The current study aimed to investigate the protective effects of dietary thiamine supplementation on the regulation of colonic integrity and mucosal inflammation in goats fed a high-concentrate (HC) diet. Twenty-four Boer goats (live weight of 35.62 ± 2.4 kg) were allocated to 3 groups (CON: concentrate/forage = 30:70; HC; concentrate/forage = 70:30; HCT: concentrate/forage = 70:30 with 200 mg thiamine/kg DMI) for 12 weeks. Results showed that compared with the HC treatment, the HCT group had a significantly higher ruminal pH value from 0 to 12 h after the feeding. The H&E (hematoxylin-eosin) staining showed that desquamation and severe cellular damage was observed in the colon epithelium of the HC group, whereas the HCT group exhibited more structural integrity of the epithelial cell morphology. Compared with the HC treatment, the HCT group showed a markedly increased in pyruvate dehydrogenase (PDH) and α-Ketoglutarate dehydrogenase (α-KGDH) enzymes activity and a markedly decreased in matrix metalloproteinase (MMP)-2, MMP-9, Caspase-3, Caspase-8 and lactate dehydrogenase (LDH) enzymes activity. The mRNA expression in the colonic epithelium of SLC19A2, SLC19A3, SLC25A19, Bcl-2, Occludin, Claudin-1, Claudin-4 and ZO-1 in the HCT group were significantly increased, whereas the mRNA expression of NFκB, IL-1β, IL-6, IL-10, CXCL-10, CXCL-13, MMP-9, MMP-13 and Bax were significantly decreased in comparison with the HC diet treatment. Compared with the HC treatment, the HCT diet significantly increased the protein expression of claudin-1 and significantly decreased the protein expression of NFκB-related proteins p65. The results show that dietary thiamine supplementation could improve the colon epithelial barrier function and alleviate mucosal inflammation injury in goats after LPS and low pH challenge.

The early identification and prediction of hand-foot-and-mouth disease (HFMD) play an important role in the disease prevention and control. However, suitable models are different in regions due to the differences in geography, social economy factors. We collected data associated with daily reported HFMD cases and weather factors of Zibo city in 2010~2019 and used the generalised additive model (GAM) to evaluate the effects of weather factors on HFMD cases. Then, GAM, support vectors regression (SVR) and random forest regression (RFR) models are used to compare predictive results. The annual average incidence was 129.72/100 000 from 2010 to 2019. Its distribution showed a unimodal trend, with incidence increasing from March, peaking from May to September. Our study revealed the nonlinear relationship between temperature, rainfall and relative humidity and HFMD cases and based on the predictive result, the performances of three models constructed ranked in descending order are: SVR > GAM> RFR, and SVR has the smallest prediction errors. These findings provide quantitative evidence for the prediction of HFMD for special high-risk regions and can help public health agencies implement prevention and control measures in advance.

Background: This is a population-based retrospective study of neurological and cardiac complications of COVID-19 among Ontario visible minorities: Chinese and South Asian Canadians Methods: From January 1, 2020 to September 30, 2020, using the last name algorithm, rates and types of cardiac and neurological complication of these two cohorts along with the general population in Ontario with COVID-19 were analysed by Institue of Clinical Evaluative Sciences. Results: Preliminary results show that Chinese-Canadians (N= 1,186) with COVID-19 are older with a mean age of 50.74 years old compared to general population (N= 42,547) of 47.57 years old (P< .001), while South Asians (N= 3,459) have a younger mean age of 42.08 years old (P< .001). Total cardiac and neurological complication rates, hospitalization rates and ICU admission rates are all higher for Chinese-Canadians while they are lower in South Asians and all achieving statistical significance (P < .001). Overall mortality rate is significantly higher for Chinese-Canadians at 8.1% vs 5.0% general population (P < .001). Conclusions: Chinese-Canadians with COVID-19 in Ontario were much older and have higher cardiac and neurological complication rates and overall mortality rate than the general population. These data have significant implications for proper prevention and appropriate management for these vulnerble elderly Chinese-Canadians.

