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A previous study demonstrated a higher rate of first hospitalisation for schizophrenia in twins than in singletons.
To compare the schizophrenia rates in monozygotic twins, dizygotic twins and the general population.
Through record linkage between the Young Cohort of the Danish Twin Register and the Danish Psychiatric Case Register, the rate of schizophrenia in’ monozygotic and dizygotic twins and the rate in the general population were compared.
The rate of first admission to hospital for schizophrenia in dizygotic twins was 40% greater than that in the general population. The rate in monozygotic twins was not increased. The difference between the rates in mono- and dizygotic twins was statistically significant (P < 0.001)
This result is surprising and is in the direction opposite to that expected, suggesting new possibilities in the study of risk factors.
We wished to establish whether the occurrence of schizophrenia among twins is the same as among the general population.
Through record linkage between the New Danish Twin Register and the Danish Psychiatric Case Register, the twins who have ever received a diagnosis of schizophrenia were identified. Through indirect standardisation for age, sex and dates of admission, the rate of first admission with diagnosis schizophrenia among twins is compared to the same rate in the general population.
A 28% increase in the rate of first admissions for schizophrenia in twins compared to the general population was found. This is statistically significant and does not seem to be caused by any known methodological problems. Twins also had an increased first-admission rate of any psychiatric disorders.
This increased risk does not seem to be explained by known methodological problems, but does differ from earlier studies.
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