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Teresa Connolly argues that a profound understanding of key chemistry concepts and processes is as fundamental to scientific literacy as mastering complex procedures and skills, such as performing experiments, interpreting data or communicating one’s findings using specific text types. However, she points out that such an understanding of chemical concepts is inhibited not only by learners’ poor command of academic language but also by the fact that chemical processes can be observed at different levels of abstraction. This poses a specific challenge in chemistry because learners often report having difficulties distinguishing clearly between processes at the sub-microscopic, the microscopic and the macroscopic level, which will lead to misconceptions and prevent deeper understanding. To address that issue, Connolly’s deeper learning episode on redox reactions offers engaging ways of promoting scientific reasoning through a series of student-led experiments and inquiry. Systematic guidance in academic language use will enable learners to express their findings and observations precisely and adequately and thus help them distinguish the processes occurring at various levels of abstraction with increasing ease and confidence.
This new collection enables students and general readers to appreciate Coleridge’s renewed relevance 250 years after his birth. An indispensable guide to his writing for twenty-first-century readers, it contains new perspectives that reframe his work in relation to slavery, race, war, post-traumatic stress disorder and ecological crisis. Through detailed engagement with Coleridge’s pioneering poetry, the reader is invited to explore fundamental questions on themes ranging from nature and trauma to gender and sexuality. Essays by leading Coleridge scholars analyse and render accessible his extraordinarily innovative thinking about dreams, psychoanalysis, genius and symbolism. Coleridge is often a direct and gripping writer, yet he is also elusive and diverse. This Companion’s great achievement is to offer a one-volume entry point into his incomparably rich and varied world.
This chapter considers the characteristics and contexts of three eighteenth-century encyclopaedic dictionaries: Cyclopaedia (1728) by Ephraim Chambers, A medicinal dictionary (1742–45) by Robert James, and The first part of a dictionary of chemistry (1789) by James Keir, especially in relation to their own comments on their intentions. Chambers’s is generalist, while the other two are specialist works on medicine and chemistry. The Cyclopaedia had a long and acclaimed afterlife, while James’s dictionary was translated into French and Italian, but did not reach a second edition in England. Keir’s remained unfinished. An attempt is made to position these works in their larger lexicographical and scientific context, primarily through their paratexts.
Species are fundamental units used to describe and interpret nature. Molecular delimitation methods have shown that many species cannot be diagnosed using morphological traits. We suggest that cryptic species represent an opportunity to progress Linnean taxonomy,. We examine what can be learned from sympatric cryptic species pairs that occupy the same habitat. Their sympatry is possible under two conditions, 1) reproductive isolation, 2) the effects of interspecific competition on population growth must be neutralised. Understanding the mechanisms that maintain species differences and integrating this understanding into taxonomy will help to delineate species boundaries. We first examine the mechanisms of cryptic species origin. Then we review some well-documented cases of reproductive isolation between cryptic species, focusing on prezygotic isolation mechanisms mediated by premating recognition and communication. We follow with examples of co-occurring cryptic species, focusing on mechanisms of coexistence and ecological niche differentiation. Both mate recognition and niche differentiation are grounded in the sensory worlds that animals experience. Sensory ecology provides tools to explore hitherto hidden diversity and so identify, misunderstood and unprotected in this time of rapid anthropogenic global change. We argue that the field of sensory ecology has a potential for improving taxonomy
This study investigated the molecular, chemical and morphological variation in the Usnea pectinata aggregate using 42 specimens, 22 from Tanzania and 20 from São Tomé and Príncipe. A total of 31 sequences (13 ITS, 13 nuLSU and 5 RPB1) were generated. The results are presented in two phylogenies: first a three-markers ‘backbone’ phylogeny for the U. pectinata aggregate, where six distinct, strongly supported subclades indicate considerable genetic variation in the dataset; and second, an ITS phylogeny with 47 terminals along with a mapping of morphological and chemistry data. Several well-supported monophyletic clades were recovered in both phylogenies and these may well represent separate species in the complex referred to here as the U. pectinata aggregate. Three morphotypes characterized by axis pigmentation and four by branch shape were noted. Six chemotypes were observed.
The immunohistochemistry assay has evolved over many years. Primarily based on an antibody binding to epitopes in tissue sections, the technology has come a long way from its earliest manifestation using direct fluorescence labels. Current polymer technology is the result of many variations and adaptations on technique throughout the years. Indeed, much of its continued development is owed to early pioneers who experimented and overcame technical boundaries. This chapter is a broad discussion about what immunohistochemistry is from the historical perspective, and the individuals who have contributed to its expansion. It includes a journey about protocol adaptations and explanations of their context and applications. This chapter provides a sound basis in which to explore the rest of the book.
