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Case 13 - The Disease Has Caught Up with Her

from Part 3 - Missing Important Clues in the History

Published online by Cambridge University Press:  03 November 2020

Keith Josephs
Affiliation:
Mayo Clinic Alzheimer’s Disease Research Center
Federico Rodriguez-Porcel
Affiliation:
Medical University of South Carolina
Rhonna Shatz
Affiliation:
University of Cincinnati
Daniel Weintraub
Affiliation:
University of Pennsylvania
Alberto Espay
Affiliation:
University of Cincinnati
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Summary

This 75-year-old right-handed woman presented to the clinic for an urgent follow-up due to subacute changes in her speech. She had been diagnosed with Alzheimer disease two years prior, after presenting with a four-year history of progressive memory impairment. Her symptoms were stable until three weeks prior to her follow-up visit, when she became less talkative than usual and started slurring her speech. This was initially attributed to being tired (hectic holidays), but she continued to worsen, prompting an urgent visit to the primary care physician, who ruled out infections and metabolic abnormalities. She eventually plateaued, and the family considered the impaired communication her new baseline. Three days prior to the visit, she had a fall and hit her head. Since then, her speech further declined, and she was having difficulties with dexterity on the right. Although the family was aware she had previous falls, they stated this was the first time she had hit her head.

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Publisher: Cambridge University Press
Print publication year: 2020

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References

Baechli, H., Nordmann, A., Bucher, H. C. and Gratzl, O. 2004. Demographics and prevalent risk factors of chronic subdural haematoma: results of a large single-center cohort study. Neurosurg Rev 27(4) 263266.CrossRefGoogle ScholarPubMed
Marmarou, A. et al. 2005. Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. J Neurosurg 102(6) 987997.CrossRefGoogle ScholarPubMed
Starkstein, S. E., Jorge, R. and Capizzano, A. A. 2005. Uncommon causes of cerebrovascular dementia. Int Psychogeriatr 17(Suppl 1) S5164.CrossRefGoogle ScholarPubMed

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