Book contents
- From Loss to Memory
- From Loss to Memory
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- 1 Counting Synapses
- 2 Discovering Synaptic Pruning
- 3 Else, Peter’s Mother
- 4 Richard, Peter’s Father, and Peter’s Uncle Fritz
- 5 Greiz: Kriegskinder (Children of War)
- 6 In Braubach, after the War
- 7 Arrival in America
- 8 Harvard Medical School
- 9 Understanding Sleep and Consciousness: Research at the National Institutes of Health
- 10 Entering the Cognitive Revolution: Neuroscience and Cognitive Psychology
- 11 Physician First, Scientist Second?
- 12 Comparative Brain Regions and Synapse Formation
- 13 Stimulating Progress on Developmental Brain Disorders
- 14 Neurodevelopmental Disorders and Schizophrenia: A Role for Synaptic Pruning?
- 15 Early Childhood Education
- 16 Peter and Janellen’s Collaboration
- 17 Microglial Cells and the Mechanisms of Synaptic Pruning
- 18 Looking Forward: Being a Physician and a Scientist
- 19 Parkinson’s Disease and Berlin
- 20 Auf Deutsch: Back to German
- 21 Memories and Reflections at the End: A Return Trip to Greiz
- Glossary
- Index
- References
14 - Neurodevelopmental Disorders and Schizophrenia: A Role for Synaptic Pruning?
Published online by Cambridge University Press: 10 October 2023
Book contents
- From Loss to Memory
- From Loss to Memory
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- 1 Counting Synapses
- 2 Discovering Synaptic Pruning
- 3 Else, Peter’s Mother
- 4 Richard, Peter’s Father, and Peter’s Uncle Fritz
- 5 Greiz: Kriegskinder (Children of War)
- 6 In Braubach, after the War
- 7 Arrival in America
- 8 Harvard Medical School
- 9 Understanding Sleep and Consciousness: Research at the National Institutes of Health
- 10 Entering the Cognitive Revolution: Neuroscience and Cognitive Psychology
- 11 Physician First, Scientist Second?
- 12 Comparative Brain Regions and Synapse Formation
- 13 Stimulating Progress on Developmental Brain Disorders
- 14 Neurodevelopmental Disorders and Schizophrenia: A Role for Synaptic Pruning?
- 15 Early Childhood Education
- 16 Peter and Janellen’s Collaboration
- 17 Microglial Cells and the Mechanisms of Synaptic Pruning
- 18 Looking Forward: Being a Physician and a Scientist
- 19 Parkinson’s Disease and Berlin
- 20 Auf Deutsch: Back to German
- 21 Memories and Reflections at the End: A Return Trip to Greiz
- Glossary
- Index
- References
Summary
Huda Zoghbi is an expert on the genetics of neurodevelopmental disease. Zoghbi and her research group uncovered the genetic basis of a classic postnatal neurodevelopmental disorder, Rett syndrome. It is a puzzling disorder in girls who develop normally for the first year of life or more – reaching milestones like walking and talking – and then undergo a regression at around one to two years of age. The developmental deterioration coincides with the timing when there is a switch from net synapse formation to synapse elimination. As a medical resident, Zoghbi became fascinated with understanding what is happening in Rett syndrome.
- Type
- Chapter
- Information
- From Loss to MemoryBehind the Discovery of Synaptic Pruning, pp. 92 - 99Publisher: Cambridge University PressPrint publication year: 2023
References
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