Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-05-11T08:03:33.663Z Has data issue: false hasContentIssue false

Chapter 12 - Autoimmune Hemolytic Anemia

from Section 3, Part D - Hemolytic Anemias

Published online by Cambridge University Press:  18 April 2018

By
Mark A. Murakami ,
Edward J. Benz  and
Nancy Berliner
Edited by
Edward J. Benz, Jr. ,
Nancy Berliner  and
Fred J. Schiffman
Edward J. Benz, Jr.
Affiliation:
Dana Farber Cancer Institute
Nancy Berliner
Affiliation:
Brigham and Women's Hospital, Boston
Fred J. Schiffman
Affiliation:
Children's Hospital, Boston
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Anemia
Pathophysiology, Diagnosis, and Management
 , pp. 84 - 94
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Sokol, RJ, Booker, DJ, Stamps, R. The pathology of autoimmune haemolytic anaemia. J Clin Pathol. 1992; 45(12): 1047–1052.Google Scholar
Sachs, UJ, et al. Does a negative direct antiglobulin test exclude warm autoimmune haemolytic anaemia? A prospective study of 504 cases. Br J Haematol. 2006; 132(5): 655–656.CrossRefGoogle ScholarPubMed
Wheeler, CA, Calhoun, L, Blackall, DP. Warm reactive autoantibodies: clinical and serologic correlations. Am J Clin Pathol. 2004; 122(5): 680–685.CrossRefGoogle ScholarPubMed
Vos, GH, Petz, L, Fudenberg, HH. Specificity of acquired haemolytic anaemia autoantibodies and their serological characteristics. Br J Haematol. 1970; 19(1): 57–66.CrossRefGoogle ScholarPubMed
Garratty, G, Arndt, PA. An update on drug-induced immune hemolytic anemia. Immunohematology. 2007; 23(3): 105–119.CrossRefGoogle ScholarPubMed
Worlledge, SM, Carstairs, KC, Dacie, JV. Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy. Lancet. 1966; 2(7455): 135–139.CrossRefGoogle ScholarPubMed
Garratty, G, Petz, LD. Drug-induced immune hemolytic anemia. Am J Med. 1975; 58(3): 398–407.CrossRefGoogle ScholarPubMed
Mueller-Eckhardt, C, Salama, A. Drug-induced immune cytopenias: a unifying pathogenetic concept with special emphasis on the role of drug metabolites. Transfus Med Rev. 1990;4(1): 69–77.CrossRefGoogle ScholarPubMed
Garratty, G, Arndt, PA. Positive direct antiglobulin tests and haemolytic anaemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Br J Haematol. 1998; 100(4): 777–783.Google Scholar
Leger, RM, Garratty, G. Evaluation of methods for detecting alloantibodies underlying warm autoantibodies. Transfusion. 1999;39(1): 11–16.CrossRefGoogle ScholarPubMed
Lechner, K, Jäger, U. How I treat autoimmune hemolytic anemias in adults. Blood. 2010; 116(11): 1831–1838.CrossRefGoogle Scholar
Murphy, S, LoBuglio, AF. Drug therapy of autoimmune hemolytic anemia. Semin Hematol. 1976; 13(4): 323–334.Google ScholarPubMed
Gehrs, BC, Friedberg, RC. Autoimmune hemolytic anemia. Am J Hematol. 2002; 69(4): 258–271.Google Scholar
Akpek, G, McAneny, D, Weintraub, L. Comparative response to splenectomy in Coombs-positive autoimmune hemolytic anemia with or without associated disease. Am J Hematol. 1999; 61(2): 98–102.Google Scholar
Atkinson, JP, Schreiber, AD, Frank, MM. Effects of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes. J Clin Invest. 1973; 52(6): 1509–1517.CrossRefGoogle ScholarPubMed
Casaccia, M, et al. Laparoscopic splenectomy for hematologic diseases: a preliminary analysis performed on the Italian Registry of Laparoscopic Surgery of the Spleen (IRLSS). Surg Endosc. 2006; 20(8): 1214–1220.CrossRefGoogle ScholarPubMed
Ikeda, M, et al. High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: a prospective study with contrast-enhanced CT scan. Ann Surg. 2005; 241(2): 208–216.CrossRefGoogle ScholarPubMed
Advisory Committee on Immunization Practices (ACIP) recommended immunization schedules for persons aged 0 through 18 years and adults aged 19 years and older–United States, 2013. MMWR Surveill Summ. 2013(62 Suppl 1): 1.Google Scholar
D’Arena, G, et al. Rituximab therapy for chronic lymphocytic leukemia-associated autoimmune hemolytic anemia. Am J Hematol. 2006; 81(8): 598–602.Google Scholar
Bussone, G, et al. Efficacy and safety of rituximab in adults’ warm antibody autoimmune haemolytic anemia: retrospective analysis of 27 cases. Am J Hematol. 2009; 84(3): 153–157.Google Scholar
Dierickx, D, et al. Rituximab in auto-immune haemolytic anaemia and immune thrombocytopenic purpura: a Belgian retrospective multicentric study. J Intern Med. 2009; 266(5):484–491.Google Scholar
Narat, S, et al. Rituximab in the treatment of refractory autoimmune cytopenias in adults. Haematologica. 2005; 90(9):1273–1274.Google ScholarPubMed
