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CNS demyelination in monoclonal gammopathy of undetermined significance (MGUS): possible cause of a dementia syndrome

Published online by Cambridge University Press:  16 April 2020

H Hampel ,
C Schneider ,
C Hock ,
F Müller-Spann  and
M Ackenheil
H Hampel*
Affiliation:
National Institutes of Health, National Institute on Aging, Loboratory of Neurosciences, 9000 Rockville Pike, Bethesda, MD20892, USA
C Schneider
Affiliation:
Psychiatric Hospital, Ludwig-Maximilian University, Munich, Nussbaumstr 7, 80336Munich, Germany
C Hock
Affiliation:
Psychiatric Hospital, University of Basel, Wilhelm Klein-Str 27, 4025Basel, Switzerland
F Müller-Spann
Affiliation:
Psychiatric Hospital, University of Basel, Wilhelm Klein-Str 27, 4025Basel, Switzerland
M Ackenheil
Affiliation:
Psychiatric Hospital, Ludwig-Maximilian University, Munich, Nussbaumstr 7, 80336Munich, Germany
*
*Correspondence: Dr H Hampel and Dr H Ulrich Kötter, Klinikum Innenstadt, Psychiatrische Klinik der Universität München, Nuflbaumstr 7, 80336 Munich, Germany. Reprints: Dr H Hampel, National Institute of Health (NIH), National Institute on Aging (NIA), Laboratory of Neuroscience (LNS), Bldg.10, Room 6C414, 9000 Rockville Pike, Bethesda, MD 20892, USA (from August 1, 1995 – July 6, 1996).
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Summary

In acquired peripheral demyelinating disease only few publications point out the possibility of simultaneous involvement of the CNS. We describe two patients with chronic polyneuropathy and monoclonal gammopathy of undetermined significance (MGUS) developing a progressive dementia syndrome with extensive cerebral white matter alterations.

Keywords

dementiachronic polyneuropathiesmonoclonal gammopathy of undetermined significance (MGUS)demyelinating diseasewhite matter lesions (WMLs)CNS autoantibodies
Type
Short communication
Information
European Psychiatry , Volume 11 , Issue 1 , 1996 , pp. 46 - 49
Copyright
Copyright © 1996 Elsevier, Paris

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