We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter explores how the evolving disease environments of the tropics shaped free and forced migration patterns at English sites. The globalization of forced labor markets and trade were catalysts in the spread of yellow fever and falciparum malaria, diseases that originated in Africa and that disproportionately weakened or killed English migrants to the tropics. These were the two deadliest mosquito-borne fevers that the English encountered in the tropics. The ways in which the English understood and responded to evolving tropical disease environments and their differential effects on European and non-European populations contributed to the rise of enslaved majorities in the tropics and informed ideas about human difference that would coalesce into nineteenth-century racism. The chapter will also show how epidemiology made English footholds in the tropics much more precarious and dependent on non-Europeans than the English footholds in other more temperate zones of the empire. The chapter relies on case studies of disease outbreaks in the Caribbean, on the West African Gold Coast, and in Sumatra at key points in the seventeenth century.
Despite bold commitments to reduce anemia, little change in prevalence was observed over the past decade. We aimed to generate subnational maps of anemia among women of reproductive age (WRA), malaria transmission, and hemoglobinopathies to identify priority areas, but also explore their geographical overlap.
Design:
Using the most recent Demographic and Health Surveys (DHS), we first mapped anemia clusters across Sub-Sahara Africa (SSA) and identified the WCA as a major cluster. Geographic clusters with high anemia and related etiologic factors were identified using spatial statistics. Multilevel regression models were run to identify factors associated with any, moderate and severe anemia.
Settings:
West and Central African countries (n=17).
Participants:
WRA (n= 112,024) residing in 17 WCA countries.
Results:
There was a significant overlap in geographical clusters of anemia, malaria, and hemoglobinopathies, particularly in the coastal areas of the WCA region. Low birth interval (0.86 [0.77, 0.97]), number of childbirth (1.12 [1.02, 1.23]), being in the 15-19 age range (1.47 [1.09, 1.98])) were associated with increased odds of any anemia. Unimproved toilet facility and open defecation were associated with any anemia, whereas the use of unclean cooking fuel was associated with moderate/severe anemia (P<0.05). Access to health care facility, living in malaria prone areas, and hemoglobinopathies (HbC and HbS) were all associated with any, moderate or severe anemia.
Conclusion:
Interlinkages between infection, hemoglobinopathies, and nutritional deficiencies complicate the etiology of anemia in the WCA region. Without renewed efforts to integrate activities and align various sectors in the prevention of anemia, progress is likely to remain elusive.
This chapter details the circumstances and techniques behind the colonial acquisitions and conquests of Nigeria during the late nineteenth and early twentieth centuries. It details two broad categories of methods used by colonial forces: forceful acquisitions and acquisitions achieved through diplomacy. While broad categorizations of colonial techniques are made, this chapter outlines that different techniques could and were used for every Indigenous polity involved. The strategy behind every colonial conquest depended on numerous factors such as the size, “sophistication,” geography, and local political landscape of the polity in question. However, while the techniques behind the colonial acquisitions could drastically differ, this chapter outlines the common goals behind each strategy: to drive a set of processes that weakened the power and authority of indigenous power structures. This would create a power void that, through gradual or rapid action, would be filled by colonial forces or actors aligned with colonial interests. The reactions and independent actions taken by indigenous polities are equally crucial to the history in question. Like their European counterparts, the indigenous states of Nigeria reacted to colonial meddling and the actions of their fellow polities in many different ways, with varying degrees of success.
This chapter analyses the historical evolution of the creation and aesthetics of Nigerian artists during the colonial period through local musicians and actors. Moreover, the importance of oral traditions before the interaction with Europeans – such as proverbs, panegyrics, and rituals – incorporated Christianity through schools by the Nigerian elite and Western music and instruments. In the case of music, the chapter mentions how precolonial cultural traditions shaped it, the influence of ex-enslaved people from the Caribbean (such as Brazilians) who returned to the city of Lagos, and European contributions. Methodologically, the chapter follows musicians such as Fela Sowande, Victor Olaiya, and Bobby Benson. They, in different ways, integrated precolonial elements to create a national tradition that would create unity in the colonial period. In the case of theater, the chapter also mentions its historical evolution: from traveling theater to the work of Hubert Ogunde, Kola Ogunmola, and Duro Ladipo, as icons representing creativity and aesthetics, introducing Nigerian cultural elements to theater, such as Yoruba, Hausa, and Igbo language, myths, and stories, linking with Western traditions such as Christianity. The chapter concludes that the artists of the colonial period sought, through their musical and theatrical works, to preserve precolonial traditions.
