The articles in this special issue of Business and Politics weigh in on the domestic political dynamics that continue to shape the international political economy, with a focus on the United States case. In this issue, Richard Carney discusses the role of New Deal–era farmers in shaping modern global financial standards, Daniel Kono analyzes the relationship between social policy and support for freer trade, and Kathleen Rehbein and Douglas Schuler examine the characteristics of business firms that are most likely to gain legislative and executive branch access in the area of trade policy. The two final articles provide insights into critical issues in ongoing policy debates. Irja Vormedal discusses the role of business strategies and “tipping points” in determining the support and failure of federal environmental regulation from 1990 through 2010, while Emily Yixuan Cao, Yong Cao, Rashmi Prasad, and Zhengping Shen argue that domestic politics continues (and will continue) to influence the character of U.S.-China exchange rate negotiations. This introduction to the special issue summarizes the contributions of these five articles and also situates them in relation to other contemporary political science debates.