Google Scholar
Kemp, EA, Hakenewerth, AM, Laurent, SL, Gravitt, PE, Stoerker, J. Human papillomavirus prevalence in pregnancy. Obstet Gynecol 1992; 79: 649–56.Google Scholar
Smith, EM, Johnson, SR, Cripe, T, et al. Perinatal transmission and maternal risks of human papillomavirus infection. Cancer Detect Prev 1995; 19: 196205.Google Scholar
Kjellberg, L, Hallmans, G, Ahren, AM, et al. Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intraepithelial neoplasia in relation to human papillomavirus infection. Br J Cancer 2000; 82: 1332–8.Google Scholar
Schneider, A, Hotz, M, Gissmann, L. Increased prevalence of human papillomaviruses in the lower genital tract of pregnant women. Int J Cancer 1987; 40: 198201.Google Scholar
Rando, RF, Lindheim, S, Hasty, L, et al. Increased frequency of detection of human papillomavirus DNA in exfoliated cervical cells during pregnancy. Am J Obstet Gynecol 1989; 161: 50–4.Google Scholar
Sedlaceck, TV, Lindheim, S, Eder, C. Mechanism for human papillomavirus transmission at birth. Am J Obstet Gynecol 1989; 161: 55–9.Google Scholar
Kashima, HK, Shah, K. Recurrent respiratory papillomatosis: clinical overview and management principles. Obstet Gynecol Clin North Am 1987; 14: 581–8.Google Scholar
Hallden, C, Majmudar, B. The relationship between juvenile laryngeal papillomatosis and maternal condylomata acuminata. J Reprod Med 1986; 31: 804–7.Google Scholar
Milczuk, HA. Intralesional cidofovir for the treatment of severe juvenile recurrent respiratory papillomatosis: long-term results in 4 children. Otolaryngol Head Neck Surg 2003; 128: 788–94.Google Scholar
Auborn, KJ. Therapy for recurrent respiratory papillomatosis. Antivir Ther 2002; 7: 19.Google Scholar
Allen, AL, Siegfried, EC. The natural history of condylomas in children. J Am Acad Dermatol 1998; 39: 951–5.Google Scholar
Markowitz, LE, Dunne, EF, Saraiya, M, et al.; Centers for Disease Control and Prevention (CDC). Quadrivalent human papillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2007; 56 (RR-2): 124.Google Scholar
Tenti, P, Zappatore, R, Migliora, P, et al. Perinatal transmission of human papillomavirus from gravidas with latent infections. Obstet Gynecol 1999; 93: 475–9.Google Scholar
Armbruster-Moraes, E, Ioshimoto, LM, Leao, E, Zugaib, M. Presence of human papillomavirus DNA in amniotic fluids of pregnant women with cervical lesions. Gynecol Oncol 1994; 54: 152–8.Google Scholar
Watts, DH, Koutsky, LA, Holmes, KK, et al. Low risk of perinatal transmission of human papillomavirus: results from a prospective cohort study. Am J Obstet Gynecol 1998; 178: 365–73.Google Scholar
Sarkola, ME, Grénman, SE, Rintala, MA, Syrjänen, KJ, Syrjänen, SM. Human papillomavirus in the placenta and umbilical cord blood. Acta Obstet Gynecol Scand 2008; 87: 1181–8.Google Scholar
Rombaldi, RL, Serafini, EP, Mandelli, J, Zimmermann, E, Losquiavo, KP. Transplacental transmission of human papillomavirus. Virol J 2008; 5: 106.Google Scholar
Cason, J, Kaye, JN, Jewers, RJ, et al. Perinatal infection and persistence of human papillomavirus 16 and 18 in infants. J Med Virol 1995; 47: 209–18.Google Scholar
Smith, EM, Johnson, SR, Cripe, TP, Pignatari, S, Turek, L. Perinatal vertical transmission of human papillomavirus and subsequent development of respiratory tract papillomatosis. Ann Otol Rhinol Laryngol 1991; 100: 479–83.Google Scholar
Favre, M, Majewski, S, De Jesus, N, et al. A possible vertical transmission of human papillomavirus genotypes associated with epidermodysplasia verruciformis. J Invest Dermatol 1998; 111: 333–6.Google Scholar
Tseng, CJ, Liang, CC, Soong, YK, Pao, CC. Perinatal transmission of human papillomavirus in infants: relationship between infection rate and mode of delivery. Obstet Gynecol 1998; 91: 92–6.Google Scholar
Tseng, CJ, Lin, CY, Wang, RL, et al. Possible transplacental transmission of human papillomavirus. Am J Obstet Gynecol 1992; 166: 3540.Google Scholar
Lawton, B, Howe, AS, Turner, N, et al. Association of prior HPV vaccination with reduced preterm birth: a population based study. Vaccine 2018; 36: 134–40. doi: 10.1016/j.vaccine.2017.11.020.Google Scholar
Committee Opinion No. 641. Human papillomavirus vaccination. Obstet Gynecol 2015; 126: e38–43.Google Scholar
Petrosky, E, Bocchini, JA, Hariri, S, et al.; Centers for Disease Control and Prevention (CDC). Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. MMWR Morb Mortal Wkly Rep 2015; 64: 300–4.Google Scholar
Markowitz, LE, Dunne, EF, Saraiya, M, et al.; Centers for Disease Control and Prevention (CDC). Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2014; 63 (RR-05): 130.Google Scholar
FUTURE II Study Group. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N Engl J Med 2007; 356: 1915–27.Google Scholar
Descamps, D, Hardt, K, Spiessens, B, et al. Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention: a pooled analysis of 11 clinical trials. Hum Vaccin 2009; 5: 332–40.Google Scholar
Einstein, MH, Takacs, P, Chatterjee, A, et al.; HPV-010 Study Group. Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: end-of-study analysis of a phase III randomized trial. Hum Vaccin Immunother 2014; 10: 3435–45.Google Scholar
Castellsagué, X, Muñoz, N, Pitisuttithum, P, et al. End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24–45 years of age. Br J Cancer 2011; 105: 2837.Google Scholar
Guevara, AM, Suarez, E, Victoria, A, et al. Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine. Hum Vaccin Immunother 2019; 15: 141–5. https://doi.org/10.1080/21645515.2018.1514227.Google Scholar
Eskelinen, A, Mashkilleyson, N. Optimum treatment of genital warts. Drugs 1987; 34: 599603.Google Scholar
Piper, JM, Wen, TT, Xenakis, EM. Interferon therapy in primary care. Prim Care Update Obstet Gynecol 2001; 8: 163–9.Google Scholar
Schwartz, DB, Greenberg, MD, Daoud, Y, Reid, R. Genital condylomas in pregnancy: use of trichloroacetic acid and laser therapy. Am J Obstet Gynecol 1988; 158: 1407–16.Google Scholar
Snoeck, R, Bossens, M, Parent, D, et al. Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection. Clin Infect Dis 2001; 33: 597602.Google Scholar

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