This chapter discusses the extent to which standard economic efficiency analysis can be applied to the economics of reducing ill health caused by environmental factors. This type of analysis is relevant when production functions can be applied to public health environmental situations such as those involving the public supply of safe water and sanitation. On the other hand, different analytical approaches are required to assess more holistically the social economic efficiency of public policies to control most environmentally related diseases. Concrete theoretical evidence about the analytical significance of the presence of externalities is backed up with examples. These cases include cadmium poisoning, drinking water contaminations, issues involved in the control of COVID-19, and the willingness of individuals to vaccinate against infectious diseases. In addition, particular attention is paid to problems involved in determining the social economic efficiency of the amount and use of methods of controlling environmentally related diseases when their effectiveness declines with use.
Chapter 5 builds on the argument that the Brazilian military government largely ignored the social and environmental costs of its big dams because it was under pressure to build them quickly and cheaply and because it believed that its pharaonic environmentalism would satisfy its critics. It covers the twenty-year period from the late 1970s to the late 1990s, when reservoir floodwaters submerged cherished land and waterscapes that had been protected as national parks, engendered profound transformations to local fisheries, and set in motion ecological changes that led to devastating mosquito-related torments among communities living along the margins of reservoirs. To be sure, not all changes spelled disaster. Fisheries boomed in the decades following the formation of reservoirs, and malaria outbreaks were mild by historic standards. But in many places, disregard for the environment led to a series of local disasters that drew attention to the high environmental costs of big dams.
Naturally acquired immunity to the different types of malaria in humans occurs in areas of endemic transmission and results in asymptomatic infection of peripheral blood. The current study examined the possibility of naturally acquired immunity in Bornean orangutans, Pongo pygmaeus, exposed to endemic Plasmodium pitheci malaria. A total of 2140 peripheral blood samples were collected between January 2017 and December 2022 from a cohort of 135 orangutans housed at a natural forested Rescue and Rehabilitation Centre in West Kalimantan, Indonesia. Each individual was observed for an average of 4.3 years during the study period. Blood samples were examined by microscopy and polymerase chain reaction for the presence of plasmodial parasites. Infection rates and parasitaemia levels were measured among age groups and all 20 documented clinical malaria cases were reviewed to estimate the incidence of illness and risk ratios among age groups. A case group of all 17 individuals that had experienced clinical malaria and a control group of 34 individuals having an event of >2000 parasites μL−1 blood but with no outward or clinical sign of illness were studied. Immature orangutans had higher-grade and more frequent parasitaemia events, but mature individuals were more likely to suffer from clinical malaria than juveniles. The case orangutans having patent clinical malaria were 256 times more likely to have had no parasitaemia event in the prior year relative to asymptomatic control orangutans. The findings are consistent with rapidly acquired immunity to P. pitheci illness among orangutans that wanes without re-exposure to the pathogen.
This review aims to assess the prevalence of malaria in pregnancy during antenatal visits and delivery, species-specific burden together with regional variation in the burden of disease. It also aims to estimate the proportions of adverse pregnancy outcomes in malaria-positive women. Based on the PRISMA guidelines, a thorough and systematic search was conducted in July 2023 across two electronic databases (including PubMed and CENTRAL). Forest plots were constructed for each outcome of interest highlighting the effect measure, confidence interval, sample size, and its associated weightage. All the statistical meta-analysis were conducted using R-Studio version 2022.07. Sensitivity analyses, publication bias assessment, and meta-regression analyses were also performed to ensure robustness of the review. According to the pooled estimates of 253 studies, the overall prevalence of malaria was 18.95% (95% CI: 16.95–21.11), during antenatal visits was 20.09% (95% CI: 17.43–23.06), and at delivery was 17.32% (95% CI: 14.47–20.61). The highest proportion of malarial infection was observed in Africa approximating 21.50% (95% CI: 18.52–24.81) during ANC and 20.41% (95% CI: 17.04–24.24) at the time of delivery. Our analysis also revealed that the odds of having anaemia were 2.40 times (95% CI: 1.87–3.06), having low birthweight were 1.99 times (95% CI: 1.60–2.48), having preterm birth were 1.65 times (95% CI: 1.29–2.10), and having stillbirths were 1.40 times (95% CI: 1.15–1.71) in pregnant women with malaria.
This article examines a policy of scaling up LLINs by 10 percentage points from 2020 levels with a 90% cap in the 29 highest-burden countries in Africa along with social and behavioral change (SBC) and information education and communication (IEC) campaigns to increase the use and effectiveness of LLINs. The incremental cost of this scenario compared to a baseline of maintaining malaria interventions at 2020 levels has a present-day (2023) value of 5.7 billion US$ 2021 discounted at 8% over the period 2023–2030 (undiscounted starting at US$ 416 million in 2023 increasing to US$ 1.4 billion in 2030). This investment will prevent 1.07 billion clinical cases and save 1,337,069 lives. With standardized Copenhagen Consensus Center assumptions, the mortality benefit translates to a present value of US$ 225.9 billion. The direct economic gain is also substantial: the incremental scenarios lead to US$ 7.7 billion in reduced health system expenditure from the reduced treatment of cases, a reduction in the cost of delivering malaria control activities, and reduced household out-of-pocket expenses for malaria treatment. The productivity gains from averted employee and caretaker absenteeism and presenteeism add benefits with a present value of US$ 41.7 billion. Each dollar spent on the incremental scenario delivers US$ 48 in social and economic benefits.
