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Safety and tolerability of olanzapine compared with other antipsychotics in the treatment of elderly patients with schizophrenia: a naturalistic study

Published online by Cambridge University Press:  16 April 2020

Antonio Ciudad ,
José-Manuel Montes ,
José-Manuel Olivares ,
Juan-Carlos Gómez  and
the EFESO study group
Antonio Ciudad*
Affiliation:
Lilly Research Laboratories, 30 Avenida de la Industria, Alcobendas CP28108, Madrid, Spain
José-Manuel Montes
Affiliation:
Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain
José-Manuel Olivares
Affiliation:
Department of Psychiatry, Complejo Hospitalario Xeral, Spain
Juan-Carlos Gómez
Affiliation:
Lilly Research Laboratories, 30 Avenida de la Industria, Alcobendas CP28108, Madrid, Spain
*
*Corresponding author. Email address: ciudad_antonio@lilly.com (A. Ciudad).
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Abstract

Objective

To evaluate the safety and tolerability of olanzapine in the treatment of elderly patients with schizophrenia.

Methods

A total of 135 outpatients with schizophrenia ≥60 years of age were treated with olanzapine (n = 105) or another antipsychotic (n = 30) and followed up for 6 months. Safety measures included the recording of spontaneous adverse events and extrapyramidal symptoms (EPS). Clinical status and effectiveness of the medications were measured using the Clinical Global Impressions-Severity of Illness and the Global Assessment of Function (GAF) scales. Quality of life was assessed by means of the Spanish version of the EuroQol. The Awad scale was applied to evaluate patients’ subjective attitude towards medication.

Results

The incidence of overall adverse events and EPS was non-significantly lower in patients treated with olanzapine than in patients treated with other antipsychotics. The use of anticholinergic drugs was significantly lower (P = 0.04) in patients treated with olanzapine. Both groups of patients experienced similar improvements in Clinical Global Impressions-Severity and GAF scores. Non-significantly greater improvement in the acceptance of medication occurred at endpoint in olanzapine-treated patients than in control patients as measured by the Awad scale. The improvement in the EuroQol quality of life scale achieved at the end of study did not differ between both treatment groups.

Conclusions

Results from this naturalistic study showed that olanzapine was as safe and effective as other antipsychotic drugs in the treatment of elderly patients with schizophrenia.

Keywords

SafetyQuality of lifeElderlySchizophreniaOlanzapine
Type
Original manuscript
Information
European Psychiatry , Volume 19 , Issue 6 , September 2004 , pp. 358 - 365
Copyright
Copyright © 2004 European Psychiatric Association

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