This paper first uses a low-speed stereoscopic particle image velocimetry (SPIV) system to measure the convergent statistical quantities of the flow field and then simultaneously measure the time-resolved flow field and the wall mass transfer rate by a high-speed SPIV system and an electrochemical system, respectively. We measure the flow field and wall mass transfer rate under upstream pipe Reynolds numbers between 25 000 and 55 000 at three specific locations behind the orifice plate. Moreover, we apply proper orthogonal decomposition (POD), stochastic estimation and spectral analysis to study the properties of the flow field and the wall mass transfer rate. More importantly, we investigate the large-scale coherent structures’ effects on the wall mass transfer rate. The collapse of the wall mass transfer rates’ spectra by the corresponding time scales at the three specific positions of orifice flow suggest that the physics of low-frequency wall mass transfer rates are probably the same, although the flow fields away from the wall are quite different. Furthermore, the spectra of the velocity reconstructed by the most energetic eigenmodes agree well with the wall mass transfer rate in the low-frequency region, suggesting that the first several energetic eigenmodes capture the flow dynamics relevant to the low-frequency variation of the wall mass transfer. Stochastic estimation results of the velocity field associated with large wall mass transfer rate at all three specific locations further reveal that the most energetic coherent structures are correlated with the wall mass transfer rate.

This study investigates water waves generated by a bottom obstacle translating at a subcritical speed in constant water depth, using a combination of analytical and numerical approaches. The newly derived analytical solutions reveal two types of waves – the transient free waves that propagate radially outwards, and the trapped wave that stays on top of the translating bottom obstacle. Closed-form asymptotic solutions for both the free surface and the flow velocities are derived in the far field, and near the leading wave or in the shallow water limit. The far-field leading waves are mathematically shown to be insensitive to the exact shape of the obstacle. Numerical long-wave models are employed to examine effects unaccountable by the linear analytical solutions. Nonlinear effects are found to cause only small deviations from the linear solutions. The effects of the obstacle's acceleration and deceleration are also examined numerically. Overall, the idealised linear analytical solutions predict well the characteristics of water waves generated by a bottom obstacle, and therefore can serve as the cornerstone of a theory-based model for quickly predicting the tsunamis generated by a submarine landslide.

Stratospheric airships are lighter-than-air vehicles that work at an altitude of 20km in the lower calm portion of the stratosphere. They can be used as real-time surveillance platforms for environment monitoring and civil communication. Solar energy is the ideal power choice for long-endurance stratospheric airships. Attitude control is important for airships so that they can point at a target for observation or adjust the attitude to improve the output performance of solar panels. Stratospheric airships have a large volume and semi-flexible structure. The typical actuators used are aerodynamic surfaces, vectored thrust and ballonets. However, not all these actuators can work well under special working conditions, such as low density and low speed. In this study, moving-mass control is introduced to stratospheric airships because its control efficiency is independent of airspeed and atmospheric density. A nonlinear feedback controller based on generalised inverse with a nonlinear mapping module is designed to implement moving-mass control. Such a new station keeping scheme with moving masses is proposed for airships with different working situations.

We hypothesized that children receiving medium-chain triglyceride ketogenic diet (MCTKD) experience similar seizure reduction despite lower ketosis compared with classic ketogenic diet (CKD). Children initiating CKD or MCTKD were enrolled in a prospective observational study. Forty-five children completed 6 months of KD (n = 17 MCTKD, n = 28 CKD). The proportion achieving ≥50% seizure reduction was 71% CKD group and 59% MCTKD group; ≥90% reduction was 32% and 36% in CKD and MCTKD groups, respectively. CKD had higher urine ketones (≥8 mmol/L: 79% vs. 36%, p = 0.005). Children receiving MCTKD experience similar seizure control to CKD despite lower urine ketone measures.

We investigate the European call option pricing problem under the fractional stochastic volatility model. The stochastic volatility model is driven by both fractional Brownian motion and standard Brownian motion. We obtain an analytical solution of the European option price via the Itô’s formula for fractional Brownian motion, Malliavin calculus, derivative replication and the fundamental solution method. Some numerical simulations are given to illustrate the impact of parameters on option prices, and the results of comparison with other models are presented.

A multi-agent engagement scenario is considered in which a high-value aircraft launches two defenders to intercept two homing missiles aimed at the aircraft. Under the assumption that all aircrafts have first-order linear dynamic characteristics, a combined multiple-mode adaptive estimation (MMAE) and a two-way cooperative optimal guidance law are proposed for the target–defenders team. Considering the full cooperation of the target and both the two defenders, the two-way cooperative strategies provide the analytical expressions for their optimal control input, enabling the target–defenders team to intercept the missiles with minimal control effort. To successfully intercept the missiles, MMAE is used to identify the guidance laws adopted by the missiles and estimate their states. The simulation results show that the target cooperating with the defenders to perform lure manoeuvres for the missiles can improve the guidance performance of the defenders as well as reduce the control effort of the defenders for intercepting the missiles.