Book contents
- From Loss to Memory
- From Loss to Memory
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- 1 Counting Synapses
- 2 Discovering Synaptic Pruning
- 3 Else, Peter’s Mother
- 4 Richard, Peter’s Father, and Peter’s Uncle Fritz
- 5 Greiz: Kriegskinder (Children of War)
- 6 In Braubach, after the War
- 7 Arrival in America
- 8 Harvard Medical School
- 9 Understanding Sleep and Consciousness: Research at the National Institutes of Health
- 10 Entering the Cognitive Revolution: Neuroscience and Cognitive Psychology
- 11 Physician First, Scientist Second?
- 12 Comparative Brain Regions and Synapse Formation
- 13 Stimulating Progress on Developmental Brain Disorders
- 14 Neurodevelopmental Disorders and Schizophrenia: A Role for Synaptic Pruning?
- 15 Early Childhood Education
- 16 Peter and Janellen’s Collaboration
- 17 Microglial Cells and the Mechanisms of Synaptic Pruning
- 18 Looking Forward: Being a Physician and a Scientist
- 19 Parkinson’s Disease and Berlin
- 20 Auf Deutsch: Back to German
- 21 Memories and Reflections at the End: A Return Trip to Greiz
- Glossary
- Index
- References
2 - Discovering Synaptic Pruning
Published online by Cambridge University Press: 10 October 2023
Book contents
- From Loss to Memory
- From Loss to Memory
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- 1 Counting Synapses
- 2 Discovering Synaptic Pruning
- 3 Else, Peter’s Mother
- 4 Richard, Peter’s Father, and Peter’s Uncle Fritz
- 5 Greiz: Kriegskinder (Children of War)
- 6 In Braubach, after the War
- 7 Arrival in America
- 8 Harvard Medical School
- 9 Understanding Sleep and Consciousness: Research at the National Institutes of Health
- 10 Entering the Cognitive Revolution: Neuroscience and Cognitive Psychology
- 11 Physician First, Scientist Second?
- 12 Comparative Brain Regions and Synapse Formation
- 13 Stimulating Progress on Developmental Brain Disorders
- 14 Neurodevelopmental Disorders and Schizophrenia: A Role for Synaptic Pruning?
- 15 Early Childhood Education
- 16 Peter and Janellen’s Collaboration
- 17 Microglial Cells and the Mechanisms of Synaptic Pruning
- 18 Looking Forward: Being a Physician and a Scientist
- 19 Parkinson’s Disease and Berlin
- 20 Auf Deutsch: Back to German
- 21 Memories and Reflections at the End: A Return Trip to Greiz
- Glossary
- Index
- References
Summary
Peering at thousands of neurons under an electron microscope in the 1970s, Peter sought to understand how the structures through which neurons communicate, known as “synapses,” change during development of the human brain. How are these billions of synapses formed and refined? How do these circuits change, and allow us to remember, and to learn? What happens when these connections go awry and what is their relationship to human disease?
- Type
- Chapter
- Information
- From Loss to MemoryBehind the Discovery of Synaptic Pruning, pp. 5 - 12Publisher: Cambridge University PressPrint publication year: 2023
References
Huttenlocher, P. R.. Neural Plasticity: The Effects of Environment on the Development of the Cerebral Cortex. Harvard University Press, 2002.CrossRefGoogle Scholar
Wiesel, T. N. and Hubel, D. H.. Effects of visual deprivation on morphology and physiology of cells in the cats lateral geniculate body. J Neurophysiol 1963; 26: 978–93.CrossRefGoogle ScholarPubMed
Hubel, D. H and Wiesel, T. N.. The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol 1970; 206(2): 419–36.Google Scholar
Huttenlocher, P. R.. Synaptic and dendritic development and mental defect. UCLA Forum Med Sci 1975; 18: 123–40.Google Scholar
Huttenlocher, P. R., Synaptic density in human frontal cortex: Developmental changes and effects of aging. Brain Res 1979; 163: 195–205.Google ScholarPubMed
Sretavan, D. and Shatz, C. J., Prenatal development of individual retinogeniculate axons during the period of segregation. Nature 1984; 308: 845–8.CrossRefGoogle ScholarPubMed
Hansel, C.. Memory Makes the Brain: The Biological Machinery That Uses Experiences to Shape Individual Brains. World Scientific, 2021.Google Scholar