Anderson, D, et al. Guidelines on the use of intravenous immune globulin for hematologic conditions. Transfus Med Rev. 2007; 21(2 Suppl 1):S9–56.CrossRefGoogle ScholarPubMed
Gertz, MA. Cold agglutinin disease and cryoglobulinemia. Clin Lymphoma. 2005; 5(4):290–293.CrossRefGoogle ScholarPubMed
Bessman, JD, Banks, D. Spurious macrocytosis, a common clue to erythrocyte cold agglutinins. Am J Clin Pathol. 1980; 74(6):797–800.CrossRefGoogle ScholarPubMed
Rosse, WF, Adams, JP. The variability of hemolysis in the cold agglutinin syndrome. Blood. 1980; 56(3):409–16.CrossRefGoogle ScholarPubMed
Feizi, T. Monotypic cold agglutinins in infection by mycoplasma pneumoniae. Nature. 1967; 215(5100):540–542.CrossRefGoogle ScholarPubMed
Horwitz, CA, et al. Cold agglutinins in infectious mononucleosis and heterophil-antibody-negative mononucleosis-like syndromes. Blood. 1977; 50(2):195–202.CrossRefGoogle ScholarPubMed
Swiecicki, PL, Hegerova, LT, Gertz, MA. Cold agglutinin disease. Blood. 2013; 122(7):1114–1121.CrossRefGoogle ScholarPubMed
Nydegger, UE, Kazatchkine, MD, Miescher, PA. Immunopathologic and clinical features of hemolytic anemia due to cold agglutinins. Semin Hematol. 1991; 28(1):66–77.Google ScholarPubMed
Jaffe, CJ, Atkinson, JP, Frank, MM. The role of complement in the clearance of cold agglutinin-sensitized erythrocytes in man. J Clin Invest. 1976; 58(4):942–949.CrossRefGoogle ScholarPubMed
Mickley, H, Sorensen, PG. Immune haemolytic anaemia associated with ampicillin dependent warm antibodies and high titre cold agglutinins in a patient with Mycoplasma pneumonia. Scand J Haematol. 1984; 32(3):323–326.Google Scholar
Ulvestad, E. Paradoxical haemolysis in a patient with cold agglutinin disease. Eur J Haematol. 1998; 60(2):93–100.CrossRefGoogle Scholar
Berentsen, S, et al. High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease. Blood. 2010; 116(17):3180–3184.CrossRefGoogle ScholarPubMed
Berentsen, S, et al. Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients. Blood. 2004; 103(8):2925–2928.CrossRefGoogle ScholarPubMed
Berentsen, S, et al. Primary chronic cold agglutinin disease: a population based clinical study of 86 patients. Haematologica. 2006; 91(4):460–466.Google ScholarPubMed
Schollkopf, C, et al. Rituximab in chronic cold agglutinin disease: a prospective study of 20 patients. Leuk Lymphoma. 2006; 47(2):253–260.CrossRefGoogle ScholarPubMed
Ghielmini, M, et al. Effect of single-agent rituximab given at the standard schedule or as prolonged treatment in patients with mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research (SAKK). J Clin Oncol. 2005; 23(4):705–711.CrossRefGoogle ScholarPubMed
Hoppe, B, et al. Response to intravenous immunoglobulin G in an infant with immunoglobulin A-associated autoimmune haemolytic anaemia. Vox Sang. 2004; 86(2):151–153.CrossRefGoogle Scholar
Geurs, F, et al. Successful plasmapheresis in corticosteroid-resistant hemolysis in infectious mononucleosis: role of autoantibodies against triosephosphate isomerase. Acta Haematol. 1992; 88(2–3):142–146.Google Scholar
Berentsen, S. How I manage cold agglutinin disease. Br J Haematol. 2011; 153(3):309–317.CrossRefGoogle Scholar
Heddle, NM. Acute paroxysmal cold hemoglobinuria. Transfus Med Rev. 1989; 3(3):219–229.CrossRefGoogle ScholarPubMed
Sivakumaran, M, et al. Paroxysmal cold haemoglobinuria caused by non-Hodgkin’s lymphoma. Br J Haematol. 1999; 105(1):278–279.Google Scholar
Ries, CA, et al. Paroxysmal cold hemoglobinuria: report of a case with an exceptionally high thermal range Donath-Landsteiner antibody. Blood. 1971; 38(4):491–499.Google Scholar
Rausen, AR, et al. Compatible transfusion therapy for paroxysmal cold hemoglobinuria. Pediatrics. 1975; 55(2):275–278.Google Scholar
Koppel, A, et al. Rituximab as successful therapy in a patient with refractory paroxysmal cold hemoglobinuria. Transfusion. 2007; 47(10):1902–1904.Google Scholar
Gregory, GP, et al. Failure of eculizumab to correct paroxysmal cold hemoglobinuria. Ann Hematol. 2011; 90(8):989–990.CrossRefGoogle ScholarPubMed
Schrier, SL. Clinical Features and Diagnosis of Autoimmune Hemolytic Anemia: Warm Agglutinins. UpToDate; 2013. Retrieved April 7, 2014, from www.uptodate.com/contents/clinical-features-and-diagnosis-of-autoimmune-hemolytic-anemia-warm-agglutinins?source=search_result&search=autoimmune+hemolytic+anemia&selectedTitle=1~128.Google Scholar
Lichtman, MA, Williams, WJ. Williams hematology. 7th ed. New York: McGraw-Hill, Medical Pub. Division; 2006.Google Scholar
Kauke, T, Reininger, AJ. Images in clinical medicine. Livedo reticularis and cold agglutinins. N Engl J Med. 2007; 356(3):284.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×