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Perampanel

Published online by Cambridge University Press:  01 June 2018

Philip N. Patsalos  and
Erik K. St Louis
Philip N. Patsalos
Affiliation:
UCL Institute for Neurology
Erik K. St Louis
Affiliation:
Mayo Clinic
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The Epilepsy Prescriber's Guide to Antiepileptic Drugs , pp. 204 - 213
Publisher: Cambridge University Press
Print publication year: 2018

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References

Suggested Reading

Auvin, S, Dozieres, B, Ilea, A, Delanoë, C. Use of perampanel in children and adolescents with Lennox–Gastaut syndrome. Epilepsy and Behavior 2017; 74: 59–63.CrossRefGoogle ScholarPubMed
Besag, FMC, Patsalos, PN. Clinical efficacy of perampanel for partial-onset and primary generalized tonic-clonic seizures. Neuropsychiatric Decease and Treatment 2016; 12: 1215–1220.Google ScholarPubMed
Crespel, A, Gelisse, P, Tang, NPL, Genton, P. Perampanel in 12 patients with Unverricht–Lundborg disease. Epilepsia 2017; 58: 543–547.Google Scholar
French, JA, Krauss, GL, Biton, V, Squillacote, D, Yang, H, Laurenza, A, Kumar, D, Rogawski, MA. Adjunctive perampanel for refractory partial-onset seizures. Randomized phase III study 304. Neurology 2011; 79: 589–596.Google Scholar
French, JA, Krauss, GL, Wechsler, RT, Wang, XF, DiVentura, B, Brandt, C, Trinke, E, O’Brien, TJ, Laurenza, A, Patten, A, Bibbiani, F. Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy. A randomized trial. Neurology 2015; 85: 950–957.CrossRefGoogle ScholarPubMed
Goldsmith, D, Minassian, BA. Efficacy and tolerability of perampanel in ten patients with Lafora disease. Epilepsy and Behavior 2016; 62: 132–135.CrossRefGoogle ScholarPubMed
Hanada, T, Hashizume, Y, Tokuhara, N, Takenaka, O, Kohmura, N, Ogasawara, A, Hatekeyama, S, Ohgoh, M, Ueno, M, Nishizawa, Y. Perampanel: a novel, orally active, noncompetitive AMPA-receptotr antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia 2011; 52: 1331–1340.CrossRefGoogle ScholarPubMed
Heyman, E, Lahat, E, Levin, N, Epstein, O, Lazinger, M, Berkovitch, M Gandelman-Marton, R. Tolerability and efficacy of perampanel in children with refractory epilepsy. Developmental Medicine and Child Neurology 2017; 59: 441–444.CrossRefGoogle ScholarPubMed
Krauss, GL, Bar, M, Biton, V, Klapper, JA, Rektor, I, Vaiciene-Magistris, N, Squillacote, D, Kumar, D. Tolerability and safety of perampanel: two randomized dose-escalation studies. Acta Neurologica Scandinavica 2012; 125: 8–15.Google Scholar
Krauss, GL, Serratosa, JM, Villanueva, V, Endziniene, E, Hong, Z, French, J, Yang, H, Squillacote, D, Edwards, HB, Zhu, J, Laurenza, A. Randomized phase III study 306. Adjunctive perampanel for refractory partial-onset seizures. Neurology 2012; 78: 1408–1415.CrossRefGoogle ScholarPubMed
Ledingham, DRM, Patsalos, PN. Perampanel: what is its place in the management of partial epilepsy? Neurology and Therapy 2013; 2: 13–24.CrossRefGoogle Scholar
Leppik, IE, Wechsler, RT, Williams, B, Yang, H, Zhou, S, Laurenza, A. Efficacy and safety of perampanel in the subgroup of elderly patients included in the phase III epilepsy clinical trials. Epilepsy Research 2015; 110: 216–220.CrossRefGoogle ScholarPubMed
Patsalos, PN. The clinical pharmacology profile of the new antiepileptic drug perampanel: a novel noncompetitive AMPA receptor antagonist. Epilepsia 2015; 56: 12–27.CrossRefGoogle ScholarPubMed
Patsalos, PN. Gougoulaki, N, Sander, JW. Perampanel serum concentrations in adults with epilepsy: effect of dose, age, sex and concomitant anti-epileptic drugs. Therapeutic Drug Monitoring 2016; 38: 358–364.CrossRefGoogle ScholarPubMed
Patsalos, PN, Zugman, M, Lake, C, James, A, Ratnaraj, N, Sander, JW. Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: a comparison of free non-protein-bound concentrations. Epilepsia, 2017; 58: 1234–1243.CrossRefGoogle Scholar
Redecker, J, Wittstock, M, Benecke, R, Rosche, J. Efficacy of perampanel in refractory nonconvulsive stutas epilepticus and simple partial status epilepticus. Epilepsy and Behavior 2015; 45: 176–179.Google Scholar

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