Development and utilization of dicamba-, glufosinate-, and 2,4-D-resistant crop cultivars will potentially have a significant influence on weed management in the southern United States. However, off-site movement to adjacent nontolerant crops and other plants is a concern in many areas of eastern North Carolina and other portions of the southeastern United States, especially where sensitive crops are grown. Cotton, peanut, and soybean are not resistant to these herbicides, will most likely be grown in proximity, and applicators will need to consider potential adverse effects on nonresistant crops when these herbicides are used. Research was conducted with rates of glufosinate, dicamba, and 2,4-D designed to simulate drift on cotton, peanut, and soybean to determine effects on yield and quality and to test correlations of visual estimates of percent injury with crop yield and a range of growth and quality parameters. Experiments were conducted in North Carolina near Lewiston-Woodville and Rocky Mount during 2009 and 2010. Cotton and peanut (Lewiston-Woodville and Rocky Mount) and soybean (two separate fields [Rocky Mount] during each year were treated with dicamba and the amine formulation of 2,4-D at 1/2, 1/8, 1/32, 1/128, and 1/512 the manufacturer's suggested use rate of 280 g ai ha−1 and 540 g ai ha−1, respectively. Glufosinate was applied at rates equivalent to 1/2, 1/4, 1/8, 1/16, and 1/32 the manufacturer's suggested use rate of 604 g ai ha−1. A wide range of visible injury was noted at both 1 and 2 wk after treatment (WAT) for all crops. Crop yield was reduced for most crops when herbicides were applied at the highest rate. Although correlations of injury 1 and 2 WAT with yield were significant (P ≤ 0.05), coefficients ranged from −0.25 to −0.50, −0.36 to −0.62, and −0.40 to −0.67 for injury 1 WAT vs. yield for cotton, peanut, and soybean, respectively. These respective crops had ranges of correlations of −0.17 to −0.43, −0.34 to −0.64, and −0.41 to −0.60 for injury 2 WAT. Results from these experiments will be used to emphasize the need for diligence in application of these herbicides in proximity to crops that are susceptible as well as the need to clean sprayers completely before spraying sensitive crops.