In France, a consolidated research ecosystem, including different national structures, has been developed to promote excellence in academic research. While research-oriented curricula are well organized at doctoral and master levels, the national policy perspective has not yet considered introducing academic research at undergraduate level. However, various initiatives exist within the institutions to encourage the participation of undergraduate students in research activities. In this chapter, we introduce some initiatives developed towards undergraduate research in the context of the French national system of education.
Chemical structure is a vital consideration early in the drug development process. Its role in analysis of safety and efficacy is relatively diminished after drugs are approved for clinical use. This interdisciplinary study explores a strategy by which readily available clinical data may be used along with structural features of drugs to identify associations with potential utility for both clinical decision-making and drug development.
Methods:
Chemical functional groups and structural groups (SGs) of 261 drugs were manually classified in tiers, and their incidence of gastrointestinal (GI) and central nervous system (CNS) adverse drug reactions (ADRs) were obtained from a clinical database. Drugs with an GI or CNS ADR incidence of at least 10% were analyzed for correlations with their functional and SGs.
Results:
Eight statistically significant associations were detected by preliminary analysis: piperazine and methylene groups were associated with higher rate of CNS ADRs; while amides, secondary alcohols, and di-substituted phenyl groups were associated with lower rates of GI or CNS ADRs or both.
Conclusions:
Although further study is necessary to understand these associations and build upon this strategy, this exploratory analysis establishes a methodology by which chemical properties of drugs may be used to aid in clinical decision-making when choosing between otherwise equivalent drug therapy options, as the presence of specific groups on drugs may be associated with increased or decreased risks of specific ADRs.
Chapter 6 chronicles how money as social technology was reconfigured during the eighteenth and nineteenth centuries. It examines economic and philanthropic discourse as well as government practice between 1750 and 1850 to explain the motives for a quick succession of currency reforms in the nineteenth century, that profoundly transformed the material properties of public money in circulation. Cheap but precise mass production was especially important in order to issue low-denomination coins, used primarily for wage payments and retail, that would be fully conversant with the official monetary standard. In order to explain why the Dutch came to take a more hostile stance towards multiple currencies circulating in their territory, the chapter delineates how a 'national economy', forged through monetary exchange, became first an ideological and then a bureaucratic reality. While national currency did not do away with plurality of money in use, especially in the Dutch–Prussian borderland that is the main locale of this book, the strong discourse of technological superiority of uniform, centrally managed currency made it more difficult to think about plurality as something other than chaos.
Chapter 4 explores how artisanal knowledge helped sustain early modern monetary order by making and unmaking the intrinsic value of precious metal. Intrinsic value was a conceptual tool and a material practice that allowed people to collapse many coins into one another and to forge units from multiples. Effectively, this meant establishing a network of corresponding values between specific batches of coins. The papers of a family of assayers from The Hague offer a fine-grained picture of the processes involved. Small differences in the precious metal content of coins aroused creeping suspicion, anger, and even physical violence because it was believed that the metal of a coin reflected the mettle of a person. This was particularly true for the masters of the mint, whose reputation was tied to the reputation of their coins. Making coins, and making them work, involved financial and legal expertise, but the artisanal knowledge of assayers and other metal-workers was key. Their practices such as sampling, using high-precision balances and powerful acids, note-taking, the rule of three, and algebraic calculation allowed people to hold on to the convention that metals had an intrinsic, quantifiable value in spite of fluctuations in the price of silver and gold, both across time and across the globe.
The risk of wide-scale cryptanalysis pervades narratives about quantum computing. We argue in this chapter that Feynman's vision for quantum computing will ultimately prevail, despite the discovery of Peter Shor's factoring algorithm that generated excitement about a use of quantum computers that people could understand---and dread. Feynman's vision of quantum devices that simulate complex quantum interactions is more exciting and strategically relevant, yet also more difficult to portray popular descriptions of technology. The Feynman vision for quantum computing will lead to applications that benefit humans in multifarious and unforeseen ways, just like the classical computing revolution improved our lives. Feynman's vision may also enable a ``winner-take-all'' outcome in building a large quantum computer. \par To explain this outcome, we canvass the three primary applications that have been developed for quantum computing: Feynman's vision of simulating quantum mechanical
This chapter explores how the scientific and literary preoccupation with the sources of sensation and sensibility in the Romantic period results in a reassessment of the relationship between matter and spirit. The chemistry of Joseph Priestley and Humphry Davy on matter and respiration is read in the context of devotional practice and the poetry of Anna Letitia Barbauld, Samuel Taylor Coleridge, and Erasmus Darwin.