Malaria is endemic in Guinea; however, the extent and role in transmission of asymptomatic malaria are not well understood. In May 2023, we conducted a rapid community survey to determine Plasmodium falciparum (P. falciparum) prevalence among asymptomatic individuals in Middle Guinea (Prefecture Dalaba) and Forest Guinea (Prefecture Guéckédou). In Dalaba, 6 of 239 (2.1%, confidence interval (CI) 0.9–4.8%) individuals tested positive for P. falciparum by a rapid diagnostic test (RDT), while in Guéckédou, 147 of 235 (60.9%, CI 54.5–66.9%) participants tested positive. Asymptomatic malaria needs to be considered more strongly as a driver of transmission when designing control strategies, especially in Forest Guinea and potentially other hyper-endemic settings.
Migration is an important risk factor for malaria transmission for malaria transmission, creating networks that connect Plasmodium between communities. This study aims to understand the timing of why people in the Peruvian Amazon migrated and how characteristics of these migrants are associated with malaria risk. A cohort of 2,202 participants was followed for three years (July 2006 - October 2009), with thrice-weekly active surveillance to record infection and recent travel, which included travel destination(s) and duration away. Migration occurred more frequently in the dry season, but the 7-day rolling mean (7DRM) streamflow was positively correlated with migration events (OR 1.25 (95% CI: 1.138, 1.368)). High-frequency and low-frequency migrant populations reported 9.7 (IRR 7.59 (95% CI:.381, 13.160)) and 4.1 (IRR 2.89 (95% CI: 1.636, 5.099)) times more P. vivax cases than those considered non-migrants and 30.7 (IRR 32.42 (95% CI: 7.977, 131.765)) and 7.4 (IRR 7.44 (95% CI: 1.783, 31.066)) times more P. falciparum cases, respectively. High-frequency migrants employed in manual labour within their community were at 2.45 (95% CI: 1.113, 5.416) times higher risk than non-employed low-frequency migrants. This study confirms the importance of migration for malaria risk as well as factors increasing risk among the migratory community, including, sex, occupation, and educational status.
About 40 million people travel from abroad to the United States per annum; many international travelers arrive in urban centers, and those who are ill will seek care there. Clinicians working in urban hospitals or near points of international arrival must be familiar with diseases commonly acquired abroad as well as uncommon but potentially serious conditions such as emerging and re-emerging infectious diseases. The assessment of the ill international traveler begins with a thorough history including the patient’s itinerary, activities, and risk factors. A familiarity with conditions endemic to the region of travel, timing of exposure, and knowledge of incubation period will allow the clinician to form a focused differential diagnosis. Knowledge of the specific diseases for which the patient is at risk, their potential complications, and the patient’s clinical status will determine need for diagnostic testing, empiric treatment, and ultimate disposition.
Intermittent fever is a historical diagnosis with a contested meaning. Historians have associated it with both benign malaria and severe epidemics during the Early Modern Era and early nineteenth century. Where other older medical diagnoses perished under changing medical paradigms, intermittent fever ‘survived’ into the twentieth century. This article studies the development in how intermittent fever was framed in Denmark between 1826 and 1886 through terminology, clinical symptoms and aetiology. In the 1820s and 1830s, intermittent fever was a broad disease category, which the diagnosis ‘koldfeber’. Danish physicians were inspired by Hippocratic teachings in the early nineteenth century, and patients were seen as having unique constitutions. For that reason, intermittent fevers presented itself as both benign and severe with a broad spectrum of clinical symptoms. As the Parisian school gradually replaced humoral pathology in the mid-nineteenth century, intermittent fever and koldfeber became synonymous for one disease condition with a nosography that resembles modern malaria. The nosography of intermittent fever remained consistent throughout the second half of the nineteenth century. Although intermittent fever was conceptualized as caused by miasmas throughout most of the nineteenth century, the discovery of the Plasmodium parasite in 1880 led to a change in the conceptualization of what miasmas were. The article concludes that the development of how intermittent fever was framed follows the changing scientific paradigms that shaped Danish medicine in the nineteenth century.
