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5 results

  • Chapter 11 - Benign adult familial myoclonic epilepsy
    • from Section 2 - Idiopathic epilepsy
  • Edited by Simon D. Shorvon, Frederick Andermann, Renzo Guerrini
  • Book: The Causes of Epilepsy
  • Published online: 05 March 2012
  • Print publication: 14 April 2011, pp 85-90
  • View abstract

    Summary

    Epilepsy is a disease of the brain characterized by recurring unprovoked epileptic seizures, caused by a transient abnormality of neuronal activity which results in synchronized electrical discharges of neurons within the central nervous system (CNS). This chapter focuses on the most important characteristics of voltage- and ligand-gated ion channels, their role in determining neuronal excitability, and the impact of some reported mutations on epileptogenesis in idiopathic epilepsies. It describes the importance of the thalamocortical loop and thalamic ion channels for the generation of generalized seizures. The binding of transmitters and the coupling to channel opening are complex processes which can consequently be influenced by amino acid changes in many different regions of these channels. Most anticonvulsant drugs that are in clinical use today act by modulating the function of ion channels and the chapter describes how ion channel function can be altered by genetic defects associated with idiopathic epilepsies.
  • Epileptic, organic and genetic vulnerabilities for timing of the development of interictal psychosis
  • Naoto Adachi, Nozomi Akanuma, Masumi Ito, Masaaki Kato, Tsunekatsu Hara, Yasunori Oana, Masato Matsuura, Yoshiro Okubo, Teiichi Onuma
  • Journal: The British Journal of Psychiatry / Volume 196 / Issue 3 / March 2010
  • Published online by Cambridge University Press: 02 January 2018, pp. 212-216
  • Print publication: March 2010
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  • View abstract
    Background

    Age at the first psychotic episode and an interval between the onset of epilepsy and that of psychosis reflect developmental processes of interictal psychosis. However, factors relating to these indices remain unknown.

    Aims

    To identify clinical variables that are associated with the timing of the development of interictal psychosis.

    Method

    In 285 adults with epilepsy with interictal psychosis, effects of epileptic (epilepsy type), organic (intellectual functioning) and genetic (family history of psychosis) variables on timing of the development of psychosis were examined.

    Results

    The mean interval between the onset of epilepsy and that of psychosis was 14.4 years. Some psychosis occurred within a few years of the first seizure. Generalised epilepsy, normal intellectual function and a positive family history of psychosis were associated with early onset of psychosis.

    Conclusions

    Early development of interictal psychosis in people with epilepsy may reflect other individual vulnerabilities to psychosis rather than epilepsy-related damage.