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Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial

Pediatric Heart Network

Suma P. Goudar, Victor Zak, Andrew M. Atz, Karen Altmann, Steven D. Colan, Christine B. Falkensammer, Mark K. Friedberg, Michele Frommelt, Kevin D. Hill, Daphne T. Hsu, Jami C. Levine, Renee Margossian, Christopher R. Mart, Joshua Sticka, Peter Shrader, Girish Shirali, for the Pediatric Heart Network Investigators
Journal: Cardiology in the Young / Volume 29 / Issue 10 / October 2019
Published online by Cambridge University Press: 03 September 2019, pp. 1248-1256
Print publication: October 2019
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Background:
While echocardiographic parameters are used to quantify ventricular function in infants with single ventricle physiology, there are few data comparing these to invasive measurements. This study correlates echocardiographic measures of diastolic function with ventricular end-diastolic pressure in infants with single ventricle physiology prior to superior cavopulmonary anastomosis.
Methods:
Data from 173 patients enrolled in the Pediatric Heart Network Infant Single Ventricle enalapril trial were analysed. Those with mixed ventricular types (n = 17) and one outlier (end-diastolic pressure = 32 mmHg) were excluded from the analysis, leaving a total sample size of 155 patients. Echocardiographic measurements were correlated to end-diastolic pressure using Spearman’s test.
Results:
Median age at echocardiogram was 4.6 (range 2.5–7.4) months. Median ventricular end-diastolic pressure was 7 (range 3–19) mmHg. Median time difference between the echocardiogram and catheterisation was 0 days (range −35 to 59 days). Examining the entire cohort of 155 patients, no echocardiographic diastolic function variable correlated with ventricular end-diastolic pressure. When the analysis was limited to the 86 patients who had similar sedation for both studies, the systolic:diastolic duration ratio had a significant but weak negative correlation with end-diastolic pressure (r = −0.3, p = 0.004). The remaining echocardiographic variables did not correlate with ventricular end-diastolic pressure.
Conclusion:
In this cohort of infants with single ventricle physiology prior to superior cavopulmonary anastomosis, most conventional echocardiographic measures of diastolic function did not correlate with ventricular end-diastolic pressure at cardiac catheterisation. These limitations should be factored into the interpretation of quantitative echo data in this patient population.

Chapter 5 - Pragmatism, Experience, and Answerability
from Part II
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 157-191
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Introduction
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 1-18
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Pragmatism, Objectivity, and Experience - Title page
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp iii-iii
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Chapter 3 - Communication, Perception, and Objectivity
from Part I
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 82-120
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Conclusion
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 235-242
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Acknowledgments
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp viii-x
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References
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 243-253
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Dedication
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp v-vi
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Copyright page
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp iv-iv
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Chapter 2 - Brandom, Pragmatism, and Experience
from Part I
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 43-81
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Part II
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 121-234
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Part I
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 19-120
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Contents
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp vii-vii
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Chapter 1 - Rorty and the Rejection of Objectivity
from Part I
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 21-42
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Chapter 6 - Meaning, Habit, and the Myth of the Given
from Part II
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 192-234
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Index
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 254-262
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Chapter 4 - An Experiential Account of Objectivity
from Part II
Steven Levine, University of Massachusetts, Boston
Book: Pragmatism, Objectivity, and Experience
Published online: 17 January 2019
Print publication: 24 January 2019, pp 123-156
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Pragmatism, Objectivity, and Experience
Steven Levine
Published online: 17 January 2019
Print publication: 24 January 2019
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View description

In this book Steven Levine explores the relation between objectivity and experience from a pragmatic point of view. Like many new pragmatists he aims to rehabilitate objectivity in the wake of Richard Rorty's rejection of the concept. But he challenges the idea, put forward by pragmatists like Robert Brandom, that objectivity is best rehabilitated in communicative-theoretic terms - namely, in terms that can be cashed out by capacities that agents gain through linguistic communication. Levine proposes instead that objectivity is best understood in experiential-theoretic terms. He explains how, in order to meet the aims of the new pragmatists, we need to do more than see objectivity as a norm of rationality embedded in our social-linguistic practices; we also need to see it as emergent from our experiential interaction with the world. Innovative and carefully argued, this book redeems and re-actualizes for contemporary philosophy a key insight developed by the classical pragmatists.

Chapter 21 - Cerebrovascular Complications of Fabry Disease*
from Section 3 - Hereditary and Genetic Conditions and Malformations
- By Panayiotis D. Mitsias, Steven R. Levine
Edited by Louis Caplan, José Biller
Book: Uncommon Causes of Stroke
Published online: 15 June 2018
Print publication: 05 July 2018, pp 158-169
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Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial

Chapter 5 - Pragmatism, Experience, and Answerability

Introduction

Pragmatism, Objectivity, and Experience - Title page

Chapter 3 - Communication, Perception, and Objectivity

Conclusion

Acknowledgments

References

Dedication

Copyright page

Chapter 2 - Brandom, Pragmatism, and Experience

Part II

Part I

Contents

Chapter 1 - Rorty and the Rejection of Objectivity

Chapter 6 - Meaning, Habit, and the Myth of the Given

Index

Chapter 4 - An Experiential Account of Objectivity

Pragmatism, Objectivity, and Experience

Chapter 21 - Cerebrovascular Complications of Fabry Disease*

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81 results