Experiments were conducted at 12 locations in North Carolina and Virginia to determine soybean response to postemergence application of 2,4-DB in combination with 420 g ae ha-1 of sodium salt of acifluorfen, 13 g ae ha-1 of ethyl ester of chlorimuron, and 70 g ae ha-1 of ammonium salt of imazethapyr. Adding dimethylamine salt of 2,4-DB at 35 or 70 g ae ha-1 to acifluorfen, chlorimuron, or imazethapyr increased soybean injury 2 to 14% 7 d after application. Soybean quickly recovered and no injury was observed 21 d after application. Acifluorfen, chlorimuron, or imazethapyr alone or in combination with 2,4-DB at 35 g ha-1 did not reduce soybean yield. Adding 2,4-DB at 70 g ha-1 reduced yield at four of the 12 locations.