A broad range of parasites were present in ancient Egypt and Nubia, with 15 different species, including ectoparasites, helminths, and protozoa. Some are spread directly from one person to another (such as pinworm and head lice), some pass through animals as part of their life cycle (such as Taenia tapeworms, fish tapeworm, and trichinella), while others require biting insect vectors to spread them (such as malaria, leishmaniasis, and filariasis). Around 40% of ancient Nubians had head lice, 10% of Nubians were infected by visceral leishmaniasis, 22% of Egyptian mummies were positive for malaria, and 17% were positive for schistosomiasis. As malaria and schistosomiasis cause chronic anaemia and fatigue during physical work, they must have been responsible for a considerable drain upon the capabilities of the workforce in these civilizations along the Nile.
Despite major investment in sanitation infrastructure, intestinal parasites spread by faecal contamination of food and water were a particular problem everywhere in the Roman world. Similarly, ectoparasites such as lice and fleas were common despite the Roman enthusiasm for washing in communal bathhouses and the use of delousing combs. However, some parasites seem to be much more regional in their distribution, likely due to climate variations. Fish and Taenia tapeworms, spread by eating raw or undercooked fish, pork, or beef were more common in northern Europe than southern Europe, possibly due to the fact that the hot climate in the south made raw fish and meat go off faster than in the cooler north. In contrast, malaria seems to have been much more common in the Mediterranean region than in northern Europe, as the warm climate of the south created breeding sites for the Anophales mosquito, which transmitted the parasite. Roman period medical texts by Galen and other physicians showed awareness of a number of parasites and tried to explain them in the context of the humoral theory. Treatment involved trying to rebalance the humours in order to return the individual to health.
We have explored some of the ways in which parasites can tell us about past human migrations. Sometimes an expansion to the endemic area of a parasite shows that migration had found an environment receptive to that species’ life cycle. Examples date across evolutionary time, from lice in our hominin ancestors to transatlantic slavery in the last few hundred years. In contrast, in many more examples the parasite failed to become endemic in the new region due to the lack of key elements required for its life cycle. The role of human ectoparasites in the spread of epidemic and pandemic disease has been vitally important throughout human history. As humans move they take their ectoparasites with them, their bodies acting as an incubator for bacterial infectious diseases. While bubonic plague is certainly the best recorded and researched of these epidemics, many others such as epidemic typhus and trench fever would have caused disease and death in past societies. Although human fleas and lice in themselves have only limited impact upon health, it seems likely that far more of our ancestors have died from diseases spread by their ectoparasites than ever died from intestinal parasites.
The generation of transgenic plants and animals is discussed in Chapter 16. The technology is now well established, but remains a controversial area in terms of public perception and acceptance. Scientific, regulatory, ethical, political and commercial factors together present a complex framework within which the development of transgenic plants and animals is placed. As well as considering the technical procedures used to generate transgenics, these broader aspects (and their impact on the success or failure of a transgenic product) are considered. The development of Golden Rice, and the subsequent political issues around its deployment, illustrate the complexity of the topic. Paradoxically, transgenic animals often generate less negative reaction from the anti-GMO (genetically modified organism) movement than transgenic plants, with most concerns being around animal welfare issues. This is particularly true where the product is, for example, a demonstrably positive therapeutic; when transgenic animals are generated for consumption, the GMO debate tends to become polarised to the same extent as transgenic crops.
Chapter 6 investigates the WHO’s malaria and tuberculosis control programs in the 1950s and 1960s, which made use of statistical collection and analysis. Numbers had become omnipresent in program design and implementation by this time, and experts at the WHO and in the Taiwanese government used their public health knowledge to justify their selection of statistics. WHO experts and Taiwanese health officers also used numbers to advocate for their programs. In particular, experts curated numbers to bolster their arguments in the context of ongoing policy debates at the WHO. Their ways of curating numbers were different as they occupied different positions within global health policy-making. Experts within the WHO mobilized their knowledge on the diseases in question to justify their selection of certain statistics over others, while their Taiwanese colleagues used numbers to present Taiwan as a viable testing ground for WHO policies, with a view to obtaining financial and technical support.
Long-haul tourists visiting South Africa are always fascinated by the clicks of isiXhosa. Foreign to their ears, the eighteen click consonants can be grouped into three types: the ‘c’ is a dental click made by the tongue at the back of the mouth, the lateral ‘x’ is made by the tongue at the sides of the mouth, and the alveolar ‘q’ is made by the tip of the tongue on the roof of the mouth.
IsiXhosa is part of the Nguni language group, which also includes Zulu and southern and northern Ndebele. Yet few of these or the other South African vernacular languages have clicks, and those that do have them use them far less. How is it that isiXhosa came to use clicks so commonly?
One clue comes from the other languages of southern Africa that also make use of clicks – and there are lots of them.