Thomas Kuhn's The Structure of Scientific Revolutions offers an insightful and engaging theory of science that speaks to scholars across many disciplines. Though initially widely misunderstood, it had a profound impact on the way intellectuals and educated laypeople thought about science. K. Brad Wray traces the influences on Kuhn as he wrote Structure, including his 'Aristotle epiphany', his interactions, and his studies of the history of chemistry. Wray then considers the impact of Structure on the social sciences, on the history of science, and on the philosophy of science, where the problem of theory change has set the terms of contemporary realism/anti-realism debates. He examines Kuhn's frustrations with the Strong Programme sociologists' appropriations of his views, and debunks several popular claims about what influenced Kuhn as he wrote Structure. His book is a rich and comprehensive assessment of one of the most influential works in the modern sciences.
This chapter examines the influence of the history of chemistry on Kuhn's thinking as he wrote SSR. Many of the examples he draws on in the book come from the history of chemistry.
During the eighteenth century, chemists in the Kingdom of Naples (the South of Italy) were very busy analyzing the chemical composition of ash from Mount Vesuvius. Undoubtedly, after a huge eruption this dusty phenomenon was the most important scientific object of debate. In fact, it was crucial to determine if there were dangerous elements in the ash so that the population could be warned about the potential hazards, such as polluted drinking water. This was not at all a simple issue, as on the other hand there were scholars who realized that ash could be beneficial as a fertilizer, even as clouds of ash had obscured the sun. As chemical inquiries became more precise and the toxic concentration of many elements became known, this double life of Vesuvian ash as a scientific object gradually died.
This chapter offers an overview of key points of entry for the study of eighteenth-century science. The first section addresses how seventeenth-century philosophers challenged Aristotelianism and ancient cosmologies. The second details the importance of empiricism in the new study of the natural world. The third focuses on the roles of specific instruments and institutions in natural philosophical inquiry. Sections four and five cover two of the fiercest philosophical debates of the period: first, about gravity and action at a distance, and second, about theories of matter and spirit. The final section examines encyclopaedism and the emergence toward the end of the century of three new sub-disciplines: chemistry, botany, and geology. A distinguishing feature of eighteenth-century science is how closely it was interwoven with theology. Theories about providence and intelligent design were central to nearly every scientific debate because it was assumed that studying the causes of natural phenomena was the best way to understand the Prime Mover’s intentions for humankind. Accordingly, a recurrent theme in this chapter is the interconnection of religion and science.
Dermanyssus gallinae (De Geer 1778), commonly named the poultry red mite (PRM), is considered to be the most harmful ectoparasite in poultry farms in Europe. This species feeds on the blood of laying hens, but spends most of its time hidden in cracks and crevices around hen nests. To control PRM populations in poultry houses, chemical pesticides are currently used; however, concern is growing regarding the harmful residues found in eggs and hens, along with the increased resistance of mites against several compounds. Alternatives to synthetic compounds are now being explored, including vaccines, biological control, physical control and semiochemical control based on the chemical ecology of PRM. This review focused on the different volatile organic compounds (VOCs) identified from D. gallinae and other mite species that have been discovered to control them. Pheromones (aggregation pheromone, sex pheromone and alarm pheromone) and kairomones promoting attraction behaviour in D. gallinae and other mite species are presented, while VOCs from essential oils and plant extracts with repellent properties are also explored. Finally, devices using VOCs on PRM in the field are described, with devices that have been tested on other Acari species being mentioned as potential directions for the future control of PRM.
The first Laser-Induced Breakdown Spectroscopy (LIBS) instrument for extraterrestrial applications is part of the ChemCam instrument suite onboard the Curiosity Mars rover. ChemCam may be used in a number of operational modes depending on the science questions of interest, including active (with laser) and passive (spectrometers only) modes, and there is important synergy between ChemCam and other payload instruments. Notable discoveries made with ChemCam LIBS data include the characterization of hydrogen in rocks and soils, discovery of boron on Mars, and characterization of other trace elements (Li, F, Rb, Sr, Ba) that were previously never or rarely quantified on Mars, depth-dependent chemical trends on rock surfaces, and a much broader range of bulk-rock chemical compositions than was previously recognized, including highly evolved igneous rocks. In addition to ChemCam, another LIBS instrument is slated to fly to Mars on the Mars 2020 rover mission as part of the combined Raman-LIBS SuperCam instrument.
Chapter One explores ancestors of the idea that the physical sciences were relevant and significant to the study of obscure powers associated with the human body and mind. In the late eighteenth and early nineteenth centuries, practitioners of animal magnetism and mesmerism linked the study of a supposed new imponderable ‘magnetic’ fluid affecting health to better-known physical imponderables. In the mid-nineteenth century the German chemist Karl von Reichenbach and his followers stimulated much debate for their alleged discovery of new imponderable ‘od’ that they believed extended the domain of physics into the realm of physiology. From the 1840s onwards ’Modern Spiritualism’ prompted many natural philosophers to intervene on controversies over its startling physical effects. The final section of the chapter contextualises these attempts to link physical and psychical realms in terms of the fluid state of the physical sciences in the early and mid-nineteenth century.