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Chapter 24 - Clinical Value of Sperm Function Tests

Published online by Cambridge University Press:  05 April 2021

Ashok Agarwal
The Cleveland Clinic Foundation, Cleveland, OH
Ralf Henkel
University of the Western Cape, South Africa
Ahmad Majzoub
Hamad Medical Corporation, Doha
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Infertility is a major public health concern affecting up to 25 percent of couples worldwide [1]. It is defined by the failure of a couple to achieve conception after one year of regular, unprotected intercourse. The male contributes to roughly 50 percent of the causes of infertility among couples highlighting the importance of research and development in this field of medicine [2]. Conventional semen analysis is the cornerstone test for evaluating the male factor [3]. While the test can provide a general understanding of the male fertility potential, it cannot be used as an accurate predictor of fecundity. About 10 percent of men with normal semen analysis are unable to conceive. On the contrary, an equal percentage of men with abnormal semen analysis have no issues with fertility [4]. Therefore, during the past few decades, the low predictive power of standard semen analysis has triggered researchers to look for more sensitive and specific tests of sperm function. This chapter aims to explore the clinical utility of various tests of sperm function that have been described in literature.

Publisher: Cambridge University Press
Print publication year: 2021

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